GREMLIN Database
RHSB - Protein RhsB
UniProt: P16917 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10847
Length: 1411 (1171)
Sequences: 117 (88)
Seq/√Len: 2.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
995_D1000_R5.0770.84
54_G93_G4.3050.72
54_G95_G3.9050.63
66_L147_A3.8240.62
1221_D1238_P3.7880.61
1221_D1243_D3.7880.61
1238_P1243_D3.7880.61
879_Y885_L3.6810.59
80_S96_W3.5960.57
78_Y93_G3.5940.57
66_L72_F3.5790.56
78_Y95_G3.5610.56
147_A160_Q3.5380.55
576_D580_Q3.4800.54
994_Y1000_R3.4440.53
992_Y1003_K3.4280.53
173_Y176_T3.3510.51
1221_D1246_G3.3200.50
1238_P1246_G3.3200.50
1243_D1246_G3.3200.50
173_Y183_W3.2810.49
54_G96_W3.2380.48
173_Y177_N3.2000.47
618_D622_K3.1680.47
860_N939_Y3.1570.46
1208_R1221_D3.0980.45
1208_R1238_P3.0980.45
1208_R1243_D3.0980.45
72_F147_A3.0720.44
80_S93_G3.0550.44
177_N183_W3.0420.44
54_G80_S3.0100.43
904_D908_N2.9610.42
1204_Y1209_Y2.9200.41
1221_D1234_Y2.7900.38
1234_Y1238_P2.7900.38
1234_Y1243_D2.7900.38
860_N864_E2.7840.38
1174_G1246_G2.7800.38
80_S95_G2.7620.38
638_D642_R2.7590.37
940_D944_R2.7490.37
1221_D1244_P2.7080.36
1238_P1244_P2.7080.36
54_G66_L2.7010.36
1210_Y1234_Y2.6420.35
405_A582_I2.6380.35
1208_R1246_G2.6370.35
633_R903_T2.6320.35
176_T183_W2.5660.33
63_D66_L2.5650.33
54_G78_Y2.5490.33
1014_G1162_G2.5130.32
66_L160_Q2.4990.32
154_R160_Q2.4790.32
1212_P1234_Y2.4760.32
54_G68_G2.4410.31
68_G95_G2.4000.30
1201_G1212_P2.3850.30
96_W104_L2.3090.28
93_G96_W2.3060.28
1221_D1237_N2.2980.28
1237_N1243_D2.2980.28
1234_Y1246_G2.2900.28
316_W320_G2.2700.28
800_G1212_P2.2600.27
63_D72_F2.2380.27
1201_G1246_G2.2160.27
150_D154_R2.1990.26
659_D663_R2.1700.26
700_D704_R2.1670.26
721_D1217_Y2.1620.26
439_G1194_Q2.1590.26
1000_R1152_G2.1580.25
537_G908_N2.1530.25
937_Y1000_R2.1510.25
275_D279_G2.1400.25
249_L252_Q2.1360.25
1208_R1234_Y2.1340.25
147_A154_R2.1320.25
131_D136_S2.1120.25
658_Y775_Y2.1010.25
817_R1206_R2.0870.24
748_G940_D2.0810.24
68_G93_G2.0790.24
967_Y1025_T2.0740.24
940_D1000_R2.0640.24
1174_G1208_R2.0630.24
1208_R1244_P2.0520.24
992_Y996_P2.0460.24
249_L254_Q2.0390.23
54_G90_G2.0370.23
576_D1232_Y2.0340.23
493_G637_Y2.0240.23
744_Y1170_Y2.0220.23
361_Y671_D2.0190.23
488_E497_Q2.0170.23
1221_D1232_Y2.0120.23
1232_Y1238_P2.0120.23
1232_Y1243_D2.0120.23
901_Y1216_R2.0080.23
1212_P1246_G1.9890.23
