MURG - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MURG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

UniProt:	P17443	Sequences: MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFIRISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGREGPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKGSQQSVEQAYAEAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRVARA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10623
Length:	355 (306)
Sequences:	18025 (13901)
Seq/√Len:	794.7

ECOLI - MURG
BACSU - MURG YOJK YJIC UGTP YDHE YKON SPSG
SULSO - Q97VW9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_R	35_Q	3.171	1.00
261_S	278_F	3.167	1.00
295_L	301_A	3.139	1.00
328_T	331_E	2.985	1.00
28_H	31_A	2.807	1.00
278_F	292_A	2.680	1.00
88_R	116_S	2.631	1.00
210_D	315_A	2.599	1.00
315_A	319_A	2.593	1.00
296_E	303_I	2.591	1.00
326_L	330_A	2.557	1.00
320_G	325_T	2.548	1.00
277_L	321_W	2.504	1.00
10_V	26_A	2.491	1.00
37_R	58_D	2.461	1.00
28_H	32_Q	2.404	1.00
293_L	297_K	2.384	1.00
302_K	320_G	2.337	1.00
47_A	51_P	2.305	1.00
332_R	335_A	2.284	1.00
257_V	269_I	2.258	1.00
37_R	94_Y	2.254	1.00
206_A	311_V	2.252	1.00
269_I	276_A	2.171	1.00
92_K	117_L	2.101	1.00
328_T	332_R	2.061	1.00
89_A	93_A	2.055	1.00
327_L	331_E	2.007	1.00
35_Q	56_E	2.004	1.00
7_R	37_R	1.999	1.00
203_Q	311_V	1.953	1.00
333_A	337_S	1.920	1.00
259_C	276_A	1.892	1.00
101_G	121_V	1.884	1.00
266_V	295_L	1.876	1.00
305_E	308_Q	1.867	1.00
302_K	317_T	1.852	1.00
184_R	213_T	1.839	1.00
241_T	244_I	1.803	1.00
313_A	317_T	1.774	1.00
182_P	213_T	1.717	1.00
179_R	213_T	1.715	1.00
256_V	318_L	1.697	1.00
331_E	335_A	1.686	1.00
322_S	325_T	1.678	1.00
256_V	321_W	1.677	1.00
48_D	52_K	1.675	1.00
325_T	328_T	1.671	1.00
246_D	249_A	1.657	1.00
257_V	265_T	1.656	1.00
302_K	325_T	1.645	1.00
329_M	332_R	1.644	1.00
130_A	133_T	1.643	1.00
8_L	98_V	1.640	1.00
293_L	296_E	1.639	1.00
78_L	82_N	1.635	1.00
28_H	342_T	1.627	1.00
9_M	39_L	1.588	1.00
8_L	29_L	1.578	1.00
257_V	274_L	1.545	1.00
185_V	258_V	1.522	1.00
324_E	327_L	1.514	1.00
156_E	160_N	1.503	1.00
330_A	333_A	1.500	1.00
186_L	254_A	1.498	1.00
99_V	114_A	1.475	1.00
8_L	34_W	1.470	1.00
325_T	329_M	1.470	1.00
88_R	117_L	1.466	1.00
277_L	317_T	1.447	1.00
185_V	256_V	1.435	1.00
311_V	315_A	1.430	1.00
86_Q	89_A	1.428	1.00
