GREMLIN Database
MURG - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
UniProt: P17443 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10623
Length: 355 (306)
Sequences: 18025 (13901)
Seq/√Len: 794.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_R35_Q3.1711.00
261_S278_F3.1671.00
295_L301_A3.1391.00
328_T331_E2.9851.00
28_H31_A2.8071.00
278_F292_A2.6801.00
88_R116_S2.6311.00
210_D315_A2.5991.00
315_A319_A2.5931.00
296_E303_I2.5911.00
326_L330_A2.5571.00
320_G325_T2.5481.00
277_L321_W2.5041.00
10_V26_A2.4911.00
37_R58_D2.4611.00
28_H32_Q2.4041.00
293_L297_K2.3841.00
302_K320_G2.3371.00
47_A51_P2.3051.00
332_R335_A2.2841.00
257_V269_I2.2581.00
37_R94_Y2.2541.00
206_A311_V2.2521.00
269_I276_A2.1711.00
92_K117_L2.1011.00
328_T332_R2.0611.00
89_A93_A2.0551.00
327_L331_E2.0071.00
35_Q56_E2.0041.00
7_R37_R1.9991.00
203_Q311_V1.9531.00
333_A337_S1.9201.00
259_C276_A1.8921.00
101_G121_V1.8841.00
266_V295_L1.8761.00
305_E308_Q1.8671.00
302_K317_T1.8521.00
184_R213_T1.8391.00
241_T244_I1.8031.00
313_A317_T1.7741.00
182_P213_T1.7171.00
179_R213_T1.7151.00
256_V318_L1.6971.00
331_E335_A1.6861.00
322_S325_T1.6781.00
256_V321_W1.6771.00
48_D52_K1.6751.00
325_T328_T1.6711.00
246_D249_A1.6571.00
257_V265_T1.6561.00
302_K325_T1.6451.00
329_M332_R1.6441.00
130_A133_T1.6431.00
8_L98_V1.6401.00
293_L296_E1.6391.00
78_L82_N1.6351.00
28_H342_T1.6271.00
9_M39_L1.5881.00
8_L29_L1.5781.00
257_V274_L1.5451.00
185_V258_V1.5221.00
324_E327_L1.5141.00
156_E160_N1.5031.00
330_A333_A1.5001.00
186_L254_A1.4981.00
99_V114_A1.4751.00
8_L34_W1.4701.00
325_T329_M1.4701.00
88_R117_L1.4661.00
277_L317_T1.4471.00
185_V256_V1.4351.00
311_V315_A1.4301.00
86_Q89_A1.4281.00
202_P206_A1.4211.00
323_R327_L1.4191.00
198_N202_P1.3751.00
113_A117_L1.3741.00
208_L214_I1.3721.00
42_A59_F1.3641.00
295_L300_A1.3501.00
324_E328_T1.3451.00
296_E302_K1.3421.00
180_E213_T1.3351.00
209_G237_Q1.3321.00
294_P297_K1.3201.00
316_N320_G1.3161.00
26_A55_I1.2951.00
174_Q178_G1.2931.00
170_P173_Q1.2921.00
206_A209_G1.2881.00
207_K315_A1.2791.00
111_G121_V1.2761.00
84_W88_R1.2721.00
158_V161_P1.2691.00
48_D51_P1.2681.00
203_Q206_A1.2501.00
17_G21_P1.2461.00
58_D93_A1.2371.00
217_Q244_I1.2321.00
85_R89_A1.2291.00
27_H55_I1.2191.00
9_M96_P1.2171.00
70_I73_L1.2131.00
224_Q227_E1.2101.00
29_L34_W1.2051.00
302_K321_W1.1961.00
182_P211_S1.1931.00
75_A79_R1.1871.00
289_Y305_E1.1871.00
83_A86_Q1.1851.00
16_G20_F1.1831.00
