GREMLIN Database
CHBR - HTH-type transcriptional regulator ChbR
UniProt: P17410 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10143
Length: 280 (237)
Sequences: 34321 (29151)
Seq/√Len: 1893.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_K224_E3.2801.00
231_K264_T3.2491.00
239_Y247_E3.1431.00
182_H225_I2.9661.00
227_I264_T2.8561.00
193_E203_Q2.8521.00
180_K184_K2.7731.00
229_F232_K2.6571.00
184_K187_F2.6541.00
224_E263_L2.5951.00
260_F271_Y2.5051.00
233_Q247_E2.4361.00
230_A256_F2.3481.00
177_T206_L2.2851.00
239_Y243_D2.1241.00
210_T221_I2.1041.00
233_Q248_A2.1021.00
191_A194_N2.1011.00
56_F63_R2.0541.00
266_F274_K2.0201.00
180_K198_L1.9531.00
185_E225_I1.9421.00
233_Q239_Y1.9011.00
56_F65_L1.8631.00
219_M223_N1.8401.00
178_V214_Y1.8131.00
240_S243_D1.7861.00
174_L214_Y1.7851.00
181_M222_I1.7741.00
177_T199_S1.7621.00
253_P257_I1.7551.00
58_E63_R1.7521.00
227_I263_L1.7211.00
259_T262_K1.7011.00
231_K271_Y1.6861.00
205_Y209_A1.6791.00
67_E70_D1.6571.00
192_L207_T1.6471.00
54_R65_L1.6241.00
242_T253_P1.6201.00
229_F233_Q1.6181.00
195_M218_P1.6171.00
179_E183_D1.6161.00
225_I229_F1.6081.00
51_L92_L1.5961.00
232_K236_M1.5871.00
216_K220_Q1.5771.00
266_F270_S1.5731.00
203_Q207_T1.5341.00
52_T90_R1.5041.00
243_D246_F1.4891.00
185_E229_F1.4811.00
58_E81_Q1.4651.00
56_F83_F1.4641.00
206_L218_P1.4591.00
243_D247_E1.4591.00
242_T246_F1.4451.00
205_Y208_R1.4441.00
171_P213_Y1.4351.00
182_H221_I1.4341.00
234_L241_V1.4321.00
178_V182_H1.4311.00
244_I248_A1.4081.00
230_A248_A1.4051.00
201_K205_Y1.4031.00
186_Q247_E1.4031.00
229_F248_A1.3981.00
255_L259_T1.3951.00
250_Y259_T1.3921.00
54_R67_E1.3711.00
204_E208_R1.3661.00
218_P222_I1.3611.00
181_M225_I1.3401.00
269_K273_K1.3361.00
126_L130_E1.3341.00
45_Y76_L1.3321.00
217_T220_Q1.3281.00
156_N160_H1.3261.00
194_N198_L1.3231.00
254_S257_I1.3191.00
225_I228_N1.2991.00
60_N78_S1.2931.00
177_T195_M1.2931.00
224_E228_N1.2921.00
207_T218_P1.2771.00
223_N259_T1.2761.00
193_E197_A1.2471.00
173_W201_K1.2121.00
201_K206_L1.2071.00
187_F194_N1.2041.00
51_L90_R1.1971.00
257_I267_T1.1951.00
231_K235_E1.1941.00
75_P78_S1.1841.00
202_S205_Y1.1781.00
237_T272_R1.1701.00
180_K190_S1.1651.00
52_T68_R1.1501.00
209_A212_R1.1331.00
258_K262_K1.1241.00
257_I269_K1.1191.00
186_Q229_F1.1151.00
196_V203_Q1.1151.00
172_Q176_S1.0981.00
239_Y244_I1.0961.00
127_T130_E1.0941.00
228_N231_K1.0911.00
127_T131_T1.0831.00
267_T270_S1.0811.00
152_F156_N1.0681.00
209_A213_Y1.0631.00
192_L218_P1.0491.00
188_S251_S1.0461.00
39_L79_H1.0371.00
270_S273_K1.0361.00
269_K272_R1.0231.00
130_E134_S1.0181.00
175_K179_E1.0141.00
