GREMLIN Database
PHNP - Phosphoribosyl 1,2-cyclic phosphodiesterase
UniProt: P16692 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10725
Length: 252 (222)
Sequences: 8732 (6620)
Seq/√Len: 444.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_A181_P4.5721.00
151_L158_R3.4901.00
173_L212_V3.4091.00
182_Q216_P3.2891.00
217_R241_E3.0341.00
97_P121_H2.6871.00
45_K50_I2.6231.00
97_P119_F2.3811.00
210_N218_V2.3151.00
192_P204_N2.3121.00
183_V219_I2.2901.00
53_I152_L2.2281.00
130_D135_Q2.2071.00
49_A70_Q2.1921.00
43_V50_I2.1861.00
141_L149_G2.1071.00
57_L61_A2.0221.00
185_V221_T1.9851.00
139_L175_F1.9431.00
160_A176_L1.8991.00
141_L147_T1.8741.00
71_Q97_P1.8671.00
208_A212_V1.8441.00
73_L136_V1.8341.00
124_E127_V1.8141.00
186_M201_C1.7991.00
178_N214_R1.7491.00
58_H61_A1.7361.00
174_K177_R1.7281.00
205_T208_A1.6911.00
159_V185_V1.6851.00
128_V137_T1.6841.00
135_Q153_E1.6781.00
73_L150_Y1.6541.00
217_R239_G1.6381.00
102_P122_T1.6061.00
158_R181_P1.5971.00
59_D62_D1.5901.00
55_A74_L1.5821.00
58_H62_D1.5711.00
51_T71_Q1.5651.00
137_T153_E1.5151.00
105_Q109_D1.5141.00
219_I241_E1.4981.00
158_R182_Q1.4891.00
153_E158_R1.4431.00
162_L186_M1.4401.00
151_L160_A1.4211.00
57_L60_L1.4141.00
74_L85_L1.4101.00
40_C161_W1.4081.00
141_L162_L1.3991.00
176_L181_P1.3971.00
157_S182_Q1.3851.00
142_N166_A1.3631.00
46_F133_G1.3351.00
25_A243_G1.3351.00
128_V135_Q1.3321.00
101_P148_F1.3111.00
23_C26_C1.3101.00
38_Q59_D1.3091.00
210_N215_S1.3011.00
147_T163_S1.2971.00
115_G118_D1.2901.00
71_Q99_Y1.2831.00
241_E247_M1.2681.00
244_F247_M1.2641.00
53_I73_L1.2551.00
202_D205_T1.2501.00
162_L165_T1.2431.00
203_L207_L1.2361.00
177_R214_R1.2311.00
99_Y121_H1.2281.00
49_A132_Q1.2261.00
107_C111_F1.2151.00
151_L181_P1.1991.00
95_P119_F1.1931.00
219_I243_G1.1811.00
112_K115_G1.1651.00
173_L209_L1.1601.00
188_C220_L1.1561.00
75_T150_Y1.1531.00
137_T175_F1.1511.00
44_V152_L1.1451.00
107_C113_H1.1441.00
237_P240_F1.1391.00
114_P117_L1.1371.00
176_L213_I1.1331.00
109_D112_K1.1321.00
106_G110_L1.1301.00
51_T136_V1.1111.00
53_I150_Y1.1031.00
173_L177_R1.1021.00
208_A211_Q1.0981.00
138_P150_Y1.0861.00
221_T243_G1.0851.00
81_H222_H1.0791.00
171_K174_K1.0791.00
72_F85_L1.0701.00
204_N208_A1.0701.00
51_T134_L1.0681.00
111_F114_P1.0611.00
43_V52_L1.0561.00
219_I249_I1.0541.00
215_S218_V1.0531.00
183_V217_R1.0521.00
73_L129_F1.0521.00
243_G247_M1.0501.00
100_G104_E1.0491.00
79_M83_Q1.0391.00
136_V152_L1.0361.00
