CYST - ECOLI - GREMLIN Contacts

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CYST - Sulfate transport system permease protein CysT

UniProt:	P16701	Sequences: MFAVSSRRVLPGFTLSLGTSLLFVCLILLLPLSALVMQLAQMSWAQYWEVITNPQVVAAYKVTLLSAFVASIFNGVFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLFSVNGFYGEWLAKFDIKVTYTWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFCKVVLPELSPALVAGVALSFTRSLGEFGAVIFIAGNIAWKTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFSINTLQSRFGRRVVGH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10197
Length:	277 (241)
Sequences:	79005 (50229)
Seq/√Len:	3235.6

ECOLI - CYST CYSW POTH THIP PSTC YCJO POTB YDCU UGPA MALG YNJC PSTA POTI YCJP POTC MODB YDCV MALF UGPE YEHY SSUC YEHW TAUC PHNE PROW METI YECS GLNP
BACSU - GANP AMYD ARAP YESP YQGI YURN YTEP GANQ MDXF YQGH MDXG LPLB YESQ YVGM YURM AMYC ARAQ LPLC YTCP OPUAB SSUC YTLD TCYB METP TCYL YXEN OPUCB OPUBD OPUBB OPUCD ARTQ GLNP
HALSA - Q9HPK3 Q9HMT4 Q9HR05 Q9HML6 Q9HP01 Q9HP02 Q9HHQ7 Q9HS11 Q9HHQ6 Q9HNI9 Q9HS12 Q9HML7
SULSO - Q97YY2 Q97UZ0 Q97Z98 Q97YY3 Q97UF4 Q97ZT7 Q97UF3 Q97VC0 Q97ZC2 Q97UY9 Q97ZC1 Q97ZT6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
183_Q	187_K	4.031	1.00
61_K	65_L	3.292	1.00
175_E	184_S	3.087	1.00
160_Q	164_E	2.846	1.00
174_A	184_S	2.613	1.00
171_E	189_V	2.576	1.00
87_R	171_E	2.575	1.00
180_T	183_Q	2.567	1.00
39_L	47_Y	2.540	1.00
58_A	61_K	2.507	1.00
73_F	148_A	2.485	1.00
182_W	186_C	2.446	1.00
162_V	196_A	2.384	1.00
69_V	144_A	2.384	1.00
45_A	48_W	2.346	1.00
181_R	184_S	2.296	1.00
71_S	201_V	2.239	1.00
57_V	61_K	2.227	1.00
159_V	197_L	2.170	1.00
90_F	93_R	2.146	1.00
45_A	49_E	2.133	1.00
48_W	52_T	2.122	1.00
241_D	244_A	2.121	1.00
227_E	235_V	2.096	1.00
86_T	164_E	2.035	1.00
179_A	183_Q	2.025	1.00
183_Q	186_C	1.989	1.00
170_Y	192_E	1.951	1.00
79_L	185_F	1.950	1.00
59_A	232_M	1.893	1.00
171_E	184_S	1.887	1.00
33_S	37_M	1.856	1.00
163_L	193_L	1.854	1.00
232_M	236_R	1.795	1.00
155_V	200_G	1.753	1.00
175_E	181_R	1.752	1.00
58_A	62_V	1.748	1.00
174_A	179_A	1.747	1.00
171_E	175_E	1.735	1.00
67_A	205_F	1.727	1.00
65_L	140_W	1.674	1.00
261_F	265_T	1.666	1.00
78_G	155_V	1.664	1.00
79_L	159_V	1.651	1.00
79_L	193_L	1.650	1.00
65_L	69_V	1.636	1.00
75_G	201_V	1.631	1.00
85_L	156_V	1.613	1.00
81_M	156_V	1.606	1.00
136_V	139_T	1.601	1.00
97_D	160_Q	1.594	1.00
82_A	159_V	1.542	1.00
30_L	34_A	1.493	1.00
76_V	80_L	1.488	1.00
89_R	93_R	1.450	1.00
70_A	208_S	1.442	1.00
155_V	204_S	1.431	1.00
