GREMLIN Database
BETB - NAD/NADP-dependent betaine aldehyde dehydrogenase
UniProt: P17445 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10110
Length: 490 (456)
Sequences: 36494 (21812)
Seq/√Len: 1021.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
296_A399_E5.1891.00
239_A244_S3.5421.00
296_A397_T3.2291.00
268_D305_K3.1511.00
299_K397_T2.9651.00
378_S381_M2.7981.00
263_D295_P2.7981.00
25_E37_T2.7901.00
54_Q221_G2.7871.00
356_D370_A2.7841.00
331_F335_D2.6581.00
272_D309_R2.5961.00
343_K382_T2.5671.00
303_E395_I2.5611.00
187_K190_E2.5491.00
342_A346_E2.5441.00
80_R114_E2.4901.00
263_D297_K2.4231.00
82_R85_E2.4041.00
341_I369_V2.3431.00
421_T427_A2.3201.00
54_Q223_A2.3011.00
25_E34_V2.2751.00
42_G45_D2.2141.00
193_S199_D2.1931.00
75_A192_Y2.1481.00
83_N107_V2.1391.00
338_L342_A2.1171.00
350_R376_D2.0711.00
141_E477_K2.0671.00
78_I194_E2.0661.00
401_E426_R2.0421.00
338_L357_V2.0401.00
328_L337_V2.0291.00
180_V330_S2.0041.00
214_Q218_E1.9891.00
412_D458_H1.9881.00
343_K347_E1.9761.00
307_L311_E1.9481.00
259_L274_A1.9341.00
338_L369_V1.9171.00
429_R433_Q1.9141.00
71_I197_L1.9121.00
85_E187_K1.9011.00
352_L375_T1.8991.00
140_R471_Q1.8941.00
301_A305_K1.8901.00
345_K351_V1.8731.00
264_D426_R1.8351.00
236_K239_A1.8071.00
293_F407_R1.7981.00
51_K221_G1.7961.00
435_E457_K1.7951.00
84_D103_T1.7931.00
235_K458_H1.7651.00
140_R474_T1.7631.00
293_F404_V1.7561.00
47_D215_Y1.7511.00
78_I81_E1.7391.00
295_P398_Y1.7331.00
82_R194_E1.7241.00
78_I195_A1.7181.00
384_V396_L1.7071.00
401_E429_R1.6951.00
47_D51_K1.6771.00
78_I191_I1.6751.00
310_V373_V1.6741.00
379_D407_R1.6671.00
374_F383_I1.6631.00
350_R375_T1.6431.00
307_L352_L1.6381.00
403_E406_R1.6301.00
189_A204_V1.6271.00
89_L187_K1.6241.00
73_R114_E1.6211.00
274_A302_F1.6211.00
299_K303_E1.6021.00
34_V37_T1.5911.00
279_F310_V1.5771.00
382_T386_E1.5731.00
113_L164_A1.5681.00
399_E403_E1.5661.00
57_Q61_A1.5631.00
172_A201_V1.5611.00
304_Q308_A1.5541.00
80_R110_A1.5471.00
64_T67_E1.5471.00
218_E241_S1.5401.00
267_L305_K1.5391.00
292_V393_M1.5371.00
77_D81_E1.5281.00
339_R382_T1.5251.00
351_V374_F1.5191.00
47_D219_H1.5161.00
208_V211_E1.5111.00
300_A397_T1.5061.00
305_K308_A1.4971.00
331_F367_A1.4771.00
74_R77_D1.4611.00
293_F398_Y1.4561.00
263_D426_R1.4541.00
67_E70_R1.4531.00
73_R121_P1.4511.00
271_A305_K1.4501.00
33_N365_N1.4461.00
417_A436_A1.4461.00
32_G365_N1.4431.00
