GREMLIN Database
CHBF - 6-phospho-beta-glucosidase
UniProt: P17411 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10144
Length: 450 (422)
Sequences: 1757 (1008)
Seq/√Len: 49.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R138_E5.6991.00
78_L140_C4.2641.00
83_F329_Y4.1541.00
74_R135_D3.9821.00
193_D213_N3.6411.00
105_S427_E3.5251.00
136_V145_V3.4141.00
52_F70_K3.3021.00
362_G367_T3.2951.00
136_V166_K3.2741.00
402_F426_R3.2221.00
327_A334_A3.2181.00
209_D216_S3.1541.00
75_R135_D3.0781.00
406_L425_A3.0781.00
73_D76_E3.0711.00
35_E67_K2.9271.00
108_Y424_L2.9191.00
338_V361_L2.8681.00
35_E69_Y2.7771.00
137_E163_T2.7221.00
347_D374_H2.6871.00
215_K220_E2.6451.00
6_K37_W2.5941.00
52_F56_Q2.5811.00
375_F383_I2.5371.00
345_Q355_V2.5281.00
109_L269_L2.5121.00
405_V425_A2.4721.00
119_L393_A2.4211.00
169_I366_A2.3811.00
399_S404_D2.3751.00
90_V128_V2.3701.00
37_W69_Y2.3271.00
49_D53_D2.3111.00
239_F262_Y2.3041.00
291_K295_E2.2581.00
276_Y287_Q2.2481.00
338_V359_C2.2221.00
106_H423_L2.1981.00
343_H351_A2.1951.00
212_I217_R2.1911.00
134_K137_E2.1821.00
133_V159_V2.1721.00
190_D193_D2.1671.00
161_R395_N2.1651.00
136_V140_C2.1571.00
247_L250_S2.1471.00
131_D134_K2.1181.00
348_N380_M2.0501.00
108_Y116_A2.0471.00
106_H427_E2.0351.00
126_I158_A2.0291.00
349_I383_I2.0141.00
344_G351_A1.9720.99
75_R139_L1.9530.99
49_D52_F1.9500.99
30_E326_N1.9440.99
217_R220_E1.9160.99
160_Y341_P1.8560.99
59_I68_L1.8280.99
144_W167_R1.8030.99
21_L36_L1.7900.99
76_E79_K1.7830.99
130_F158_A1.7670.99
37_W71_T1.7620.99
292_Q308_E1.7530.99
126_I154_M1.7470.99
395_N404_D1.7390.99
206_F263_F1.7380.99
98_L431_A1.7370.99
328_I331_D1.7250.99
395_N399_S1.7200.98
326_N330_N1.6910.98
401_E404_D1.6890.98
6_K35_E1.6770.98
83_F328_I1.6750.98
333_Q362_G1.6630.98
125_T128_V1.6450.98
220_E224_G1.6360.98
186_L221_L1.6350.98
298_K302_L1.6290.98
404_D407_L1.6210.98
43_G49_D1.6050.98
142_N167_R1.6010.98
129_I159_V1.5930.97
360_K369_H1.5920.97
159_V168_F1.5830.97
116_A415_V1.5790.97
162_H398_L1.5710.97
82_D142_N1.5610.97
53_D56_Q1.5460.97
69_Y76_E1.5440.97
119_L389_F1.5220.97
114_N386_I1.5210.97
380_M384_H1.5180.97
197_D209_D1.5130.97
13_G40_D1.5060.96
347_D373_T1.5050.96
335_E360_K1.5010.96
137_E164_G1.4990.96
31_L325_I1.4950.96
362_G365_G1.4740.96
8_V81_A1.4550.96
133_V136_V1.4410.95
397_A400_G1.4260.95
362_G366_A1.4100.95
307_K310_E1.4050.95
348_N373_T1.3910.94
106_H424_L1.3840.94
71_T77_A1.3810.94
126_I397_A1.3490.93
396_A405_V1.3450.93
8_V78_L1.3400.93
347_D351_A1.3380.93
336_H361_L1.3260.93
8_V37_W1.3250.93
84_V136_V1.3170.93
42_E92_Q1.3160.93
108_Y420_D1.3130.93
102_I431_A1.2920.92
59_I66_M1.2890.92
98_L432_H1.2780.91
