GREMLIN Database
PTQC - N,N'-diacetylchitobiose permease IIC component
UniProt: P17334 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10141
Length: 452 (412)
Sequences: 2121 (1535)
Seq/√Len: 75.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_F118_G4.8281.00
381_I411_V4.2441.00
310_T342_N4.1961.00
312_G419_A3.7961.00
371_I418_I3.7181.00
273_T290_F3.0191.00
314_I345_I2.8931.00
246_F358_F2.8741.00
102_I153_I2.8551.00
382_P405_S2.8381.00
406_V410_L2.8371.00
367_I422_I2.7491.00
368_L419_A2.7421.00
321_S431_N2.6841.00
95_S152_G2.5261.00
269_E291_H2.4501.00
371_I411_V2.4101.00
207_L217_I2.3851.00
432_K436_A2.3541.00
368_L415_N2.3521.00
364_V367_I2.3241.00
417_G421_L2.2481.00
110_R164_T2.2321.00
99_P121_S2.1971.00
364_V422_I2.1821.00
107_A117_A2.1531.00
202_I206_A2.1261.00
367_I418_I2.1191.00
166_I195_I2.0891.00
273_T289_T2.0751.00
436_A440_E2.0501.00
24_H106_L2.0411.00
320_A424_L2.0151.00
110_R161_E1.9971.00
414_F418_I1.9931.00
434_Q437_I1.9791.00
23_P110_R1.9771.00
274_Y289_T1.9441.00
382_P407_A1.9251.00
249_I254_A1.9231.00
239_I366_P1.9181.00
372_T376_Y1.9051.00
232_V370_A1.8881.00
103_G117_A1.8881.00
399_F409_L1.8851.00
315_L416_L1.8821.00
236_A366_P1.8721.00
411_V415_N1.8711.00
375_A380_I1.8691.00
357_M430_A1.8571.00
323_R431_N1.8561.00
321_S427_V1.8431.00
374_A378_M1.8391.00
435_N439_K1.8371.00
372_T415_N1.8021.00
24_H161_E1.7911.00
316_A319_I1.7751.00
398_A412_A1.7701.00
375_A411_V1.7571.00
351_I357_M1.7101.00
310_T337_G1.7031.00
9_E14_P1.6791.00
161_E164_T1.6691.00
61_F79_L1.6551.00
128_V155_I1.6551.00
398_A408_A1.6531.00
402_T408_A1.6451.00
395_G409_L1.6441.00
243_L247_F1.6401.00
312_G420_T1.6381.00
294_A384_V1.6351.00
364_V419_A1.6301.00
380_I407_A1.6301.00
273_T286_A1.6171.00
261_G265_P1.6121.00
23_P109_E1.6081.00
113_D185_R1.5990.99
286_A289_T1.5810.99
104_M115_L1.5680.99
103_G118_G1.5610.99
312_G416_L1.5550.99
156_G160_A1.5470.99
316_A420_T1.5440.99
421_L424_L1.5390.99
372_T411_V1.5360.99
164_T168_R1.5310.99
375_A381_I1.5260.99
407_A410_L1.5190.99
165_F169_R1.5150.99
290_F383_P1.5100.99
252_A307_S1.5040.99
397_G412_A1.4970.99
245_W251_G1.4940.99
236_A370_A1.4910.99
309_A368_L1.4890.99
326_Y430_A1.4800.99
44_M48_I1.4710.99
28_I157_L1.4660.99
213_N216_Q1.4610.99
54_S59_S1.4610.99
274_Y385_T1.4600.99
430_A434_Q1.4590.99
100_F122_V1.4510.99
273_T287_G1.4500.99
7_S11_V1.4390.99
166_I171_W1.4240.99
106_L161_E1.4190.99
325_D434_Q1.4140.99
176_P179_V1.4040.99
124_A200_M1.4020.99
316_A427_V1.4020.99
380_I411_V1.4010.99
327_R331_K1.3920.99
171_W195_I1.3880.99
395_G413_L1.3850.99
358_F362_V1.3830.99
31_G101_F1.3750.98