10_V22_G1.1681.00
186_L217_Q1.1661.00
273_G334_R1.1631.00
186_L246_D1.1611.00
215_W250_A1.1611.00
331_E334_R1.1601.00
88_R92_K1.1571.00
330_A334_R1.1541.00
313_A316_N1.1521.00
183_V255_D1.1461.00
289_Y293_L1.1441.00
238_H241_T1.1431.00
85_R88_R1.1401.00
73_L76_A1.1361.00
213_T239_K1.1361.00
184_R254_A1.1361.00
235_Q238_H1.1291.00
299_G328_T1.1131.00
220_K242_E1.1111.00
130_A134_N1.1111.00
327_L330_A1.1101.00
10_V100_L1.1101.00
323_R326_L1.1011.00
334_R337_S1.1001.00
278_F295_L1.0951.00
293_L303_I1.0941.00
210_D311_V1.0891.00
273_G333_A1.0861.00
325_T332_R1.0781.00
30_M55_I1.0761.00
20_F243_F1.0741.00
310_S313_A1.0721.00
332_R336_A1.0711.00
76_A79_R1.0701.00
98_V122_V1.0691.00
300_A332_R1.0631.00
9_M91_M1.0611.00
270_A300_A1.0611.00
209_G233_A1.0601.00
114_A121_V1.0471.00
304_I317_T1.0461.00
27_H53_H1.0411.00
89_A92_K1.0331.00
317_T320_G1.0331.00
212_V319_A1.0311.00
276_A301_A1.0281.00
27_H30_M1.0231.00
61_R86_Q1.0201.00
47_A57_I1.0181.00
321_W325_T1.0161.00
163_R166_V1.0131.00
15_T192_Q1.0131.00
76_A80_I1.0101.00
79_R82_N1.0021.00
299_G332_R1.0021.00
22_G38_W1.0021.00
83_A87_A0.9931.00
207_K311_V0.9921.00
308_Q313_A0.9881.00
72_A76_A0.9861.00
27_H31_A0.9851.00
258_V279_V0.9841.00
84_W112_L0.9831.00
195_R199_Q0.9781.00
277_L302_K0.9741.00
334_R338_I0.9741.00
84_W87_A0.9721.00
326_L332_R0.9641.00
174_Q177_A0.9621.00
266_V291_N0.9611.00
30_M36_V0.9611.00
294_P298_A0.9571.00
157_V160_N0.9561.00
99_V119_I0.9541.00
312_D316_N0.9541.00
101_G110_G0.9531.00
204_V208_L0.9421.00
266_V276_A0.9381.00
156_E159_G0.9351.00
186_L250_A0.9251.00
196_I306_Q0.9221.00
64_G67_G0.9181.00
7_R94_Y0.9171.00
184_R215_W0.9141.00
154_N160_N0.9061.00
65_L68_K0.9051.00
88_R91_M0.9011.00
49_L52_K0.8981.00
326_L333_A0.8851.00
196_I199_Q0.8821.00
34_W97_D0.8801.00
64_G68_K0.8791.00
207_K314_V0.8781.00
52_K245_D0.8771.00
325_T333_A0.8751.00
185_V212_V0.8751.00
27_H165_D0.8731.00
84_W116_S0.8701.00
126_Q129_I0.8691.00
169_L172_P0.8671.00
84_W90_I0.8611.00
205_A238_H0.8601.00
23_L27_H0.8601.00
72_A75_A0.8601.00
193_G281_F0.8581.00
309_L314_V0.8571.00
276_A295_L0.8571.00
69_G72_A0.8561.00
292_A303_I0.8551.00
164_T167_L0.8541.00
35_Q94_Y0.8511.00
215_W239_K0.8471.00
75_A78_L0.8431.00
78_L81_F0.8421.00
227_E233_A0.8411.00
37_R56_E0.8381.00
227_E234_G0.8371.00
278_F301_A0.8311.00
254_A274_L0.8281.00
83_A88_R0.8261.00
288_Q291_N0.8251.00
77_P80_I0.8201.00
62_I65_L0.8191.00
187_V208_L0.8191.00