43_S	46_Q	1.408	1.00
49_E	244_A	1.400	1.00
92_G	95_L	1.396	1.00
168_P	171_E	1.390	1.00
36_V	250_S	1.382	1.00
227_E	232_M	1.374	1.00
163_L	189_V	1.358	1.00
18_G	22_L	1.353	1.00
180_T	184_S	1.341	1.00
34_A	38_Q	1.331	1.00
86_T	160_Q	1.330	1.00
190_L	197_L	1.322	1.00
49_E	52_T	1.308	1.00
174_A	188_V	1.299	1.00
143_I	215_V	1.293	1.00
199_A	203_L	1.287	1.00
212_F	216_I	1.286	1.00
159_V	200_G	1.272	1.00
87_R	168_P	1.245	1.00
168_P	172_E	1.245	1.00
74_N	204_S	1.228	1.00
44_W	48_W	1.227	1.00
62_V	65_L	1.205	1.00
146_A	218_I	1.189	1.00
166_L	192_E	1.185	1.00
152_I	156_V	1.182	1.00
79_L	197_L	1.180	1.00
228_V	231_L	1.172	1.00
169_E	172_E	1.170	1.00
55_Q	58_A	1.169	1.00
83_W	163_L	1.165	1.00
138_Y	141_L	1.150	1.00
214_A	218_I	1.146	1.00
86_T	163_L	1.139	1.00
265_T	268_S	1.137	1.00
47_Y	250_S	1.136	1.00
69_V	72_I	1.126	1.00
236_R	241_D	1.117	1.00
95_L	98_A	1.106	1.00
136_V	141_L	1.102	1.00
22_L	26_L	1.090	1.00
80_L	84_I	1.085	1.00
13_F	17_L	1.077	1.00
15_L	19_T	1.076	1.00
72_I	76_V	1.053	1.00
95_L	99_L	1.046	1.00
221_N	225_K	1.044	1.00
83_W	185_F	1.037	1.00
35_L	250_S	1.036	1.00
262_S	266_L	1.035	1.00
219_A	226_T	1.033	1.00
135_K	138_Y	1.030	1.00
91_P	94_T	1.026	1.00
171_E	181_R	1.018	1.00
232_M	235_V	1.017	1.00
179_A	184_S	1.012	1.00
27_I	31_P	1.012	1.00
73_F	144_A	1.008	1.00
158_T	200_G	1.004	1.00
63_T	229_T	1.004	1.00
69_V	73_F	1.000	1.00
212_F	234_F	0.994	1.00
227_E	236_R	0.991	1.00
64_L	68_F	0.991	1.00
194_S	198_V	0.989	1.00
51_I	57_V	0.989	1.00
70_A	74_N	0.978	1.00
192_E	195_P	0.974	1.00
93_R	164_E	0.970	1.00
38_Q	246_S	0.970	1.00
230_S	236_R	0.970	1.00
119_F	142_G	0.968	1.00
49_E	53_N	0.967	1.00
70_A	147_M	0.966	1.00
144_A	148_A	0.964	1.00
81_M	152_I	0.957	1.00
137_T	141_L	0.948	1.00
227_E	231_L	0.945	1.00
211_E	215_V	0.945	1.00
34_A	37_M	0.943	1.00
147_M	208_S	0.943	1.00
236_R	239_E	0.940	1.00
159_V	196_A	0.931	1.00
75_G	197_L	0.930	1.00
137_T	140_W	0.928	1.00
139_T	226_T	0.921	1.00
225_K	230_S	0.919	1.00
115_L	146_A	0.917	1.00
15_L	18_G	0.915	1.00
184_S	187_K	0.915	1.00
68_F	72_I	0.912	1.00
78_G	156_V	0.905	1.00
83_W	181_R	0.901	1.00
82_A	163_L	0.899	1.00
232_M	248_I	0.898	1.00
262_S	265_T	0.897	1.00
85_L	97_D	0.895	1.00
225_K	236_R	0.895	1.00
215_V	228_V	0.895	1.00
82_A	86_T	0.894	1.00
69_V	148_A	0.892	1.00
140_W	226_T	0.887	1.00
185_F	190_L	0.885	1.00
60_Y	64_L	0.882	1.00
141_L	145_V	0.878	1.00
181_R	185_F	0.874	1.00
37_M	41_Q	0.871	1.00
14_T	18_G	0.869	1.00
162_V	193_L	0.868	1.00
