GUTQ - ECOLI - GREMLIN Contacts

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GUTQ - Arabinose 5-phosphate isomerase GutQ

UniProt:	P17115	Sequences: MSEALLNAGRQTLMLELQEASRLPERLGDDFVRAANIILHCEGKVVVSGIGKSGHIGKKIAATLASTGTPAFFVHPAEALHGDLGMIESRDVMLFISYSGGAKELDLIIPRLEDKSIALLAMTGKPTSPLGLAAKAVLDISVEREACPMHLAPTSSTVNTLMMGDALAMAVMQARGFNEEDFARSHPAGALGARLLNKVHHLMRRDDAIPQVALTASVMDAMLELSRTGLGLVAVCDAQQQVQGVFTDGDLRRWLVGGGALTTPVNEAMTVGGTTLQSQSRAIDAKEILMKRKITAAPVVDENGKLTGAINLQDFYQAGII	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10973
Length:	321 (311)
Sequences:	2120 (1390)
Seq/√Len:	78.8

ECOLI - GUTQ KDSD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_I	161_L	4.247	1.00
101_G	129_P	3.789	1.00
121_A	134_A	3.498	1.00
50_I	77_A	3.122	1.00
11_Q	173_Q	3.090	1.00
274_T	292_R	3.056	1.00
246_F	265_V	3.000	1.00
13_L	162_M	2.871	1.00
234_A	298_P	2.854	1.00
221_A	265_V	2.826	1.00
224_E	228_T	2.813	1.00
47_V	57_G	2.771	1.00
26_R	139_D	2.708	1.00
45_V	69_T	2.705	1.00
63_T	168_A	2.624	1.00
140_I	163_M	2.607	1.00
214_L	243_Q	2.597	1.00
215_T	266_N	2.588	1.00
14_M	24_P	2.496	1.00
140_I	160_T	2.474	1.00
237_D	241_Q	2.471	1.00
42_E	90_R	2.461	1.00
17_L	21_S	2.457	1.00
276_L	280_S	2.456	1.00
41_C	92_V	2.450	1.00
45_V	94_L	2.446	1.00
60_I	64_L	2.397	1.00
96_I	160_T	2.368	1.00
264_P	267_E	2.365	1.00
48_S	95_F	2.359	1.00
17_L	20_A	2.340	1.00
34_A	120_L	2.280	1.00
298_P	306_L	2.265	1.00
50_I	76_P	2.262	1.00
37_I	136_A	2.244	1.00
200_H	279_Q	2.219	1.00
34_A	136_A	2.183	1.00
44_K	88_E	2.159	1.00
17_L	24_P	2.084	1.00
242_V	306_L	1.981	1.00
6_L	27_L	1.978	1.00
93_M	112_L	1.957	1.00
61_A	71_A	1.946	1.00
39_L	174_A	1.917	1.00
287_E	291_K	1.911	1.00
74_V	87_I	1.872	1.00
295_T	311_N	1.869	1.00
9_G	31_F	1.839	1.00
18_Q	21_S	1.812	1.00
14_M	18_Q	1.808	1.00
17_L	162_M	1.780	1.00
221_A	233_V	1.764	1.00
48_S	93_M	1.738	1.00
19_E	155_S	1.722	1.00
37_I	118_A	1.722	1.00
38_I	45_V	1.714	1.00
123_T	137_V	1.683	1.00
276_L	297_A	1.678	1.00
6_L	32_V	1.674	1.00
47_V	94_L	1.663	1.00
124_G	139_D	1.584	1.00
211_Q	234_A	1.579	1.00
39_L	175_R	1.576	1.00
113_E	135_K	1.570	1.00
15_L	155_S	1.560	0.99
280_S	284_D	1.560	0.99
22_R	143_E	1.549	0.99
230_L	309_A	1.537	0.99
212_V	235_V	1.536	0.99
278_S	307_T	1.535	0.99
8_A	12_T	1.531	0.99
242_V	298_P	1.519	0.99
65_A	86_M	1.516	0.99
75_H	78_E	1.509	0.99
103_K	107_L	1.506	0.99
