GREMLIN Database
GUTQ - Arabinose 5-phosphate isomerase GutQ
UniProt: P17115 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10973
Length: 321 (311)
Sequences: 2120 (1390)
Seq/√Len: 78.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_I161_L4.2471.00
101_G129_P3.7891.00
121_A134_A3.4981.00
50_I77_A3.1221.00
11_Q173_Q3.0901.00
274_T292_R3.0561.00
246_F265_V3.0001.00
13_L162_M2.8711.00
234_A298_P2.8541.00
221_A265_V2.8261.00
224_E228_T2.8131.00
47_V57_G2.7711.00
26_R139_D2.7081.00
45_V69_T2.7051.00
63_T168_A2.6241.00
140_I163_M2.6071.00
214_L243_Q2.5971.00
215_T266_N2.5881.00
14_M24_P2.4961.00
140_I160_T2.4741.00
237_D241_Q2.4711.00
42_E90_R2.4611.00
17_L21_S2.4571.00
276_L280_S2.4561.00
41_C92_V2.4501.00
45_V94_L2.4461.00
60_I64_L2.3971.00
96_I160_T2.3681.00
264_P267_E2.3651.00
48_S95_F2.3591.00
17_L20_A2.3401.00
34_A120_L2.2801.00
298_P306_L2.2651.00
50_I76_P2.2621.00
37_I136_A2.2441.00
200_H279_Q2.2191.00
34_A136_A2.1831.00
44_K88_E2.1591.00
17_L24_P2.0841.00
242_V306_L1.9811.00
6_L27_L1.9781.00
93_M112_L1.9571.00
61_A71_A1.9461.00
39_L174_A1.9171.00
287_E291_K1.9111.00
74_V87_I1.8721.00
295_T311_N1.8691.00
9_G31_F1.8391.00
18_Q21_S1.8121.00
14_M18_Q1.8081.00
17_L162_M1.7801.00
221_A233_V1.7641.00
48_S93_M1.7381.00
19_E155_S1.7221.00
37_I118_A1.7221.00
38_I45_V1.7141.00
123_T137_V1.6831.00
276_L297_A1.6781.00
6_L32_V1.6741.00
47_V94_L1.6631.00
124_G139_D1.5841.00
211_Q234_A1.5791.00
39_L175_R1.5761.00
113_E135_K1.5701.00
15_L155_S1.5600.99
280_S284_D1.5600.99
22_R143_E1.5490.99
230_L309_A1.5370.99
212_V235_V1.5360.99
278_S307_T1.5350.99
8_A12_T1.5310.99
242_V298_P1.5190.99
65_A86_M1.5160.99
75_H78_E1.5090.99
103_K107_L1.5060.99
38_I92_V1.4960.99
131_G137_V1.4960.99
248_D252_R1.4780.99
8_A173_Q1.4660.99
57_G96_I1.4340.99
36_N40_H1.4170.99
204_R314_D1.4120.99
154_T169_M1.3980.99
118_A135_K1.3890.99
232_L309_A1.3800.99
126_P139_D1.3690.99
200_H278_S1.3560.99
202_L310_I1.3440.98
26_R141_S1.3310.98
214_L266_N1.3210.98
277_Q302_E1.3080.98
122_M163_M1.2790.98
214_L271_V1.2750.98
199_V285_A1.2690.98
241_Q305_K1.2560.98
259_G262_T1.2340.97
240_Q306_L1.2340.97
274_T294_I1.2260.97
138_L163_M1.2200.97
204_R230_L1.2170.97
61_A65_A1.2150.97
263_T267_E1.2150.97
254_W268_A1.2020.97
240_Q305_K1.2000.97
60_I94_L1.1920.97
213_A238_A1.1860.97
126_P137_V1.1810.96
72_F86_M1.1760.96
57_G73_F1.1690.96
234_A306_L1.1640.96
12_T170_A1.1550.96
23_L159_N1.1520.96
214_L237_D1.1500.96
224_E227_R1.1490.96
96_I122_M1.1370.96