77_D114_E1.4361.00
190_E194_E1.4311.00
273_I420_V1.4301.00
262_F426_R1.4291.00
299_K375_T1.4191.00
119_L122_A1.4161.00
402_D433_Q1.4151.00
23_T37_T1.4121.00
62_S433_Q1.4091.00
274_A292_V1.4051.00
84_D88_K1.3981.00
294_V302_F1.3951.00
309_R312_R1.3941.00
301_A304_Q1.3921.00
88_K92_L1.3921.00
76_V114_E1.3791.00
113_L160_L1.3791.00
148_G173_M1.3761.00
342_A345_K1.3671.00
139_R432_H1.3651.00
91_T101_T1.3591.00
45_D48_R1.3521.00
63_M67_E1.3501.00
340_Y388_I1.3501.00
262_F398_Y1.3481.00
238_M461_I1.3431.00
403_E407_R1.3401.00
82_R187_K1.3331.00
337_V390_G1.3301.00
88_K319_F1.3291.00
27_I34_V1.3211.00
314_R322_Q1.3201.00
224_K250_T1.3041.00
57_Q172_A1.3041.00
334_R369_V1.2861.00
22_R40_A1.2851.00
189_A202_F1.2801.00
28_N31_N1.2801.00
398_Y407_R1.2781.00
334_R338_L1.2781.00
400_S403_E1.2731.00
347_E382_T1.2721.00
159_A175_F1.2721.00
335_D339_R1.2671.00
308_A311_E1.2661.00
50_V219_H1.2611.00
311_E353_C1.2591.00
334_R357_V1.2581.00
300_A304_Q1.2551.00
262_F430_V1.2511.00
303_E307_L1.2341.00
405_I430_V1.2301.00
98_Y103_T1.2171.00
331_F334_R1.2161.00
192_Y202_F1.2101.00
76_V80_R1.2071.00
260_I404_V1.2021.00
295_P400_S1.2001.00
86_L187_K1.1921.00
295_P298_C1.1891.00
468_M471_Q1.1771.00
380_D385_R1.1751.00
308_A312_R1.1731.00
344_G374_F1.1701.00
51_K55_Q1.1661.00
349_A374_F1.1641.00
140_R476_V1.1631.00
314_R324_N1.1631.00
91_T318_V1.1601.00
306_I393_M1.1581.00
137_Y428_H1.1551.00
200_G203_N1.1551.00
179_E210_A1.1551.00
298_C301_A1.1541.00
40_A208_V1.1531.00
50_V221_G1.1531.00
215_Y219_H1.1481.00
316_G323_T1.1461.00
88_K98_Y1.1451.00
417_A439_C1.1411.00
302_F306_I1.1401.00
126_S467_V1.1361.00
63_M71_I1.1311.00
214_Q236_K1.1301.00
75_A197_L1.1271.00
75_A191_I1.1261.00
467_V471_Q1.1261.00
303_E352_L1.1251.00
303_E375_T1.1241.00
305_K309_R1.1241.00
379_D410_D1.1241.00
50_V222_I1.1211.00
431_I479_I1.1191.00
179_E208_V1.1161.00
385_R410_D1.1141.00
163_S202_F1.1141.00
339_R343_K1.1121.00
46_V212_T1.1121.00
233_S236_K1.1101.00
74_R78_I1.1091.00
427_A441_I1.1091.00
75_A113_L1.1001.00
313_I325_F1.0971.00
385_R412_D1.0951.00
28_N317_D1.0921.00
30_A318_V1.0921.00
126_S468_M1.0921.00
148_G226_S1.0881.00
52_S203_N1.0811.00
143_L224_K1.0751.00
259_L289_G1.0731.00
454_G463_R1.0721.00
260_I430_V1.0691.00
43_R215_Y1.0691.00
359_K364_D1.0681.00
232_A236_K1.0671.00
402_D406_R1.0631.00
311_E370_A1.0611.00
186_L206_P1.0591.00
238_M249_V1.0591.00
