BETB - ECOLI - GREMLIN Contacts

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BETB - NAD/NADP-dependent betaine aldehyde dehydrogenase

UniProt:	P17445	Sequences: MSRMAEQQLYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIWASMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLIPALEGSQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKGDGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMAKFQSIF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10110
Length:	490 (456)
Sequences:	36494 (21812)
Seq/√Len:	1021.4

ECOLI - BETB PUUC GABD ALDB FEAB ABDH ALDA ASTD EUTE SAD PUTA PAAZ PROA ADHE
BACSU - ALDH4 ALDH1 ROCA ROCA2 ALDH5 IOLA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HMJ6 Q9HQZ2 Q9HRB5 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
296_A	399_E	5.189	1.00
239_A	244_S	3.542	1.00
296_A	397_T	3.229	1.00
268_D	305_K	3.151	1.00
299_K	397_T	2.965	1.00
378_S	381_M	2.798	1.00
263_D	295_P	2.798	1.00
25_E	37_T	2.790	1.00
54_Q	221_G	2.787	1.00
356_D	370_A	2.784	1.00
331_F	335_D	2.658	1.00
272_D	309_R	2.596	1.00
343_K	382_T	2.567	1.00
303_E	395_I	2.561	1.00
187_K	190_E	2.549	1.00
342_A	346_E	2.544	1.00
80_R	114_E	2.490	1.00
263_D	297_K	2.423	1.00
82_R	85_E	2.404	1.00
341_I	369_V	2.343	1.00
421_T	427_A	2.320	1.00
54_Q	223_A	2.301	1.00
25_E	34_V	2.275	1.00
42_G	45_D	2.214	1.00
193_S	199_D	2.193	1.00
75_A	192_Y	2.148	1.00
83_N	107_V	2.139	1.00
338_L	342_A	2.117	1.00
350_R	376_D	2.071	1.00
141_E	477_K	2.067	1.00
78_I	194_E	2.066	1.00
401_E	426_R	2.042	1.00
338_L	357_V	2.040	1.00
328_L	337_V	2.029	1.00
180_V	330_S	2.004	1.00
214_Q	218_E	1.989	1.00
412_D	458_H	1.988	1.00
343_K	347_E	1.976	1.00
307_L	311_E	1.948	1.00
259_L	274_A	1.934	1.00
338_L	369_V	1.917	1.00
429_R	433_Q	1.914	1.00
71_I	197_L	1.912	1.00
85_E	187_K	1.901	1.00
352_L	375_T	1.899	1.00
140_R	471_Q	1.894	1.00
301_A	305_K	1.890	1.00
345_K	351_V	1.873	1.00
264_D	426_R	1.835	1.00
236_K	239_A	1.807	1.00
293_F	407_R	1.798	1.00
51_K	221_G	1.796	1.00
435_E	457_K	1.795	1.00
84_D	103_T	1.793	1.00
235_K	458_H	1.765	1.00
140_R	474_T	1.763	1.00
293_F	404_V	1.756	1.00
47_D	215_Y	1.751	1.00
78_I	81_E	1.739	1.00
295_P	398_Y	1.733	1.00
82_R	194_E	1.724	1.00
78_I	195_A	1.718	1.00
384_V	396_L	1.707	1.00
401_E	429_R	1.695	1.00
47_D	51_K	1.677	1.00
78_I	191_I	1.675	1.00
310_V	373_V	1.674	1.00
379_D	407_R	1.667	1.00
374_F	383_I	1.663	1.00
350_R	375_T	1.643	1.00
307_L	352_L	1.638	1.00