276_L285_A1.1360.96
202_L282_A1.1250.95
80_L188_A1.1190.95
234_A242_V1.1130.95
121_A130_L1.1100.95
127_T132_L1.1060.95
232_L245_V1.1060.95
11_Q144_R1.0980.95
246_F251_L1.0950.95
44_K86_M1.0920.95
276_L299_V1.0920.95
60_I96_I1.0910.94
8_A11_Q1.0850.94
224_E233_V1.0850.94
123_T131_G1.0840.94
87_I93_M1.0760.94
122_M140_I1.0710.94
37_I92_V1.0710.94
14_M17_L1.0650.94
115_K185_S1.0610.94
94_L122_M1.0590.94
65_A72_F1.0490.93
67_T171_V1.0490.93
45_V64_L1.0460.93
21_S25_E1.0420.93
124_G163_M1.0400.93
237_D243_Q1.0390.93
38_I64_L1.0280.93
6_L10_R1.0250.92
30_D33_R1.0240.92
121_A137_V1.0210.92
46_V72_F1.0150.92
46_V87_I1.0130.92
216_A220_D1.0080.92
38_I69_T1.0040.92
296_A311_N0.9910.91
57_G160_T0.9760.90
105_L130_L0.9710.90
14_M21_S0.9670.90
284_D287_E0.9660.90
126_P131_G0.9650.90
241_Q304_G0.9630.90
212_V216_A0.9560.90
232_L296_A0.9550.89
13_L23_L0.9520.89
11_Q15_L0.9440.89
212_V233_V0.9420.89
29_D33_R0.9410.89
35_A167_L0.9380.89
15_L144_R0.9360.89
226_S252_R0.9250.88
246_F268_A0.9240.88
33_R36_N0.9190.88
148_P172_M0.9180.88
285_A297_A0.9160.87
183_A193_A0.9160.87
38_I41_C0.9160.87
209_I306_L0.9110.87
92_V118_A0.9100.87
124_G142_V0.9040.87
26_R124_G0.8990.86
124_G140_I0.8970.86
221_A246_F0.8960.86
218_V221_A0.8940.86
19_E22_R0.8900.86
211_Q306_L0.8880.86
55_H79_A0.8770.85
10_R14_M0.8750.85
21_S24_P0.8720.85
114_D281_R0.8700.85
22_R26_R0.8640.84
304_G307_T0.8630.84
61_A72_F0.8620.84
240_Q243_Q0.8600.84
211_Q240_Q0.8580.84
214_L238_A0.8550.84
12_T160_T0.8490.83
9_G32_V0.8470.83
102_A105_L0.8430.83
67_T172_M0.8430.83
197_N286_K0.8420.83
275_T300_V0.8370.82
199_V276_L0.8370.82
10_R24_P0.8340.82
32_V36_N0.8330.82
80_L107_L0.8310.82
19_E143_E0.8270.81
295_T312_L0.8230.81
8_A170_A0.8210.81
95_F119_L0.8190.81
44_K70_P0.8150.81
120_L136_A0.8140.80
35_A170_A0.8110.80
236_C243_Q0.8090.80
78_E86_M0.8070.80
244_G269_M0.8040.80
277_Q280_S0.8020.79
182_F191_L0.8000.79
70_P88_E0.7980.79
212_V224_E0.7970.79
18_Q143_E0.7960.79
54_G76_P0.7950.79
28_G31_F0.7940.79
106_D129_P0.7930.79
36_N174_A0.7910.79
241_Q303_N0.7850.78
285_A310_I0.7850.78
16_E146_A0.7830.78
282_A315_F0.7830.78
22_R25_E0.7810.78
33_R37_I0.7800.78
278_S302_E0.7800.78
148_P151_L0.7800.78
60_I164_G0.7790.77
314_D317_Q0.7740.77
33_R118_A0.7690.77
246_F254_W0.7680.76
111_R184_R0.7680.76
249_G253_R0.7650.76
214_L236_C0.7640.76
139_D142_V0.7630.76
42_E305_K0.7620.76
213_A216_A0.7550.75
215_T265_V0.7550.75
171_V177_F0.7540.75
222_M255_L0.7520.75