83_N103_T1.0571.00
405_I433_Q1.0571.00
73_R118_G1.0561.00
358_L370_A1.0551.00
36_A183_L1.0541.00
307_L353_C1.0521.00
463_R475_Q1.0511.00
260_I408_A1.0501.00
256_K290_T1.0491.00
24_F40_A1.0481.00
154_Y285_V1.0461.00
468_M476_V1.0421.00
402_D429_R1.0411.00
347_E381_M1.0391.00
163_S173_M1.0381.00
266_D422_A1.0251.00
147_A222_I1.0191.00
40_A211_E1.0141.00
354_G372_T1.0121.00
86_L191_I1.0111.00
56_G172_A1.0111.00
81_E194_E1.0081.00
423_D426_R1.0021.00
398_Y404_V1.0001.00
337_V392_V0.9991.00
317_D320_D0.9951.00
186_L204_V0.9951.00
82_R191_I0.9951.00
235_K246_L0.9901.00
147_A216_L0.9891.00
58_K406_R0.9861.00
109_G160_L0.9851.00
334_R367_A0.9831.00
354_G370_A0.9781.00
401_E430_V0.9771.00
239_A243_A0.9751.00
58_K435_E0.9711.00
32_G367_A0.9701.00
139_R479_I0.9701.00
20_S42_G0.9601.00
258_P417_A0.9581.00
69_S121_P0.9571.00
120_I168_A0.9561.00
266_D269_L0.9551.00
143_L248_E0.9451.00
223_A435_E0.9431.00
179_E209_G0.9401.00
82_R190_E0.9401.00
456_Y475_Q0.9391.00
277_A289_G0.9391.00
145_V172_A0.9381.00
28_N92_L0.9341.00
190_E193_S0.9331.00
96_K105_D0.9321.00
377_C381_M0.9311.00
54_Q58_K0.9251.00
58_K62_S0.9221.00
300_A303_E0.9191.00
85_E88_K0.9181.00
340_Y343_K0.9161.00
418_G444_W0.9151.00
214_Q241_S0.9151.00
278_N290_T0.9141.00
141_E432_H0.9121.00
268_D301_A0.9111.00
43_R211_E0.9101.00
343_K346_E0.9091.00
92_L319_F0.9071.00
269_L273_I0.9051.00
145_V222_I0.9041.00
43_R47_D0.9031.00
275_M309_R0.9031.00
271_A306_I0.9011.00
406_R410_D0.9011.00
61_A435_E0.9011.00
28_N33_N0.9001.00
73_R117_A0.9001.00
262_F401_E0.9001.00
248_E475_Q0.8981.00
238_M243_A0.8971.00
230_G233_S0.8951.00
299_K395_I0.8931.00
146_V224_K0.8911.00
218_E244_S0.8871.00
136_V451_M0.8861.00
70_R74_R0.8841.00
337_V388_I0.8811.00
141_E456_Y0.8781.00
340_Y382_T0.8771.00
267_L271_A0.8751.00
259_L420_V0.8721.00
94_T181_T0.8711.00
339_R342_A0.8711.00
335_D338_L0.8691.00
79_L109_G0.8691.00
69_S73_R0.8681.00
46_V147_A0.8671.00
78_I82_R0.8661.00
349_A381_M0.8661.00
76_V117_A0.8661.00
348_G381_M0.8651.00
396_L407_R0.8641.00
65_A69_S0.8621.00
379_D396_L0.8581.00
355_G372_T0.8541.00
262_F421_T0.8501.00
109_G156_I0.8491.00
404_V407_R0.8491.00
271_A309_R0.8491.00
143_L171_N0.8431.00
180_V332_P0.8431.00
345_K374_F0.8421.00
213_G217_T0.8391.00
451_M478_S0.8381.00
238_M242_A0.8381.00
235_K239_A0.8361.00
428_H432_H0.8351.00
417_A434_L0.8341.00
69_S117_A0.8331.00
236_K241_S0.8311.00