207_K210_D0.8181.00
187_V214_I0.8161.00
86_Q90_I0.8161.00
261_S292_A0.8151.00
329_M333_A0.8131.00
178_G213_T0.8101.00
164_T168_A0.8061.00
175_R179_R0.8051.00
12_A22_G0.7981.00
199_Q202_P0.7971.00
259_C265_T0.7921.00
283_H287_Q0.7921.00
63_S66_R0.7911.00
70_I77_P0.7901.00
42_A47_A0.7901.00
90_I94_Y0.7891.00
157_V161_P0.7891.00
18_H102_M0.7871.00
302_K305_E0.7861.00
258_V314_V0.7861.00
290_W293_L0.7861.00
77_P81_F0.7841.00
21_P264_L0.7841.00
316_N319_A0.7841.00
42_A61_R0.7811.00
234_G240_V0.7811.00
207_K312_D0.7801.00
162_V165_D0.7771.00
271_A337_S0.7701.00
317_T321_W0.7691.00
154_N158_V0.7681.00
10_V29_L0.7681.00
135_K151_A0.7681.00
74_I78_L0.7651.00
62_I66_R0.7631.00
260_R288_Q0.7581.00
63_S67_G0.7571.00
7_R97_D0.7561.00
24_A27_H0.7541.00
273_G329_M0.7521.00
58_D90_I0.7511.00
326_L329_M0.7501.00
211_S319_A0.7491.00
92_K116_S0.7481.00
188_V257_V0.7441.00
205_A216_H0.7421.00
188_V265_T0.7391.00
36_V55_I0.7391.00
25_V161_P0.7371.00
83_A90_I0.7341.00
11_M110_G0.7321.00
90_I93_A0.7281.00
163_R167_L0.7281.00
87_A91_M0.7271.00
270_A295_L0.7241.00
70_I78_L0.7241.00
181_G252_A0.7241.00
322_S327_L0.7241.00
186_L251_Y0.7211.00
47_A50_V0.7191.00
247_M272_A0.7181.00
183_V323_R0.7151.00
198_N201_M0.7141.00
225_S233_A0.7121.00
246_D251_Y0.7121.00
223_Q242_E0.7071.00
154_N159_G0.7071.00
259_C266_V0.7061.00
199_Q203_Q0.7011.00
102_M126_Q0.6971.00
216_H219_G0.6971.00
269_I278_F0.6961.00
156_E161_P0.6951.00
201_M218_S0.6951.00
165_D168_A0.6941.00
304_I313_A0.6921.00
47_A59_F0.6841.00
259_C278_F0.6831.00
273_G330_A0.6781.00
73_L77_P0.6771.00
203_Q207_K0.6761.00
207_K318_L0.6721.00
22_G102_M0.6701.00
246_D268_E0.6691.00
84_W113_A0.6691.00
204_V207_K0.6671.00
185_V214_I0.6651.00
69_G73_L0.6651.00
63_S68_K0.6631.00
214_I217_Q0.6621.00
125_E129_I0.6611.00
187_V258_V0.6601.00
70_I75_A0.6591.00
71_K75_A0.6541.00
333_A336_A0.6541.00
244_I250_A0.6531.00
270_A333_A0.6511.00
234_G238_H0.6511.00
220_K223_Q0.6471.00
115_W118_G0.6451.00
58_D94_Y0.6441.00
95_K119_I0.6431.00
188_V247_M0.6431.00
181_G184_R0.6431.00
91_M117_L0.6421.00
25_V102_M0.6421.00
204_V315_A0.6411.00
251_Y257_V0.6411.00
39_L87_A0.6401.00
184_R253_W0.6371.00
26_A36_V0.6361.00
180_E183_V0.6351.00
277_L304_I0.6341.00
47_A52_K0.6331.00
38_W55_I0.6321.00
209_G235_Q0.6311.00
37_R96_P0.6281.00
105_Y108_G0.6241.00
74_I77_P0.6211.00
209_G236_P0.6191.00
210_D312_D0.6191.00
322_S328_T0.6141.00
110_G114_A0.6121.00
218_S223_Q0.6111.00
183_V212_V0.6111.00