202_P	206_A	1.421	1.00
323_R	327_L	1.419	1.00
198_N	202_P	1.375	1.00
113_A	117_L	1.374	1.00
208_L	214_I	1.372	1.00
42_A	59_F	1.364	1.00
295_L	300_A	1.350	1.00
324_E	328_T	1.345	1.00
296_E	302_K	1.342	1.00
180_E	213_T	1.335	1.00
209_G	237_Q	1.332	1.00
294_P	297_K	1.320	1.00
316_N	320_G	1.316	1.00
26_A	55_I	1.295	1.00
174_Q	178_G	1.293	1.00
170_P	173_Q	1.292	1.00
206_A	209_G	1.288	1.00
207_K	315_A	1.279	1.00
111_G	121_V	1.276	1.00
84_W	88_R	1.272	1.00
158_V	161_P	1.269	1.00
48_D	51_P	1.268	1.00
203_Q	206_A	1.250	1.00
17_G	21_P	1.246	1.00
58_D	93_A	1.237	1.00
217_Q	244_I	1.232	1.00
85_R	89_A	1.229	1.00
27_H	55_I	1.219	1.00
9_M	96_P	1.217	1.00
70_I	73_L	1.213	1.00
224_Q	227_E	1.210	1.00
29_L	34_W	1.205	1.00
302_K	321_W	1.196	1.00
182_P	211_S	1.193	1.00
75_A	79_R	1.187	1.00
289_Y	305_E	1.187	1.00
83_A	86_Q	1.185	1.00
16_G	20_F	1.183	1.00
10_V	22_G	1.168	1.00
186_L	217_Q	1.166	1.00
273_G	334_R	1.163	1.00
186_L	246_D	1.161	1.00
215_W	250_A	1.161	1.00
331_E	334_R	1.160	1.00
88_R	92_K	1.157	1.00
330_A	334_R	1.154	1.00
313_A	316_N	1.152	1.00
183_V	255_D	1.146	1.00
289_Y	293_L	1.144	1.00
238_H	241_T	1.143	1.00
85_R	88_R	1.140	1.00
73_L	76_A	1.136	1.00
213_T	239_K	1.136	1.00
184_R	254_A	1.136	1.00
235_Q	238_H	1.129	1.00
299_G	328_T	1.113	1.00
220_K	242_E	1.111	1.00
130_A	134_N	1.111	1.00
327_L	330_A	1.110	1.00
10_V	100_L	1.110	1.00
323_R	326_L	1.101	1.00
334_R	337_S	1.100	1.00
278_F	295_L	1.095	1.00
293_L	303_I	1.094	1.00
210_D	311_V	1.089	1.00
273_G	333_A	1.086	1.00
325_T	332_R	1.078	1.00
30_M	55_I	1.076	1.00
20_F	243_F	1.074	1.00
310_S	313_A	1.072	1.00
332_R	336_A	1.071	1.00
76_A	79_R	1.070	1.00
98_V	122_V	1.069	1.00
300_A	332_R	1.063	1.00
9_M	91_M	1.061	1.00
270_A	300_A	1.061	1.00
209_G	233_A	1.060	1.00
114_A	121_V	1.047	1.00
304_I	317_T	1.046	1.00
27_H	53_H	1.041	1.00
89_A	92_K	1.033	1.00
317_T	320_G	1.033	1.00
212_V	319_A	1.031	1.00
276_A	301_A	1.028	1.00
27_H	30_M	1.023	1.00
61_R	86_Q	1.020	1.00
47_A	57_I	1.018	1.00
321_W	325_T	1.016	1.00
163_R	166_V	1.013	1.00
15_T	192_Q	1.013	1.00
76_A	80_I	1.010	1.00
79_R	82_N	1.002	1.00
299_G	332_R	1.002	1.00
22_G	38_W	1.002	1.00
83_A	87_A	0.993	1.00
207_K	311_V	0.992	1.00
308_Q	313_A	0.988	1.00
72_A	76_A	0.986	1.00
27_H	31_A	0.985	1.00
258_V	279_V	0.984	1.00
84_W	112_L	0.983	1.00
195_R	199_Q	0.978	1.00