170_E212_V1.0361.00
188_C206_V1.0341.00
108_D112_K1.0321.00
166_A205_T1.0251.00
50_I70_Q1.0241.00
46_F49_A1.0241.00
109_D113_H1.0231.00
114_P118_D1.0221.00
188_C203_L1.0191.00
50_I68_S1.0061.00
149_G162_L1.0021.00
186_M206_V0.9971.00
44_V53_I0.9911.00
165_T172_T0.9811.00
207_L210_N0.9781.00
37_R245_D0.9701.00
108_D111_F0.9661.00
42_G221_T0.9651.00
106_G113_H0.9621.00
106_G114_P0.9611.00
42_G185_V0.9601.00
24_A248_E0.9591.00
105_Q108_D0.9581.00
108_D115_G0.9561.00
172_T175_F0.9541.00
111_F115_G0.9471.00
170_E173_L0.9421.00
154_T157_S0.9351.00
70_Q94_D0.9351.00
177_R212_V0.9301.00
65_S68_S0.9291.00
151_L175_F0.9201.00
110_L114_P0.9181.00
186_M209_L0.9141.00
123_V129_F0.9011.00
219_I247_M0.9011.00
191_P203_L0.8991.00
211_Q237_P0.8971.00
191_P194_A0.8971.00
46_F134_L0.8961.00
139_L172_T0.8931.00
113_H116_L0.8871.00
190_H195_D0.8851.00
181_P215_S0.8821.00
184_M210_N0.8781.00
49_A134_L0.8781.00
166_A201_C0.8771.00
103_D122_T0.8651.00
25_A42_G0.8601.00
77_Y104_E0.8561.00
123_V150_Y0.8561.00
153_E156_H0.8561.00
189_S224_S0.8531.00
106_G109_D0.8501.00
130_D133_G0.8411.00
105_Q112_K0.8411.00
102_P124_E0.8381.00
51_T73_L0.8371.00
49_A133_G0.8331.00
210_N220_L0.8321.00
112_K117_L0.8321.00
110_L113_H0.8301.00
204_N235_A0.8261.00
112_K118_D0.8261.00
107_C110_L0.8251.00
72_F96_I0.8251.00
173_L213_I0.8171.00
24_A45_K0.8171.00
162_L172_T0.8071.00
235_A238_S0.8061.00
159_V183_V0.8061.00
127_V138_P0.8031.00
77_Y103_D0.8011.00
125_P140_P0.8001.00
49_A131_L0.7961.00
24_A27_A0.7961.00
52_L55_A0.7931.00
137_T151_L0.7811.00
86_F90_W0.7801.00
53_I161_W0.7791.00
178_N181_P0.7781.00
109_D114_P0.7731.00
144_S199_N0.7721.00
113_H117_L0.7711.00
191_P235_A0.7661.00
190_H198_R0.7551.00
139_L149_G0.7511.00
207_L240_F0.7421.00
74_L104_E0.7411.00
107_C115_G0.7391.00
167_G205_T0.7391.00
223_I242_V0.7381.00
162_L184_M0.7371.00
44_V159_V0.7341.00
26_C41_S0.7341.00
25_A219_I0.7301.00
206_V210_N0.7301.00
169_P172_T0.7261.00
139_L151_L0.7261.00
49_A71_Q0.7231.00
123_V148_F0.7191.00
106_G111_F0.7171.00
77_Y82_V0.7171.00
166_A199_N0.7141.00
108_D118_D0.7141.00
108_D113_H0.7131.00
112_K116_L0.7131.00
78_H143_H0.7111.00
123_V138_P0.7101.00
223_I227_F0.7101.00
73_L99_Y0.7041.00
52_L69_F0.7031.00
106_G116_L0.7011.00
85_L98_V0.6991.00
55_A72_F0.6991.00
101_P104_E0.6921.00
42_G161_W0.6901.00
23_C27_A0.6891.00
111_F116_L0.6881.00
23_C185_V0.6861.00
128_V138_P0.6861.00
46_F154_T0.6831.00
57_L62_D0.6821.00
138_P148_F0.6801.00