130_F398_L1.2760.91
409_L428_M1.2730.91
364_D367_T1.2730.91
127_P397_A1.2610.91
424_L428_M1.2590.91
86_T129_I1.2530.91
212_I215_K1.2470.90
97_E101_R1.2460.90
79_K139_L1.2360.90
377_D388_G1.2340.90
80_D142_N1.2250.90
288_K292_Q1.2180.89
7_V31_L1.2160.89
199_F208_K1.2120.89
193_D212_I1.2060.89
49_D70_K1.1950.88
430_L433_E1.1950.88
195_S211_L1.1790.88
348_N384_H1.1740.88
266_K417_S1.1720.87
246_G250_S1.1670.87
34_S67_K1.1650.87
84_V143_A1.1620.87
216_S219_A1.1600.87
30_E332_K1.1500.86
78_L139_L1.1380.86
39_V77_A1.1370.86
335_E369_H1.1280.85
204_M386_I1.1260.85
99_D124_R1.1240.85
285_V289_V1.1220.85
409_L421_A1.1170.85
378_K407_L1.1130.85
219_A252_N1.1130.85
402_F425_A1.1080.84
50_I298_K1.1050.84
5_L329_Y1.1020.84
56_Q60_D1.0990.84
129_I155_V1.0950.84
199_F375_F1.0900.83
163_T166_K1.0840.83
256_C259_L1.0810.83
89_R96_R1.0750.82
295_E298_K1.0660.82
296_L299_N1.0650.82
243_F246_G1.0600.82
187_M190_D1.0570.81
103_P428_M1.0490.81
266_K420_D1.0490.81
345_Q357_M1.0490.81
108_Y416_H1.0490.81
55_C68_L1.0460.81
120_F429_I1.0400.80
10_I145_V1.0350.80
389_F409_L1.0350.80
157_E391_I1.0350.80
103_P106_H1.0340.80
340_I359_C1.0320.80
346_I355_V1.0230.79
88_L132_I1.0220.79
43_G72_L1.0210.79
406_L421_A1.0210.79
360_K367_T1.0180.79
48_L70_K1.0170.79
8_V39_V1.0170.79
204_M382_L1.0160.79
135_D139_L1.0130.79
94_P98_L1.0100.78
88_L152_A1.0100.78
296_L308_E1.0080.78
245_E249_R1.0070.78
188_L212_I1.0060.78
134_K163_T1.0040.78
246_G249_R1.0020.78
406_L422_E1.0010.78
95_A98_L1.0000.78
96_R100_E0.9990.78
220_E223_D0.9930.77
243_F247_L0.9910.77
161_R391_I0.9890.77
177_G181_F0.9840.77
405_V429_I0.9820.76
400_G438_N0.9810.76
247_L253_L0.9800.76
331_D363_R0.9790.76
402_F422_E0.9780.76
340_I361_L0.9770.76
83_F325_I0.9730.76
237_N240_D0.9720.76
353_W387_K0.9710.76
179_K196_I0.9690.75
42_E46_P0.9680.75
335_E358_T0.9670.75
119_L409_L0.9630.75
169_I328_I0.9610.75
116_A409_L0.9560.74
153_G390_E0.9560.74
402_F429_I0.9550.74
273_M276_Y0.9540.74
120_F432_H0.9510.74
10_I132_I0.9500.74
229_Q232_A0.9480.74
172_C203_H0.9460.74
198_L207_I0.9460.74
348_N355_V0.9450.74
118_G124_R0.9420.73
240_D244_S0.9380.73
258_Y261_Y0.9360.73
195_S335_E0.9330.73
155_V158_A0.9310.72
107_G273_M0.9310.72
197_D372_I0.9300.72
134_K138_E0.9270.72
209_D218_F0.9220.72
415_V421_A0.9160.71
110_G117_G0.9160.71
157_E161_R0.9020.70
410_N421_A0.8990.70
416_H420_D0.8990.70
257_S260_L0.8980.70
198_L205_V0.8970.70
323_E334_A0.8960.69
113_T118_G0.8950.69
423_L426_R0.8950.69
244_S247_L0.8900.69
101_R284_Q0.8890.69
361_L366_A0.8870.69
180_M191_S0.8810.68
122_G354_A0.8800.68
122_G126_I0.8740.68
409_L424_L0.8710.67
103_P424_L0.8680.67
247_L251_L0.8660.67
