GREMLIN Database
MREC - Cell shape-determining protein MreC
UniProt: P16926 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10609
Length: 367 (287)
Sequences: 1180 (781)
Seq/√Len: 46.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_I268_L7.6991.00
183_I235_V7.6401.00
141_S164_V6.2501.00
84_L87_K5.3281.00
83_E88_N4.5601.00
236_A254_A4.4681.00
237_V255_R3.6861.00
145_V161_V3.5921.00
76_E81_R3.5171.00
121_T266_L3.4641.00
214_I238_V3.2561.00
151_V171_V3.2421.00
77_N80_L3.1411.00
185_V220_L2.9711.00
103_R265_Y2.9481.00
187_R213_D2.9461.00
137_I171_V2.8761.00
157_V181_L2.8721.00
93_M98_K2.8541.00
100_E105_R2.7981.00
157_V222_T2.7021.00
239_S255_R2.6881.00
141_S166_K2.6881.00
187_R218_D2.5901.00
137_I169_S2.5321.00
236_A257_T2.4151.00
289_A292_R2.1331.00
110_S120_V2.0891.00
73_L77_N2.0220.99
214_I241_V1.9970.99
186_L221_V1.9810.99
90_E95_G1.8690.99
183_I194_A1.8480.99
142_V167_L1.8270.99
162_V172_L1.8070.99
97_Y101_N1.7990.99
77_N81_R1.7860.99
202_D239_S1.7740.98
186_L219_V1.7680.98
175_C260_L1.7630.98
219_V237_V1.7590.98
161_V169_S1.7320.98
237_V257_T1.7230.98
185_V214_I1.6890.98
137_I151_V1.6840.98
90_E94_L1.6560.98
203_L256_P1.6100.97
83_E86_L1.5870.97
135_V173_L1.5790.97
67_L71_D1.5570.96
158_V266_L1.5130.96
143_N167_L1.5070.96
142_V166_K1.4850.95
101_N105_R1.3990.94
188_N266_L1.3980.94
285_V290_N1.3960.94
179_H229_F1.3940.94
161_V171_V1.3730.93
94_L139_K1.3620.93
285_V289_A1.3570.93
145_V268_L1.3430.92
219_V257_T1.3360.92
231_E264_R1.3360.92
234_P257_T1.3130.91
194_A235_V1.3060.91
119_M270_W1.3030.91
75_L79_A1.2870.90
121_T139_K1.2810.90
195_A206_E1.2640.90
156_G217_G1.2360.89
7_R11_L1.2350.89
117_Q270_W1.2230.88
9_P14_R1.2150.88
76_E79_A1.2070.87
158_V263_L1.2060.87
287_R290_N1.1970.87
153_S258_A1.1940.87
185_V188_N1.1910.87
163_A170_R1.1900.87
174_I239_S1.1880.86
194_A205_L1.1860.86
287_R291_E1.1710.86
172_L176_D1.1700.86
28_A161_V1.1640.85
103_R268_L1.1590.85
286_H291_E1.1470.84
122_Q138_D1.1460.84
187_R191_R1.1430.84
27_I161_V1.1260.83
148_G160_Q1.1180.83
205_L279_P1.1150.83
69_S145_V1.1060.82
21_V145_V1.1030.82
288_V291_E1.1000.82
157_V233_Y1.1000.82
33_G36_S1.0980.82
151_V266_L1.0960.82
16_I82_Q1.0960.82
103_R107_L1.0890.81
216_V239_S1.0890.81
89_S221_V1.0850.81
240_S253_Q1.0800.81
124_I168_T1.0770.81
123_V135_V1.0700.80
146_Y268_L1.0550.79
220_L236_A1.0540.79
84_L246_Q1.0540.79
287_R292_R1.0520.79
127_V220_L1.0500.79
158_V258_A1.0480.79
96_Q189_D1.0410.78
104_L196_G1.0270.77
288_V292_R1.0230.77
79_A268_L1.0230.77
107_L176_D1.0200.77
214_I252_I1.0200.77
174_I206_E1.0150.76
176_D196_G1.0060.76
197_N204_Q1.0020.75
202_D253_Q1.0000.75
119_M145_V1.0000.75
48_P176_D0.9990.75
70_R226_G0.9970.75
170_R265_Y0.9960.75
181_L222_T0.9940.75
149_Q233_Y0.9920.75
176_D217_G0.9850.74
95_G99_Q0.9830.74
189_D231_E0.9760.74
285_V292_R0.9710.73
224_G230_P0.9610.72
119_M139_K0.9550.72
101_N108_L0.9540.72
184_Q231_E0.9510.72
48_P218_D0.9450.71
101_N187_R0.9420.71
111_P269_L0.9420.71
148_G182_P0.9310.70
146_Y215_R0.9310.70
177_A226_G0.9300.70
105_R213_D0.9270.70
82_Q85_L0.9220.69
102_A254_A0.9160.69
