MEND - ECOLI - GREMLIN Contacts

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MEND - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

UniProt:	P17109	Sequences: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRICDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPQSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETAFADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10579
Length:	556 (518)
Sequences:	14248 (9179)
Seq/√Len:	403.3

ECOLI - MEND OXC ILVB ILVG ILVI GCL POXB
BACSU - MEND ILVX ILVB IOLD YDAP
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q97U16 Q97V62 Q97XR3 Q980V7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
499_H	502_A	4.945	1.00
468_N	534_E	3.791	1.00
375_R	518_E	3.772	1.00
59_G	89_A	3.621	1.00
509_H	523_D	3.401	1.00
24_R	71_Q	3.081	1.00
236_K	335_E	3.065	1.00
513_N	516_E	3.042	1.00
510_R	536_V	2.986	1.00
242_Q	258_Q	2.862	1.00
379_Y	522_A	2.815	1.00
236_K	331_A	2.742	1.00
210_K	340_E	2.712	1.00
68_V	432_S	2.700	1.00
19_T	46_A	2.680	1.00
226_A	237_V	2.637	1.00
328_A	333_W	2.601	1.00
509_H	531_T	2.562	1.00
507_K	529_T	2.558	1.00
375_R	378_D	2.505	1.00
25_H	48_I	2.458	1.00
512_Q	516_E	2.424	1.00
212_R	307_W	2.414	1.00
425_A	438_A	2.321	1.00
509_H	520_A	2.318	1.00
285_L	330_I	2.270	1.00
279_A	282_V	2.263	1.00
77_V	86_L	2.262	1.00
510_R	534_E	2.182	1.00
507_K	523_D	2.178	1.00
345_W	349_I	2.163	1.00
496_H	499_H	2.157	1.00
378_D	518_E	2.144	1.00
72_P	157_G	2.121	1.00
12_A	40_A	2.114	1.00
446_L	504_F	2.079	1.00
52_H	58_L	2.078	1.00
284_Q	287_S	2.065	1.00
101_I	153_D	2.064	1.00
84_A	88_P	2.061	1.00
309_V	333_W	2.040	1.00
90_L	102_L	2.029	1.00
500_A	503_M	2.005	1.00
224_V	241_A	1.973	1.00
215_F	324_R	1.966	1.00
215_F	281_I	1.944	1.00
104_T	165_H	1.938	1.00
511_P	520_A	1.923	1.00
215_F	305_E	1.923	1.00
216_F	283_V	1.922	1.00
16_E	20_R	1.897	1.00
498_E	508_Y	1.896	1.00
124_G	127_A	1.895	1.00
148_L	166_I	1.884	1.00
381_P	384_G	1.863	1.00
241_A	248_L	1.860	1.00
377_C	402_Q	1.853	1.00
72_P	101_I	1.841	1.00
63_L	67_K	1.827	1.00
445_A	449_L	1.818	1.00
206_L	336_L	1.816	1.00
429_Q	461_P	1.815	1.00
12_A	43_E	1.802	1.00
205_R	208_S	1.781	1.00
211_Q	214_W	1.780	1.00
456_R	506_L	1.768	1.00
518_E	522_A	1.767	1.00
522_A	526_R	1.763	1.00
239_L	243_T	1.747	1.00
507_K	531_T	1.746	1.00
214_W	218_R	1.743	1.00
243_T	338_P	1.723	1.00
466_V	532_V	1.712	1.00
8_R	16_E	1.702	1.00
