GREMLIN Database
CYST - Sulfate transport system permease protein CysT
UniProt: P16701 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10197
Length: 277 (241)
Sequences: 79005 (50229)
Seq/√Len: 3235.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_Q187_K4.0311.00
61_K65_L3.2921.00
175_E184_S3.0871.00
160_Q164_E2.8461.00
174_A184_S2.6131.00
171_E189_V2.5761.00
87_R171_E2.5751.00
180_T183_Q2.5671.00
39_L47_Y2.5401.00
58_A61_K2.5071.00
73_F148_A2.4851.00
182_W186_C2.4461.00
162_V196_A2.3841.00
69_V144_A2.3841.00
45_A48_W2.3461.00
181_R184_S2.2961.00
71_S201_V2.2391.00
57_V61_K2.2271.00
159_V197_L2.1701.00
90_F93_R2.1461.00
45_A49_E2.1331.00
48_W52_T2.1221.00
241_D244_A2.1211.00
227_E235_V2.0961.00
86_T164_E2.0351.00
179_A183_Q2.0251.00
183_Q186_C1.9891.00
170_Y192_E1.9511.00
79_L185_F1.9501.00
59_A232_M1.8931.00
171_E184_S1.8871.00
33_S37_M1.8561.00
163_L193_L1.8541.00
232_M236_R1.7951.00
155_V200_G1.7531.00
175_E181_R1.7521.00
58_A62_V1.7481.00
174_A179_A1.7471.00
171_E175_E1.7351.00
67_A205_F1.7271.00
65_L140_W1.6741.00
261_F265_T1.6661.00
78_G155_V1.6641.00
79_L159_V1.6511.00
79_L193_L1.6501.00
65_L69_V1.6361.00
75_G201_V1.6311.00
85_L156_V1.6131.00
81_M156_V1.6061.00
136_V139_T1.6011.00
97_D160_Q1.5941.00
82_A159_V1.5421.00
30_L34_A1.4931.00
76_V80_L1.4881.00
89_R93_R1.4501.00
70_A208_S1.4421.00
155_V204_S1.4311.00
43_S46_Q1.4081.00
49_E244_A1.4001.00
92_G95_L1.3961.00
168_P171_E1.3901.00
36_V250_S1.3821.00
227_E232_M1.3741.00
163_L189_V1.3581.00
18_G22_L1.3531.00
180_T184_S1.3411.00
34_A38_Q1.3311.00
86_T160_Q1.3301.00
190_L197_L1.3221.00
49_E52_T1.3081.00
174_A188_V1.2991.00
143_I215_V1.2931.00
199_A203_L1.2871.00
212_F216_I1.2861.00
159_V200_G1.2721.00
87_R168_P1.2451.00
168_P172_E1.2451.00
74_N204_S1.2281.00
44_W48_W1.2271.00
62_V65_L1.2051.00
146_A218_I1.1891.00
166_L192_E1.1851.00
152_I156_V1.1821.00
79_L197_L1.1801.00
228_V231_L1.1721.00
169_E172_E1.1701.00
55_Q58_A1.1691.00
83_W163_L1.1651.00
138_Y141_L1.1501.00
214_A218_I1.1461.00
86_T163_L1.1391.00
265_T268_S1.1371.00
47_Y250_S1.1361.00
69_V72_I1.1261.00
236_R241_D1.1171.00
95_L98_A1.1061.00
136_V141_L1.1021.00
22_L26_L1.0901.00
80_L84_I1.0851.00
13_F17_L1.0771.00
15_L19_T1.0761.00
72_I76_V1.0531.00
95_L99_L1.0461.00
221_N225_K1.0441.00
83_W185_F1.0371.00
35_L250_S1.0361.00
262_S266_L1.0351.00
219_A226_T1.0331.00
135_K138_Y1.0301.00
91_P94_T1.0261.00
171_E181_R1.0181.00
232_M235_V1.0171.00
179_A184_S1.0121.00
27_I31_P1.0121.00
73_F144_A1.0081.00
158_T200_G1.0041.00
63_T229_T1.0041.00
69_V73_F1.0001.00
212_F234_F0.9941.00
227_E236_R0.9911.00
64_L68_F0.9911.00
