GREMLIN Database
CYSM - Cysteine synthase B
UniProt: P16703 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10193
Length: 303 (273)
Sequences: 21152 (11039)
Seq/√Len: 668.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_A87_M4.0661.00
125_L128_E3.4991.00
26_E274_V3.4371.00
15_K26_E3.0851.00
236_D265_R2.6681.00
158_I276_V2.6541.00
97_Q101_A2.6321.00
168_H196_V2.5531.00
243_E247_R2.5471.00
51_E55_R2.5411.00
10_N160_Q2.4711.00
201_E233_H2.3821.00
86_R109_E2.3731.00
93_D114_T2.3471.00
53_E85_Y2.3331.00
194_T228_E2.3291.00
51_E145_D2.3111.00
63_V88_K2.2401.00
90_L129_M2.2331.00
88_K109_E2.2321.00
270_N273_A2.2291.00
128_E132_R2.0951.00
10_N161_Q2.0651.00
50_V83_K2.0611.00
28_W274_V2.0531.00
259_A277_A2.0461.00
202_E234_Q2.0261.00
183_S225_L2.0231.00
156_P185_F2.0101.00
88_K111_I1.9961.00
233_H236_D1.9701.00
142_N219_G1.9481.00
183_S195_I1.9241.00
13_L276_V1.9111.00
151_Y188_E1.9021.00
190_S193_V1.8161.00
53_E56_G1.8141.00
173_M197_G1.8101.00
169_F186_M1.7971.00
198_L262_G1.7921.00
196_V228_E1.7771.00
204_S208_G1.7651.00
244_L252_C1.7581.00
151_Y184_R1.6921.00
127_L131_N1.6851.00
37_A78_M1.6841.00
228_E269_A1.6701.00
28_W162_T1.6581.00
166_I276_V1.6531.00
139_D142_N1.6361.00
240_T261_A1.6131.00
167_T274_V1.6071.00
244_L260_V1.5941.00
243_E264_L1.5901.00
167_T273_A1.5851.00
15_K28_W1.5801.00
187_R227_D1.5781.00
169_F182_V1.5761.00
15_K20_G1.5411.00
68_T73_G1.5271.00
155_G182_V1.5091.00
29_L279_I1.5051.00
100_R112_L1.4921.00
46_L50_V1.4901.00
53_E83_K1.4891.00
159_W189_Q1.4741.00
101_A104_R1.4681.00
168_H270_N1.4261.00
168_H273_A1.4231.00
100_R104_R1.4171.00
179_I226_V1.4071.00
111_I125_L1.4061.00
123_R127_L1.3991.00
155_G186_M1.3841.00
170_V266_V1.3791.00
130_A137_L1.3271.00
48_M143_N1.3161.00
240_T264_L1.3041.00
97_Q100_R1.3001.00
165_R274_V1.2991.00
170_V198_L1.2911.00
168_H194_T1.2911.00
91_M103_M1.2871.00
22_D243_E1.2851.00
118_G121_G1.2741.00
50_V54_K1.2621.00
155_G185_F1.2561.00
261_A265_R1.2471.00
184_R222_N1.2321.00
252_C279_I1.2271.00
236_D261_A1.2251.00
103_M108_A1.2211.00
212_W258_G1.2191.00
266_V269_A1.2161.00
51_E54_K1.2121.00
162_T166_I1.2121.00
47_S152_T1.2101.00
186_M193_V1.2061.00
201_E231_D1.2061.00
90_L125_L1.1881.00
18_R248_E1.1831.00
73_G103_M1.1811.00
127_L130_A1.1761.00
100_R110_L1.1721.00
16_L29_L1.1721.00
159_W185_F1.1651.00
207_P231_D1.1641.00
22_D247_R1.1631.00
256_S279_I1.1621.00
94_N115_K1.1581.00
185_F189_Q1.1561.00
265_R268_K1.1551.00
239_N243_E1.1461.00
179_I195_I1.1451.00
14_V31_L1.1391.00
240_T260_V1.1391.00
156_P160_Q1.1211.00
12_P34_N1.1201.00
204_S231_D1.1141.00
63_V86_R1.1131.00
93_D115_K1.1121.00
13_L162_T1.1001.00
124_D128_E1.0931.00
13_L158_I1.0921.00
236_D239_N1.0851.00
124_D127_L1.0781.00
49_I64_L1.0721.00
232_I261_A1.0691.00
47_S149_A1.0671.00
120_E124_D1.0631.00
235_R239_N1.0581.00
64_L80_A1.0541.00
211_R214_T1.0521.00
197_G229_V1.0491.00
162_T276_V1.0461.00
230_L262_G1.0451.00