238_A	242_Q	1.699	1.00
121_R	124_G	1.694	1.00
524_A	533_I	1.693	1.00
224_V	283_V	1.691	1.00
516_E	519_T	1.687	1.00
224_V	246_W	1.683	1.00
389_G	440_V	1.674	1.00
385_Q	428_V	1.674	1.00
138_R	141_Q	1.658	1.00
243_T	342_R	1.652	1.00
512_Q	536_V	1.614	1.00
374_H	378_D	1.607	1.00
502_A	507_K	1.596	1.00
389_G	444_S	1.588	1.00
420_G	424_T	1.581	1.00
376_I	439_I	1.577	1.00
28_I	49_H	1.575	1.00
219_Q	222_G	1.545	1.00
38_T	49_H	1.545	1.00
16_E	19_T	1.542	1.00
235_K	239_L	1.540	1.00
371_Q	514_W	1.536	1.00
487_R	490_L	1.531	1.00
285_L	309_V	1.528	1.00
486_E	490_L	1.524	1.00
130_P	165_H	1.517	1.00
410_Y	428_V	1.499	1.00
498_E	510_R	1.496	1.00
69_S	431_A	1.489	1.00
134_I	166_I	1.488	1.00
519_T	523_D	1.484	1.00
429_Q	460_A	1.482	1.00
316_L	327_I	1.481	1.00
349_I	353_A	1.472	1.00
216_F	281_I	1.469	1.00
379_Y	518_E	1.468	1.00
208_S	211_Q	1.466	1.00
455_L	506_L	1.461	1.00
131_T	162_G	1.449	1.00
14_I	168_C	1.445	1.00
371_Q	375_R	1.443	1.00
17_A	150_S	1.442	1.00
278_Q	348_E	1.436	1.00
57_G	451_A	1.435	1.00
519_T	522_A	1.431	1.00
465_I	533_I	1.426	1.00
375_R	379_Y	1.425	1.00
384_G	435_P	1.413	1.00
86_L	102_L	1.412	1.00
465_I	521_F	1.400	1.00
103_L	168_C	1.399	1.00
452_L	506_L	1.398	1.00
305_E	323_G	1.390	1.00
455_L	462_L	1.388	1.00
449_L	500_A	1.379	1.00
52_H	61_L	1.360	1.00
72_P	153_D	1.357	1.00
240_W	244_L	1.354	1.00
487_R	491_M	1.354	1.00
139_P	175_Y	1.350	1.00
385_Q	432_S	1.350	1.00
219_Q	281_I	1.346	1.00
381_P	435_P	1.344	1.00
380_L	437_L	1.343	1.00
372_L	535_M	1.338	1.00
90_L	100_L	1.331	1.00
213_D	337_H	1.326	1.00
25_H	430_R	1.325	1.00
429_Q	435_P	1.323	1.00
48_I	458_V	1.322	1.00
21_H	153_D	1.321	1.00
109_P	171_A	1.317	1.00
19_T	45_S	1.316	1.00
437_L	525_W	1.310	1.00
281_I	307_W	1.308	1.00
350_P	353_A	1.307	1.00
430_R	460_A	1.307	1.00
59_G	86_L	1.302	1.00
317_D	322_R	1.301	1.00
463_V	524_A	1.299	1.00
527_T	531_T	1.297	1.00
147_W	151_T	1.296	1.00
507_K	527_T	1.293	1.00
465_I	535_M	1.291	1.00
21_H	150_S	1.290	1.00
210_K	214_W	1.287	1.00
408_P	434_K	1.286	1.00
240_W	334_L	1.280	1.00
382_E	404_P	1.280	1.00
213_D	340_E	1.277	1.00
461_P	529_T	1.276	1.00
418_I	447_Y	1.275	1.00
426_A	455_L	1.273	1.00
83_V	104_T	1.271	1.00
367_F	535_M	1.271	1.00
498_E	502_A	1.269	1.00
223_V	279_A	1.269	1.00
348_E	352_L	1.268	1.00
14_I	149_V	1.264	1.00
470_N	494_N	1.248	1.00
347_V	351_R	1.246	1.00
500_A	504_F	1.246	1.00
435_P	525_W	1.240	1.00