394_T416_L1.3520.98
413_L417_G1.3460.98
106_L110_R1.3420.98
76_L79_L1.3390.98
268_L272_A1.3300.98
301_F376_Y1.3280.98
22_Q161_E1.3240.98
124_A196_I1.3240.98
317_I330_A1.3180.98
158_V199_V1.3170.98
302_I369_A1.3150.98
24_H157_L1.3150.98
311_L416_L1.3140.98
323_R438_D1.3030.98
271_I386_N1.2980.98
31_G105_A1.2980.98
172_V188_S1.2930.98
326_Y434_Q1.2850.98
371_I375_A1.2840.98
370_A374_A1.2830.98
316_A424_L1.2820.98
436_A439_K1.2730.97
239_I243_L1.2730.97
6_A10_K1.2690.97
373_L377_Y1.2560.97
346_L361_F1.2520.97
99_P152_G1.2360.97
323_R435_N1.2350.97
123_A197_L1.2320.97
371_I415_N1.2300.97
142_N147_A1.2250.97
402_T405_S1.2240.97
99_P156_G1.2230.97
405_S408_A1.2180.97
38_L97_M1.2160.97
98_A149_I1.2160.97
356_V429_V1.2010.96
79_L83_G1.1980.96
162_M196_I1.1970.96
87_Y92_G1.1930.96
103_G121_S1.1850.96
129_T215_H1.1830.96
50_N84_G1.1830.96
328_Q331_K1.1810.96
257_A261_G1.1780.96
315_L420_T1.1680.96
34_R101_F1.1600.96
337_G342_N1.1590.96
35_L101_F1.1550.95
232_V236_A1.1550.95
7_S14_P1.1540.95
295_K299_D1.1510.95
289_T385_T1.1490.95
120_L193_G1.1460.95
175_L179_V1.1260.95
42_G90_T1.1240.95
271_I275_Q1.1230.95
99_P118_G1.1230.95
266_W291_H1.1200.95
152_G156_G1.1190.95
8_L429_V1.1180.95
329_V333_A1.1160.95
225_P230_G1.1140.94
306_G310_T1.1000.94
392_M400_F1.0990.94
324_A328_Q1.0970.94
206_A209_T1.0930.94
53_L56_G1.0910.94
45_F86_V1.0860.94
376_Y383_P1.0740.93
269_E273_T1.0680.93
8_L14_P1.0660.93
40_L190_L1.0650.93
23_P161_E1.0640.93
316_A320_A1.0620.93
99_P103_G1.0610.93
86_V201_G1.0570.93
268_L271_I1.0550.93
318_F334_L1.0520.93
51_V56_G1.0500.93
105_A108_E1.0490.92
304_L309_A1.0470.92
363_L367_I1.0460.92
112_V164_T1.0440.92
395_G412_A1.0440.92
135_E138_A1.0430.92
233_V236_A1.0420.92
151_S215_H1.0420.92
158_V200_M1.0390.92
318_F330_A1.0350.92
305_G311_L1.0320.92
272_A275_Q1.0320.92
108_E114_A1.0270.92
394_T412_A1.0270.92
433_A436_A1.0270.92
301_F402_T1.0190.91
364_V368_L1.0190.91
374_A377_Y1.0130.91
27_A109_E1.0090.91
175_L178_S1.0070.91
376_Y384_V1.0040.91
428_V431_N1.0020.91
314_I330_A0.9960.90
88_N92_G0.9950.90
49_N84_G0.9930.90
31_G156_G0.9930.90
31_G102_I0.9900.90
160_A164_T0.9880.90
155_I200_M0.9870.90
106_L160_A0.9850.90
233_V237_Y0.9730.89
316_A330_A0.9730.89
104_M114_A0.9720.89
125_F152_G0.9710.89
342_N346_L0.9680.89
56_G61_F0.9680.89
260_N295_K0.9670.89
361_F423_Y0.9650.89
112_V167_V0.9600.89
320_A420_T0.9560.89
375_A378_M0.9560.89
56_G76_L0.9490.88
305_G308_G0.9470.88
32_F98_A0.9430.88
312_G315_L0.9370.87
375_A379_G0.9360.87
385_T405_S0.9330.87
431_N438_D0.9310.87
96_L126_M0.9250.87
289_T383_P0.9230.87
6_A11_V0.9230.87
287_G290_F0.9180.86