173_W209_A1.0081.00
223_N262_K1.0001.00
42_H80_H0.9981.00
233_Q244_I0.9971.00
151_T157_R0.9961.00
178_V221_I0.9961.00
220_Q223_N0.9891.00
252_S258_K0.9821.00
180_K199_S0.9791.00
40_H80_H0.9781.00
149_M152_F0.9771.00
156_N159_R0.9741.00
241_V244_I0.9691.00
259_T263_L0.9681.00
257_I261_K0.9621.00
55_Y89_T0.9591.00
264_T271_Y0.9561.00
194_N197_A0.9531.00
192_L203_Q0.9521.00
139_R143_L0.9501.00
180_K195_M0.9481.00
173_W199_S0.9471.00
181_M218_P0.9431.00
176_S198_L0.9381.00
42_H46_E0.9371.00
153_Y156_N0.9331.00
195_M198_L0.9301.00
190_S195_M0.9281.00
204_E207_T0.9191.00
220_Q224_E0.9091.00
176_S179_E0.9041.00
199_S206_L0.9031.00
124_A127_T0.9031.00
115_A118_V0.9031.00
46_E80_H0.9021.00
220_Q263_L0.8931.00
231_K260_F0.8891.00
58_E83_F0.8891.00
50_V55_Y0.8851.00
174_L177_T0.8781.00
144_E148_E0.8711.00
223_N263_L0.8671.00
227_I259_T0.8621.00
153_Y159_R0.8611.00
39_L81_Q0.8581.00
174_L209_A0.8461.00
145_E149_M0.8441.00
270_S274_K0.8431.00
255_L258_K0.8421.00
210_T214_Y0.8411.00
261_K267_T0.8391.00
48_T93_N0.8371.00
122_N126_L0.8361.00
46_E95_G0.8241.00
59_I62_K0.8191.00
188_S194_N0.8181.00
184_K198_L0.8181.00
176_S199_S0.8171.00
146_F149_M0.8171.00
175_K178_V0.8131.00
201_K209_A0.8131.00
185_E222_I0.8121.00
153_Y157_R0.8101.00
234_L244_I0.8091.00
45_Y73_F0.8041.00
219_M222_I0.8031.00
55_Y66_L0.8031.00
210_T218_P0.7961.00
89_T93_N0.7941.00
237_T244_I0.7931.00
123_N127_T0.7931.00
226_R248_A0.7901.00
98_K102_E0.7891.00
185_E248_A0.7881.00
174_L178_V0.7881.00
246_F251_S0.7851.00
124_A131_T0.7761.00
54_R85_E0.7741.00
234_L272_R0.7721.00
208_R212_R0.7691.00
187_F190_S0.7691.00
221_I225_I0.7681.00
207_T211_Q0.7671.00
227_I256_F0.7661.00
245_A253_P0.7631.00
219_M255_L0.7631.00
266_F271_Y0.7601.00
174_L213_Y0.7541.00
58_E61_G0.7531.00
235_E271_Y0.7521.00
178_V210_T0.7501.00
184_K194_N0.7491.00
207_T219_M0.7491.00
177_T180_K0.7481.00
145_E148_E0.7451.00
49_L71_F0.7451.00
148_E151_T0.7411.00
155_I159_R0.7371.00
170_V212_R0.7331.00
230_A233_Q0.7281.00
261_K270_S0.7271.00
115_A119_Y0.7261.00
157_R161_Y0.7261.00
55_Y65_L0.7201.00
121_T124_A0.7101.00
185_E226_R0.7081.00
116_S119_Y0.7071.00
240_S244_I0.7061.00
100_F103_Q0.7061.00
153_Y158_L0.7051.00
131_T135_S0.7031.00
173_W176_S0.6991.00
128_Y131_T0.6971.00
171_P209_A0.6971.00
256_F260_F0.6951.00
181_M221_I0.6931.00
57_Q72_V0.6931.00
66_L72_V0.6921.00
150_V153_Y0.6921.00
195_M206_L0.6881.00
133_I137_N0.6811.00
251_S255_L0.6811.00
188_S191_A0.6751.00
157_R160_H0.6741.00
253_P256_F0.6721.00
177_T218_P0.6721.00
134_S138_F0.6721.00
207_T217_T0.6711.00
44_Y95_G0.6691.00
123_N126_L0.6681.00
131_T134_S0.6671.00