211_Q	215_F	1.237	1.00
347_V	350_P	1.236	1.00
125_M	129_H	1.234	1.00
27_C	65_L	1.233	1.00
332_D	335_E	1.230	1.00
136_L	143_I	1.230	1.00
367_F	372_L	1.229	1.00
50_H	430_R	1.226	1.00
461_P	528_P	1.225	1.00
438_A	464_L	1.223	1.00
11_A	40_A	1.216	1.00
331_A	335_E	1.205	1.00
517_L	535_M	1.203	1.00
204_P	333_W	1.203	1.00
63_L	92_E	1.200	1.00
274_S	278_Q	1.194	1.00
209_E	340_E	1.192	1.00
169_P	172_E	1.192	1.00
149_V	166_I	1.191	1.00
350_P	354_E	1.187	1.00
65_L	431_A	1.187	1.00
66_A	99_K	1.178	1.00
499_H	503_M	1.174	1.00
9_R	12_A	1.172	1.00
17_A	149_V	1.168	1.00
239_L	242_Q	1.165	1.00
101_I	156_L	1.164	1.00
385_Q	436_T	1.163	1.00
213_D	217_W	1.162	1.00
285_L	334_L	1.160	1.00
351_R	355_Q	1.158	1.00
453_A	457_Q	1.154	1.00
239_L	338_P	1.153	1.00
501_A	506_L	1.153	1.00
240_W	338_P	1.152	1.00
141_Q	147_W	1.151	1.00
506_L	532_V	1.151	1.00
237_V	334_L	1.150	1.00
520_A	533_I	1.150	1.00
501_A	532_V	1.149	1.00
110_E	171_A	1.142	1.00
26_I	41_A	1.141	1.00
356_A	360_V	1.139	1.00
91_I	415_A	1.136	1.00
523_D	527_T	1.135	1.00
382_E	405_A	1.133	1.00
222_G	280_Q	1.133	1.00
24_R	48_I	1.130	1.00
224_V	240_W	1.129	1.00
68_V	428_V	1.118	1.00
134_I	151_T	1.116	1.00
204_P	336_L	1.104	1.00
509_H	533_I	1.098	1.00
63_L	98_E	1.096	1.00
236_K	239_L	1.095	1.00
501_A	508_Y	1.090	1.00
23_V	74_A	1.090	1.00
329_N	332_D	1.089	1.00
94_G	163_G	1.082	1.00
151_T	155_A	1.082	1.00
75_V	86_L	1.078	1.00
221_R	278_Q	1.076	1.00
270_A	274_S	1.076	1.00
517_L	521_F	1.072	1.00
217_W	342_R	1.071	1.00
134_I	148_L	1.070	1.00
25_H	50_H	1.067	1.00
87_Y	125_M	1.066	1.00
429_Q	436_T	1.066	1.00
343_Q	347_V	1.066	1.00
235_K	238_A	1.065	1.00
57_G	448_D	1.064	1.00
64_G	68_V	1.062	1.00
8_R	176_G	1.061	1.00
9_R	176_G	1.060	1.00
40_A	43_E	1.057	1.00
13_V	177_E	1.054	1.00
336_L	339_A	1.051	1.00
34_S	37_L	1.050	1.00
380_L	386_L	1.047	1.00
109_P	175_Y	1.046	1.00
429_Q	433_G	1.045	1.00
463_V	531_T	1.043	1.00
155_A	164_V	1.043	1.00
84_A	125_M	1.039	1.00
239_L	335_E	1.037	1.00
212_R	326_L	1.034	1.00
224_V	237_V	1.034	1.00
508_Y	532_V	1.032	1.00
144_P	148_L	1.030	1.00
59_G	75_V	1.024	1.00
523_D	526_R	1.023	1.00
203_A	336_L	1.023	1.00
386_L	401_S	1.020	1.00
435_P	463_V	1.019	1.00
511_P	516_E	1.019	1.00
212_R	324_R	1.015	1.00
112_I	135_S	1.014	1.00
206_L	340_E	1.011	1.00
77_V	102_L	1.010	1.00
236_K	338_P	1.009	1.00
14_I	103_L	1.006	1.00
50_H	458_V	1.006	1.00
383_Q	434_K	1.005	1.00
