MREC - ECOLI - GREMLIN Contacts

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MREC - Cell shape-determining protein MreC

UniProt:	P16926	Sequences: MKPIFSRGPSLQIRLILAVLVALGIIIADSRLGTFSQIRTYMDTAVSPFYFVSNAPRELLDGVSQTLASRDQLELENRALRQELLLKNSELLMLGQYKQENARLRELLGSPLRQDEQKMVTQVISTVNDPYSDQVVIDKGSVNGVYEGQPVISDKGVVGQVVAVAKLTSRVLLICDATHALPIQVLRNDIRVIAAGNGCTDDLQLEHLPANTDIRVGDVLVTSGLGGRFPEGYPVAVVSSVKLDTQRAYTVIQARPTAGLQRLRYLLLLWGADRNGANPMTPEEVHRVANERLMQMMPQVLPSPDAMGPKLPEPATGIAQPTPQQPATGNAATAPAAPTQPAANRSPQRATPPQSGAQPPARAPGGQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10609
Length:	367 (287)
Sequences:	1180 (781)
Seq/√Len:	46.1

ECOLI - MREC
BACSU - MREC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
137_I	268_L	7.699	1.00
183_I	235_V	7.640	1.00
141_S	164_V	6.250	1.00
84_L	87_K	5.328	1.00
83_E	88_N	4.560	1.00
236_A	254_A	4.468	1.00
237_V	255_R	3.686	1.00
145_V	161_V	3.592	1.00
76_E	81_R	3.517	1.00
121_T	266_L	3.464	1.00
214_I	238_V	3.256	1.00
151_V	171_V	3.242	1.00
77_N	80_L	3.141	1.00
185_V	220_L	2.971	1.00
103_R	265_Y	2.948	1.00
187_R	213_D	2.946	1.00
137_I	171_V	2.876	1.00
157_V	181_L	2.872	1.00
93_M	98_K	2.854	1.00
100_E	105_R	2.798	1.00
157_V	222_T	2.702	1.00
239_S	255_R	2.688	1.00
141_S	166_K	2.688	1.00
187_R	218_D	2.590	1.00
137_I	169_S	2.532	1.00
236_A	257_T	2.415	1.00
289_A	292_R	2.133	1.00
110_S	120_V	2.089	1.00
73_L	77_N	2.022	0.99
214_I	241_V	1.997	0.99
186_L	221_V	1.981	0.99
90_E	95_G	1.869	0.99
183_I	194_A	1.848	0.99
142_V	167_L	1.827	0.99
162_V	172_L	1.807	0.99
97_Y	101_N	1.799	0.99
77_N	81_R	1.786	0.99
202_D	239_S	1.774	0.98
186_L	219_V	1.768	0.98
175_C	260_L	1.763	0.98
219_V	237_V	1.759	0.98
161_V	169_S	1.732	0.98
237_V	257_T	1.723	0.98
185_V	214_I	1.689	0.98
137_I	151_V	1.684	0.98
90_E	94_L	1.656	0.98
203_L	256_P	1.610	0.97
83_E	86_L	1.587	0.97
135_V	173_L	1.579	0.97
67_L	71_D	1.557	0.96
158_V	266_L	1.513	0.96
143_N	167_L	1.507	0.96
142_V	166_K	1.485	0.95
101_N	105_R	1.399	0.94
188_N	266_L	1.398	0.94
285_V	290_N	1.396	0.94
179_H	229_F	1.394	0.94
161_V	171_V	1.373	0.93
94_L	139_K	1.362	0.93
285_V	289_A	1.357	0.93
145_V	268_L	1.343	0.92
219_V	257_T	1.336	0.92
231_E	264_R	1.336	0.92
234_P	257_T	1.313	0.91
194_A	235_V	1.306	0.91
119_M	270_W	1.303	0.91
75_L	79_A	1.287	0.90
121_T	139_K	1.281	0.90
195_A	206_E	1.264	0.90
156_G	217_G	1.236	0.89
7_R	11_L	1.235	0.89
117_Q	270_W	1.223	0.88
9_P	14_R	1.215	0.88
76_E	79_A	1.207	0.87
158_V	263_L	1.206	0.87
287_R	290_N	1.197	0.87
153_S	258_A	1.194	0.87
185_V	188_N	1.191	0.87
163_A	170_R	1.190	0.87
174_I	239_S	1.188	0.86
194_A	205_L	1.186	0.86
287_R	291_E	1.171	0.86
172_L	176_D	1.170	0.86
28_A	161_V	1.164	0.85
103_R	268_L	1.159	0.85
286_H	291_E	1.147	0.84
122_Q	138_D	1.146	0.84
187_R	191_R	1.143	0.84
27_I	161_V	1.126	0.83