277_L	302_K	0.974	1.00
334_R	338_I	0.974	1.00
84_W	87_A	0.972	1.00
326_L	332_R	0.964	1.00
174_Q	177_A	0.962	1.00
266_V	291_N	0.961	1.00
30_M	36_V	0.961	1.00
294_P	298_A	0.957	1.00
157_V	160_N	0.956	1.00
99_V	119_I	0.954	1.00
312_D	316_N	0.954	1.00
101_G	110_G	0.953	1.00
204_V	208_L	0.942	1.00
266_V	276_A	0.938	1.00
156_E	159_G	0.935	1.00
186_L	250_A	0.925	1.00
196_I	306_Q	0.922	1.00
64_G	67_G	0.918	1.00
7_R	94_Y	0.917	1.00
184_R	215_W	0.914	1.00
154_N	160_N	0.906	1.00
65_L	68_K	0.905	1.00
88_R	91_M	0.901	1.00
49_L	52_K	0.898	1.00
326_L	333_A	0.885	1.00
196_I	199_Q	0.882	1.00
34_W	97_D	0.880	1.00
64_G	68_K	0.879	1.00
207_K	314_V	0.878	1.00
52_K	245_D	0.877	1.00
325_T	333_A	0.875	1.00
185_V	212_V	0.875	1.00
27_H	165_D	0.873	1.00
84_W	116_S	0.870	1.00
126_Q	129_I	0.869	1.00
169_L	172_P	0.867	1.00
84_W	90_I	0.861	1.00
205_A	238_H	0.860	1.00
23_L	27_H	0.860	1.00
72_A	75_A	0.860	1.00
193_G	281_F	0.858	1.00
309_L	314_V	0.857	1.00
276_A	295_L	0.857	1.00
69_G	72_A	0.856	1.00
292_A	303_I	0.855	1.00
164_T	167_L	0.854	1.00
35_Q	94_Y	0.851	1.00
215_W	239_K	0.847	1.00
75_A	78_L	0.843	1.00
78_L	81_F	0.842	1.00
227_E	233_A	0.841	1.00
37_R	56_E	0.838	1.00
227_E	234_G	0.837	1.00
278_F	301_A	0.831	1.00
254_A	274_L	0.828	1.00
83_A	88_R	0.826	1.00
288_Q	291_N	0.825	1.00
77_P	80_I	0.820	1.00
62_I	65_L	0.819	1.00
187_V	208_L	0.819	1.00
207_K	210_D	0.818	1.00
187_V	214_I	0.816	1.00
86_Q	90_I	0.816	1.00
261_S	292_A	0.815	1.00
329_M	333_A	0.813	1.00
178_G	213_T	0.810	1.00
164_T	168_A	0.806	1.00
175_R	179_R	0.805	1.00
12_A	22_G	0.798	1.00
199_Q	202_P	0.797	1.00
259_C	265_T	0.792	1.00
283_H	287_Q	0.792	1.00
63_S	66_R	0.791	1.00
70_I	77_P	0.790	1.00
42_A	47_A	0.790	1.00
90_I	94_Y	0.789	1.00
157_V	161_P	0.789	1.00
18_H	102_M	0.787	1.00
302_K	305_E	0.786	1.00
258_V	314_V	0.786	1.00
290_W	293_L	0.786	1.00
77_P	81_F	0.784	1.00
21_P	264_L	0.784	1.00
316_N	319_A	0.784	1.00
42_A	61_R	0.781	1.00
234_G	240_V	0.781	1.00
207_K	312_D	0.780	1.00
162_V	165_D	0.777	1.00
271_A	337_S	0.770	1.00
317_T	321_W	0.769	1.00
154_N	158_V	0.768	1.00
10_V	29_L	0.768	1.00
135_K	151_A	0.768	1.00
74_I	78_L	0.765	1.00
62_I	66_R	0.763	1.00
260_R	288_Q	0.758	1.00
63_S	67_G	0.757	1.00
7_R	97_D	0.756	1.00
24_A	27_H	0.754	1.00
273_G	329_M	0.752	1.00
58_D	90_I	0.751	1.00
326_L	329_M	0.750	1.00