194_S198_V0.9891.00
51_I57_V0.9891.00
70_A74_N0.9781.00
192_E195_P0.9741.00
93_R164_E0.9701.00
38_Q246_S0.9701.00
230_S236_R0.9701.00
119_F142_G0.9681.00
49_E53_N0.9671.00
70_A147_M0.9661.00
144_A148_A0.9641.00
81_M152_I0.9571.00
137_T141_L0.9481.00
227_E231_L0.9451.00
211_E215_V0.9451.00
34_A37_M0.9431.00
147_M208_S0.9431.00
236_R239_E0.9401.00
159_V196_A0.9311.00
75_G197_L0.9301.00
137_T140_W0.9281.00
139_T226_T0.9211.00
225_K230_S0.9191.00
115_L146_A0.9171.00
15_L18_G0.9151.00
184_S187_K0.9151.00
68_F72_I0.9121.00
78_G156_V0.9051.00
83_W181_R0.9011.00
82_A163_L0.8991.00
232_M248_I0.8981.00
262_S265_T0.8971.00
85_L97_D0.8951.00
225_K236_R0.8951.00
215_V228_V0.8951.00
82_A86_T0.8941.00
69_V148_A0.8921.00
140_W226_T0.8871.00
185_F190_L0.8851.00
60_Y64_L0.8821.00
141_L145_V0.8781.00
181_R185_F0.8741.00
37_M41_Q0.8711.00
14_T18_G0.8691.00
162_V193_L0.8681.00
179_A187_K0.8671.00
65_L68_F0.8651.00
101_D157_R0.8641.00
108_T150_T0.8641.00
159_V193_L0.8591.00
60_Y229_T0.8591.00
44_W47_Y0.8581.00
115_L218_I0.8581.00
155_V159_V0.8571.00
25_C29_L0.8551.00
186_C190_L0.8531.00
193_L196_A0.8531.00
106_L111_A0.8521.00
211_E214_A0.8481.00
70_A144_A0.8471.00
194_S197_L0.8471.00
227_E230_S0.8411.00
73_F76_V0.8391.00
56_V248_I0.8361.00
140_W144_A0.8321.00
117_S121_V0.8321.00
17_L21_L0.8161.00
146_A214_A0.8101.00
30_L33_S0.8091.00
66_S140_W0.8051.00
35_L246_S0.8011.00
230_S234_F0.7961.00
185_F189_V0.7951.00
112_G213_G0.7901.00
49_E241_D0.7891.00
72_I201_V0.7871.00
61_K64_L0.7811.00
74_N78_G0.7801.00
258_L262_S0.7771.00
82_A156_V0.7771.00
116_A120_S0.7761.00
204_S208_S0.7741.00
168_P175_E0.7711.00
46_Q243_P0.7711.00
46_Q49_E0.7711.00
143_I147_M0.7691.00
78_G159_V0.7631.00
91_P95_L0.7591.00
94_T97_D0.7591.00
159_V163_L0.7581.00
184_S189_V0.7531.00
71_S205_F0.7501.00
138_Y221_N0.7491.00
84_I90_F0.7471.00
112_G217_F0.7471.00
226_T230_S0.7461.00
74_N151_S0.7451.00
235_V238_Q0.7431.00
50_V251_V0.7411.00
257_L261_F0.7391.00
85_L160_Q0.7321.00
151_S204_S0.7311.00
189_V192_E0.7311.00
67_A71_S0.7311.00
66_S228_V0.7301.00
230_S233_I0.7251.00
196_A200_G0.7251.00
226_T236_R0.7251.00
74_N155_V0.7201.00
62_V140_W0.7181.00
227_E234_F0.7161.00
77_F152_I0.7161.00
170_Y188_V0.7151.00
19_T22_L0.7151.00
16_S20_S0.7111.00
104_F153_P0.7101.00
59_A62_V0.7081.00
85_L96_L0.7071.00
89_R94_T0.7041.00
65_L141_L0.7021.00
66_S147_M0.7011.00
263_I266_L0.6921.00
35_L249_A0.6911.00
71_S208_S0.6911.00
120_S137_T0.6901.00
77_F148_A0.6881.00
75_G159_V0.6841.00
231_L235_V0.6801.00
216_I231_L0.6771.00
111_A149_F0.6771.00
236_R248_I0.6771.00
142_G146_A0.6741.00
256_S260_L0.6731.00