403_E	406_R	1.630	1.00
189_A	204_V	1.627	1.00
89_L	187_K	1.624	1.00
73_R	114_E	1.621	1.00
274_A	302_F	1.621	1.00
299_K	303_E	1.602	1.00
34_V	37_T	1.591	1.00
279_F	310_V	1.577	1.00
382_T	386_E	1.573	1.00
113_L	164_A	1.568	1.00
399_E	403_E	1.566	1.00
57_Q	61_A	1.563	1.00
172_A	201_V	1.561	1.00
304_Q	308_A	1.554	1.00
80_R	110_A	1.547	1.00
64_T	67_E	1.547	1.00
218_E	241_S	1.540	1.00
267_L	305_K	1.539	1.00
292_V	393_M	1.537	1.00
77_D	81_E	1.528	1.00
339_R	382_T	1.525	1.00
351_V	374_F	1.519	1.00
47_D	219_H	1.516	1.00
208_V	211_E	1.511	1.00
300_A	397_T	1.506	1.00
305_K	308_A	1.497	1.00
331_F	367_A	1.477	1.00
74_R	77_D	1.461	1.00
293_F	398_Y	1.456	1.00
263_D	426_R	1.454	1.00
67_E	70_R	1.453	1.00
73_R	121_P	1.451	1.00
271_A	305_K	1.450	1.00
33_N	365_N	1.446	1.00
417_A	436_A	1.446	1.00
32_G	365_N	1.443	1.00
77_D	114_E	1.436	1.00
190_E	194_E	1.431	1.00
273_I	420_V	1.430	1.00
262_F	426_R	1.429	1.00
299_K	375_T	1.419	1.00
119_L	122_A	1.416	1.00
402_D	433_Q	1.415	1.00
23_T	37_T	1.412	1.00
62_S	433_Q	1.409	1.00
274_A	292_V	1.405	1.00
84_D	88_K	1.398	1.00
294_V	302_F	1.395	1.00
309_R	312_R	1.394	1.00
301_A	304_Q	1.392	1.00
88_K	92_L	1.392	1.00
76_V	114_E	1.379	1.00
113_L	160_L	1.379	1.00
148_G	173_M	1.376	1.00
342_A	345_K	1.367	1.00
139_R	432_H	1.365	1.00
91_T	101_T	1.359	1.00
45_D	48_R	1.352	1.00
63_M	67_E	1.350	1.00
340_Y	388_I	1.350	1.00
262_F	398_Y	1.348	1.00
238_M	461_I	1.343	1.00
403_E	407_R	1.340	1.00
82_R	187_K	1.333	1.00
337_V	390_G	1.330	1.00
88_K	319_F	1.329	1.00
27_I	34_V	1.321	1.00
314_R	322_Q	1.320	1.00
224_K	250_T	1.304	1.00
57_Q	172_A	1.304	1.00
334_R	369_V	1.286	1.00
22_R	40_A	1.285	1.00
189_A	202_F	1.280	1.00
28_N	31_N	1.280	1.00
398_Y	407_R	1.278	1.00
334_R	338_L	1.278	1.00
400_S	403_E	1.273	1.00
347_E	382_T	1.272	1.00
159_A	175_F	1.272	1.00
335_D	339_R	1.267	1.00
308_A	311_E	1.266	1.00
50_V	219_H	1.261	1.00
311_E	353_C	1.259	1.00
334_R	357_V	1.258	1.00
300_A	304_Q	1.255	1.00
262_F	430_V	1.251	1.00
303_E	307_L	1.234	1.00
405_I	430_V	1.230	1.00
98_Y	103_T	1.217	1.00
331_F	334_R	1.216	1.00
192_Y	202_F	1.210	1.00
76_V	80_R	1.207	1.00
260_I	404_V	1.202	1.00
295_P	400_S	1.200	1.00
86_L	187_K	1.192	1.00
295_P	298_C	1.189	1.00
468_M	471_Q	1.177	1.00
380_D	385_R	1.175	1.00
308_A	312_R	1.173	1.00
344_G	374_F	1.170	1.00
51_K	55_Q	1.166	1.00
349_A	374_F	1.164	1.00
140_R	476_V	1.163	1.00
314_R	324_N	1.163	1.00
91_T	318_V	1.160	1.00
306_I	393_M	1.158	1.00