314_I317_I0.9160.86
238_V259_D0.9150.86
417_G420_T0.9100.86
24_H110_R0.9100.86
330_A427_V0.9090.86
100_F115_L0.9060.86
158_V162_M0.9060.86
345_I351_I0.9030.85
96_L144_L0.9030.85
120_L196_I0.9020.85
285_A288_K0.8970.85
320_A427_V0.8900.85
46_V91_L0.8880.85
309_A312_G0.8860.84
273_T288_K0.8860.84
31_G157_L0.8860.84
35_L98_A0.8840.84
191_I195_I0.8840.84
108_E111_K0.8790.84
204_A208_N0.8780.84
274_Y290_F0.8770.84
114_A118_G0.8730.84
139_V144_L0.8720.83
319_I424_L0.8710.83
410_L414_F0.8710.83
216_Q220_D0.8700.83
427_V431_N0.8680.83
267_A296_P0.8680.83
50_N391_T0.8680.83
30_N109_E0.8660.83
308_G342_N0.8640.83
415_N419_A0.8640.83
93_I97_M0.8640.83
301_F372_T0.8620.83
117_A163_F0.8620.83
313_L423_Y0.8600.83
337_G345_I0.8580.82
61_F76_L0.8570.82
162_M199_V0.8550.82
95_S99_P0.8550.82
49_N83_G0.8540.82
133_V138_A0.8540.82
381_I405_S0.8530.82
312_G421_L0.8510.82
130_P225_P0.8510.82
346_L351_I0.8500.82
112_V168_R0.8470.82
381_I407_A0.8450.81
319_I431_N0.8440.81
36_M39_T0.8360.81
395_G398_A0.8360.81
388_A401_N0.8330.81
219_M223_S0.8300.80
371_I414_F0.8290.80
305_G309_A0.8260.80
286_A290_F0.8260.80
292_I373_L0.8180.79
364_V418_I0.8160.79
8_L90_T0.8160.79
406_V409_L0.8150.79
306_G342_N0.8140.79
98_A102_I0.8140.79
340_Q390_W0.8080.78
273_T285_A0.8060.78
235_W369_A0.8050.78
431_N435_N0.8030.78
356_V433_A0.8020.78
222_I244_L0.7990.78
155_I159_V0.7960.77
96_L122_V0.7960.77
245_W250_H0.7940.77
429_V433_A0.7940.77
416_L420_T0.7910.77
19_I25_V0.7900.77
173_I179_V0.7890.77
379_G383_P0.7890.77
154_I218_I0.7850.76
143_W216_Q0.7820.76
409_L412_A0.7810.76
124_A159_V0.7790.76
381_I408_A0.7790.76
238_V255_L0.7790.76
272_A285_A0.7790.76
30_N182_S0.7760.76
50_N53_L0.7740.75
159_V200_M0.7720.75
320_A327_R0.7660.75
242_P303_F0.7660.75
266_W269_E0.7650.75
184_S188_S0.7630.74
173_I176_P0.7620.74
375_A414_F0.7610.74
10_K14_P0.7610.74
180_P344_P0.7600.74
242_P307_S0.7580.74
308_G361_F0.7570.74
318_F331_K0.7560.74
424_L427_V0.7530.73
21_K119_L0.7490.73
343_E347_F0.7480.73
317_I349_L0.7440.73
250_H343_E0.7430.72
159_V196_I0.7420.72
46_V87_Y0.7410.72
212_T217_I0.7410.72
25_V353_M0.7380.72
437_I440_E0.7360.72
125_F144_L0.7360.72
162_M195_I0.7360.72
313_L427_V0.7350.72
175_L187_F0.7340.72
126_M144_L0.7330.71
17_V21_K0.7300.71
9_E13_L0.7300.71
15_F19_I0.7290.71
25_V29_K0.7280.71
435_N438_D0.7250.71
264_T268_L0.7250.71
414_F417_G0.7230.70
411_V414_F0.7230.70
55_F59_S0.7220.70
384_V402_T0.7200.70
199_V202_I0.7190.70
333_A345_I0.7180.70
399_F404_G0.7180.70
297_M372_T0.7170.70
167_V170_N0.7150.70
395_G416_L0.7150.70
415_N418_I0.7130.69
292_I297_M0.7110.69
14_P17_V0.7090.69