1174_G1221_D1.9840.23
1174_G1238_P1.9840.23
1174_G1243_D1.9840.23
1201_G1208_R1.9800.22
634_S647_T1.9790.22
706_T756_T1.9760.22
1217_Y1220_Q1.9700.22
1210_Y1221_D1.9630.22
1210_Y1238_P1.9630.22
1210_Y1243_D1.9630.22
92_L98_M1.9590.22
132_G136_S1.9570.22
745_D749_R1.9540.22
285_R292_S1.9500.22
1173_W1190_R1.9490.22
66_L93_G1.9330.22
362_D365_G1.9220.22
575_Y786_P1.9190.22
482_G1201_G1.9130.21
744_Y786_P1.9120.21
93_G147_A1.9050.21
995_D1025_T1.8840.21
608_P674_T1.8820.21
692_G1025_T1.8770.21
859_W1210_Y1.8520.20
35_A48_P1.8480.20
220_Q224_R1.8460.20
54_G72_F1.8370.20
1234_Y1244_P1.8260.20
994_Y998_G1.8240.20
995_D1152_G1.8210.20
908_N1230_N1.8130.20
829_G1193_G1.8120.20
720_Y744_Y1.8060.20
170_P173_Y1.8060.20
731_H738_V1.8050.20
271_S275_D1.7990.20
446_P860_N1.7920.20
1174_G1201_G1.7880.20
1224_G1228_G1.7830.19
66_L104_L1.7790.19
68_G74_L1.7760.19
1237_N1246_G1.7740.19
1210_Y1244_P1.7660.19
523_D527_S1.7650.19
274_P277_L1.7560.19
940_D995_D1.7450.19
72_F78_Y1.7440.19
754_R1014_G1.7440.19
468_Y699_Y1.7400.19
157_A171_H1.7360.19
1201_G1221_D1.7350.19
1201_G1238_P1.7350.19
1201_G1243_D1.7350.19
1210_Y1230_N1.7320.19
447_D788_S1.7310.19
880_S1200_S1.7300.19
940_D969_Y1.7300.19
721_D727_T1.7290.19
382_Y879_Y1.7230.19
785_I1239_I1.7220.19
1174_G1193_G1.7210.19
1216_R1230_N1.7160.18
66_L76_R1.7160.18
1215_G1237_N1.7130.18
168_L173_Y1.7090.18
1208_R1237_N1.7090.18
212_L456_I1.7060.18
35_A41_G1.7040.18
937_Y940_D1.7030.18
153_H160_Q1.7000.18
72_F93_G1.6960.18
54_G147_A1.6960.18
291_L314_Y1.6930.18
78_Y96_W1.6910.18
54_G160_Q1.6850.18
1261_G1264_G1.6840.18
776_N780_L1.6830.18
536_Y849_N1.6790.18
1212_P1221_D1.6670.18
1212_P1238_P1.6670.18
1212_P1243_D1.6670.18
271_S276_T1.6630.18
901_Y1215_G1.6600.18
1215_G1221_D1.6550.18
1215_G1238_P1.6550.18
1215_G1243_D1.6550.18
54_G104_L1.6440.18
388_T392_S1.6410.17
721_D901_Y1.6370.17
468_Y802_L1.6340.17
554_H1244_P1.6300.17
244_H249_L1.6270.17
882_T1207_H1.6270.17
945_L967_Y1.6240.17
940_D992_Y1.6230.17
880_S1172_E1.6040.17
995_D1001_V1.5970.17
879_Y1244_P1.5910.17
72_F160_Q1.5830.17
1216_R1237_N1.5820.17
539_L1001_V1.5750.17
276_T279_G1.5720.17
93_G160_Q1.5700.17
669_G1217_Y1.5580.16
485_L857_Y1.5540.16
523_D526_G1.5540.16
744_Y857_Y1.5530.16
352_T355_P1.5200.16
439_G901_Y1.5180.16
880_S888_V1.5180.16
68_G90_G1.5010.16
480_P560_M1.5000.16