211_S	319_A	0.749	1.00
92_K	116_S	0.748	1.00
188_V	257_V	0.744	1.00
205_A	216_H	0.742	1.00
188_V	265_T	0.739	1.00
36_V	55_I	0.739	1.00
25_V	161_P	0.737	1.00
83_A	90_I	0.734	1.00
11_M	110_G	0.732	1.00
90_I	93_A	0.728	1.00
163_R	167_L	0.728	1.00
87_A	91_M	0.727	1.00
270_A	295_L	0.724	1.00
70_I	78_L	0.724	1.00
181_G	252_A	0.724	1.00
322_S	327_L	0.724	1.00
186_L	251_Y	0.721	1.00
47_A	50_V	0.719	1.00
247_M	272_A	0.718	1.00
183_V	323_R	0.715	1.00
198_N	201_M	0.714	1.00
225_S	233_A	0.712	1.00
246_D	251_Y	0.712	1.00
223_Q	242_E	0.707	1.00
154_N	159_G	0.707	1.00
259_C	266_V	0.706	1.00
199_Q	203_Q	0.701	1.00
102_M	126_Q	0.697	1.00
216_H	219_G	0.697	1.00
269_I	278_F	0.696	1.00
156_E	161_P	0.695	1.00
201_M	218_S	0.695	1.00
165_D	168_A	0.694	1.00
304_I	313_A	0.692	1.00
47_A	59_F	0.684	1.00
259_C	278_F	0.683	1.00
273_G	330_A	0.678	1.00
73_L	77_P	0.677	1.00
203_Q	207_K	0.676	1.00
207_K	318_L	0.672	1.00
22_G	102_M	0.670	1.00
246_D	268_E	0.669	1.00
84_W	113_A	0.669	1.00
204_V	207_K	0.667	1.00
185_V	214_I	0.665	1.00
69_G	73_L	0.665	1.00
63_S	68_K	0.663	1.00
214_I	217_Q	0.662	1.00
125_E	129_I	0.661	1.00
187_V	258_V	0.660	1.00
70_I	75_A	0.659	1.00
71_K	75_A	0.654	1.00
333_A	336_A	0.654	1.00
244_I	250_A	0.653	1.00
270_A	333_A	0.651	1.00
234_G	238_H	0.651	1.00
220_K	223_Q	0.647	1.00
115_W	118_G	0.645	1.00
58_D	94_Y	0.644	1.00
95_K	119_I	0.643	1.00
188_V	247_M	0.643	1.00
181_G	184_R	0.643	1.00
91_M	117_L	0.642	1.00
25_V	102_M	0.642	1.00
204_V	315_A	0.641	1.00
251_Y	257_V	0.641	1.00
39_L	87_A	0.640	1.00
184_R	253_W	0.637	1.00
26_A	36_V	0.636	1.00
180_E	183_V	0.635	1.00
277_L	304_I	0.634	1.00
47_A	52_K	0.633	1.00
38_W	55_I	0.632	1.00
209_G	235_Q	0.631	1.00
37_R	96_P	0.628	1.00
105_Y	108_G	0.624	1.00
74_I	77_P	0.621	1.00
209_G	236_P	0.619	1.00
210_D	312_D	0.619	1.00
322_S	328_T	0.614	1.00
110_G	114_A	0.612	1.00
218_S	223_Q	0.611	1.00
183_V	212_V	0.611	1.00
112_L	116_S	0.610	1.00
40_G	57_I	0.610	1.00
71_K	78_L	0.609	1.00
108_G	133_T	0.609	1.00
111_G	115_W	0.608	1.00
223_Q	227_E	0.607	1.00
186_L	244_I	0.606	1.00
100_L	122_V	0.603	1.00
24_A	163_R	0.601	1.00
260_R	287_Q	0.601	1.00
217_Q	243_F	0.600	1.00
107_S	110_G	0.600	1.00
29_L	33_G	0.597	1.00
280_P	292_A	0.597	1.00
206_A	233_A	0.596	1.00
101_G	111_G	0.596	1.00
195_R	222_S	0.595	1.00