38_I	92_V	1.496	0.99
131_G	137_V	1.496	0.99
248_D	252_R	1.478	0.99
8_A	173_Q	1.466	0.99
57_G	96_I	1.434	0.99
36_N	40_H	1.417	0.99
204_R	314_D	1.412	0.99
154_T	169_M	1.398	0.99
118_A	135_K	1.389	0.99
232_L	309_A	1.380	0.99
126_P	139_D	1.369	0.99
200_H	278_S	1.356	0.99
202_L	310_I	1.344	0.98
26_R	141_S	1.331	0.98
214_L	266_N	1.321	0.98
277_Q	302_E	1.308	0.98
122_M	163_M	1.279	0.98
214_L	271_V	1.275	0.98
199_V	285_A	1.269	0.98
241_Q	305_K	1.256	0.98
259_G	262_T	1.234	0.97
240_Q	306_L	1.234	0.97
274_T	294_I	1.226	0.97
138_L	163_M	1.220	0.97
204_R	230_L	1.217	0.97
61_A	65_A	1.215	0.97
263_T	267_E	1.215	0.97
254_W	268_A	1.202	0.97
240_Q	305_K	1.200	0.97
60_I	94_L	1.192	0.97
213_A	238_A	1.186	0.97
126_P	137_V	1.181	0.96
72_F	86_M	1.176	0.96
57_G	73_F	1.169	0.96
234_A	306_L	1.164	0.96
12_T	170_A	1.155	0.96
23_L	159_N	1.152	0.96
214_L	237_D	1.150	0.96
224_E	227_R	1.149	0.96
96_I	122_M	1.137	0.96
276_L	285_A	1.136	0.96
202_L	282_A	1.125	0.95
80_L	188_A	1.119	0.95
234_A	242_V	1.113	0.95
121_A	130_L	1.110	0.95
127_T	132_L	1.106	0.95
232_L	245_V	1.106	0.95
11_Q	144_R	1.098	0.95
246_F	251_L	1.095	0.95
44_K	86_M	1.092	0.95
276_L	299_V	1.092	0.95
60_I	96_I	1.091	0.94
8_A	11_Q	1.085	0.94
224_E	233_V	1.085	0.94
123_T	131_G	1.084	0.94
87_I	93_M	1.076	0.94
122_M	140_I	1.071	0.94
37_I	92_V	1.071	0.94
14_M	17_L	1.065	0.94
115_K	185_S	1.061	0.94
94_L	122_M	1.059	0.94
65_A	72_F	1.049	0.93
67_T	171_V	1.049	0.93
45_V	64_L	1.046	0.93
21_S	25_E	1.042	0.93
124_G	163_M	1.040	0.93
237_D	243_Q	1.039	0.93
38_I	64_L	1.028	0.93
6_L	10_R	1.025	0.92
30_D	33_R	1.024	0.92
121_A	137_V	1.021	0.92
46_V	72_F	1.015	0.92
46_V	87_I	1.013	0.92
216_A	220_D	1.008	0.92
38_I	69_T	1.004	0.92
296_A	311_N	0.991	0.91
57_G	160_T	0.976	0.90
105_L	130_L	0.971	0.90
14_M	21_S	0.967	0.90
284_D	287_E	0.966	0.90
126_P	131_G	0.965	0.90
241_Q	304_G	0.963	0.90
212_V	216_A	0.956	0.90
232_L	296_A	0.955	0.89
13_L	23_L	0.952	0.89
11_Q	15_L	0.944	0.89
212_V	233_V	0.942	0.89
29_D	33_R	0.941	0.89
35_A	167_L	0.938	0.89
15_L	144_R	0.936	0.89
226_S	252_R	0.925	0.88
246_F	268_A	0.924	0.88
33_R	36_N	0.919	0.88
148_P	172_M	0.918	0.88
285_A	297_A	0.916	0.87
183_A	193_A	0.916	0.87
38_I	41_C	0.916	0.87
209_I	306_L	0.911	0.87
92_V	118_A	0.910	0.87
124_G	142_V	0.904	0.87
26_R	124_G	0.899	0.86
124_G	140_I	0.897	0.86
221_A	246_F	0.896	0.86
218_V	221_A	0.894	0.86