684_K703_D1.4970.16
673_R1207_H1.4960.16
209_L726_L1.4950.16
837_Y1027_Y1.4920.16
176_T182_P1.4910.16
170_P177_N1.4890.16
1232_Y1246_G1.4850.15
1193_G1246_G1.4840.15
744_Y901_Y1.4810.15
940_D994_Y1.4800.15
246_R249_L1.4790.15
147_A159_W1.4730.15
992_Y1000_R1.4670.15
36_C50_N1.4650.15
482_G1152_G1.4560.15
1210_Y1237_N1.4560.15
1055_P1060_E1.4540.15
994_Y1221_D1.4520.15
994_Y1238_P1.4520.15
994_Y1243_D1.4520.15
939_Y943_G1.4460.15
994_Y1208_R1.4450.15
995_D1028_G1.4410.15
439_G999_R1.4380.15
883_G1175_N1.4350.15
517_L522_E1.4330.15
880_S1221_D1.4270.15
880_S1238_P1.4270.15
880_S1243_D1.4270.15
969_Y992_Y1.4240.15
877_Y1220_Q1.4230.15
1086_G1091_F1.4220.15
1193_G1244_P1.4220.15
945_L948_K1.4200.15
937_Y946_T1.4200.15
859_W864_E1.4190.15
1232_Y1244_P1.4190.15
555_D647_T1.4180.15
1233_G1236_L1.4180.15
79_S160_Q1.4150.15
56_K66_L1.4140.15
663_R679_H1.4110.15
477_A746_E1.4080.15
857_Y879_Y1.4080.15
66_L154_R1.4030.15
1210_Y1246_G1.4030.15
580_Q1222_P1.4020.14
1201_G1210_Y1.4020.14
888_V1172_E1.3980.14
576_D1244_P1.3970.14
207_R210_T1.3970.14
1204_Y1208_R1.3960.14
54_G74_L1.3920.14
248_V253_A1.3910.14
576_D888_V1.3890.14
322_L995_D1.3860.14
93_G104_L1.3850.14
673_R903_T1.3840.14
510_Y724_G1.3840.14
90_G98_M1.3820.14
967_Y995_D1.3800.14
580_Q622_K1.3800.14
90_G93_G1.3790.14
1000_R1162_G1.3790.14
48_P106_L1.3790.14
426_D490_D1.3770.14
651_G1001_V1.3760.14
947_E974_R1.3750.14
1208_R1232_Y1.3720.14
375_G435_T1.3710.14
621_G699_Y1.3710.14
982_Q997_L1.3690.14
582_I706_T1.3680.14
136_S141_L1.3650.14
74_L90_G1.3640.14
702_A1217_Y1.3630.14
247_L251_T1.3620.14
580_Q618_D1.3590.14
901_Y1217_Y1.3590.14
1222_P1244_P1.3540.14
427_A475_T1.3520.14
649_E1190_R1.3510.14
80_S147_A1.3500.14
433_A843_L1.3500.14
1209_Y1221_D1.3460.14
1209_Y1238_P1.3460.14
1209_Y1243_D1.3460.14
439_G496_I1.3440.14
78_Y1244_P1.3430.14
558_G994_Y1.3430.14
214_D217_G1.3410.14
490_D1221_D1.3370.14
490_D1238_P1.3370.14
490_D1243_D1.3370.14
575_Y720_Y1.3350.14
558_G943_G1.3310.14
314_Y540_L1.3310.14
1237_N1244_P1.3280.14
490_D1208_R1.3270.14
429_G621_G1.3270.14
104_L154_R1.3240.14
72_F80_S1.3210.14
944_R996_P1.3210.14
322_L1210_Y1.3200.14
994_Y1001_V1.3150.14
1193_G1215_G1.3140.14
904_D1219_T1.3130.13
1201_G1234_Y1.3130.13
78_Y90_G1.3110.13
880_S1174_G1.3100.13
534_S796_T1.3050.13
1197_D1208_R1.3050.13