62_S432_H0.8291.00
56_G201_V0.8291.00
27_I367_A0.8281.00
270_A274_A0.8251.00
261_V302_F0.8251.00
398_Y403_E0.8211.00
344_G388_I0.8201.00
271_A302_F0.8191.00
143_L475_Q0.8181.00
419_I430_V0.8171.00
48_R52_S0.8171.00
137_Y481_V0.8171.00
405_I409_N0.8151.00
225_V237_V0.8141.00
175_F185_A0.8091.00
257_S290_T0.8061.00
24_F208_V0.8031.00
234_G253_L0.8001.00
162_K464_E0.8001.00
424_L427_A0.7991.00
238_M246_L0.7971.00
341_I392_V0.7961.00
165_P469_T0.7941.00
30_A368_W0.7921.00
189_A193_S0.7921.00
44_E48_R0.7911.00
159_A163_S0.7891.00
186_L190_E0.7881.00
169_A474_T0.7851.00
375_T397_T0.7851.00
304_Q307_L0.7841.00
52_S200_G0.7821.00
94_T329_V0.7811.00
79_L110_A0.7811.00
44_E47_D0.7801.00
197_L202_F0.7791.00
60_W201_V0.7781.00
53_A203_N0.7751.00
48_R51_K0.7731.00
337_V369_V0.7721.00
299_K376_D0.7711.00
72_L168_A0.7711.00
271_A275_M0.7691.00
73_R77_D0.7671.00
55_Q58_K0.7661.00
436_A439_C0.7651.00
234_G251_M0.7651.00
166_A173_M0.7641.00
91_T98_Y0.7641.00
99_S324_N0.7631.00
35_L92_L0.7601.00
210_A214_Q0.7591.00
41_A45_D0.7581.00
315_A358_L0.7571.00
66_M121_P0.7551.00
177_P206_P0.7551.00
241_S244_S0.7531.00
147_A225_V0.7521.00
227_F233_S0.7521.00
270_A302_F0.7511.00
41_A49_A0.7511.00
160_L188_L0.7511.00
359_K365_N0.7471.00
267_L298_C0.7421.00
207_G212_T0.7421.00
258_P408_A0.7421.00
148_G162_K0.7391.00
98_Y319_F0.7381.00
87_A91_T0.7361.00
55_Q59_I0.7361.00
313_I324_N0.7351.00
74_R195_A0.7351.00
156_I184_T0.7331.00
197_L201_V0.7331.00
306_I373_V0.7321.00
295_P401_E0.7301.00
87_A98_Y0.7291.00
310_V353_C0.7291.00
58_K61_A0.7281.00
217_T237_V0.7281.00
320_D323_T0.7271.00
225_V242_A0.7271.00
87_A103_T0.7191.00
231_V458_H0.7181.00
275_M306_I0.7171.00
28_N319_F0.7171.00
294_V298_C0.7151.00
80_R83_N0.7151.00
147_A213_G0.7131.00
71_I195_A0.7121.00
262_F295_P0.7091.00
235_K244_S0.7091.00
332_P335_D0.7081.00
80_R107_V0.7061.00
268_D309_R0.7051.00
340_Y386_E0.7041.00
90_E93_D0.6971.00
180_V329_V0.6941.00
92_L183_L0.6941.00
211_E214_Q0.6941.00
171_N474_T0.6901.00
400_S406_R0.6901.00
307_L310_V0.6891.00
175_F202_F0.6891.00
159_A185_A0.6871.00
212_T215_Y0.6871.00
59_I63_M0.6861.00
27_I32_G0.6841.00
103_T107_V0.6831.00
293_F384_V0.6791.00
422_A425_N0.6781.00
401_E405_I0.6781.00
22_R211_E0.6781.00
47_D221_G0.6771.00
334_R358_L0.6771.00
424_L481_V0.6761.00
310_V313_I0.6741.00
84_D98_Y0.6731.00
353_C373_V0.6731.00
264_D421_T0.6721.00
60_W71_I0.6711.00