19_E	22_R	0.890	0.86
211_Q	306_L	0.888	0.86
55_H	79_A	0.877	0.85
10_R	14_M	0.875	0.85
21_S	24_P	0.872	0.85
114_D	281_R	0.870	0.85
22_R	26_R	0.864	0.84
304_G	307_T	0.863	0.84
61_A	72_F	0.862	0.84
240_Q	243_Q	0.860	0.84
211_Q	240_Q	0.858	0.84
214_L	238_A	0.855	0.84
12_T	160_T	0.849	0.83
9_G	32_V	0.847	0.83
102_A	105_L	0.843	0.83
67_T	172_M	0.843	0.83
197_N	286_K	0.842	0.83
275_T	300_V	0.837	0.82
199_V	276_L	0.837	0.82
10_R	24_P	0.834	0.82
32_V	36_N	0.833	0.82
80_L	107_L	0.831	0.82
19_E	143_E	0.827	0.81
295_T	312_L	0.823	0.81
8_A	170_A	0.821	0.81
95_F	119_L	0.819	0.81
44_K	70_P	0.815	0.81
120_L	136_A	0.814	0.80
35_A	170_A	0.811	0.80
236_C	243_Q	0.809	0.80
78_E	86_M	0.807	0.80
244_G	269_M	0.804	0.80
277_Q	280_S	0.802	0.79
182_F	191_L	0.800	0.79
70_P	88_E	0.798	0.79
212_V	224_E	0.797	0.79
18_Q	143_E	0.796	0.79
54_G	76_P	0.795	0.79
28_G	31_F	0.794	0.79
106_D	129_P	0.793	0.79
36_N	174_A	0.791	0.79
241_Q	303_N	0.785	0.78
285_A	310_I	0.785	0.78
16_E	146_A	0.783	0.78
282_A	315_F	0.783	0.78
22_R	25_E	0.781	0.78
33_R	37_I	0.780	0.78
278_S	302_E	0.780	0.78
148_P	151_L	0.780	0.78
60_I	164_G	0.779	0.77
314_D	317_Q	0.774	0.77
33_R	118_A	0.769	0.77
246_F	254_W	0.768	0.76
111_R	184_R	0.768	0.76
249_G	253_R	0.765	0.76
214_L	236_C	0.764	0.76
139_D	142_V	0.763	0.76
42_E	305_K	0.762	0.76
213_A	216_A	0.755	0.75
215_T	265_V	0.755	0.75
171_V	177_F	0.754	0.75
222_M	255_L	0.752	0.75
33_R	136_A	0.750	0.75
142_V	159_N	0.750	0.75
155_S	162_M	0.749	0.75
219_M	256_V	0.748	0.75
209_I	234_A	0.746	0.74
87_I	112_L	0.744	0.74
227_R	256_V	0.743	0.74
47_V	96_I	0.730	0.73
55_H	58_K	0.730	0.73
54_G	65_A	0.730	0.73
193_A	318_A	0.729	0.73
258_G	261_L	0.728	0.73
66_S	182_F	0.727	0.72
234_A	309_A	0.725	0.72
13_L	24_P	0.724	0.72
114_D	290_M	0.722	0.72
101_G	190_A	0.718	0.71
105_L	108_I	0.718	0.71
295_T	316_Y	0.718	0.71
144_R	150_H	0.714	0.71
274_T	288_I	0.713	0.71
50_I	78_E	0.712	0.71
183_A	196_L	0.711	0.71
138_L	167_L	0.710	0.71
155_S	159_N	0.709	0.71
125_K	142_V	0.708	0.70
211_Q	236_C	0.707	0.70
16_E	158_V	0.703	0.70
223_L	226_S	0.701	0.70
193_A	196_L	0.701	0.70
218_V	246_F	0.701	0.70
29_D	32_V	0.701	0.70
54_G	61_A	0.701	0.70
111_R	115_K	0.700	0.70
30_D	136_A	0.698	0.69
47_V	62_A	0.695	0.69
149_M	172_M	0.693	0.69
35_A	174_A	0.691	0.69
185_S	246_F	0.689	0.68
217_S	220_D	0.688	0.68
38_I	94_L	0.683	0.68