202_D206_V0.6791.00
141_L165_T0.6781.00
41_S57_L0.6771.00
169_P173_L0.6751.00
43_V64_W0.6741.00
27_A31_R0.6661.00
207_L211_Q0.6641.00
89_R96_I0.6631.00
109_D115_G0.6611.00
23_C44_V0.6581.00
51_T152_L0.6561.00
72_F88_L0.6541.00
176_L184_M0.6521.00
230_W233_E0.6501.00
107_C112_K0.6491.00
107_C117_L0.6430.99
168_L171_K0.6400.99
141_L163_S0.6370.99
66_P88_L0.6340.99
162_L187_D0.6330.99
203_L227_F0.6270.99
42_G53_I0.6260.99
106_G112_K0.6250.99
168_L172_T0.6240.99
241_E244_F0.6220.99
103_D146_L0.6190.99
75_T161_W0.6160.99
220_L240_F0.6150.99
228_D231_L0.6140.99
111_F118_D0.6140.99
143_H164_D0.6130.99
108_D116_L0.6130.99
136_V150_Y0.6110.99
128_V131_L0.6100.99
36_R59_D0.6100.99
184_M215_S0.6090.99
51_T131_L0.6080.99
110_L116_L0.6050.99
58_H87_P0.6040.99
27_A30_R0.6040.99
168_L173_L0.6010.99
181_P184_M0.5970.99
71_Q131_L0.5940.99
111_F117_L0.5860.99
187_D201_C0.5840.99
142_N199_N0.5820.99
129_F138_P0.5820.99
165_T201_C0.5790.99
41_S52_L0.5770.99
160_A184_M0.5750.99
142_N167_G0.5750.99
41_S56_G0.5740.99
77_Y100_G0.5740.99
23_C225_H0.5720.99
187_D200_H0.5720.99
194_A227_F0.5710.99
134_L152_L0.5630.99
85_L89_R0.5620.99
161_W185_V0.5620.99
166_A196_A0.5610.99
178_N216_P0.5560.98
160_A175_F0.5540.98
53_I75_T0.5500.98
109_D118_D0.5500.98
206_V215_S0.5490.98
108_D114_P0.5490.98
86_F89_R0.5490.98
76_H81_H0.5480.98
165_T186_M0.5480.98
201_C209_L0.5470.98
76_H80_D0.5460.98
149_G160_A0.5440.98
165_T187_D0.5430.98
170_E174_K0.5390.98
106_G117_L0.5320.98
126_F171_K0.5310.98
167_G170_E0.5310.98
231_L234_N0.5300.98
209_L212_V0.5270.98
167_G208_A0.5260.98
151_L178_N0.5250.98
35_Y228_D0.5230.98
210_N214_R0.5210.98
92_V96_I0.5210.98
101_P140_P0.5200.98
140_P148_F0.5150.97
60_L246_G0.5140.97
126_F140_P0.5100.97
25_A30_R0.5100.97
113_H118_D0.5090.97
108_D117_L0.5070.97
210_N213_I0.5070.97
186_M218_V0.5060.97
140_P146_L0.5040.97
188_C202_D0.5010.97
209_L213_I0.5010.97
52_L72_F0.5010.97
233_E242_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g1pA 2 0.9841 100 0.275 Contact Map
3jxpA 2 0.9762 100 0.345 Contact Map
3zwfA 2 0.869 100 0.37 Contact Map
2cbnA 2 0.9087 100 0.384 Contact Map
1y44A 2 0.9087 100 0.387 Contact Map
3md7A 2 0.9563 100 0.389 Contact Map
1zkpA 2 0.9087 100 0.433 Contact Map
4ojvA 2 0.9087 100 0.462 Contact Map
2e7yA 2 0.8532 100 0.477 Contact Map
4qn9A 2 0.9365 100 0.546 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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