70_I	76_A	0.594	1.00
111_G	114_A	0.591	1.00
322_S	326_L	0.591	1.00
312_D	315_A	0.590	1.00
162_V	271_A	0.586	1.00
81_F	85_R	0.586	1.00
87_A	90_I	0.583	1.00
259_C	269_I	0.582	1.00
211_S	237_Q	0.582	1.00
27_H	164_T	0.581	1.00
204_V	314_V	0.579	1.00
15_T	18_H	0.575	1.00
39_L	90_I	0.574	1.00
12_A	102_M	0.572	1.00
279_V	306_Q	0.570	1.00
290_W	294_P	0.569	1.00
305_E	313_A	0.568	1.00
256_V	277_L	0.567	1.00
186_L	257_V	0.566	1.00
188_V	217_Q	0.565	1.00
70_I	80_I	0.562	1.00
56_E	94_Y	0.561	1.00
24_A	28_H	0.561	1.00
162_V	166_V	0.553	1.00
218_S	240_V	0.552	1.00
247_M	268_E	0.552	1.00
50_V	53_H	0.552	1.00
274_L	326_L	0.551	1.00
178_G	184_R	0.551	1.00
178_G	183_V	0.550	1.00
73_L	80_I	0.549	1.00
78_L	109_P	0.549	1.00
31_A	164_T	0.549	1.00
69_G	74_I	0.548	1.00
164_T	169_L	0.546	1.00
34_W	37_R	0.546	1.00
338_I	341_A	0.545	1.00
335_A	339_P	0.545	1.00
51_P	57_I	0.544	1.00
160_N	163_R	0.540	1.00
122_V	125_E	0.538	1.00
9_M	94_Y	0.538	1.00
77_P	82_N	0.538	1.00
175_R	246_D	0.537	1.00
44_R	47_A	0.537	1.00
74_I	81_F	0.536	1.00
9_M	37_R	0.536	1.00
292_A	296_E	0.535	1.00
157_V	163_R	0.534	1.00
280_P	288_Q	0.533	1.00
191_S	288_Q	0.533	1.00
263_A	267_S	0.532	1.00
260_R	264_L	0.531	1.00
186_L	189_G	0.531	1.00
213_T	237_Q	0.528	1.00
70_I	79_R	0.528	1.00
167_L	170_P	0.527	1.00
270_A	329_M	0.527	1.00
264_L	268_E	0.527	1.00
206_A	210_D	0.527	1.00
282_Q	287_Q	0.526	1.00
75_A	80_I	0.523	1.00
25_V	100_L	0.521	1.00
158_V	162_V	0.521	1.00
109_P	114_A	0.520	1.00
245_D	249_A	0.517	1.00
50_V	54_G	0.517	1.00
219_G	222_S	0.515	1.00
51_P	54_G	0.513	1.00
83_A	91_M	0.512	1.00
29_L	36_V	0.510	1.00
175_R	178_G	0.510	1.00
273_G	337_S	0.510	1.00
281_F	306_Q	0.508	1.00
261_S	266_V	0.508	1.00
40_G	44_R	0.507	1.00
166_V	169_L	0.506	1.00
76_A	81_F	0.505	1.00
58_D	61_R	0.504	1.00
16_G	243_F	0.503	1.00
266_V	278_F	0.502	1.00
279_V	309_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2iyaA	1	0.938	100	0.347	Contact Map
2pq6A	1	0.9324	100	0.355	Contact Map
3rscA	1	0.9437	100	0.362	Contact Map
2vchA	1	0.9549	100	0.365	Contact Map
1rrvA	1	0.9352	100	0.366	Contact Map
2iyfA	1	0.9408	100	0.368	Contact Map
2c1xA	1	0.9408	100	0.371	Contact Map
3hbfA	1	0.9606	100	0.373	Contact Map
3ia7A	2	0.938	100	0.375	Contact Map
3otiA	2	0.9437	100	0.376	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.