137_Y	428_H	1.155	1.00
200_G	203_N	1.155	1.00
179_E	210_A	1.155	1.00
298_C	301_A	1.154	1.00
40_A	208_V	1.153	1.00
50_V	221_G	1.153	1.00
215_Y	219_H	1.148	1.00
316_G	323_T	1.146	1.00
88_K	98_Y	1.145	1.00
417_A	439_C	1.141	1.00
302_F	306_I	1.140	1.00
126_S	467_V	1.136	1.00
63_M	71_I	1.131	1.00
214_Q	236_K	1.130	1.00
75_A	197_L	1.127	1.00
75_A	191_I	1.126	1.00
467_V	471_Q	1.126	1.00
303_E	352_L	1.125	1.00
303_E	375_T	1.124	1.00
305_K	309_R	1.124	1.00
379_D	410_D	1.124	1.00
50_V	222_I	1.121	1.00
431_I	479_I	1.119	1.00
179_E	208_V	1.116	1.00
385_R	410_D	1.114	1.00
163_S	202_F	1.114	1.00
339_R	343_K	1.112	1.00
46_V	212_T	1.112	1.00
233_S	236_K	1.110	1.00
74_R	78_I	1.109	1.00
427_A	441_I	1.109	1.00
75_A	113_L	1.100	1.00
313_I	325_F	1.097	1.00
385_R	412_D	1.095	1.00
28_N	317_D	1.092	1.00
30_A	318_V	1.092	1.00
126_S	468_M	1.092	1.00
148_G	226_S	1.088	1.00
52_S	203_N	1.081	1.00
143_L	224_K	1.075	1.00
259_L	289_G	1.073	1.00
454_G	463_R	1.072	1.00
260_I	430_V	1.069	1.00
43_R	215_Y	1.069	1.00
359_K	364_D	1.068	1.00
232_A	236_K	1.067	1.00
402_D	406_R	1.063	1.00
311_E	370_A	1.061	1.00
186_L	206_P	1.059	1.00
238_M	249_V	1.059	1.00
83_N	103_T	1.057	1.00
405_I	433_Q	1.057	1.00
73_R	118_G	1.056	1.00
358_L	370_A	1.055	1.00
36_A	183_L	1.054	1.00
307_L	353_C	1.052	1.00
463_R	475_Q	1.051	1.00
260_I	408_A	1.050	1.00
256_K	290_T	1.049	1.00
24_F	40_A	1.048	1.00
154_Y	285_V	1.046	1.00
468_M	476_V	1.042	1.00
402_D	429_R	1.041	1.00
347_E	381_M	1.039	1.00
163_S	173_M	1.038	1.00
266_D	422_A	1.025	1.00
147_A	222_I	1.019	1.00
40_A	211_E	1.014	1.00
354_G	372_T	1.012	1.00
86_L	191_I	1.011	1.00
56_G	172_A	1.011	1.00
81_E	194_E	1.008	1.00
423_D	426_R	1.002	1.00
398_Y	404_V	1.000	1.00
337_V	392_V	0.999	1.00
317_D	320_D	0.995	1.00
186_L	204_V	0.995	1.00
82_R	191_I	0.995	1.00
235_K	246_L	0.990	1.00
147_A	216_L	0.989	1.00
58_K	406_R	0.986	1.00
109_G	160_L	0.985	1.00
334_R	367_A	0.983	1.00
354_G	370_A	0.978	1.00
401_E	430_V	0.977	1.00
239_A	243_A	0.975	1.00
58_K	435_E	0.971	1.00
32_G	367_A	0.970	1.00
139_R	479_I	0.970	1.00
20_S	42_G	0.960	1.00
258_P	417_A	0.958	1.00
69_S	121_P	0.957	1.00
120_I	168_A	0.956	1.00
266_D	269_L	0.955	1.00
143_L	248_E	0.945	1.00
223_A	435_E	0.943	1.00
179_E	209_G	0.940	1.00
82_R	190_E	0.940	1.00
456_Y	475_Q	0.939	1.00
277_A	289_G	0.939	1.00
145_V	172_A	0.938	1.00
28_N	92_L	0.934	1.00
190_E	193_S	0.933	1.00
96_K	105_D	0.932	1.00
377_C	381_M	0.931	1.00
54_Q	58_K	0.925	1.00