33_R136_A0.7500.75
142_V159_N0.7500.75
155_S162_M0.7490.75
219_M256_V0.7480.75
209_I234_A0.7460.74
87_I112_L0.7440.74
227_R256_V0.7430.74
47_V96_I0.7300.73
55_H58_K0.7300.73
54_G65_A0.7300.73
193_A318_A0.7290.73
258_G261_L0.7280.73
66_S182_F0.7270.72
234_A309_A0.7250.72
13_L24_P0.7240.72
114_D290_M0.7220.72
101_G190_A0.7180.71
105_L108_I0.7180.71
295_T316_Y0.7180.71
144_R150_H0.7140.71
274_T288_I0.7130.71
50_I78_E0.7120.71
183_A196_L0.7110.71
138_L167_L0.7100.71
155_S159_N0.7090.71
125_K142_V0.7080.70
211_Q236_C0.7070.70
16_E158_V0.7030.70
223_L226_S0.7010.70
193_A196_L0.7010.70
218_V246_F0.7010.70
29_D32_V0.7010.70
54_G61_A0.7010.70
111_R115_K0.7000.70
30_D136_A0.6980.69
47_V62_A0.6950.69
149_M172_M0.6930.69
35_A174_A0.6910.69
185_S246_F0.6890.68
217_S220_D0.6880.68
38_I94_L0.6830.68
115_K184_R0.6810.67
202_L318_A0.6780.67
266_N271_V0.6770.67
215_T238_A0.6770.67
210_P311_N0.6760.67
92_V120_L0.6750.67
7_N10_R0.6740.67
215_T264_P0.6730.67
222_M226_S0.6720.66
98_Y289_L0.6710.66
148_P152_A0.6710.66
13_L155_S0.6700.66
295_T313_Q0.6690.66
217_S265_V0.6660.66
20_A23_L0.6650.66
13_L17_L0.6610.65
118_A136_A0.6590.65
243_Q306_L0.6570.65
288_I292_R0.6540.64
142_V155_S0.6540.64
55_H263_T0.6500.64
242_V270_T0.6500.64
275_T304_G0.6500.64
98_Y150_H0.6480.64
101_G132_L0.6480.64
23_L163_M0.6460.63
243_Q271_V0.6460.63
215_T302_E0.6440.63
200_H277_Q0.6440.63
55_H78_E0.6430.63
249_G252_R0.6410.63
18_Q22_R0.6400.63
147_C152_A0.6400.63
48_S74_V0.6390.63
124_G141_S0.6390.63
147_C191_L0.6380.62
98_Y141_S0.6360.62
74_V79_A0.6350.62
110_P183_A0.6350.62
32_V35_A0.6330.62
34_A92_V0.6270.61
198_K201_H0.6260.61
103_K188_A0.6260.61
98_Y124_G0.6230.61
34_A138_L0.6220.60
151_L195_L0.6220.60
198_K245_V0.6210.60
47_V134_A0.6200.60
136_A160_T0.6180.60
40_H217_S0.6180.60
31_F35_A0.6130.59
218_V265_V0.6130.59
12_T169_M0.6110.59
87_I117_I0.6100.59
203_M308_G0.6090.59
35_A185_S0.6090.59
290_M313_Q0.6090.59
56_I126_P0.6060.58
229_G248_D0.6060.58
109_I133_A0.6060.58
218_V263_T0.6010.58
219_M223_L0.6010.58
134_A137_V0.5980.57
55_H74_V0.5980.57
237_D305_K0.5970.57
199_V280_S0.5960.57
216_A266_N0.5960.57
38_I235_V0.5950.57
74_V80_L0.5950.57
9_G12_T0.5940.57
102_A194_R0.5930.57
67_T147_C0.5910.57
103_K193_A0.5900.56
159_N163_M0.5890.56
204_R316_Y0.5870.56
260_A263_T0.5860.56
149_M191_L0.5840.56
299_V307_T0.5830.56
142_V290_M0.5820.55
209_I233_V0.5810.55
211_Q233_V0.5810.55
107_L185_S0.5810.55
96_I140_I0.5800.55
146_A154_T0.5790.55
226_S296_A0.5790.55