115_K	184_R	0.681	0.67
202_L	318_A	0.678	0.67
266_N	271_V	0.677	0.67
215_T	238_A	0.677	0.67
210_P	311_N	0.676	0.67
92_V	120_L	0.675	0.67
7_N	10_R	0.674	0.67
215_T	264_P	0.673	0.67
222_M	226_S	0.672	0.66
98_Y	289_L	0.671	0.66
148_P	152_A	0.671	0.66
13_L	155_S	0.670	0.66
295_T	313_Q	0.669	0.66
217_S	265_V	0.666	0.66
20_A	23_L	0.665	0.66
13_L	17_L	0.661	0.65
118_A	136_A	0.659	0.65
243_Q	306_L	0.657	0.65
288_I	292_R	0.654	0.64
142_V	155_S	0.654	0.64
55_H	263_T	0.650	0.64
242_V	270_T	0.650	0.64
275_T	304_G	0.650	0.64
98_Y	150_H	0.648	0.64
101_G	132_L	0.648	0.64
23_L	163_M	0.646	0.63
243_Q	271_V	0.646	0.63
215_T	302_E	0.644	0.63
200_H	277_Q	0.644	0.63
55_H	78_E	0.643	0.63
249_G	252_R	0.641	0.63
18_Q	22_R	0.640	0.63
147_C	152_A	0.640	0.63
48_S	74_V	0.639	0.63
124_G	141_S	0.639	0.63
147_C	191_L	0.638	0.62
98_Y	141_S	0.636	0.62
74_V	79_A	0.635	0.62
110_P	183_A	0.635	0.62
32_V	35_A	0.633	0.62
34_A	92_V	0.627	0.61
198_K	201_H	0.626	0.61
103_K	188_A	0.626	0.61
98_Y	124_G	0.623	0.61
34_A	138_L	0.622	0.60
151_L	195_L	0.622	0.60
198_K	245_V	0.621	0.60
47_V	134_A	0.620	0.60
136_A	160_T	0.618	0.60
40_H	217_S	0.618	0.60
31_F	35_A	0.613	0.59
218_V	265_V	0.613	0.59
12_T	169_M	0.611	0.59
87_I	117_I	0.610	0.59
203_M	308_G	0.609	0.59
35_A	185_S	0.609	0.59
290_M	313_Q	0.609	0.59
56_I	126_P	0.606	0.58
229_G	248_D	0.606	0.58
109_I	133_A	0.606	0.58
218_V	263_T	0.601	0.58
219_M	223_L	0.601	0.58
134_A	137_V	0.598	0.57
55_H	74_V	0.598	0.57
237_D	305_K	0.597	0.57
199_V	280_S	0.596	0.57
216_A	266_N	0.596	0.57
38_I	235_V	0.595	0.57
74_V	80_L	0.595	0.57
9_G	12_T	0.594	0.57
102_A	194_R	0.593	0.57
67_T	147_C	0.591	0.57
103_K	193_A	0.590	0.56
159_N	163_M	0.589	0.56
204_R	316_Y	0.587	0.56
260_A	263_T	0.586	0.56
149_M	191_L	0.584	0.56
299_V	307_T	0.583	0.56
142_V	290_M	0.582	0.55
209_I	233_V	0.581	0.55
211_Q	233_V	0.581	0.55
107_L	185_S	0.581	0.55
96_I	140_I	0.580	0.55
146_A	154_T	0.579	0.55
226_S	296_A	0.579	0.55
92_V	136_A	0.578	0.55
238_A	262_T	0.578	0.55
147_C	169_M	0.576	0.55
67_T	177_F	0.574	0.54
210_P	248_D	0.573	0.54
270_T	273_G	0.573	0.54
217_S	264_P	0.572	0.54
97_S	121_A	0.570	0.54
108_I	117_I	0.569	0.54
48_S	105_L	0.569	0.54
37_I	120_L	0.568	0.54
235_V	269_M	0.566	0.53
67_T	152_A	0.565	0.53
289_L	296_A	0.564	0.53
149_M	179_E	0.563	0.53
31_F	159_N	0.562	0.53
234_A	245_V	0.560	0.53
62_A	157_T	0.560	0.53