58_K	62_S	0.922	1.00
300_A	303_E	0.919	1.00
85_E	88_K	0.918	1.00
340_Y	343_K	0.916	1.00
418_G	444_W	0.915	1.00
214_Q	241_S	0.915	1.00
278_N	290_T	0.914	1.00
141_E	432_H	0.912	1.00
268_D	301_A	0.911	1.00
43_R	211_E	0.910	1.00
343_K	346_E	0.909	1.00
92_L	319_F	0.907	1.00
269_L	273_I	0.905	1.00
145_V	222_I	0.904	1.00
43_R	47_D	0.903	1.00
275_M	309_R	0.903	1.00
271_A	306_I	0.901	1.00
406_R	410_D	0.901	1.00
61_A	435_E	0.901	1.00
28_N	33_N	0.900	1.00
73_R	117_A	0.900	1.00
262_F	401_E	0.900	1.00
248_E	475_Q	0.898	1.00
238_M	243_A	0.897	1.00
230_G	233_S	0.895	1.00
299_K	395_I	0.893	1.00
146_V	224_K	0.891	1.00
218_E	244_S	0.887	1.00
136_V	451_M	0.886	1.00
70_R	74_R	0.884	1.00
337_V	388_I	0.881	1.00
141_E	456_Y	0.878	1.00
340_Y	382_T	0.877	1.00
267_L	271_A	0.875	1.00
259_L	420_V	0.872	1.00
94_T	181_T	0.871	1.00
339_R	342_A	0.871	1.00
335_D	338_L	0.869	1.00
79_L	109_G	0.869	1.00
69_S	73_R	0.868	1.00
46_V	147_A	0.867	1.00
78_I	82_R	0.866	1.00
349_A	381_M	0.866	1.00
76_V	117_A	0.866	1.00
348_G	381_M	0.865	1.00
396_L	407_R	0.864	1.00
65_A	69_S	0.862	1.00
379_D	396_L	0.858	1.00
355_G	372_T	0.854	1.00
262_F	421_T	0.850	1.00
109_G	156_I	0.849	1.00
404_V	407_R	0.849	1.00
271_A	309_R	0.849	1.00
143_L	171_N	0.843	1.00
180_V	332_P	0.843	1.00
345_K	374_F	0.842	1.00
213_G	217_T	0.839	1.00
451_M	478_S	0.838	1.00
238_M	242_A	0.838	1.00
235_K	239_A	0.836	1.00
428_H	432_H	0.835	1.00
417_A	434_L	0.834	1.00
69_S	117_A	0.833	1.00
236_K	241_S	0.831	1.00
62_S	432_H	0.829	1.00
56_G	201_V	0.829	1.00
27_I	367_A	0.828	1.00
270_A	274_A	0.825	1.00
261_V	302_F	0.825	1.00
398_Y	403_E	0.821	1.00
344_G	388_I	0.820	1.00
271_A	302_F	0.819	1.00
143_L	475_Q	0.818	1.00
419_I	430_V	0.817	1.00
48_R	52_S	0.817	1.00
137_Y	481_V	0.817	1.00
405_I	409_N	0.815	1.00
225_V	237_V	0.814	1.00
175_F	185_A	0.809	1.00
257_S	290_T	0.806	1.00
24_F	208_V	0.803	1.00
234_G	253_L	0.800	1.00
162_K	464_E	0.800	1.00
424_L	427_A	0.799	1.00
238_M	246_L	0.797	1.00
341_I	392_V	0.796	1.00
165_P	469_T	0.794	1.00
30_A	368_W	0.792	1.00
189_A	193_S	0.792	1.00
44_E	48_R	0.791	1.00
159_A	163_S	0.789	1.00
186_L	190_E	0.788	1.00
169_A	474_T	0.785	1.00
375_T	397_T	0.785	1.00
304_Q	307_L	0.784	1.00
52_S	200_G	0.782	1.00
94_T	329_V	0.781	1.00
79_L	110_A	0.781	1.00
44_E	47_D	0.780	1.00
197_L	202_F	0.779	1.00
60_W	201_V	0.778	1.00
53_A	203_N	0.775	1.00
48_R	51_K	0.773	1.00
337_V	369_V	0.772	1.00
299_K	376_D	0.771	1.00
72_L	168_A	0.771	1.00