50_V53_G0.6651.00
216_K221_I0.6651.00
56_F85_E0.6631.00
41_Q79_H0.6601.00
177_T210_T0.6601.00
170_V173_W0.6571.00
252_S255_L0.6521.00
48_T74_I0.6481.00
211_Q217_T0.6461.00
177_T181_M0.6451.00
185_E190_S0.6411.00
230_A244_I0.6411.00
158_L161_Y0.6411.00
228_N263_L0.6401.00
113_F117_Q0.6401.00
195_M199_S0.6391.00
113_F116_S0.6371.00
50_V91_I0.6371.00
171_P175_K0.6361.00
52_T88_A0.6351.00
48_T91_I0.6341.00
254_S267_T0.6321.00
244_I272_R0.6291.00
260_F266_F0.6281.00
227_I250_Y0.6231.00
190_S194_N0.6221.00
182_H229_F0.6201.00
155_I158_L0.6191.00
180_K194_N0.6171.00
74_I80_H0.6151.00
196_V199_S0.6131.00
151_T155_I0.6131.00
124_A128_Y0.6121.00
231_K266_F0.6071.00
197_A200_A0.6031.00
170_V213_Y0.5951.00
50_V66_L0.5951.00
127_T134_S0.5941.00
60_N79_H0.5931.00
114_V119_Y0.5921.00
48_T72_V0.5911.00
228_N264_T0.5901.00
47_F73_F0.5881.00
238_N244_I0.5871.00
254_S258_K0.5861.00
150_V155_I0.5811.00
172_Q213_Y0.5791.00
233_Q236_M0.5761.00
256_F268_P0.5751.00
236_M239_Y0.5751.00
63_R83_F0.5751.00
168_D171_P0.5721.00
223_N255_L0.5721.00
91_I94_V0.5721.00
175_K213_Y0.5661.00
135_S139_R0.5651.00
214_Y221_I0.5631.00
143_L147_V0.5621.00
128_Y132_V0.5611.00
46_E74_I0.5601.00
222_I226_R0.5561.00
142_G145_E0.5551.00
223_N227_I0.5521.00
49_L129_V0.5521.00
45_Y98_K0.5501.00
124_A156_N0.5491.00
47_F71_F0.5471.00
132_V135_S0.5461.00
149_M156_N0.5421.00
48_T57_Q0.5381.00
177_T198_L0.5371.00
232_K235_E0.5371.00
192_L219_M0.5371.00
45_Y48_T0.5331.00
156_N161_Y0.5301.00
55_Y82_S0.5301.00
188_S226_R0.5281.00
252_S262_K0.5281.00
143_L146_F0.5281.00
49_L122_N0.5271.00
245_A250_Y0.5241.00
211_Q214_Y0.5231.00
241_V269_K0.5201.00
220_Q262_K0.5191.00
105_Y108_L0.5191.00
228_N232_K0.5191.00
229_F247_E0.5171.00
54_R86_F0.5161.00
192_L204_E0.5151.00
199_S203_Q0.5141.00
92_L95_G0.5141.00
136_L139_R0.5131.00
50_V89_T0.5131.00
130_E133_I0.5131.00
113_F118_V0.5111.00
177_T209_A0.5091.00
153_Y160_H0.5081.00
190_S226_R0.5081.00
107_P111_Y0.5071.00
98_K101_F0.5071.00
109_L112_C0.5041.00
223_N250_Y0.5041.00
174_L206_L0.5031.00
106_L110_P0.5031.00
93_N96_I0.5021.00
259_T264_T0.5021.00
181_M190_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8893 100 0.255 Contact Map
1bl0A 1 0.3929 100 0.491 Contact Map
3oouA 1 0.375 100 0.493 Contact Map
3oioA 1 0.4 100 0.495 Contact Map
3mn2A 1 0.3786 100 0.498 Contact Map
3w6vA 1 0.3893 100 0.502 Contact Map
3mklA 1 0.3964 100 0.503 Contact Map
2k9sA 1 0.3821 100 0.504 Contact Map
3lsgA 2 0.3643 99.9 0.513 Contact Map
1d5yA 1 0.3929 99.9 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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