293_K	317_Q	0.559	0.53
242_V	275_T	0.559	0.53
98_Y	149_M	0.558	0.52
235_V	243_Q	0.557	0.52
218_V	260_A	0.554	0.52
44_K	72_F	0.553	0.52
127_T	305_K	0.552	0.52
60_I	226_S	0.551	0.51
69_T	171_V	0.551	0.51
245_V	271_V	0.549	0.51
226_S	229_G	0.547	0.51
131_G	139_D	0.547	0.51
30_D	126_P	0.546	0.51
17_L	155_S	0.545	0.51
204_R	317_Q	0.545	0.51
275_T	298_P	0.544	0.51
16_E	166_A	0.544	0.51
76_P	218_V	0.543	0.50
98_Y	140_I	0.542	0.50
110_P	142_V	0.541	0.50
29_D	127_T	0.540	0.50
60_I	313_Q	0.540	0.50
19_E	170_A	0.537	0.50
226_S	233_V	0.537	0.50
291_K	304_G	0.535	0.49
54_G	78_E	0.534	0.49
190_A	194_R	0.534	0.49
215_T	220_D	0.534	0.49
65_A	196_L	0.534	0.49
121_A	131_G	0.534	0.49
69_T	191_L	0.534	0.49
170_A	174_A	0.533	0.49
222_M	251_L	0.533	0.49
7_N	215_T	0.532	0.49
258_G	263_T	0.531	0.49
98_Y	229_G	0.531	0.49
205_R	209_I	0.531	0.49
114_D	184_R	0.530	0.49
106_D	193_A	0.529	0.49
238_A	277_Q	0.529	0.49
56_I	200_H	0.528	0.49
7_N	11_Q	0.528	0.49
9_G	163_M	0.528	0.49
218_V	261_L	0.528	0.49
263_T	268_A	0.528	0.49
176_G	260_A	0.527	0.48
197_N	202_L	0.527	0.48
280_S	288_I	0.527	0.48
218_V	222_M	0.526	0.48
50_I	108_I	0.526	0.48
109_I	129_P	0.526	0.48
223_L	261_L	0.525	0.48
295_T	309_A	0.525	0.48
23_L	27_L	0.523	0.48
102_A	129_P	0.523	0.48
197_N	200_H	0.522	0.48
64_L	171_V	0.521	0.48
12_T	16_E	0.521	0.48
220_D	256_V	0.520	0.48
10_R	27_L	0.520	0.48
93_M	119_L	0.520	0.48
55_H	102_A	0.520	0.48
35_A	273_G	0.519	0.47
119_L	133_A	0.518	0.47
208_A	228_T	0.517	0.47
36_N	271_V	0.516	0.47
236_C	240_Q	0.515	0.47
300_V	304_G	0.514	0.47
312_L	316_Y	0.514	0.47
134_A	277_Q	0.512	0.46
230_L	295_T	0.512	0.46
56_I	205_R	0.511	0.46
256_V	263_T	0.510	0.46
35_A	246_F	0.510	0.46
40_H	302_E	0.508	0.46
259_G	263_T	0.508	0.46
48_S	109_I	0.508	0.46
56_I	60_I	0.503	0.45
178_N	181_D	0.502	0.45
239_Q	304_G	0.501	0.45
257_G	303_N	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fxaA	4	0.5919	100	0.717	Contact Map
3etnA	4	0.595	100	0.735	Contact Map
3euaA	2	0.8629	100	0.738	Contact Map
3fj1A	2	0.9377	100	0.739	Contact Map
3c3jA	2	0.9034	100	0.74	Contact Map
2pocA	4	0.9221	100	0.744	Contact Map
1moqA	2	0.9128	100	0.745	Contact Map
3hbaA	2	0.8692	100	0.745	Contact Map
3fkjA	2	0.8692	100	0.749	Contact Map
4amvA	2	0.9377	100	0.749	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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