148_G	160_Q	1.118	0.83
205_L	279_P	1.115	0.83
69_S	145_V	1.106	0.82
21_V	145_V	1.103	0.82
288_V	291_E	1.100	0.82
157_V	233_Y	1.100	0.82
33_G	36_S	1.098	0.82
151_V	266_L	1.096	0.82
16_I	82_Q	1.096	0.82
103_R	107_L	1.089	0.81
216_V	239_S	1.089	0.81
89_S	221_V	1.085	0.81
240_S	253_Q	1.080	0.81
124_I	168_T	1.077	0.81
123_V	135_V	1.070	0.80
146_Y	268_L	1.055	0.79
220_L	236_A	1.054	0.79
84_L	246_Q	1.054	0.79
287_R	292_R	1.052	0.79
127_V	220_L	1.050	0.79
158_V	258_A	1.048	0.79
96_Q	189_D	1.041	0.78
104_L	196_G	1.027	0.77
288_V	292_R	1.023	0.77
79_A	268_L	1.023	0.77
107_L	176_D	1.020	0.77
214_I	252_I	1.020	0.77
174_I	206_E	1.015	0.76
176_D	196_G	1.006	0.76
197_N	204_Q	1.002	0.75
202_D	253_Q	1.000	0.75
119_M	145_V	1.000	0.75
48_P	176_D	0.999	0.75
70_R	226_G	0.997	0.75
170_R	265_Y	0.996	0.75
181_L	222_T	0.994	0.75
149_Q	233_Y	0.992	0.75
176_D	217_G	0.985	0.74
95_G	99_Q	0.983	0.74
189_D	231_E	0.976	0.74
285_V	292_R	0.971	0.73
224_G	230_P	0.961	0.72
119_M	139_K	0.955	0.72
101_N	108_L	0.954	0.72
184_Q	231_E	0.951	0.72
48_P	218_D	0.945	0.71
101_N	187_R	0.942	0.71
111_P	269_L	0.942	0.71
148_G	182_P	0.931	0.70
146_Y	215_R	0.931	0.70
177_A	226_G	0.930	0.70
105_R	213_D	0.927	0.70
82_Q	85_L	0.922	0.69
102_A	254_A	0.916	0.69
220_L	232_G	0.913	0.68
92_L	198_G	0.912	0.68
56_P	182_P	0.908	0.68
192_V	205_L	0.905	0.68
219_V	234_P	0.904	0.68
74_E	78_R	0.902	0.67
180_A	195_A	0.900	0.67
223_S	230_P	0.895	0.67
49_F	157_V	0.895	0.67
123_V	247_R	0.894	0.67
216_V	285_V	0.884	0.66
172_L	193_I	0.880	0.66
189_D	264_R	0.877	0.65
15_L	25_I	0.876	0.65
70_R	74_E	0.874	0.65
56_P	101_N	0.873	0.65
285_V	288_V	0.872	0.65
158_V	268_L	0.866	0.64
187_R	215_R	0.862	0.64
99_Q	273_D	0.859	0.64
205_L	218_D	0.859	0.64
122_Q	174_I	0.856	0.63
276_G	288_V	0.851	0.63
73_L	80_L	0.848	0.63
81_R	227_G	0.843	0.62
92_L	96_Q	0.837	0.62
134_Q	170_R	0.833	0.61
141_S	146_Y	0.829	0.61
145_V	164_V	0.828	0.61
111_P	118_K	0.828	0.61
147_E	222_T	0.826	0.61
214_I	240_S	0.816	0.60
22_A	29_D	0.813	0.59
137_I	161_V	0.811	0.59
185_V	218_D	0.811	0.59
184_Q	221_V	0.810	0.59
70_R	73_L	0.807	0.59
235_V	249_Y	0.806	0.59
121_T	145_V	0.804	0.59
149_Q	268_L	0.802	0.58
133_D	261_Q	0.802	0.58
284_E	287_R	0.792	0.57
127_V	207_H	0.791	0.57
29_D	39_R	0.789	0.57
14_R	160_Q	0.782	0.56
133_D	258_A	0.780	0.56
283_E	290_N	0.779	0.56
150_P	230_P	0.778	0.56
101_N	104_L	0.777	0.56
182_P	191_R	0.775	0.56
222_T	227_G	0.771	0.55
55_A	59_L	0.768	0.55
242_K	251_V	0.767	0.55
283_E	286_H	0.766	0.55
40_T	43_D	0.764	0.55
172_L	183_I	0.764	0.55
194_A	254_A	0.757	0.54
45_A	138_D	0.757	0.54
80_L	156_G	0.753	0.54
22_A	39_R	0.743	0.53
28_A	35_F	0.741	0.52
107_L	152_I	0.740	0.52
132_S	175_C	0.731	0.51
120_V	267_L	0.730	0.51
19_V	229_F	0.729	0.51
29_D	160_Q	0.725	0.51