112_L116_S0.6101.00
40_G57_I0.6101.00
71_K78_L0.6091.00
108_G133_T0.6091.00
111_G115_W0.6081.00
223_Q227_E0.6071.00
186_L244_I0.6061.00
100_L122_V0.6031.00
24_A163_R0.6011.00
260_R287_Q0.6011.00
217_Q243_F0.6001.00
107_S110_G0.6001.00
29_L33_G0.5971.00
280_P292_A0.5971.00
206_A233_A0.5961.00
101_G111_G0.5961.00
195_R222_S0.5951.00
70_I76_A0.5941.00
111_G114_A0.5911.00
322_S326_L0.5911.00
312_D315_A0.5901.00
162_V271_A0.5861.00
81_F85_R0.5861.00
87_A90_I0.5831.00
259_C269_I0.5821.00
211_S237_Q0.5821.00
27_H164_T0.5811.00
204_V314_V0.5791.00
15_T18_H0.5751.00
39_L90_I0.5741.00
12_A102_M0.5721.00
279_V306_Q0.5701.00
290_W294_P0.5691.00
305_E313_A0.5681.00
256_V277_L0.5671.00
186_L257_V0.5661.00
188_V217_Q0.5651.00
70_I80_I0.5621.00
56_E94_Y0.5611.00
24_A28_H0.5611.00
162_V166_V0.5531.00
218_S240_V0.5521.00
247_M268_E0.5521.00
50_V53_H0.5521.00
274_L326_L0.5511.00
178_G184_R0.5511.00
178_G183_V0.5501.00
73_L80_I0.5491.00
78_L109_P0.5491.00
31_A164_T0.5491.00
69_G74_I0.5481.00
164_T169_L0.5461.00
34_W37_R0.5461.00
338_I341_A0.5451.00
335_A339_P0.5451.00
51_P57_I0.5441.00
160_N163_R0.5401.00
122_V125_E0.5381.00
9_M94_Y0.5381.00
77_P82_N0.5381.00
175_R246_D0.5371.00
44_R47_A0.5371.00
74_I81_F0.5361.00
9_M37_R0.5361.00
292_A296_E0.5351.00
157_V163_R0.5341.00
280_P288_Q0.5331.00
191_S288_Q0.5331.00
263_A267_S0.5321.00
260_R264_L0.5311.00
186_L189_G0.5311.00
213_T237_Q0.5281.00
70_I79_R0.5281.00
167_L170_P0.5271.00
270_A329_M0.5271.00
264_L268_E0.5271.00
206_A210_D0.5271.00
282_Q287_Q0.5261.00
75_A80_I0.5231.00
25_V100_L0.5211.00
158_V162_V0.5211.00
109_P114_A0.5201.00
245_D249_A0.5171.00
50_V54_G0.5171.00
219_G222_S0.5151.00
51_P54_G0.5131.00
83_A91_M0.5121.00
29_L36_V0.5101.00
175_R178_G0.5101.00
273_G337_S0.5101.00
281_F306_Q0.5081.00
261_S266_V0.5081.00
40_G44_R0.5071.00
166_V169_L0.5061.00
76_A81_F0.5051.00
58_D61_R0.5041.00
16_G243_F0.5031.00
266_V278_F0.5021.00
279_V309_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.938 100 0.347 Contact Map
2pq6A 1 0.9324 100 0.355 Contact Map
3rscA 1 0.9437 100 0.362 Contact Map
2vchA 1 0.9549 100 0.365 Contact Map
1rrvA 1 0.9352 100 0.366 Contact Map
2iyfA 1 0.9408 100 0.368 Contact Map
2c1xA 1 0.9408 100 0.371 Contact Map
3hbfA 1 0.9606 100 0.373 Contact Map
3ia7A 2 0.938 100 0.375 Contact Map
3otiA 2 0.9437 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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