97_M123_A0.7080.69
317_I427_V0.7080.69
321_S326_Y0.7080.69
214_F217_I0.7040.68
222_I225_P0.7030.68
398_A409_L0.7010.68
161_E165_F0.6970.68
93_I96_L0.6970.68
27_A31_G0.6970.68
232_V374_A0.6970.68
125_F129_T0.6960.67
85_N204_A0.6960.67
89_G126_M0.6950.67
314_I337_G0.6950.67
301_F381_I0.6930.67
167_V172_V0.6900.67
188_S191_I0.6890.67
117_A160_A0.6870.66
19_I370_A0.6850.66
170_N174_K0.6840.66
418_I422_I0.6820.66
8_L12_L0.6820.66
245_W353_M0.6800.66
329_V345_I0.6800.66
330_A333_A0.6790.66
326_Y357_M0.6790.66
365_Q423_Y0.6740.65
235_W298_L0.6730.65
259_D263_M0.6730.65
40_L389_P0.6710.65
377_Y382_P0.6700.65
311_L338_I0.6670.64
180_P187_F0.6650.64
49_N86_V0.6650.64
117_A159_V0.6640.64
229_L237_Y0.6610.63
23_P27_A0.6600.63
304_L311_L0.6600.63
236_A369_A0.6590.63
319_I330_A0.6590.63
368_L372_T0.6580.63
122_V144_L0.6550.63
33_I370_A0.6530.63
177_D181_A0.6530.63
186_S190_L0.6530.63
420_T424_L0.6530.63
22_Q110_R0.6510.62
311_L337_G0.6500.62
309_A419_A0.6480.62
227_A265_P0.6470.62
27_A106_L0.6460.62
320_A331_K0.6440.61
307_S361_F0.6440.61
305_G342_N0.6430.61
326_Y330_A0.6390.61
46_V49_N0.6380.61
380_I414_F0.6370.61
220_D224_T0.6350.60
6_A9_E0.6340.60
193_G197_L0.6320.60
308_G423_Y0.6310.60
30_N105_A0.6300.60
326_Y427_V0.6280.60
314_I427_V0.6270.59
151_S155_I0.6270.59
318_F349_L0.6260.59
363_L366_P0.6260.59
162_M166_I0.6250.59
318_F431_N0.6230.59
171_W191_I0.6190.58
185_R188_S0.6170.58
100_F103_G0.6170.58
424_L428_V0.6160.58
103_G107_A0.6150.58
180_P183_V0.6150.58
31_G98_A0.6140.58
429_V432_K0.6130.58
334_L338_I0.6110.57
381_I389_P0.6110.57
156_G159_V0.6100.57
306_G423_Y0.6090.57
315_L359_I0.6080.57
363_L422_I0.6080.57
178_S335_P0.6070.57
103_G160_A0.6060.57
32_F47_L0.6010.56
56_G59_S0.6010.56
128_V200_M0.5990.56
384_V408_A0.5990.56
231_S234_G0.5950.55
11_V322_R0.5950.55
84_G87_Y0.5940.55
250_H347_F0.5940.55
48_I165_F0.5940.55
107_A160_A0.5910.55
242_P361_F0.5900.55
351_I361_F0.5900.55
8_L11_V0.5900.55
271_I274_Y0.5890.55
221_T410_L0.5890.55
382_P408_A0.5880.55
251_G365_Q0.5880.55
7_S10_K0.5870.54
428_V435_N0.5870.54
176_P180_P0.5850.54
194_F198_S0.5850.54
51_V55_F0.5840.54
22_Q106_L0.5830.54
225_P229_L0.5830.54
101_F105_A0.5820.54
80_K84_G0.5810.54
207_L210_W0.5810.54
325_D431_N0.5800.54
245_W343_E0.5790.53
323_R326_Y0.5790.53
102_I157_L0.5780.53
322_R428_V0.5780.53
31_G103_G0.5760.53
273_T383_P0.5750.53
357_M423_Y0.5740.53
83_G201_G0.5740.53
166_I170_N0.5720.53
428_V432_K0.5710.52
94_M264_T0.5690.52
342_N361_F0.5690.52
297_M376_Y0.5690.52
89_G127_T0.5680.52
324_A327_R0.5680.52
134_G137_Y0.5670.52
16_A22_Q0.5670.52
42_G189_A0.5670.52
11_V15_F0.5660.52