92_V136_A0.5780.55
238_A262_T0.5780.55
147_C169_M0.5760.55
67_T177_F0.5740.54
210_P248_D0.5730.54
270_T273_G0.5730.54
217_S264_P0.5720.54
97_S121_A0.5700.54
108_I117_I0.5690.54
48_S105_L0.5690.54
37_I120_L0.5680.54
235_V269_M0.5660.53
67_T152_A0.5650.53
289_L296_A0.5640.53
149_M179_E0.5630.53
31_F159_N0.5620.53
234_A245_V0.5600.53
62_A157_T0.5600.53
293_K317_Q0.5590.53
242_V275_T0.5590.53
98_Y149_M0.5580.52
235_V243_Q0.5570.52
218_V260_A0.5540.52
44_K72_F0.5530.52
127_T305_K0.5520.52
60_I226_S0.5510.51
69_T171_V0.5510.51
245_V271_V0.5490.51
226_S229_G0.5470.51
131_G139_D0.5470.51
30_D126_P0.5460.51
17_L155_S0.5450.51
204_R317_Q0.5450.51
275_T298_P0.5440.51
16_E166_A0.5440.51
76_P218_V0.5430.50
98_Y140_I0.5420.50
110_P142_V0.5410.50
29_D127_T0.5400.50
60_I313_Q0.5400.50
19_E170_A0.5370.50
226_S233_V0.5370.50
291_K304_G0.5350.49
54_G78_E0.5340.49
190_A194_R0.5340.49
215_T220_D0.5340.49
65_A196_L0.5340.49
121_A131_G0.5340.49
69_T191_L0.5340.49
170_A174_A0.5330.49
222_M251_L0.5330.49
7_N215_T0.5320.49
258_G263_T0.5310.49
98_Y229_G0.5310.49
205_R209_I0.5310.49
114_D184_R0.5300.49
106_D193_A0.5290.49
238_A277_Q0.5290.49
56_I200_H0.5280.49
7_N11_Q0.5280.49
9_G163_M0.5280.49
218_V261_L0.5280.49
263_T268_A0.5280.49
176_G260_A0.5270.48
197_N202_L0.5270.48
280_S288_I0.5270.48
218_V222_M0.5260.48
50_I108_I0.5260.48
109_I129_P0.5260.48
223_L261_L0.5250.48
295_T309_A0.5250.48
23_L27_L0.5230.48
102_A129_P0.5230.48
197_N200_H0.5220.48
64_L171_V0.5210.48
12_T16_E0.5210.48
220_D256_V0.5200.48
10_R27_L0.5200.48
93_M119_L0.5200.48
55_H102_A0.5200.48
35_A273_G0.5190.47
119_L133_A0.5180.47
208_A228_T0.5170.47
36_N271_V0.5160.47
236_C240_Q0.5150.47
300_V304_G0.5140.47
312_L316_Y0.5140.47
134_A277_Q0.5120.46
230_L295_T0.5120.46
56_I205_R0.5110.46
256_V263_T0.5100.46
35_A246_F0.5100.46
40_H302_E0.5080.46
259_G263_T0.5080.46
48_S109_I0.5080.46
56_I60_I0.5030.45
178_N181_D0.5020.45
239_Q304_G0.5010.45
257_G303_N0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxaA 4 0.5919 100 0.717 Contact Map
3etnA 4 0.595 100 0.735 Contact Map
3euaA 2 0.8629 100 0.738 Contact Map
3fj1A 2 0.9377 100 0.739 Contact Map
3c3jA 2 0.9034 100 0.74 Contact Map
2pocA 4 0.9221 100 0.744 Contact Map
1moqA 2 0.9128 100 0.745 Contact Map
3hbaA 2 0.8692 100 0.745 Contact Map
3fkjA 2 0.8692 100 0.749 Contact Map
4amvA 2 0.9377 100 0.749 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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