96_W147_A1.3010.13
272_A275_D1.2980.13
145_G704_R1.2970.13
118_G127_F1.2950.13
446_P939_Y1.2940.13
842_Q1151_R1.2930.13
1212_P1237_N1.2880.13
469_N888_V1.2870.13
485_L555_D1.2870.13
683_G998_G1.2820.13
132_G135_R1.2810.13
131_D134_S1.2800.13
477_A730_S1.2770.13
65_A72_F1.2750.13
90_G96_W1.2710.13
96_W160_Q1.2660.13
939_Y1003_K1.2660.13
769_H817_R1.2650.13
550_T721_D1.2610.13
494_R699_Y1.2560.13
995_D1210_Y1.2550.13
482_G829_G1.2550.13
663_R1149_D1.2550.13
940_D998_G1.2540.13
224_R1158_I1.2530.13
785_I860_N1.2530.13
469_N1153_L1.2520.13
251_T254_Q1.2490.13
426_D447_D1.2470.13
93_G98_M1.2440.13
115_D123_F1.2420.13
111_L116_N1.2410.13
362_D447_D1.2400.13
580_Q879_Y1.2400.13
970_D1209_Y1.2360.13
1087_G1090_V1.2360.13
246_R251_T1.2350.13
145_G1234_Y1.2320.13
944_R1149_D1.2310.13
800_G1201_G1.2300.13
995_D998_G1.2300.13
66_L80_S1.2210.13
1166_W1215_G1.2210.13
430_R1175_N1.2190.13
110_T114_S1.2180.12
437_A849_N1.2150.12
1206_R1222_P1.2130.12
128_P132_G1.2130.12
1215_G1220_Q1.2110.12
131_D138_S1.2100.12
177_N182_P1.2100.12
503_G841_G1.2090.12
306_L310_P1.2080.12
944_R971_S1.2060.12
1197_D1221_D1.2040.12
1197_D1243_D1.2040.12
1197_D1238_P1.2040.12
1204_Y1221_D1.2030.12
1204_Y1238_P1.2030.12
1204_Y1243_D1.2030.12
160_Q177_N1.2020.12
943_G1197_D1.2000.12
275_D278_P1.1960.12
303_P310_P1.1960.12
575_Y658_Y1.1960.12
901_Y914_E1.1950.12
943_G1221_D1.1950.12
943_G1238_P1.1950.12
943_G1243_D1.1950.12
115_D130_E1.1930.12
992_Y998_G1.1910.12
150_D160_Q1.1910.12
943_G1208_R1.1900.12
757_V975_L1.1900.12
66_L96_W1.1890.12
923_M1153_L1.1890.12
1100_D1104_S1.1880.12
1152_G1201_G1.1860.12
1216_R1232_Y1.1850.12
883_G1190_R1.1830.12
745_D1003_K1.1820.12
361_Y994_Y1.1810.12
638_D904_D1.1790.12
79_S96_W1.1770.12
937_Y995_D1.1770.12
209_L937_Y1.1760.12
1197_D1209_Y1.1760.12
48_P143_R1.1750.12
490_D994_Y1.1750.12
943_G1162_G1.1740.12
972_Q995_D1.1720.12
115_D124_E1.1680.12
1230_N1237_N1.1680.12
54_G159_W1.1670.12
206_Y210_T1.1670.12
430_R890_T1.1660.12
63_D134_S1.1650.12
425_F505_I1.1590.12
731_H890_T1.1590.12
940_D1003_K1.1590.12
613_N857_Y1.1560.12
637_Y994_Y1.1550.12
880_S1208_R1.1540.12
1222_P1238_P1.1530.12
1222_P1243_D1.1530.12
179_P1234_Y1.1520.12
493_G683_G1.1520.12
1215_G1244_P1.1520.12
1194_Q1206_R1.1510.12
475_T836_A1.1500.12
149_L159_W1.1490.12
110_T120_S1.1480.12
903_T1172_E1.1480.12