271_I385_T0.5650.52
29_K113_D0.5630.51
312_G423_Y0.5630.51
241_V303_F0.5610.51
22_Q27_A0.5600.51
29_K33_I0.5600.51
10_K363_L0.5590.51
314_I334_L0.5590.51
12_L392_M0.5580.51
223_S227_A0.5570.51
382_P385_T0.5570.51
11_V413_L0.5560.51
326_Y349_L0.5560.51
367_I371_I0.5560.51
25_V30_N0.5530.50
237_Y317_I0.5530.50
87_Y91_L0.5530.50
26_N109_E0.5520.50
10_K239_I0.5520.50
265_P268_L0.5510.50
224_T228_S0.5490.50
5_I358_F0.5480.50
310_T333_A0.5470.49
382_P409_L0.5470.49
190_L389_P0.5460.49
85_N322_R0.5450.49
392_M398_A0.5440.49
178_S324_A0.5440.49
292_I376_Y0.5420.49
388_A400_F0.5420.49
93_I126_M0.5420.49
266_W294_A0.5410.49
323_R330_A0.5400.49
224_T227_A0.5400.49
313_L341_I0.5390.48
267_A294_A0.5390.48
241_V252_A0.5390.48
360_P426_F0.5370.48
38_L123_A0.5370.48
236_A239_I0.5370.48
18_K154_I0.5360.48
311_L420_T0.5360.48
245_W347_F0.5360.48
321_S325_D0.5350.48
404_G408_A0.5340.48
319_I420_T0.5340.48
28_I149_I0.5340.48
305_G313_L0.5330.48
183_V186_S0.5320.48
315_L338_I0.5320.48
143_W215_H0.5300.47
246_F355_P0.5300.47
346_L352_I0.5290.47
245_W307_S0.5290.47
201_G204_A0.5290.47
319_I331_K0.5280.47
287_G439_K0.5280.47
26_N29_K0.5280.47
229_L234_G0.5280.47
299_D384_V0.5270.47
180_P261_G0.5270.47
112_V160_A0.5270.47
338_I439_K0.5270.47
7_S378_M0.5260.47
296_P384_V0.5230.46
230_G266_W0.5230.46
183_V389_P0.5220.46
390_W394_T0.5220.46
312_G321_S0.5200.46
174_K177_D0.5200.46
39_T149_I0.5190.46
77_N80_K0.5180.46
418_I421_L0.5180.46
308_G365_Q0.5180.46
333_A337_G0.5170.46
264_T295_K0.5170.46
128_V214_F0.5160.46
235_W293_W0.5150.45
79_L82_I0.5150.45
25_V263_M0.5150.45
47_L223_S0.5140.45
335_P358_F0.5140.45
48_I199_V0.5130.45
251_G361_F0.5130.45
106_L164_T0.5120.45
157_L161_E0.5120.45
52_F76_L0.5110.45
314_I410_L0.5100.45
163_F189_A0.5100.45
293_W372_T0.5080.45
250_H253_L0.5070.44
20_G25_V0.5070.44
163_F382_P0.5070.44
312_G316_A0.5070.44
339_F390_W0.5060.44
27_A157_L0.5060.44
8_L338_I0.5060.44
230_G291_H0.5050.44
196_I199_V0.5050.44
127_T197_L0.5040.44
38_L120_L0.5040.44
38_L400_F0.5020.44
409_L413_L0.5020.44
18_K21_K0.5010.44
202_I205_W0.5010.44
181_A184_S0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9314 100 0.333 Contact Map
2kluA 1 0.1261 35.3 0.972 Contact Map
4rp9A 2 0.8252 16.3 0.976 Contact Map
2rddB 1 0.0819 15.5 0.976 Contact Map
2kncB 1 0.135 10.5 0.978 Contact Map
3zuxA 1 0.5907 10.4 0.978 Contact Map
4lz6A 1 0.3429 8.8 0.979 Contact Map
3wo6A 1 0.1748 8.6 0.979 Contact Map
4x5mA 2 0.208 7.4 0.979 Contact Map
2cfqA 1 0.4226 7.3 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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