284_Q	289_L	1.005	1.00
511_P	517_L	1.000	1.00
223_V	249_I	0.997	1.00
470_N	536_V	0.996	1.00
349_I	352_L	0.995	1.00
296_Q	299_A	0.992	1.00
133_S	165_H	0.991	1.00
87_Y	129_H	0.991	1.00
75_V	102_L	0.987	1.00
218_R	305_E	0.984	1.00
488_F	491_M	0.978	1.00
136_L	148_L	0.977	1.00
26_I	74_A	0.975	1.00
486_E	489_Y	0.974	1.00
322_R	325_R	0.974	1.00
261_P	275_E	0.968	1.00
130_P	133_S	0.968	1.00
445_A	466_V	0.965	1.00
387_F	438_A	0.965	1.00
452_L	532_V	0.961	1.00
455_L	464_L	0.961	1.00
234_G	238_A	0.960	1.00
368_G	541_D	0.960	1.00
387_F	436_T	0.956	1.00
422_L	445_A	0.955	1.00
106_D	167_N	0.951	1.00
250_G	260_L	0.951	1.00
466_V	497_F	0.949	1.00
498_E	534_E	0.948	1.00
332_D	336_L	0.944	1.00
452_L	464_L	0.942	1.00
421_L	438_A	0.939	1.00
524_A	531_T	0.937	1.00
238_A	258_Q	0.936	1.00
157_G	161_A	0.936	1.00
144_P	147_W	0.935	1.00
309_V	326_L	0.933	1.00
326_L	333_W	0.932	1.00
83_V	126_F	0.930	1.00
449_L	504_F	0.929	1.00
213_D	341_K	0.927	1.00
372_L	467_V	0.925	1.00
14_I	37_L	0.924	1.00
429_Q	529_T	0.923	1.00
373_A	439_I	0.923	1.00
463_V	525_W	0.921	1.00
219_Q	280_Q	0.921	1.00
357_M	360_V	0.921	1.00
37_L	168_C	0.920	1.00
377_C	401_S	0.917	1.00
467_V	537_V	0.916	1.00
218_R	281_I	0.916	1.00
459_S	528_P	0.915	1.00
506_L	530_T	0.915	1.00
520_A	524_A	0.915	1.00
379_Y	521_F	0.910	1.00
10_W	143_I	0.908	1.00
203_A	332_D	0.905	1.00
463_V	533_I	0.905	1.00
223_V	276_L	0.904	1.00
59_G	100_L	0.903	1.00
212_R	281_I	0.897	1.00
476_S	491_M	0.893	1.00
90_L	126_F	0.891	1.00
207_E	210_K	0.890	1.00
405_A	408_P	0.889	1.00
445_A	532_V	0.889	1.00
67_K	98_E	0.886	1.00
356_A	359_A	0.885	1.00
12_A	16_E	0.884	1.00
502_A	508_Y	0.883	1.00
453_A	504_F	0.881	1.00
301_C	304_E	0.881	1.00
427_G	431_A	0.880	1.00
516_E	520_A	0.879	1.00
223_V	282_V	0.879	1.00
132_H	148_L	0.877	1.00
132_H	155_A	0.877	1.00
84_A	91_I	0.876	1.00
39_L	42_A	0.876	1.00
61_L	455_L	0.875	1.00
217_W	341_K	0.875	1.00
215_F	307_W	0.875	1.00
87_Y	126_F	0.874	1.00
41_A	47_F	0.872	1.00
486_E	491_M	0.871	1.00
397_I	439_I	0.870	1.00
509_H	527_T	0.870	1.00
352_L	355_Q	0.869	1.00
233_E	236_K	0.866	1.00
124_G	128_S	0.865	1.00
17_A	21_H	0.864	1.00
443_L	472_G	0.863	1.00
214_W	217_W	0.861	1.00
64_G	424_T	0.860	1.00
8_R	13_V	0.859	1.00
71_Q	157_G	0.858	1.00
371_Q	517_L	0.857	1.00
520_A	523_D	0.854	1.00
97_G	160_H	0.853	1.00
348_E	351_R	0.852	1.00
351_R	354_E	0.850	1.00
377_C	404_P	0.848	1.00
74_A	101_I	0.844	1.00