151_V	268_L	0.723	0.51
91_L	94_L	0.723	0.51
220_L	254_A	0.722	0.51
170_R	229_F	0.718	0.50
254_A	260_L	0.718	0.50
39_R	233_Y	0.718	0.50
107_L	221_V	0.715	0.50
56_P	203_L	0.714	0.50
156_G	238_V	0.714	0.50
78_R	277_A	0.711	0.49
138_D	143_N	0.710	0.49
192_V	241_V	0.709	0.49
79_A	82_Q	0.708	0.49
158_V	286_H	0.708	0.49
46_V	71_D	0.708	0.49
282_P	285_V	0.707	0.49
46_V	152_I	0.706	0.49
149_Q	192_V	0.705	0.49
189_D	238_V	0.704	0.49
181_L	236_A	0.702	0.49
56_P	258_A	0.702	0.49
214_I	228_R	0.701	0.48
238_V	252_I	0.700	0.48
45_A	150_P	0.700	0.48
108_L	172_L	0.700	0.48
240_S	281_T	0.695	0.48
183_I	205_L	0.695	0.48
263_L	266_L	0.695	0.48
77_N	84_L	0.692	0.48
171_V	268_L	0.691	0.47
98_K	165_A	0.689	0.47
42_M	46_V	0.688	0.47
16_I	84_L	0.688	0.47
137_I	266_L	0.687	0.47
19_V	63_V	0.685	0.47
72_Q	138_D	0.683	0.47
259_G	263_L	0.683	0.47
191_R	250_T	0.683	0.47
56_P	97_Y	0.681	0.46
38_I	166_K	0.679	0.46
84_L	265_Y	0.676	0.46
241_V	257_T	0.672	0.46
189_D	265_Y	0.668	0.45
20_L	78_R	0.667	0.45
125_S	134_Q	0.667	0.45
106_E	109_G	0.667	0.45
108_L	176_D	0.665	0.45
173_L	224_G	0.664	0.45
63_V	229_F	0.664	0.45
37_Q	41_Y	0.661	0.45
79_A	83_E	0.656	0.44
48_P	196_G	0.656	0.44
96_Q	123_V	0.655	0.44
7_R	10_S	0.655	0.44
203_L	225_L	0.653	0.44
50_Y	158_V	0.652	0.44
129_D	203_L	0.651	0.44
40_T	167_L	0.649	0.43
87_K	246_Q	0.648	0.43
175_C	225_L	0.648	0.43
111_P	146_Y	0.647	0.43
169_S	237_V	0.647	0.43
36_S	40_T	0.646	0.43
110_S	229_F	0.646	0.43
106_E	155_K	0.645	0.43
29_D	191_R	0.640	0.42
53_S	250_T	0.638	0.42
121_T	138_D	0.637	0.42
64_S	218_D	0.636	0.42
184_Q	257_T	0.633	0.42
208_L	252_I	0.632	0.42
216_V	240_S	0.632	0.42
226_G	236_A	0.631	0.42
248_A	252_I	0.630	0.42
139_K	174_I	0.626	0.41
23_L	32_L	0.624	0.41
63_V	66_T	0.624	0.41
209_P	276_G	0.623	0.41
140_G	159_G	0.621	0.41
17_L	61_D	0.621	0.41
137_I	174_I	0.618	0.40
205_L	229_F	0.616	0.40
32_L	35_F	0.616	0.40
282_P	286_H	0.614	0.40
24_G	139_K	0.613	0.40
8_G	187_R	0.613	0.40
84_L	124_I	0.613	0.40
152_I	269_L	0.612	0.40
222_T	235_V	0.612	0.40
33_G	82_Q	0.609	0.40
244_D	247_R	0.609	0.40
215_R	239_S	0.607	0.39
101_N	226_G	0.606	0.39
10_S	194_A	0.605	0.39
76_E	84_L	0.605	0.39
120_V	249_Y	0.604	0.39
66_T	69_S	0.604	0.39
60_L	164_V	0.604	0.39
142_V	275_N	0.603	0.39
181_L	194_A	0.601	0.39
286_H	289_A	0.600	0.39
283_E	287_R	0.600	0.39
25_I	141_S	0.596	0.38
75_L	237_V	0.595	0.38
149_Q	271_G	0.594	0.38
221_V	279_P	0.594	0.38
21_V	86_L	0.593	0.38
25_I	152_I	0.593	0.38
62_G	278_N	0.589	0.38
158_V	205_L	0.588	0.38
209_P	230_P	0.587	0.37
217_G	239_S	0.586	0.37
94_L	126_T	0.584	0.37
182_P	223_S	0.584	0.37
87_K	91_L	0.584	0.37
84_L	263_L	0.583	0.37
173_L	176_D	0.583	0.37
177_A	220_L	0.583	0.37
274_R	278_N	0.582	0.37
181_L	202_D	0.582	0.37
225_L	267_L	0.582	0.37
196_G	256_P	0.581	0.37