316_W336_F1.1450.12
95_G1149_D1.1450.12
249_L253_A1.1440.12
510_Y775_Y1.1440.12
618_D680_D1.1430.12
724_G775_Y1.1400.12
493_G1174_G1.1390.12
785_I944_R1.1390.12
111_L120_S1.1390.12
428_V446_P1.1350.12
890_T912_D1.1350.12
482_G493_G1.1330.12
68_G78_Y1.1310.12
783_R842_Q1.1310.12
787_D1209_Y1.1310.12
903_T1014_G1.1310.12
426_D630_G1.1300.12
277_L475_T1.1290.12
702_A1216_R1.1280.12
948_K965_H1.1270.12
786_P1208_R1.1260.12
95_G461_G1.1260.12
207_R214_D1.1250.12
357_I674_T1.1250.12
705_L799_S1.1250.12
821_H1179_E1.1240.12
1152_G1221_D1.1230.12
1152_G1238_P1.1230.12
1152_G1243_D1.1230.12
1197_D1204_Y1.1230.12
392_S396_R1.1220.12
353_G359_Y1.1210.12
868_I972_Q1.1210.12
880_S1162_G1.1200.12
80_S160_Q1.1190.12
1152_G1208_R1.1180.12
748_G884_R1.1170.12
429_G1174_G1.1160.11
460_D877_Y1.1150.11
721_D1216_R1.1140.11
111_L124_E1.1110.11
744_Y775_Y1.1110.11
114_S123_F1.1100.11
246_R252_Q1.1080.11
1192_P1217_Y1.1060.11
217_G638_D1.1050.11
884_R970_D1.1030.11
943_G1209_Y1.1020.11
494_R724_G1.1010.11
63_D68_G1.0990.11
482_G1246_G1.0990.11
817_R904_D1.0980.11
250_T254_Q1.0980.11
279_G284_G1.0980.11
884_R940_D1.0960.11
48_P51_P1.0950.11
310_P316_W1.0950.11
1221_D1230_N1.0930.11
1230_N1238_P1.0930.11
1230_N1243_D1.0930.11
35_A38_V1.0920.11
104_L147_A1.0920.11
542_F880_S1.0920.11
475_T486_R1.0900.11
842_Q1209_Y1.0900.11
800_G1174_G1.0870.11
663_R1232_Y1.0870.11
175_A183_W1.0860.11
1208_R1212_P1.0850.11
97_K104_L1.0850.11
493_G1246_G1.0850.11
98_M447_D1.0840.11
349_H355_P1.0830.11
558_G630_G1.0800.11
116_N123_F1.0780.11
143_R155_L1.0770.11
943_G1149_D1.0760.11
556_R1125_T1.0760.11
995_D1162_G1.0760.11
940_D970_D1.0720.11
346_M349_H1.0710.11
859_W1208_R1.0710.11
273_F320_G1.0700.11
168_L177_N1.0700.11
388_T391_D1.0680.11
554_H589_G1.0670.11
679_H699_Y1.0670.11
663_R699_Y1.0660.11
429_G1246_G1.0640.11
427_A450_T1.0640.11
126_L604_A1.0620.11
289_I292_S1.0620.11
621_G641_G1.0620.11
880_S994_Y1.0610.11
68_G83_T1.0600.11
889_H898_R1.0590.11
79_S494_R1.0580.11
669_G1192_P1.0570.11
93_G106_L1.0530.11
399_L775_Y1.0530.11
490_D885_L1.0530.11
446_P450_T1.0520.11
654_T1159_S1.0520.11
1206_R1217_Y1.0520.11
48_P468_Y1.0510.11
860_N943_G1.0510.11
700_D939_Y1.0510.11
389_I880_S1.0500.11
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159_W163_P0.5270.07
391_D395_R0.5270.07
255_R260_R0.5270.07