336_N339_R0.6691.00
317_D323_T0.6681.00
143_L223_A0.6681.00
315_A325_F0.6671.00
96_K100_E0.6671.00
341_I374_F0.6661.00
215_Y218_E0.6651.00
242_A249_V0.6641.00
248_E472_S0.6621.00
150_G159_A0.6621.00
89_L183_L0.6611.00
345_K356_D0.6611.00
282_S325_F0.6611.00
331_F357_V0.6601.00
174_I203_N0.6601.00
46_V50_V0.6581.00
441_I481_V0.6581.00
292_V302_F0.6581.00
136_V478_S0.6581.00
53_A172_A0.6571.00
86_L156_I0.6571.00
46_V215_Y0.6561.00
379_D384_V0.6551.00
32_G331_F0.6541.00
369_V372_T0.6541.00
54_Q57_Q0.6541.00
159_A188_L0.6531.00
293_F379_D0.6521.00
85_E190_E0.6511.00
65_A120_I0.6491.00
207_G213_G0.6491.00
333_H336_N0.6491.00
275_M313_I0.6471.00
330_S333_H0.6461.00
77_D80_R0.6461.00
274_A306_I0.6451.00
39_Q206_P0.6451.00
61_A433_Q0.6441.00
306_I395_I0.6441.00
407_R410_D0.6431.00
96_K154_Y0.6421.00
431_I441_I0.6421.00
377_C384_V0.6401.00
41_A205_L0.6401.00
261_V270_A0.6391.00
179_E336_N0.6391.00
424_L428_H0.6391.00
61_A142_P0.6381.00
377_C383_I0.6371.00
61_A141_E0.6361.00
60_W167_L0.6351.00
137_Y479_I0.6351.00
338_L341_I0.6321.00
135_F428_H0.6301.00
217_T225_V0.6271.00
59_I62_S0.6261.00
332_P336_N0.6251.00
471_Q474_T0.6251.00
355_G370_A0.6251.00
162_K226_S0.6251.00
136_V480_Q0.6241.00
192_Y197_L0.6241.00
52_S199_D0.6241.00
435_E456_Y0.6231.00
471_Q476_V0.6221.00
76_V110_A0.6211.00
23_T39_Q0.6201.00
58_K433_Q0.6181.00
421_T426_R0.6181.00
267_L301_A0.6171.00
250_T472_S0.6161.00
374_F377_C0.6151.00
38_V182_P0.6151.00
139_R477_K0.6141.00
187_K191_I0.6141.00
209_G213_G0.6131.00
388_I392_V0.6121.00
427_A431_I0.6121.00
172_A203_N0.6111.00
269_L272_D0.6101.00
106_I110_A0.6061.00
217_T241_S0.6051.00
179_E236_K0.6011.00
347_E380_D0.6011.00
328_L333_H0.6011.00
67_E71_I0.6001.00
65_A168_A0.6001.00
91_T319_F0.5991.00
90_E101_T0.5991.00
26_T36_A0.5981.00
51_K54_Q0.5971.00
241_S245_S0.5961.00
90_E184_T0.5961.00
269_L422_A0.5941.00
351_V354_G0.5941.00
419_I427_A0.5931.00
43_R218_E0.5921.00
79_L188_L0.5911.00
156_I188_L0.5911.00
90_E105_D0.5911.00
88_K91_T0.5901.00
123_L474_T0.5891.00
238_M251_M0.5891.00
259_L292_V0.5881.00
83_N87_A0.5871.00
163_S175_F0.5871.00
56_G59_I0.5861.00
214_Q217_T0.5861.00
26_T93_D0.5841.00
428_H481_V0.5841.00
264_D423_D0.5841.00
405_I429_R0.5831.00
146_V171_N0.5821.00
76_V113_L0.5821.00
351_V372_T0.5791.00
224_K472_S0.5761.00
210_A236_K0.5761.00
49_A205_L0.5741.00
358_L364_D0.5731.00
79_L113_L0.5731.00