220_L232_G0.9130.68
92_L198_G0.9120.68
56_P182_P0.9080.68
192_V205_L0.9050.68
219_V234_P0.9040.68
74_E78_R0.9020.67
180_A195_A0.9000.67
223_S230_P0.8950.67
49_F157_V0.8950.67
123_V247_R0.8940.67
216_V285_V0.8840.66
172_L193_I0.8800.66
189_D264_R0.8770.65
15_L25_I0.8760.65
70_R74_E0.8740.65
56_P101_N0.8730.65
285_V288_V0.8720.65
158_V268_L0.8660.64
187_R215_R0.8620.64
99_Q273_D0.8590.64
205_L218_D0.8590.64
122_Q174_I0.8560.63
276_G288_V0.8510.63
73_L80_L0.8480.63
81_R227_G0.8430.62
92_L96_Q0.8370.62
134_Q170_R0.8330.61
141_S146_Y0.8290.61
145_V164_V0.8280.61
111_P118_K0.8280.61
147_E222_T0.8260.61
214_I240_S0.8160.60
22_A29_D0.8130.59
137_I161_V0.8110.59
185_V218_D0.8110.59
184_Q221_V0.8100.59
70_R73_L0.8070.59
235_V249_Y0.8060.59
121_T145_V0.8040.59
149_Q268_L0.8020.58
133_D261_Q0.8020.58
284_E287_R0.7920.57
127_V207_H0.7910.57
29_D39_R0.7890.57
14_R160_Q0.7820.56
133_D258_A0.7800.56
283_E290_N0.7790.56
150_P230_P0.7780.56
101_N104_L0.7770.56
182_P191_R0.7750.56
222_T227_G0.7710.55
55_A59_L0.7680.55
242_K251_V0.7670.55
283_E286_H0.7660.55
40_T43_D0.7640.55
172_L183_I0.7640.55
194_A254_A0.7570.54
45_A138_D0.7570.54
80_L156_G0.7530.54
22_A39_R0.7430.53
28_A35_F0.7410.52
107_L152_I0.7400.52
132_S175_C0.7310.51
120_V267_L0.7300.51
19_V229_F0.7290.51
29_D160_Q0.7250.51
151_V268_L0.7230.51
91_L94_L0.7230.51
220_L254_A0.7220.51
170_R229_F0.7180.50
254_A260_L0.7180.50
39_R233_Y0.7180.50
107_L221_V0.7150.50
56_P203_L0.7140.50
156_G238_V0.7140.50
78_R277_A0.7110.49
138_D143_N0.7100.49
192_V241_V0.7090.49
79_A82_Q0.7080.49
158_V286_H0.7080.49
46_V71_D0.7080.49
282_P285_V0.7070.49
46_V152_I0.7060.49
149_Q192_V0.7050.49
189_D238_V0.7040.49
181_L236_A0.7020.49
56_P258_A0.7020.49
214_I228_R0.7010.48
238_V252_I0.7000.48
45_A150_P0.7000.48
108_L172_L0.7000.48
240_S281_T0.6950.48
183_I205_L0.6950.48
263_L266_L0.6950.48
77_N84_L0.6920.48
171_V268_L0.6910.47
98_K165_A0.6890.47
42_M46_V0.6880.47
16_I84_L0.6880.47
137_I266_L0.6870.47
19_V63_V0.6850.47
72_Q138_D0.6830.47
259_G263_L0.6830.47
191_R250_T0.6830.47
56_P97_Y0.6810.46
38_I166_K0.6790.46
84_L265_Y0.6760.46
241_V257_T0.6720.46
189_D265_Y0.6680.45
20_L78_R0.6670.45
125_S134_Q0.6670.45
106_E109_G0.6670.45
108_L176_D0.6650.45
173_L224_G0.6640.45
63_V229_F0.6640.45
37_Q41_Y0.6610.45
79_A83_E0.6560.44
48_P196_G0.6560.44
96_Q123_V0.6550.44
7_R10_S0.6550.44
203_L225_L0.6530.44
50_Y158_V0.6520.44
129_D203_L0.6510.44
40_T167_L0.6490.43
87_K246_Q0.6480.43
175_C225_L0.6480.43
111_P146_Y0.6470.43
169_S237_V0.6470.43
36_S40_T0.6460.43
110_S229_F0.6460.43
106_E155_K0.6450.43
29_D191_R0.6400.42
53_S250_T0.6380.42
121_T138_D0.6370.42
64_S218_D0.6360.42
184_Q257_T0.6330.42
208_L252_I0.6320.42
216_V240_S0.6320.42
226_G236_A0.6310.42
248_A252_I0.6300.42
139_K174_I0.6260.41
23_L32_L0.6240.41
63_V66_T0.6240.41
209_P276_G0.6230.41
140_G159_G0.6210.41
17_L61_D0.6210.41
137_I174_I0.6180.40
205_L229_F0.6160.40
32_L35_F0.6160.40
282_P286_H0.6140.40
24_G139_K0.6130.40
8_G187_R0.6130.40
84_L124_I0.6130.40
152_I269_L0.6120.40
222_T235_V0.6120.40
33_G82_Q0.6090.40