346_C	349_I	0.844	1.00
344_P	347_V	0.844	1.00
17_A	20_R	0.843	1.00
260_L	265_L	0.842	1.00
25_H	65_L	0.840	1.00
221_R	280_Q	0.840	1.00
88_P	417_G	0.837	1.00
68_V	410_Y	0.835	1.00
462_L	530_T	0.833	1.00
10_W	139_P	0.832	1.00
375_R	517_L	0.832	1.00
212_R	215_F	0.830	1.00
226_A	250_G	0.826	1.00
455_L	530_T	0.824	1.00
224_V	285_L	0.824	1.00
373_A	467_V	0.824	1.00
439_I	467_V	0.824	1.00
457_Q	493_Q	0.822	1.00
384_G	437_L	0.822	1.00
239_L	342_R	0.821	1.00
209_E	336_L	0.819	1.00
240_W	341_K	0.816	1.00
123_P	133_S	0.813	1.00
373_A	401_S	0.812	1.00
36_P	174_L	0.812	1.00
18_L	74_A	0.811	1.00
383_Q	405_A	0.811	1.00
226_A	248_L	0.810	1.00
294_L	297_W	0.807	1.00
316_L	325_R	0.806	1.00
379_Y	525_W	0.802	1.00
313_E	327_I	0.800	1.00
156_L	164_V	0.800	1.00
468_N	536_V	0.800	1.00
470_N	539_D	0.799	1.00
76_I	103_L	0.799	1.00
446_L	449_L	0.798	1.00
9_R	40_A	0.797	1.00
346_C	350_P	0.796	1.00
168_C	173_P	0.793	1.00
101_I	157_G	0.793	1.00
437_L	465_I	0.791	1.00
456_R	530_T	0.791	1.00
496_H	510_R	0.790	1.00
153_D	157_G	0.786	1.00
30_P	51_T	0.784	1.00
232_E	407_Y	0.784	1.00
463_V	528_P	0.783	1.00
393_V	444_S	0.782	1.00
34_S	76_I	0.781	1.00
131_T	164_V	0.778	1.00
228_R	253_L	0.777	1.00
206_L	210_K	0.777	1.00
13_V	144_P	0.776	1.00
515_Q	519_T	0.774	1.00
204_P	209_E	0.774	1.00
60_H	417_G	0.772	1.00
52_H	57_G	0.767	1.00
151_T	154_H	0.762	1.00
90_L	129_H	0.761	1.00
66_A	98_E	0.761	1.00
68_V	431_A	0.761	1.00
24_R	65_L	0.759	1.00
426_A	460_A	0.759	1.00
339_A	342_R	0.758	1.00
283_V	309_V	0.758	1.00
496_H	502_A	0.757	1.00
23_V	153_D	0.756	1.00
77_V	104_T	0.755	1.00
65_L	71_Q	0.755	1.00
39_L	486_E	0.753	1.00
222_G	246_W	0.751	1.00
508_Y	534_E	0.749	1.00
476_S	480_T	0.746	1.00
281_I	305_E	0.745	1.00
422_L	464_L	0.745	1.00
211_Q	324_R	0.743	1.00
153_D	156_L	0.743	1.00
425_A	462_L	0.742	1.00
491_M	539_D	0.741	1.00
37_L	173_P	0.738	1.00
56_R	85_N	0.737	1.00
236_K	334_L	0.736	1.00
388_V	409_V	0.735	1.00
66_A	100_L	0.735	1.00
139_P	144_P	0.733	1.00
19_T	24_R	0.732	1.00
148_L	151_T	0.732	1.00
439_I	465_I	0.730	1.00
464_L	506_L	0.727	1.00
132_H	164_V	0.726	1.00
446_L	495_V	0.723	1.00
252_V	398_D	0.722	1.00
29_A	86_L	0.722	1.00
333_W	336_L	0.721	1.00
262_C	265_L	0.721	1.00
132_H	151_T	0.719	1.00
456_R	505_E	0.719	1.00
217_W	340_E	0.718	1.00
435_P	461_P	0.718	1.00
123_P	135_S	0.718	1.00
27_C	61_L	0.718	1.00
367_F	514_W	0.717	1.00