106_I156_I0.5721.00
35_L183_L0.5721.00
425_N428_H0.5721.00
376_D397_T0.5721.00
357_V370_A0.5681.00
231_V235_K0.5681.00
20_S45_D0.5671.00
123_L470_L0.5671.00
425_N429_R0.5661.00
341_I372_T0.5651.00
439_C477_K0.5651.00
294_V395_I0.5651.00
294_V299_K0.5641.00
307_L373_V0.5631.00
259_L418_G0.5621.00
193_S196_G0.5611.00
79_L156_I0.5611.00
285_V288_N0.5591.00
314_R320_D0.5581.00
75_A78_I0.5541.00
71_I75_A0.5531.00
265_A270_A0.5531.00
315_A324_N0.5531.00
103_T321_P0.5521.00
115_Y119_L0.5511.00
257_S416_A0.5511.00
405_I434_L0.5501.00
264_D422_A0.5501.00
263_D398_Y0.5501.00
404_V408_A0.5491.00
278_N393_M0.5491.00
328_L369_V0.5481.00
105_D154_Y0.5481.00
87_A106_I0.5471.00
379_D406_R0.5461.00
54_Q145_V0.5461.00
419_I441_I0.5411.00
267_L270_A0.5401.00
188_L192_Y0.5401.00
26_T182_P0.5391.00
146_V173_M0.5381.00
148_G163_S0.5371.00
86_L106_I0.5371.00
383_I388_I0.5361.00
157_Q161_W0.5361.00
296_A299_K0.5351.00
292_V395_I0.5351.00
145_V223_A0.5341.00
435_E475_Q0.5311.00
116_Y165_P0.5311.00
279_F313_I0.5311.00
408_A434_L0.5301.00
53_A174_I0.5301.00
147_A174_I0.5301.00
108_T157_Q0.5291.00
169_A470_L0.5291.00
52_S56_G0.5291.00
440_W443_T0.5291.00
289_G418_G0.5271.00
79_L86_L0.5271.00
338_L345_K0.5271.00
232_A332_P0.5251.00
43_R214_Q0.5241.00
271_A298_C0.5241.00
430_V434_L0.5231.00
118_G121_P0.5231.00
401_E433_Q0.5201.00
268_D308_A0.5191.00
179_E232_A0.5191.00
347_E378_S0.5191.00
22_R42_G0.5191.00
193_S200_G0.5181.00
38_V183_L0.5171.00
94_T281_S0.5161.00
434_L439_C0.5141.00
49_A203_N0.5131.00
416_A440_W0.5121.00
119_L467_V0.5121.00
146_V226_S0.5121.00
384_V407_R0.5121.00
53_A145_V0.5111.00
217_T245_S0.5101.00
267_L302_F0.5081.00
167_L202_F0.5071.00
108_T447_S0.5061.00
83_N110_A0.5061.00
340_Y383_I0.5051.00
87_A101_T0.5051.00
306_I310_V0.5041.00
249_V461_I0.5041.00
66_M70_R0.5031.00
26_T35_L0.5031.00
74_R196_G0.5021.00
304_Q311_E0.5001.00
141_E435_E0.5001.00
71_I196_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o5hA 4 0.9776 100 0.025 Contact Map
4yweA 5 0.9673 100 0.025 Contact Map
1a4sA 4 0.9939 100 0.027 Contact Map
4qf6A 4 0.9755 100 0.028 Contact Map
4wj9A 4 0.9816 100 0.028 Contact Map
4pxlA 4 0.9837 100 0.028 Contact Map
4qtoA 4 0.9959 100 0.031 Contact Map
4pz2A 4 0.9918 100 0.032 Contact Map
1o04A 5 0.9857 100 0.032 Contact Map
3ek1A 5 0.9735 100 0.032 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0148 seconds.