179_A	187_K	0.867	1.00
65_L	68_F	0.865	1.00
101_D	157_R	0.864	1.00
108_T	150_T	0.864	1.00
159_V	193_L	0.859	1.00
60_Y	229_T	0.859	1.00
44_W	47_Y	0.858	1.00
115_L	218_I	0.858	1.00
155_V	159_V	0.857	1.00
25_C	29_L	0.855	1.00
186_C	190_L	0.853	1.00
193_L	196_A	0.853	1.00
106_L	111_A	0.852	1.00
211_E	214_A	0.848	1.00
70_A	144_A	0.847	1.00
194_S	197_L	0.847	1.00
227_E	230_S	0.841	1.00
73_F	76_V	0.839	1.00
56_V	248_I	0.836	1.00
140_W	144_A	0.832	1.00
117_S	121_V	0.832	1.00
17_L	21_L	0.816	1.00
146_A	214_A	0.810	1.00
30_L	33_S	0.809	1.00
66_S	140_W	0.805	1.00
35_L	246_S	0.801	1.00
230_S	234_F	0.796	1.00
185_F	189_V	0.795	1.00
112_G	213_G	0.790	1.00
49_E	241_D	0.789	1.00
72_I	201_V	0.787	1.00
61_K	64_L	0.781	1.00
74_N	78_G	0.780	1.00
258_L	262_S	0.777	1.00
82_A	156_V	0.777	1.00
116_A	120_S	0.776	1.00
204_S	208_S	0.774	1.00
168_P	175_E	0.771	1.00
46_Q	243_P	0.771	1.00
46_Q	49_E	0.771	1.00
143_I	147_M	0.769	1.00
78_G	159_V	0.763	1.00
91_P	95_L	0.759	1.00
94_T	97_D	0.759	1.00
159_V	163_L	0.758	1.00
184_S	189_V	0.753	1.00
71_S	205_F	0.750	1.00
138_Y	221_N	0.749	1.00
84_I	90_F	0.747	1.00
112_G	217_F	0.747	1.00
226_T	230_S	0.746	1.00
74_N	151_S	0.745	1.00
235_V	238_Q	0.743	1.00
50_V	251_V	0.741	1.00
257_L	261_F	0.739	1.00
85_L	160_Q	0.732	1.00
151_S	204_S	0.731	1.00
189_V	192_E	0.731	1.00
67_A	71_S	0.731	1.00
66_S	228_V	0.730	1.00
230_S	233_I	0.725	1.00
196_A	200_G	0.725	1.00
226_T	236_R	0.725	1.00
74_N	155_V	0.720	1.00
62_V	140_W	0.718	1.00
227_E	234_F	0.716	1.00
77_F	152_I	0.716	1.00
170_Y	188_V	0.715	1.00
19_T	22_L	0.715	1.00
16_S	20_S	0.711	1.00
104_F	153_P	0.710	1.00
59_A	62_V	0.708	1.00
85_L	96_L	0.707	1.00
89_R	94_T	0.704	1.00
65_L	141_L	0.702	1.00
66_S	147_M	0.701	1.00
263_I	266_L	0.692	1.00
35_L	249_A	0.691	1.00
71_S	208_S	0.691	1.00
120_S	137_T	0.690	1.00
77_F	148_A	0.688	1.00
75_G	159_V	0.684	1.00
231_L	235_V	0.680	1.00
216_I	231_L	0.677	1.00
111_A	149_F	0.677	1.00
236_R	248_I	0.677	1.00
142_G	146_A	0.674	1.00
256_S	260_L	0.673	1.00
16_S	19_T	0.673	1.00
221_N	226_T	0.668	1.00
166_L	193_L	0.664	1.00
244_A	248_I	0.663	1.00
101_D	104_F	0.663	1.00
57_V	60_Y	0.656	1.00
48_W	51_I	0.655	1.00
70_A	148_A	0.655	1.00
66_S	143_I	0.655	1.00
63_T	209_L	0.652	1.00
141_L	144_A	0.638	1.00
173_A	177_L	0.637	1.00
138_Y	142_G	0.634	1.00
115_L	118_L	0.633	1.00
136_V	140_W	0.631	1.00
211_E	228_V	0.631	1.00
25_C	28_L	0.630	1.00
63_T	230_S	0.630	1.00
197_L	201_V	0.625	1.00
43_S	47_Y	0.622	1.00
236_R	244_A	0.622	1.00