389_G	421_L	0.717	1.00
34_S	38_T	0.716	1.00
39_L	43_E	0.715	1.00
59_G	102_L	0.715	1.00
208_S	212_R	0.714	1.00
388_V	397_I	0.713	1.00
78_T	118_Q	0.713	1.00
422_L	440_V	0.711	1.00
233_E	331_A	0.711	1.00
388_V	411_S	0.710	1.00
135_S	167_N	0.709	1.00
104_T	167_N	0.708	1.00
345_W	352_L	0.708	1.00
308_I	322_R	0.708	1.00
26_I	76_I	0.708	1.00
380_L	384_G	0.707	1.00
91_I	129_H	0.705	1.00
367_F	513_N	0.704	1.00
222_G	281_I	0.702	1.00
344_P	348_E	0.702	1.00
456_R	493_Q	0.702	1.00
94_G	131_T	0.701	1.00
455_L	460_A	0.701	1.00
336_L	340_E	0.701	1.00
204_P	332_D	0.701	1.00
203_A	206_L	0.700	1.00
387_F	410_Y	0.698	1.00
224_V	248_L	0.697	1.00
24_R	46_A	0.697	1.00
154_H	158_T	0.696	1.00
445_A	497_F	0.694	1.00
372_L	465_I	0.694	1.00
136_L	169_P	0.692	1.00
215_F	218_R	0.692	1.00
21_H	157_G	0.691	1.00
338_P	342_R	0.690	1.00
471_G	476_S	0.686	1.00
225_V	284_Q	0.686	1.00
132_H	152_I	0.685	1.00
84_A	87_Y	0.684	1.00
360_V	374_H	0.683	1.00
98_E	420_G	0.683	1.00
335_E	339_A	0.682	1.00
465_I	517_L	0.682	1.00
446_L	497_F	0.682	1.00
437_L	463_V	0.681	0.99
93_A	100_L	0.678	0.99
139_P	172_E	0.677	0.99
244_L	341_K	0.676	0.99
438_A	444_S	0.672	0.99
77_V	83_V	0.670	0.99
506_L	529_T	0.666	0.99
42_A	486_E	0.664	0.99
345_W	348_E	0.664	0.99
520_A	531_T	0.663	0.99
260_L	264_D	0.663	0.99
152_I	156_L	0.661	0.99
154_H	157_G	0.660	0.99
241_A	244_L	0.659	0.99
387_F	428_V	0.658	0.99
229_M	310_D	0.658	0.99
264_D	276_L	0.657	0.99
109_P	169_P	0.656	0.99
422_L	451_A	0.653	0.99
109_P	137_P	0.652	0.99
238_A	241_A	0.650	0.99
335_E	338_P	0.650	0.99
231_A	329_N	0.650	0.99
225_V	251_D	0.649	0.99
85_N	88_P	0.647	0.99
274_S	277_Q	0.647	0.99
528_P	531_T	0.647	0.99
221_R	345_W	0.646	0.99
53_F	457_Q	0.646	0.99
430_R	458_V	0.644	0.99
64_G	427_G	0.644	0.99
496_H	534_E	0.643	0.99
139_P	177_E	0.642	0.99
234_G	406_G	0.642	0.99
65_L	69_S	0.642	0.99
425_A	436_T	0.642	0.99
217_W	220_K	0.637	0.99
220_K	280_Q	0.635	0.99
144_P	150_S	0.634	0.99
250_G	255_Q	0.634	0.99
260_L	263_A	0.633	0.99
480_T	487_R	0.633	0.99
216_F	244_L	0.632	0.99
309_V	330_I	0.632	0.99
117_N	416_S	0.632	0.99
217_W	339_A	0.631	0.99
426_A	454_L	0.631	0.99
126_F	165_H	0.629	0.99
511_P	533_I	0.629	0.99
42_A	488_F	0.629	0.99
423_S	451_A	0.628	0.99
36_P	173_P	0.628	0.99
65_L	73_V	0.627	0.99
513_N	519_T	0.625	0.99
461_P	530_T	0.625	0.99
495_V	503_M	0.622	0.99
383_Q	435_P	0.621	0.99
37_L	76_I	0.620	0.99
269_N	358_Q	0.617	0.99