268_M272_E0.8650.67
131_D135_D0.8630.67
265_Q269_L0.8570.66
56_Q67_K0.8550.66
128_V131_D0.8500.65
174_I257_S0.8500.65
81_A140_C0.8490.65
250_S407_L0.8410.65
134_K162_H0.8410.65
388_G391_I0.8270.63
248_I251_L0.8220.63
95_A432_H0.8210.63
78_L84_V0.8180.62
89_R100_E0.8150.62
386_I412_S0.8120.62
242_P246_G0.8120.62
103_P117_G0.8120.62
179_K191_S0.8120.62
157_E387_K0.8100.62
114_N412_S0.8090.62
392_A407_L0.8070.61
9_T85_T0.8050.61
359_C368_P0.8040.61
400_G437_P0.8030.61
130_F162_H0.8030.61
402_F406_L0.8030.61
16_Y87_Q0.8020.61
206_F255_P0.8010.61
5_L34_S0.8010.61
348_N374_H0.8010.61
353_W391_I0.8000.61
190_D212_I0.7970.60
290_E294_F0.7960.60
266_K270_A0.7910.60
241_L244_S0.7880.59
144_W328_I0.7830.59
429_I433_E0.7810.59
120_F428_M0.7790.59
6_K81_A0.7790.59
148_F321_A0.7780.59
90_V125_T0.7780.59
326_N332_K0.7760.58
279_G286_V0.7740.58
152_A175_P0.7730.58
256_C261_Y0.7720.58
46_P351_A0.7690.58
405_V437_P0.7690.58
347_D371_R0.7690.58
119_L405_V0.7670.57
146_I325_I0.7620.57
284_Q288_K0.7610.57
94_P287_Q0.7600.57
12_G421_A0.7600.57
120_F140_C0.7590.57
428_M431_A0.7580.57
99_D118_G0.7580.57
36_L66_M0.7570.56
188_L193_D0.7510.56
292_Q296_L0.7500.56
176_I324_V0.7490.56
264_K267_E0.7490.56
179_K207_I0.7490.56
346_I373_T0.7460.55
56_Q76_E0.7450.55
51_I55_C0.7440.55
381_G388_G0.7430.55
17_T87_Q0.7350.54
309_L312_R0.7350.54
46_P344_G0.7350.54
223_D249_R0.7340.54
103_P120_F0.7330.54
113_T154_M0.7330.54
113_T258_Y0.7330.54
305_K309_L0.7310.54
145_V159_V0.7300.54
61_N303_K0.7300.54
60_D194_L0.7300.54
337_Y358_T0.7290.54
116_A424_L0.7260.53
385_T411_L0.7240.53
386_I390_E0.7230.53
137_E166_K0.7220.53
43_G223_D0.7170.52
38_L55_C0.7160.52
121_K262_Y0.7160.52
274_G278_K0.7150.52
162_H395_N0.7140.52
98_L102_I0.7120.52
7_V24_F0.7100.52
160_Y168_F0.7100.52
112_E121_K0.7080.51
104_L272_E0.7050.51
74_R78_L0.7020.51
55_C59_I0.7010.51
182_I210_V0.7000.51
51_I70_K0.7000.51
185_V221_L0.6980.50
244_S422_E0.6970.50
104_L269_L0.6960.50
246_G422_E0.6960.50
178_M205_V0.6960.50
156_T170_G0.6930.50
194_L212_I0.6910.50
406_L409_L0.6890.50
158_A397_A0.6880.49
243_F422_E0.6870.49
219_A223_D0.6870.49
172_C202_N0.6860.49
114_N389_F0.6850.49
269_L272_E0.6850.49
71_T76_E0.6840.49
350_P353_W0.6840.49
250_S253_L0.6820.49
110_G390_E0.6820.49
114_N204_M0.6810.49
23_G156_T0.6810.49
145_V166_K0.6800.49
81_A84_V0.6800.49
245_E253_L0.6790.49
393_A409_L0.6790.49
10_I78_L0.6750.48
14_S19_E0.6750.48
80_D190_D0.6740.48
267_E417_S0.6740.48
293_L297_Y0.6720.48
377_D384_H0.6720.48
122_G158_A0.6720.48
57_R306_P0.6690.48
267_E270_A0.6680.47
150_N202_N0.6670.47
290_E293_L0.6670.47
198_L337_Y0.6660.47
242_P245_E0.6630.47
218_F222_L0.6630.47