55_R145_D1.0431.00
196_V230_L1.0351.00
179_I197_G1.0331.00
204_S207_P1.0311.00
150_H154_T1.0181.00
47_S51_E1.0171.00
245_A251_F1.0061.00
47_S50_V1.0031.00
24_G271_P0.9991.00
49_I83_K0.9921.00
242_R246_V0.9821.00
25_S273_A0.9821.00
17_Q21_P0.9801.00
158_I166_I0.9791.00
168_H275_V0.9701.00
91_M112_L0.9691.00
125_L129_M0.9691.00
81_A87_M0.9671.00
45_A75_A0.9611.00
76_L87_M0.9601.00
241_M257_G0.9591.00
49_I79_I0.9561.00
25_S272_D0.9551.00
65_I135_G0.9521.00
78_M106_Y0.9521.00
48_M138_L0.9381.00
18_R247_R0.9351.00
65_I126_A0.9291.00
75_A79_I0.9261.00
27_V263_A0.9261.00
182_V278_I0.9231.00
62_D134_E0.9191.00
104_R109_E0.9171.00
230_L265_R0.9161.00
18_R21_P0.9101.00
121_G124_D0.9031.00
77_A108_A0.9011.00
128_E131_N0.8981.00
151_Y185_F0.8971.00
263_A277_A0.8941.00
252_C256_S0.8851.00
7_T46_L0.8761.00
173_M179_I0.8701.00
194_T227_D0.8641.00
11_T35_N0.8631.00
216_Y219_G0.8591.00
129_M133_G0.8561.00
256_S280_C0.8551.00
52_A56_G0.8541.00
66_E89_L0.8531.00
159_W190_S0.8471.00
152_T156_P0.8401.00
156_P189_Q0.8401.00
65_I129_M0.8381.00
260_V279_I0.8371.00
52_A136_K0.8371.00
179_I222_N0.8321.00
185_F188_E0.8271.00
130_A135_G0.8251.00
251_F283_G0.8251.00
171_S182_V0.8221.00
170_V263_A0.8201.00
63_V135_G0.8181.00
259_A280_C0.8111.00
31_L279_I0.8081.00
147_P220_I0.8051.00
74_I103_M0.8031.00
101_A105_A0.7991.00
214_T217_L0.7971.00
180_T220_I0.7971.00
211_R215_E0.7961.00
209_I237_A0.7871.00
170_V262_G0.7861.00
16_L260_V0.7851.00
215_E218_P0.7841.00
104_R112_L0.7811.00
149_A152_T0.7801.00
20_G23_N0.7791.00
207_P229_V0.7791.00
62_D86_R0.7771.00
184_R188_E0.7751.00
210_R214_T0.7751.00
170_V196_V0.7711.00
154_T182_V0.7671.00
78_M82_L0.7651.00
16_L248_E0.7641.00
126_A130_A0.7641.00
126_A137_L0.7621.00
194_T273_A0.7621.00
240_T243_E0.7611.00
168_H266_V0.7611.00
166_I193_V0.7541.00
88_K135_G0.7531.00
241_M284_D0.7531.00
260_V277_A0.7501.00
209_I214_T0.7491.00
154_T278_I0.7451.00
159_W186_M0.7421.00
47_S145_D0.7421.00
65_I130_A0.7411.00
264_L268_K0.7411.00
119_M122_A0.7391.00
265_R269_A0.7371.00
205_S215_E0.7371.00
31_L34_N0.7321.00
53_E57_E0.7301.00
238_E254_V0.7301.00
81_A106_Y0.7291.00
88_K129_M0.7251.00
222_N225_L0.7241.00
74_I102_A0.7231.00
230_L269_A0.7171.00
95_M98_E0.7171.00
223_A226_V0.7151.00
164_G274_V0.7141.00
154_T178_T0.7131.00
182_V186_M0.7111.00
154_T158_I0.7071.00
173_M229_V0.7071.00
222_N226_V0.7051.00
147_P184_R0.7031.00
26_E272_D0.7011.00
206_I229_V0.7001.00
29_L277_A0.6991.00
172_S280_C0.6971.00
129_M132_R0.6961.00
113_V125_L0.6941.00
57_E85_Y0.6941.00
89_L103_M0.6941.00
162_T274_V0.6921.00
23_N243_E0.6851.00
40_V178_T0.6841.00
206_I222_N0.6801.00
166_I274_V0.6771.00
87_M108_A0.6771.00
8_I42_D0.6721.00
25_S275_V0.6711.00
209_I213_P0.6701.00
211_R217_L0.6681.00
67_A137_L0.6661.00
64_L85_Y0.6631.00
169_F278_I0.6621.00
86_R135_G0.6601.00
19_M264_L0.6581.00
139_D143_N0.6571.00
237_A258_G0.6561.00
147_P221_F0.6561.00