244_D247_R0.6090.40
215_R239_S0.6070.39
101_N226_G0.6060.39
10_S194_A0.6050.39
76_E84_L0.6050.39
120_V249_Y0.6040.39
66_T69_S0.6040.39
60_L164_V0.6040.39
142_V275_N0.6030.39
181_L194_A0.6010.39
286_H289_A0.6000.39
283_E287_R0.6000.39
25_I141_S0.5960.38
75_L237_V0.5950.38
149_Q271_G0.5940.38
221_V279_P0.5940.38
21_V86_L0.5930.38
25_I152_I0.5930.38
62_G278_N0.5890.38
158_V205_L0.5880.38
209_P230_P0.5870.37
217_G239_S0.5860.37
94_L126_T0.5840.37
182_P223_S0.5840.37
87_K91_L0.5840.37
84_L263_L0.5830.37
173_L176_D0.5830.37
177_A220_L0.5830.37
274_R278_N0.5820.37
181_L202_D0.5820.37
225_L267_L0.5820.37
196_G256_P0.5810.37
67_L79_A0.5790.37
204_Q236_A0.5790.37
128_N131_Y0.5780.37
208_L212_T0.5780.37
275_N279_P0.5760.36
146_Y270_W0.5750.36
119_M194_A0.5730.36
197_N253_Q0.5720.36
130_P187_R0.5710.36
112_L116_E0.5690.36
95_G98_K0.5690.36
14_R236_A0.5680.36
166_K280_M0.5670.36
240_S255_R0.5660.36
144_G158_V0.5660.36
120_V233_Y0.5650.35
145_V286_H0.5650.35
19_V22_A0.5610.35
113_R122_Q0.5600.35
145_V287_R0.5600.35
85_L88_N0.5590.35
62_G65_Q0.5590.35
207_H210_A0.5590.35
13_I161_V0.5580.35
70_R256_P0.5570.35
260_L263_L0.5570.35
242_K245_T0.5560.35
122_Q264_R0.5560.35
26_I29_D0.5560.35
216_V280_M0.5560.35
185_V238_V0.5540.34
18_A30_S0.5540.34
56_P191_R0.5540.34
26_I244_D0.5540.34
85_L155_K0.5530.34
11_L29_D0.5530.34
195_A236_A0.5480.34
185_V236_A0.5480.34
38_I137_I0.5470.34
119_M164_V0.5470.34
84_L259_G0.5450.34
44_T233_Y0.5450.34
29_D220_L0.5440.34
87_K174_I0.5440.34
154_D161_V0.5440.34
181_L287_R0.5440.34
56_P148_G0.5420.33
20_L138_D0.5420.33
40_T123_V0.5410.33
247_R252_I0.5410.33
19_V225_L0.5410.33
76_E80_L0.5400.33
123_V266_L0.5400.33
41_Y208_L0.5400.33
23_L31_R0.5380.33
147_E181_L0.5370.33
19_V24_G0.5340.33
73_L160_Q0.5340.33
47_S124_I0.5340.33
229_F291_E0.5300.32
225_L252_I0.5290.32
157_V270_W0.5290.32
236_A243_L0.5280.32
126_T269_L0.5280.32
122_Q188_N0.5270.32
20_L69_S0.5250.32
168_T207_H0.5220.32
126_T177_A0.5220.32
286_H292_R0.5210.32
12_Q194_A0.5210.32
121_T151_V0.5210.32
222_T266_L0.5190.31
57_R192_V0.5180.31
284_E291_E0.5170.31
45_A71_D0.5170.31
7_R157_V0.5170.31
18_A87_K0.5170.31
97_Y100_E0.5160.31
42_M280_M0.5160.31
123_V263_L0.5160.31
105_R122_Q0.5150.31
136_V192_V0.5150.31
95_G107_L0.5140.31
223_S227_G0.5140.31
241_V284_E0.5140.31
17_L222_T0.5130.31
254_A259_G0.5120.31
108_L186_L0.5120.31
75_L109_G0.5120.31
145_V239_S0.5110.31
154_D189_D0.5100.31
107_L267_L0.5100.31
174_I282_P0.5100.31
24_G28_A0.5060.30
33_G238_V0.5050.30
16_I155_K0.5040.30
69_S73_L0.5020.30
84_L266_L0.5010.30
67_L164_V0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5uA 4 0.5586 100 0.359 Contact Map
2qf4A 1 0.455 100 0.498 Contact Map
3j8bF 1 0 90.5 0.943 Contact Map
4bhqA 2 0.2698 73.9 0.954 Contact Map
2yy0A 6 0.1444 66.9 0.956 Contact Map
1go4E 4 0.1853 65.5 0.956 Contact Map
4u5tA 2 0.1008 54.6 0.959 Contact Map
3w1eA 1 0.4414 52.5 0.96 Contact Map
4cbcA 3 0.1035 45.8 0.961 Contact Map
1t6fA 2 0.1008 44.6 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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