372_L	517_L	0.617	0.99
440_V	464_L	0.617	0.99
258_Q	262_C	0.616	0.99
95_L	415_A	0.614	0.99
440_V	448_D	0.613	0.99
212_R	333_W	0.612	0.99
236_K	240_W	0.612	0.99
410_Y	420_G	0.612	0.99
208_S	326_L	0.611	0.99
131_T	158_T	0.609	0.99
106_D	112_I	0.609	0.99
60_H	92_E	0.609	0.99
284_Q	306_Y	0.609	0.99
329_N	333_W	0.608	0.99
84_A	120_I	0.608	0.99
10_W	13_V	0.608	0.99
101_I	166_I	0.607	0.99
371_Q	518_E	0.607	0.99
25_H	71_Q	0.606	0.99
223_V	275_E	0.606	0.99
103_L	149_V	0.606	0.99
385_Q	434_K	0.605	0.99
15_L	45_S	0.604	0.99
380_L	401_S	0.604	0.99
140_T	178_M	0.601	0.99
255_Q	403_L	0.600	0.99
463_V	529_T	0.600	0.99
113_D	119_A	0.599	0.99
387_F	421_L	0.599	0.99
26_I	47_F	0.598	0.99
365_D	514_W	0.597	0.99
131_T	155_A	0.595	0.99
393_V	467_V	0.595	0.99
54_D	85_N	0.595	0.99
103_L	166_I	0.594	0.99
365_D	513_N	0.592	0.99
310_D	315_R	0.590	0.99
264_D	267_L	0.590	0.99
428_V	436_T	0.589	0.99
449_L	503_M	0.588	0.99
376_I	465_I	0.588	0.99
456_R	459_S	0.587	0.99
19_T	47_F	0.587	0.99
109_P	138_R	0.585	0.98
495_V	500_A	0.584	0.98
109_P	172_E	0.580	0.98
237_V	241_A	0.579	0.98
29_A	472_G	0.577	0.98
101_I	164_V	0.577	0.98
388_V	391_S	0.574	0.98
446_L	450_N	0.574	0.98
249_I	261_P	0.574	0.98
366_A	538_N	0.573	0.98
454_L	460_A	0.573	0.98
205_R	332_D	0.572	0.98
307_W	324_R	0.571	0.98
225_V	282_V	0.571	0.98
8_R	12_A	0.570	0.98
511_P	519_T	0.570	0.98
225_V	287_S	0.569	0.98
48_I	430_R	0.568	0.98
238_A	405_A	0.568	0.98
24_R	69_S	0.568	0.98
422_L	455_L	0.567	0.98
155_A	160_H	0.566	0.98
330_I	333_W	0.564	0.98
231_A	331_A	0.564	0.98
475_F	479_P	0.563	0.98
388_V	421_L	0.563	0.98
316_L	322_R	0.562	0.98
32_S	78_T	0.562	0.98
72_P	156_L	0.561	0.98
91_I	120_I	0.558	0.98
61_L	430_R	0.557	0.98
253_L	413_R	0.554	0.98
256_T	408_P	0.553	0.98
186_Q	189_L	0.552	0.98
66_A	72_P	0.552	0.98
122_Q	165_H	0.551	0.98
453_A	495_V	0.551	0.98
245_G	346_C	0.550	0.98
34_S	105_A	0.550	0.98
502_A	509_H	0.549	0.98
239_L	339_A	0.549	0.98
233_E	330_I	0.549	0.98
17_A	153_D	0.548	0.98
63_L	424_T	0.548	0.98
147_W	150_S	0.548	0.98
440_V	444_S	0.547	0.98
243_T	341_K	0.547	0.98
160_H	312_I	0.547	0.98
207_E	211_Q	0.546	0.98
86_L	89_A	0.545	0.98
69_S	427_G	0.545	0.98
209_E	326_L	0.545	0.98
209_E	337_H	0.545	0.98
134_I	164_V	0.545	0.98
32_S	478_L	0.545	0.98
476_S	539_D	0.544	0.98
53_F	453_A	0.543	0.98
150_S	154_H	0.543	0.98
312_I	315_R	0.543	0.98
445_A	464_L	0.542	0.98