38_G282_R0.6561.00
20_G26_E0.6561.00
97_Q104_R0.6541.00
115_K121_G0.6541.00
17_Q20_G0.6521.00
210_R213_P0.6491.00
29_L260_V0.6441.00
45_A79_I0.6421.00
169_F193_V0.6361.00
252_C257_G0.6341.00
144_P147_P0.6331.00
159_W164_G0.6321.00
165_R190_S0.6301.00
67_A119_M0.6301.00
228_E266_V0.6301.00
90_L111_I0.6301.00
23_N264_L0.6281.00
95_M100_R0.6271.00
44_A48_M0.6261.00
9_G36_P0.6251.00
160_Q189_Q0.6231.00
51_E57_E0.6221.00
90_L113_V0.6181.00
244_L279_I0.6121.00
123_R126_A0.6121.00
64_L87_M0.6111.00
136_K143_N0.6111.00
77_A103_M0.6101.00
48_M146_N0.6091.00
65_I90_L0.6071.00
196_V266_V0.6071.00
94_N98_E0.6051.00
262_G266_V0.6051.00
234_Q238_E0.6041.00
25_S270_N0.6041.00
244_L248_E0.6031.00
119_M123_R0.6021.00
93_D112_L0.6021.00
16_L19_M0.6011.00
70_G73_G0.5991.00
209_I212_W0.5981.00
159_W162_T0.5981.00
21_P24_G0.5951.00
57_E136_K0.5951.00
241_M254_V0.5941.00
25_S267_A0.5931.00
244_L250_I0.5931.00
170_V275_V0.5921.00
158_I182_V0.5911.00
8_I46_L0.5901.00
20_G27_V0.5901.00
13_L28_W0.5891.00
19_M260_V0.5881.00
206_I217_L0.5841.00
42_D78_M0.5841.00
30_K157_E0.5821.00
210_R218_P0.5821.00
172_S259_A0.5811.00
73_G89_L0.5791.00
200_P212_W0.5761.00
48_M145_D0.5751.00
33_G282_R0.5711.00
7_T34_N0.5681.00
61_G86_R0.5671.00
76_L138_L0.5671.00
31_L250_I0.5661.00
198_L258_G0.5621.00
171_S179_I0.5611.00
91_M100_R0.5591.00
260_V264_L0.5591.00
66_E76_L0.5581.00
88_K133_G0.5581.00
199_Q205_S0.5571.00
37_A106_Y0.5551.00
19_M240_T0.5541.00
149_A184_R0.5531.00
95_M210_R0.5531.00
173_M206_I0.5521.00
169_F195_I0.5521.00
212_W255_S0.5511.00
64_L138_L0.5511.00
217_L220_I0.5511.00
198_L230_L0.5491.00
44_A72_T0.5491.00
102_A105_A0.5471.00
180_T184_R0.5471.00
239_N242_R0.5451.00
36_P42_D0.5441.00
25_S271_P0.5441.00
187_R225_L0.5441.00
22_D264_L0.5441.00
7_T50_V0.5401.00
91_M95_M0.5371.00
109_E133_G0.5371.00
76_L89_L0.5361.00
9_G35_N0.5361.00
19_M23_N0.5361.00
19_M247_R0.5341.00
205_S208_G0.5341.00
119_M140_Q0.5331.00
187_R224_S0.5321.00
48_M136_K0.5281.00
114_T121_G0.5271.00
20_G25_S0.5250.99
256_S259_A0.5250.99
13_L161_Q0.5230.99
29_L244_L0.5220.99
72_T151_Y0.5200.99
127_L137_L0.5190.99
19_M243_E0.5180.99
145_D149_A0.5180.99
54_K61_G0.5150.99
77_A87_M0.5140.99
197_G226_V0.5140.99
122_A126_A0.5130.99
33_G250_I0.5100.99
99_R210_R0.5080.99
121_G125_L0.5080.99
61_G134_E0.5080.99
36_P78_M0.5080.99
201_E204_S0.5060.99
232_I258_G0.5050.99
129_M135_G0.5030.99
196_V227_D0.5010.99
234_Q237_A0.5010.99
158_I278_I0.5000.99
210_R215_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v03A 2 0.967 100 0.122 Contact Map
2pqmA 2 0.9967 100 0.129 Contact Map
1y7lA 2 0.9571 100 0.14 Contact Map
4ofxA 2 0.9241 100 0.142 Contact Map
3tbhA 2 0.9802 100 0.145 Contact Map
3dwgA 2 0.9967 100 0.146 Contact Map
3x44A 3 0.9934 100 0.146 Contact Map
2q3bA 2 0.9472 100 0.146 Contact Map
4lmbA 2 0.9703 100 0.149 Contact Map
4aecA 2 1 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.