125_T397_A0.6610.47
410_N418_D0.6610.47
185_V234_S0.6600.47
102_I427_E0.6600.47
56_Q69_Y0.6590.47
11_G14_S0.6590.47
49_D367_T0.6590.47
199_F372_I0.6590.47
78_L135_D0.6570.46
192_D215_K0.6570.46
58_M143_A0.6560.46
136_V163_T0.6550.46
43_G46_P0.6550.46
204_M412_S0.6540.46
419_R423_L0.6540.46
145_V168_F0.6540.46
293_L296_L0.6540.46
148_F153_G0.6540.46
257_S261_Y0.6530.46
267_E419_R0.6530.46
424_L427_E0.6520.46
284_Q287_Q0.6500.46
114_N262_Y0.6500.46
100_E110_G0.6490.45
249_R252_N0.6490.45
244_S251_L0.6450.45
154_M417_S0.6440.45
12_G52_F0.6430.45
327_A336_H0.6420.45
425_A429_I0.6420.45
59_I65_P0.6410.45
317_Y390_E0.6400.45
326_N359_C0.6390.44
89_R390_E0.6390.44
258_Y262_Y0.6370.44
100_E112_E0.6360.44
27_R322_C0.6360.44
46_P49_D0.6350.44
173_N317_Y0.6350.44
211_L216_S0.6340.44
384_H388_G0.6340.44
171_V256_C0.6340.44
242_P250_S0.6330.44
241_L247_L0.6320.44
36_L426_R0.6310.44
286_V293_L0.6310.44
325_I373_T0.6300.44
16_Y19_E0.6300.44
389_F393_A0.6300.44
348_N375_F0.6270.43
387_K390_E0.6270.43
69_Y138_E0.6230.43
53_D70_K0.6230.43
294_F298_K0.6230.43
26_K319_D0.6220.43
16_Y93_L0.6200.43
85_T167_R0.6200.43
48_L72_L0.6160.42
132_I145_V0.6160.42
383_I407_L0.6160.42
146_I169_I0.6150.42
10_I41_V0.6150.42
153_G386_I0.6140.42
28_Y65_P0.6140.42
422_E426_R0.6140.42
20_L317_Y0.6120.42
409_L415_V0.6110.42
74_R131_D0.6110.42
333_Q360_K0.6110.42
423_L427_E0.6080.41
89_R121_K0.6080.41
56_Q142_N0.6080.41
206_F407_L0.6080.41
84_V140_C0.6070.41
58_M62_A0.6070.41
153_G204_M0.6070.41
186_L220_E0.6060.41
89_R110_G0.6060.41
43_G138_E0.6050.41
114_N154_M0.6050.41
125_T155_V0.6050.41
17_T20_L0.6010.41
79_K134_K0.6010.41
234_S237_N0.6000.41
302_L306_P0.5990.41
39_V78_L0.5980.40
57_R305_K0.5980.40
274_G279_G0.5970.40
358_T376_D0.5960.40
148_F320_A0.5950.40
266_K410_N0.5940.40
183_R206_F0.5930.40
25_I327_A0.5930.40
274_G277_Y0.5910.40
183_R194_L0.5880.39
113_T124_R0.5880.39
23_G309_L0.5870.39
168_F354_A0.5860.39
244_S252_N0.5860.39
180_M184_D0.5860.39
256_C260_L0.5840.39
113_T262_Y0.5830.39
150_N203_H0.5810.39
153_G297_Y0.5800.39
96_R113_T0.5800.39
6_K80_D0.5760.38
241_L246_G0.5760.38
7_V325_I0.5750.38
352_D397_A0.5750.38
223_D270_A0.5730.38
38_L68_L0.5730.38
196_I207_I0.5720.38
13_G41_V0.5720.38
79_K343_H0.5720.38
174_I205_V0.5710.38
47_K258_Y0.5710.38
105_S423_L0.5700.38
182_I254_L0.5660.37
100_E111_Q0.5660.37
208_K376_D0.5650.37
249_R253_L0.5650.37
64_V68_L0.5640.37
304_V307_K0.5640.37
36_L215_K0.5630.37
71_T256_C0.5630.37
244_S253_L0.5610.37
187_M215_K0.5610.37
7_V36_L0.5610.37
376_D379_V0.5600.37
392_A408_A0.5600.37
104_L279_G0.5590.37
10_I74_R0.5590.37
351_A374_H0.5590.37
150_N172_C0.5580.37