206_L	339_A	0.542	0.98
370_A	541_D	0.541	0.97
254_S	257_G	0.540	0.97
58_L	75_V	0.540	0.97
171_A	175_Y	0.539	0.97
131_T	160_H	0.539	0.97
459_S	529_T	0.539	0.97
66_A	73_V	0.538	0.97
67_K	96_T	0.537	0.97
68_V	385_Q	0.537	0.97
451_A	454_L	0.537	0.97
86_L	104_T	0.536	0.97
15_L	41_A	0.535	0.97
74_A	103_L	0.535	0.97
495_V	504_F	0.534	0.97
238_A	248_L	0.534	0.97
385_Q	410_Y	0.534	0.97
389_G	438_A	0.534	0.97
373_A	397_I	0.533	0.97
59_G	90_L	0.533	0.97
363_R	515_Q	0.532	0.97
29_A	52_H	0.532	0.97
23_V	72_P	0.531	0.97
521_F	525_W	0.531	0.97
92_E	96_T	0.530	0.97
14_I	166_I	0.530	0.97
235_K	242_Q	0.530	0.97
485_R	540_T	0.530	0.97
523_D	531_T	0.529	0.97
152_I	155_A	0.529	0.97
272_A	275_E	0.528	0.97
397_I	409_V	0.528	0.97
273_T	277_Q	0.528	0.97
27_C	430_R	0.526	0.97
429_Q	432_S	0.525	0.97
106_D	135_S	0.524	0.97
31_G	78_T	0.524	0.97
346_C	353_A	0.524	0.97
509_H	519_T	0.523	0.97
261_P	264_D	0.522	0.97
259_P	350_P	0.522	0.97
140_T	144_P	0.521	0.97
104_T	122_Q	0.520	0.97
472_G	475_F	0.519	0.97
386_L	409_V	0.518	0.97
94_G	130_P	0.518	0.97
507_K	528_P	0.517	0.97
20_R	179_D	0.517	0.97
403_L	408_P	0.516	0.97
511_P	535_M	0.516	0.97
74_A	153_D	0.516	0.97
373_A	377_C	0.516	0.97
262_C	266_W	0.515	0.97
387_F	424_T	0.514	0.97
305_E	324_R	0.514	0.97
369_E	396_L	0.513	0.97
464_L	532_V	0.512	0.97
468_N	497_F	0.512	0.97
330_I	335_E	0.510	0.96
384_G	434_K	0.510	0.96
306_Y	320_H	0.509	0.96
50_H	454_L	0.509	0.96
123_P	127_A	0.509	0.96
454_L	458_V	0.508	0.96
204_P	328_A	0.507	0.96
463_V	521_F	0.507	0.96
148_L	152_I	0.506	0.96
269_N	272_A	0.506	0.96
496_H	503_M	0.506	0.96
32_S	475_F	0.505	0.96
250_G	257_G	0.505	0.96
452_L	456_R	0.505	0.96
13_V	179_D	0.504	0.96
39_L	479_P	0.503	0.96
133_S	167_N	0.503	0.96
17_A	144_P	0.503	0.96
423_S	448_D	0.503	0.96
380_L	525_W	0.502	0.96
418_I	475_F	0.502	0.96
461_P	527_T	0.502	0.96
514_W	518_E	0.501	0.96
208_S	324_R	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ybhA	4	0.982	100	0.181	Contact Map
1ozhA	4	0.9514	100	0.182	Contact Map
3hwwA	2	0.9532	100	0.184	Contact Map
1t9bA	2	0.9766	100	0.187	Contact Map
2x7jA	4	0.9892	100	0.189	Contact Map
2panA	3	0.9658	100	0.19	Contact Map
4rjjA	5	0.955	100	0.195	Contact Map
2ihtA	4	0.9478	100	0.196	Contact Map
3eyaA	5	0.9245	100	0.198	Contact Map
2uz1A	4	0.955	100	0.2	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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