271_A	275_M	0.769	1.00
73_R	77_D	0.767	1.00
55_Q	58_K	0.766	1.00
436_A	439_C	0.765	1.00
234_G	251_M	0.765	1.00
166_A	173_M	0.764	1.00
91_T	98_Y	0.764	1.00
99_S	324_N	0.763	1.00
35_L	92_L	0.760	1.00
210_A	214_Q	0.759	1.00
41_A	45_D	0.758	1.00
315_A	358_L	0.757	1.00
66_M	121_P	0.755	1.00
177_P	206_P	0.755	1.00
241_S	244_S	0.753	1.00
147_A	225_V	0.752	1.00
227_F	233_S	0.752	1.00
270_A	302_F	0.751	1.00
41_A	49_A	0.751	1.00
160_L	188_L	0.751	1.00
359_K	365_N	0.747	1.00
267_L	298_C	0.742	1.00
207_G	212_T	0.742	1.00
258_P	408_A	0.742	1.00
148_G	162_K	0.739	1.00
98_Y	319_F	0.738	1.00
87_A	91_T	0.736	1.00
55_Q	59_I	0.736	1.00
313_I	324_N	0.735	1.00
74_R	195_A	0.735	1.00
156_I	184_T	0.733	1.00
197_L	201_V	0.733	1.00
306_I	373_V	0.732	1.00
295_P	401_E	0.730	1.00
87_A	98_Y	0.729	1.00
310_V	353_C	0.729	1.00
58_K	61_A	0.728	1.00
217_T	237_V	0.728	1.00
320_D	323_T	0.727	1.00
225_V	242_A	0.727	1.00
87_A	103_T	0.719	1.00
231_V	458_H	0.718	1.00
275_M	306_I	0.717	1.00
28_N	319_F	0.717	1.00
294_V	298_C	0.715	1.00
80_R	83_N	0.715	1.00
147_A	213_G	0.713	1.00
71_I	195_A	0.712	1.00
262_F	295_P	0.709	1.00
235_K	244_S	0.709	1.00
332_P	335_D	0.708	1.00
80_R	107_V	0.706	1.00
268_D	309_R	0.705	1.00
340_Y	386_E	0.704	1.00
90_E	93_D	0.697	1.00
180_V	329_V	0.694	1.00
92_L	183_L	0.694	1.00
211_E	214_Q	0.694	1.00
171_N	474_T	0.690	1.00
400_S	406_R	0.690	1.00
307_L	310_V	0.689	1.00
175_F	202_F	0.689	1.00
159_A	185_A	0.687	1.00
212_T	215_Y	0.687	1.00
59_I	63_M	0.686	1.00
27_I	32_G	0.684	1.00
103_T	107_V	0.683	1.00
293_F	384_V	0.679	1.00
422_A	425_N	0.678	1.00
401_E	405_I	0.678	1.00
22_R	211_E	0.678	1.00
47_D	221_G	0.677	1.00
334_R	358_L	0.677	1.00
424_L	481_V	0.676	1.00
310_V	313_I	0.674	1.00
84_D	98_Y	0.673	1.00
353_C	373_V	0.673	1.00
264_D	421_T	0.672	1.00
60_W	71_I	0.671	1.00
336_N	339_R	0.669	1.00
317_D	323_T	0.668	1.00
143_L	223_A	0.668	1.00
315_A	325_F	0.667	1.00
96_K	100_E	0.667	1.00
341_I	374_F	0.666	1.00
215_Y	218_E	0.665	1.00
242_A	249_V	0.664	1.00
248_E	472_S	0.662	1.00
150_G	159_A	0.662	1.00
89_L	183_L	0.661	1.00
345_K	356_D	0.661	1.00
282_S	325_F	0.661	1.00
331_F	357_V	0.660	1.00
174_I	203_N	0.660	1.00
46_V	50_V	0.658	1.00
441_I	481_V	0.658	1.00
292_V	302_F	0.658	1.00
136_V	478_S	0.658	1.00
53_A	172_A	0.657	1.00
86_L	156_I	0.657	1.00
46_V	215_Y	0.656	1.00
379_D	384_V	0.655	1.00
32_G	331_F	0.654	1.00
369_V	372_T	0.654	1.00
54_Q	57_Q	0.654	1.00
159_A	188_L	0.653	1.00