16_S19_T0.6731.00
221_N226_T0.6681.00
166_L193_L0.6641.00
244_A248_I0.6631.00
101_D104_F0.6631.00
57_V60_Y0.6561.00
48_W51_I0.6551.00
70_A148_A0.6551.00
66_S143_I0.6551.00
63_T209_L0.6521.00
141_L144_A0.6381.00
173_A177_L0.6371.00
138_Y142_G0.6341.00
115_L118_L0.6331.00
136_V140_W0.6311.00
211_E228_V0.6311.00
25_C28_L0.6301.00
63_T230_S0.6301.00
197_L201_V0.6251.00
43_S47_Y0.6221.00
236_R244_A0.6221.00
238_Q241_D0.6141.00
184_S188_V0.6131.00
51_I54_P0.6131.00
66_S144_A0.6101.00
42_M45_A0.6071.00
71_S75_G0.6051.00
50_V244_A0.6041.00
139_T142_G0.6031.00
97_D157_R0.6021.00
47_Y247_A0.6001.00
180_T186_C0.5991.00
31_P35_L0.5991.00
74_N148_A0.5981.00
142_G218_I0.5981.00
158_T196_A0.5921.00
147_M215_V0.5911.00
242_Y246_S0.5891.00
242_Y245_A0.5881.00
173_A176_T0.5881.00
108_T213_G0.5871.00
108_T112_G0.5861.00
197_L200_G0.5861.00
67_A209_L0.5861.00
24_V28_L0.5841.00
194_S266_L0.5811.00
84_I88_Y0.5791.00
246_S250_S0.5761.00
213_G217_F0.5761.00
207_R210_G0.5741.00
202_A263_I0.5721.00
21_L25_C0.5671.00
143_I219_A0.5671.00
94_T98_A0.5661.00
76_V79_L0.5641.00
74_N152_I0.5641.00
82_A160_Q0.5621.00
20_S24_V0.5571.00
90_F96_L0.5571.00
88_Y181_R0.5571.00
117_S120_S0.5561.00
189_V193_L0.5541.00
135_K139_T0.5541.00
65_L144_A0.5531.00
14_T17_L0.5511.00
100_M153_P0.5481.00
246_S249_A0.5481.00
111_A150_T0.5471.00
81_M84_I0.5451.00
204_S207_R0.5451.00
151_S207_R0.5451.00
172_E175_E0.5441.00
206_T210_G0.5431.00
85_L90_F0.5401.00
231_L234_F0.5401.00
93_R97_D0.5381.00
198_V201_V0.5361.00
100_M156_V0.5351.00
116_A137_T0.5351.00
74_N208_S0.5321.00
53_N57_V0.5291.00
96_L100_M0.5281.00
83_W189_V0.5261.00
200_G204_S0.5261.00
50_V248_I0.5251.00
58_A65_L0.5251.00
39_L247_A0.5241.00
89_R168_P0.5211.00
92_G96_L0.5211.00
54_P57_V0.5201.00
97_D164_E0.5191.00
55_Q227_E0.5191.00
31_P39_L0.5171.00
225_K228_V0.5151.00
111_A115_L0.5141.00
106_L110_V0.5121.00
186_C189_V0.5111.00
215_V231_L0.5081.00
66_S70_A0.5081.00
219_A227_E0.5061.00
71_S76_V0.5051.00
77_F80_L0.5041.00
104_F154_F0.5031.00
234_F237_L0.5031.00
26_L30_L0.5021.00
109_A217_F0.5011.00
29_L33_S0.5011.00
201_V204_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9061 100 0.258 Contact Map
3d31C 2 0.8953 100 0.259 Contact Map
4tquM 1 0.9747 100 0.314 Contact Map
3rlfG 1 0.935 100 0.344 Contact Map
3rlfF 1 0.9422 100 0.362 Contact Map
4tquN 1 0.9025 100 0.372 Contact Map
4ymuD 2 0.7762 100 0.462 Contact Map
3tuiA 2 0.7509 99.9 0.495 Contact Map
2m8rA 1 0.1336 7.1 0.95 Contact Map
2l2tA 2 0.1516 6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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