67_L	79_A	0.579	0.37
204_Q	236_A	0.579	0.37
128_N	131_Y	0.578	0.37
208_L	212_T	0.578	0.37
275_N	279_P	0.576	0.36
146_Y	270_W	0.575	0.36
119_M	194_A	0.573	0.36
197_N	253_Q	0.572	0.36
130_P	187_R	0.571	0.36
112_L	116_E	0.569	0.36
95_G	98_K	0.569	0.36
14_R	236_A	0.568	0.36
166_K	280_M	0.567	0.36
240_S	255_R	0.566	0.36
144_G	158_V	0.566	0.36
120_V	233_Y	0.565	0.35
145_V	286_H	0.565	0.35
19_V	22_A	0.561	0.35
113_R	122_Q	0.560	0.35
145_V	287_R	0.560	0.35
85_L	88_N	0.559	0.35
62_G	65_Q	0.559	0.35
207_H	210_A	0.559	0.35
13_I	161_V	0.558	0.35
70_R	256_P	0.557	0.35
260_L	263_L	0.557	0.35
242_K	245_T	0.556	0.35
122_Q	264_R	0.556	0.35
26_I	29_D	0.556	0.35
216_V	280_M	0.556	0.35
185_V	238_V	0.554	0.34
18_A	30_S	0.554	0.34
56_P	191_R	0.554	0.34
26_I	244_D	0.554	0.34
85_L	155_K	0.553	0.34
11_L	29_D	0.553	0.34
195_A	236_A	0.548	0.34
185_V	236_A	0.548	0.34
38_I	137_I	0.547	0.34
119_M	164_V	0.547	0.34
84_L	259_G	0.545	0.34
44_T	233_Y	0.545	0.34
29_D	220_L	0.544	0.34
87_K	174_I	0.544	0.34
154_D	161_V	0.544	0.34
181_L	287_R	0.544	0.34
56_P	148_G	0.542	0.33
20_L	138_D	0.542	0.33
40_T	123_V	0.541	0.33
247_R	252_I	0.541	0.33
19_V	225_L	0.541	0.33
76_E	80_L	0.540	0.33
123_V	266_L	0.540	0.33
41_Y	208_L	0.540	0.33
23_L	31_R	0.538	0.33
147_E	181_L	0.537	0.33
19_V	24_G	0.534	0.33
73_L	160_Q	0.534	0.33
47_S	124_I	0.534	0.33
229_F	291_E	0.530	0.32
225_L	252_I	0.529	0.32
157_V	270_W	0.529	0.32
236_A	243_L	0.528	0.32
126_T	269_L	0.528	0.32
122_Q	188_N	0.527	0.32
20_L	69_S	0.525	0.32
168_T	207_H	0.522	0.32
126_T	177_A	0.522	0.32
286_H	292_R	0.521	0.32
12_Q	194_A	0.521	0.32
121_T	151_V	0.521	0.32
222_T	266_L	0.519	0.31
57_R	192_V	0.518	0.31
284_E	291_E	0.517	0.31
45_A	71_D	0.517	0.31
7_R	157_V	0.517	0.31
18_A	87_K	0.517	0.31
97_Y	100_E	0.516	0.31
42_M	280_M	0.516	0.31
123_V	263_L	0.516	0.31
105_R	122_Q	0.515	0.31
136_V	192_V	0.515	0.31
95_G	107_L	0.514	0.31
223_S	227_G	0.514	0.31
241_V	284_E	0.514	0.31
17_L	222_T	0.513	0.31
254_A	259_G	0.512	0.31
108_L	186_L	0.512	0.31
75_L	109_G	0.512	0.31
145_V	239_S	0.511	0.31
154_D	189_D	0.510	0.31
107_L	267_L	0.510	0.31
174_I	282_P	0.510	0.31
24_G	28_A	0.506	0.30
33_G	238_V	0.505	0.30
16_I	155_K	0.504	0.30
69_S	73_L	0.502	0.30
84_L	266_L	0.501	0.30
67_L	164_V	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j5uA	4	0.5586	100	0.359	Contact Map
2qf4A	1	0.455	100	0.498	Contact Map
3j8bF	1	0	90.5	0.943	Contact Map
4bhqA	2	0.2698	73.9	0.954	Contact Map
2yy0A	6	0.1444	66.9	0.956	Contact Map
1go4E	4	0.1853	65.5	0.956	Contact Map
4u5tA	2	0.1008	54.6	0.959	Contact Map
3w1eA	1	0.4414	52.5	0.96	Contact Map
4cbcA	3	0.1035	45.8	0.961	Contact Map
1t6fA	2	0.1008	44.6	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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