238_Q	241_D	0.614	1.00
184_S	188_V	0.613	1.00
51_I	54_P	0.613	1.00
66_S	144_A	0.610	1.00
42_M	45_A	0.607	1.00
71_S	75_G	0.605	1.00
50_V	244_A	0.604	1.00
139_T	142_G	0.603	1.00
97_D	157_R	0.602	1.00
47_Y	247_A	0.600	1.00
180_T	186_C	0.599	1.00
31_P	35_L	0.599	1.00
74_N	148_A	0.598	1.00
142_G	218_I	0.598	1.00
158_T	196_A	0.592	1.00
147_M	215_V	0.591	1.00
242_Y	246_S	0.589	1.00
242_Y	245_A	0.588	1.00
173_A	176_T	0.588	1.00
108_T	213_G	0.587	1.00
108_T	112_G	0.586	1.00
197_L	200_G	0.586	1.00
67_A	209_L	0.586	1.00
24_V	28_L	0.584	1.00
194_S	266_L	0.581	1.00
84_I	88_Y	0.579	1.00
246_S	250_S	0.576	1.00
213_G	217_F	0.576	1.00
207_R	210_G	0.574	1.00
202_A	263_I	0.572	1.00
21_L	25_C	0.567	1.00
143_I	219_A	0.567	1.00
94_T	98_A	0.566	1.00
76_V	79_L	0.564	1.00
74_N	152_I	0.564	1.00
82_A	160_Q	0.562	1.00
20_S	24_V	0.557	1.00
90_F	96_L	0.557	1.00
88_Y	181_R	0.557	1.00
117_S	120_S	0.556	1.00
189_V	193_L	0.554	1.00
135_K	139_T	0.554	1.00
65_L	144_A	0.553	1.00
14_T	17_L	0.551	1.00
100_M	153_P	0.548	1.00
246_S	249_A	0.548	1.00
111_A	150_T	0.547	1.00
81_M	84_I	0.545	1.00
204_S	207_R	0.545	1.00
151_S	207_R	0.545	1.00
172_E	175_E	0.544	1.00
206_T	210_G	0.543	1.00
85_L	90_F	0.540	1.00
231_L	234_F	0.540	1.00
93_R	97_D	0.538	1.00
198_V	201_V	0.536	1.00
100_M	156_V	0.535	1.00
116_A	137_T	0.535	1.00
74_N	208_S	0.532	1.00
53_N	57_V	0.529	1.00
96_L	100_M	0.528	1.00
83_W	189_V	0.526	1.00
200_G	204_S	0.526	1.00
50_V	248_I	0.525	1.00
58_A	65_L	0.525	1.00
39_L	247_A	0.524	1.00
89_R	168_P	0.521	1.00
92_G	96_L	0.521	1.00
54_P	57_V	0.520	1.00
97_D	164_E	0.519	1.00
55_Q	227_E	0.519	1.00
31_P	39_L	0.517	1.00
225_K	228_V	0.515	1.00
111_A	115_L	0.514	1.00
106_L	110_V	0.512	1.00
186_C	189_V	0.511	1.00
215_V	231_L	0.508	1.00
66_S	70_A	0.508	1.00
219_A	227_E	0.506	1.00
71_S	76_V	0.505	1.00
77_F	80_L	0.504	1.00
104_F	154_F	0.503	1.00
234_F	237_L	0.503	1.00
26_L	30_L	0.502	1.00
109_A	217_F	0.501	1.00
29_L	33_S	0.501	1.00
201_V	204_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.9061	100	0.258	Contact Map
3d31C	2	0.8953	100	0.259	Contact Map
4tquM	1	0.9747	100	0.314	Contact Map
3rlfG	1	0.935	100	0.344	Contact Map
3rlfF	1	0.9422	100	0.362	Contact Map
4tquN	1	0.9025	100	0.372	Contact Map
4ymuD	2	0.7762	100	0.462	Contact Map
3tuiA	2	0.7509	99.9	0.495	Contact Map
2m8rA	1	0.1336	7.1	0.95	Contact Map
2l2tA	2	0.1516	6	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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