328_I332_K0.5580.37
96_R432_H0.5570.36
184_D187_M0.5570.36
110_G152_A0.5570.36
90_V132_I0.5560.36
7_V107_G0.5550.36
155_V397_A0.5550.36
121_K125_T0.5540.36
17_T24_F0.5540.36
352_D371_R0.5540.36
78_L132_I0.5530.36
432_H435_W0.5530.36
175_P337_Y0.5520.36
29_H32_P0.5520.36
397_A436_L0.5500.36
260_L271_I0.5500.36
242_P247_L0.5490.36
326_N334_A0.5480.36
174_I320_A0.5480.36
333_Q363_R0.5470.36
162_H399_S0.5470.36
126_I393_A0.5460.35
86_T149_T0.5450.35
24_F173_N0.5450.35
160_Y339_N0.5450.35
8_V79_K0.5450.35
183_R188_L0.5440.35
12_G246_G0.5440.35
28_Y326_N0.5430.35
116_A160_Y0.5430.35
10_I39_V0.5420.35
30_E325_I0.5410.35
140_C166_K0.5380.35
17_T96_R0.5380.35
154_M331_D0.5370.35
54_L405_V0.5370.35
197_D208_K0.5360.35
144_W169_I0.5350.34
244_S249_R0.5350.34
6_K34_S0.5340.34
208_K374_H0.5320.34
20_L100_E0.5320.34
188_L267_E0.5320.34
291_K404_D0.5320.34
99_D115_G0.5320.34
174_I178_M0.5310.34
403_N407_L0.5300.34
144_W255_P0.5300.34
236_K240_D0.5290.34
129_I133_V0.5290.34
67_K213_N0.5280.34
34_S65_P0.5280.34
50_I400_G0.5270.34
170_G413_P0.5270.34
244_S250_S0.5260.34
195_S209_D0.5260.34
343_H368_P0.5250.34
339_N354_A0.5250.34
36_L76_E0.5240.33
139_L193_D0.5220.33
65_P407_L0.5210.33
262_Y412_S0.5210.33
174_I235_V0.5200.33
221_L254_L0.5200.33
9_T20_L0.5190.33
19_E87_Q0.5190.33
434_K437_P0.5190.33
37_W188_L0.5180.33
279_G287_Q0.5180.33
76_E430_L0.5180.33
240_D255_P0.5180.33
54_L197_D0.5180.33
131_D138_E0.5170.33
115_G124_R0.5170.33
246_G252_N0.5160.33
28_Y327_A0.5150.33
78_L114_N0.5150.33
18_P87_Q0.5140.33
122_G154_M0.5140.33
268_M271_I0.5130.32
179_K210_V0.5130.32
259_L389_F0.5120.32
345_Q352_D0.5120.32
223_D328_I0.5110.32
159_V164_G0.5100.32
94_P434_K0.5100.32
67_K433_E0.5100.32
15_S294_F0.5100.32
331_D362_G0.5100.32
113_T121_K0.5100.32
111_Q390_E0.5100.32
197_D211_L0.5100.32
86_T145_V0.5090.32
54_L61_N0.5080.32
357_M372_I0.5070.32
392_A404_D0.5060.32
401_E438_N0.5060.32
86_T168_F0.5060.32
385_T388_G0.5050.32
130_F134_K0.5040.32
149_T435_W0.5040.32
9_T92_Q0.5040.32
137_E159_V0.5020.31
133_V339_N0.5020.31
55_C87_Q0.5010.31
89_R104_L0.5010.31
353_W394_S0.5000.31
49_D80_D0.5000.31
231_K235_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s6yA 1 0.9244 100 0.337 Contact Map
1u8xX 1 0.9467 100 0.357 Contact Map
1up7A 3 0.9178 100 0.367 Contact Map
1obbA 2 0.9556 100 0.368 Contact Map
3u95A 2 0.9578 100 0.424 Contact Map
3fefA 3 0.9044 100 0.429 Contact Map
1pzgA 4 0.7 100 0.715 Contact Map
4rorA 4 0.6933 100 0.725 Contact Map
3p7mA 4 0.6933 100 0.728 Contact Map
4plzA 4 0.6444 100 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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