293_F	379_D	0.652	1.00
85_E	190_E	0.651	1.00
65_A	120_I	0.649	1.00
207_G	213_G	0.649	1.00
333_H	336_N	0.649	1.00
275_M	313_I	0.647	1.00
330_S	333_H	0.646	1.00
77_D	80_R	0.646	1.00
274_A	306_I	0.645	1.00
39_Q	206_P	0.645	1.00
61_A	433_Q	0.644	1.00
306_I	395_I	0.644	1.00
407_R	410_D	0.643	1.00
96_K	154_Y	0.642	1.00
431_I	441_I	0.642	1.00
377_C	384_V	0.640	1.00
41_A	205_L	0.640	1.00
261_V	270_A	0.639	1.00
179_E	336_N	0.639	1.00
424_L	428_H	0.639	1.00
61_A	142_P	0.638	1.00
377_C	383_I	0.637	1.00
61_A	141_E	0.636	1.00
60_W	167_L	0.635	1.00
137_Y	479_I	0.635	1.00
338_L	341_I	0.632	1.00
135_F	428_H	0.630	1.00
217_T	225_V	0.627	1.00
59_I	62_S	0.626	1.00
332_P	336_N	0.625	1.00
471_Q	474_T	0.625	1.00
355_G	370_A	0.625	1.00
162_K	226_S	0.625	1.00
136_V	480_Q	0.624	1.00
192_Y	197_L	0.624	1.00
52_S	199_D	0.624	1.00
435_E	456_Y	0.623	1.00
471_Q	476_V	0.622	1.00
76_V	110_A	0.621	1.00
23_T	39_Q	0.620	1.00
58_K	433_Q	0.618	1.00
421_T	426_R	0.618	1.00
267_L	301_A	0.617	1.00
250_T	472_S	0.616	1.00
374_F	377_C	0.615	1.00
38_V	182_P	0.615	1.00
139_R	477_K	0.614	1.00
187_K	191_I	0.614	1.00
209_G	213_G	0.613	1.00
388_I	392_V	0.612	1.00
427_A	431_I	0.612	1.00
172_A	203_N	0.611	1.00
269_L	272_D	0.610	1.00
106_I	110_A	0.606	1.00
217_T	241_S	0.605	1.00
179_E	236_K	0.601	1.00
347_E	380_D	0.601	1.00
328_L	333_H	0.601	1.00
67_E	71_I	0.600	1.00
65_A	168_A	0.600	1.00
91_T	319_F	0.599	1.00
90_E	101_T	0.599	1.00
26_T	36_A	0.598	1.00
51_K	54_Q	0.597	1.00
241_S	245_S	0.596	1.00
90_E	184_T	0.596	1.00
269_L	422_A	0.594	1.00
351_V	354_G	0.594	1.00
419_I	427_A	0.593	1.00
43_R	218_E	0.592	1.00
79_L	188_L	0.591	1.00
156_I	188_L	0.591	1.00
90_E	105_D	0.591	1.00
88_K	91_T	0.590	1.00
123_L	474_T	0.589	1.00
238_M	251_M	0.589	1.00
259_L	292_V	0.588	1.00
83_N	87_A	0.587	1.00
163_S	175_F	0.587	1.00
56_G	59_I	0.586	1.00
214_Q	217_T	0.586	1.00
26_T	93_D	0.584	1.00
428_H	481_V	0.584	1.00
264_D	423_D	0.584	1.00
405_I	429_R	0.583	1.00
146_V	171_N	0.582	1.00
76_V	113_L	0.582	1.00
351_V	372_T	0.579	1.00
224_K	472_S	0.576	1.00
210_A	236_K	0.576	1.00
49_A	205_L	0.574	1.00
358_L	364_D	0.573	1.00
79_L	113_L	0.573	1.00
106_I	156_I	0.572	1.00
35_L	183_L	0.572	1.00
425_N	428_H	0.572	1.00
376_D	397_T	0.572	1.00
357_V	370_A	0.568	1.00
231_V	235_K	0.568	1.00
20_S	45_D	0.567	1.00
123_L	470_L	0.567	1.00
425_N	429_R	0.566	1.00
341_I	372_T	0.565	1.00
439_C	477_K	0.565	1.00
294_V	395_I	0.565	1.00
294_V	299_K	0.564	1.00