938_R941_R0.5270.07
137_E141_L0.5260.07
381_Q1114_E0.5260.07
207_R215_R0.5260.07
356_E859_W0.5250.07
48_P818_D0.5240.07
298_H321_E0.5240.07
468_Y1190_R0.5240.07
500_A769_H0.5240.07
616_Q897_I0.5240.07
35_A51_P0.5240.07
36_C39_C0.5240.07
575_Y1197_D0.5240.07
673_R1153_L0.5240.07
490_D786_P0.5230.07
818_D1203_Y0.5230.07
919_S1200_S0.5230.07
978_Y993_L0.5230.07
288_G322_L0.5220.07
168_L183_W0.5220.07
503_G1166_W0.5220.07
1032_D1048_Y0.5220.07
290_R297_T0.5210.07
210_T807_L0.5210.07
212_L318_P0.5210.07
1184_Q1188_L0.5210.07
503_G928_R0.5200.07
654_T1093_P0.5200.07
977_H1000_R0.5180.07
489_Y930_A0.5180.07
571_Q931_R0.5180.07
402_Q756_T0.5180.07
1208_R1222_P0.5170.07
38_V42_G0.5160.07
682_T1159_S0.5160.07
66_L152_G0.5160.07
648_S1148_C0.5160.07
632_T1082_G0.5150.07
147_A157_A0.5150.07
558_G800_G0.5150.07
860_N1035_T0.5150.07
494_R1150_H0.5150.07
811_P924_W0.5140.07
428_V872_R0.5140.07
670_F882_T0.5140.07
706_T1215_G0.5140.07
551_R1164_T0.5140.07
820_L1028_G0.5140.07
786_P994_Y0.5130.07
785_I923_M0.5130.07
61_E66_L0.5130.07
63_D147_A0.5130.07
496_I784_C0.5130.07
149_L212_L0.5120.07
472_N1121_S0.5120.07
1140_A1169_E0.5120.07
994_Y1209_Y0.5120.07
446_P857_Y0.5100.07
234_I821_H0.5090.07
841_G1055_P0.5090.07
246_R254_Q0.5090.07
51_P61_E0.5090.07
468_Y576_D0.5080.07
492_L514_H0.5080.07
205_P210_T0.5080.07
576_D1207_H0.5080.07
755_Q974_R0.5080.07
205_P216_F0.5080.07
802_L940_D0.5080.07
718_W994_Y0.5070.07
1222_P1246_G0.5070.07
294_V314_Y0.5070.07
510_Y943_G0.5070.07
797_Y1206_R0.5060.07
658_Y1014_G0.5060.07
436_D550_T0.5060.07
1100_D1103_E0.5040.07
368_T486_R0.5040.07
547_G610_G0.5030.07
812_L1205_N0.5030.07
160_Q377_S0.5030.07
992_Y997_L0.5020.07
534_S903_T0.5020.07
949_T1003_K0.5020.07
1072_R1080_Q0.5020.07
575_Y1234_Y0.5010.07
96_W1237_N0.5000.07
130_E143_R0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o9xA 1 0.7668 100 0.685 Contact Map
4iglB 1 0.4068 100 0.77 Contact Map
4iglA 1 0.4451 100 0.927 Contact Map
4ghbA 5 0.1425 97.4 0.981 Contact Map
2ymuA 1 0.3969 96.6 0.983 Contact Map
2ojhA 1 0.1821 96.2 0.984 Contact Map
1gxrA 2 0.2339 96.1 0.984 Contact Map
4ld1A 1 0.107 95 0.985 Contact Map
4jivD 1 0.0369 95 0.985 Contact Map
4qrjA 1 0.2119 94.9 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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