307_L	373_V	0.563	1.00
259_L	418_G	0.562	1.00
193_S	196_G	0.561	1.00
79_L	156_I	0.561	1.00
285_V	288_N	0.559	1.00
314_R	320_D	0.558	1.00
75_A	78_I	0.554	1.00
71_I	75_A	0.553	1.00
265_A	270_A	0.553	1.00
315_A	324_N	0.553	1.00
103_T	321_P	0.552	1.00
115_Y	119_L	0.551	1.00
257_S	416_A	0.551	1.00
405_I	434_L	0.550	1.00
264_D	422_A	0.550	1.00
263_D	398_Y	0.550	1.00
404_V	408_A	0.549	1.00
278_N	393_M	0.549	1.00
328_L	369_V	0.548	1.00
105_D	154_Y	0.548	1.00
87_A	106_I	0.547	1.00
379_D	406_R	0.546	1.00
54_Q	145_V	0.546	1.00
419_I	441_I	0.541	1.00
267_L	270_A	0.540	1.00
188_L	192_Y	0.540	1.00
26_T	182_P	0.539	1.00
146_V	173_M	0.538	1.00
148_G	163_S	0.537	1.00
86_L	106_I	0.537	1.00
383_I	388_I	0.536	1.00
157_Q	161_W	0.536	1.00
296_A	299_K	0.535	1.00
292_V	395_I	0.535	1.00
145_V	223_A	0.534	1.00
435_E	475_Q	0.531	1.00
116_Y	165_P	0.531	1.00
279_F	313_I	0.531	1.00
408_A	434_L	0.530	1.00
53_A	174_I	0.530	1.00
147_A	174_I	0.530	1.00
108_T	157_Q	0.529	1.00
169_A	470_L	0.529	1.00
52_S	56_G	0.529	1.00
440_W	443_T	0.529	1.00
289_G	418_G	0.527	1.00
79_L	86_L	0.527	1.00
338_L	345_K	0.527	1.00
232_A	332_P	0.525	1.00
43_R	214_Q	0.524	1.00
271_A	298_C	0.524	1.00
430_V	434_L	0.523	1.00
118_G	121_P	0.523	1.00
401_E	433_Q	0.520	1.00
268_D	308_A	0.519	1.00
179_E	232_A	0.519	1.00
347_E	378_S	0.519	1.00
22_R	42_G	0.519	1.00
193_S	200_G	0.518	1.00
38_V	183_L	0.517	1.00
94_T	281_S	0.516	1.00
434_L	439_C	0.514	1.00
49_A	203_N	0.513	1.00
416_A	440_W	0.512	1.00
119_L	467_V	0.512	1.00
146_V	226_S	0.512	1.00
384_V	407_R	0.512	1.00
53_A	145_V	0.511	1.00
217_T	245_S	0.510	1.00
267_L	302_F	0.508	1.00
167_L	202_F	0.507	1.00
108_T	447_S	0.506	1.00
83_N	110_A	0.506	1.00
340_Y	383_I	0.505	1.00
87_A	101_T	0.505	1.00
306_I	310_V	0.504	1.00
249_V	461_I	0.504	1.00
66_M	70_R	0.503	1.00
26_T	35_L	0.503	1.00
74_R	196_G	0.502	1.00
304_Q	311_E	0.500	1.00
141_E	435_E	0.500	1.00
71_I	196_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o5hA	4	0.9776	100	0.025	Contact Map
4yweA	5	0.9673	100	0.025	Contact Map
1a4sA	4	0.9939	100	0.027	Contact Map
4qf6A	4	0.9755	100	0.028	Contact Map
4wj9A	4	0.9816	100	0.028	Contact Map
4pxlA	4	0.9837	100	0.028	Contact Map
4qtoA	4	0.9959	100	0.031	Contact Map
4pz2A	4	0.9918	100	0.032	Contact Map
1o04A	5	0.9857	100	0.032	Contact Map
3ek1A	5	0.9735	100	0.032	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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