GREMLIN Database
PHNO - Protein PhnO
UniProt: P16691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10724
Length: 144 (135)
Sequences: 10802 (8528)
Seq/√Len: 733.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_R53_L3.5591.00
102_E133_Y2.9991.00
23_E85_M2.9821.00
59_V88_A2.4551.00
62_I101_A2.4351.00
100_W103_E2.3471.00
51_L58_V2.2861.00
95_S131_E2.1381.00
95_S130_R2.0971.00
50_H100_W2.0901.00
104_E108_A2.0661.00
77_G105_A2.0281.00
16_A19_A2.0051.00
52_A93_V1.9321.00
54_L88_A1.8141.00
102_E113_T1.7991.00
122_H126_R1.7931.00
104_E107_Q1.7271.00
88_A91_L1.7231.00
7_R13_D1.6571.00
53_L58_V1.5971.00
54_L91_L1.5511.00
64_L101_A1.5501.00
100_W104_E1.5461.00
9_A17_V1.5411.00
57_E85_M1.5371.00
48_R104_E1.5011.00
16_A58_V1.4831.00
126_R129_L1.4771.00
19_A85_M1.4761.00
98_L131_E1.4741.00
129_L135_Q1.4681.00
125_H129_L1.4221.00
57_E87_Q1.4151.00
135_Q138_F1.3971.00
95_S99_A1.3941.00
50_H104_E1.3911.00
53_L56_G1.3881.00
54_L59_V1.3661.00
60_G84_V1.3521.00
19_A23_E1.3451.00
99_A131_E1.3361.00
103_E107_Q1.3271.00
48_R108_A1.3131.00
5_E53_L1.2601.00
25_K28_E1.2571.00
59_V93_V1.2501.00
117_T121_R1.2441.00
66_L110_A1.2351.00
105_A110_A1.2291.00
92_N95_S1.2291.00
115_L128_Y1.2261.00
102_E106_R1.2101.00
66_L108_A1.1861.00
11_Q42_L1.1451.00
4_C54_L1.1331.00
117_T125_H1.1301.00
62_I97_L1.1111.00
119_V138_F1.1101.00
77_G110_A1.0941.00
48_R64_L1.0791.00
16_A57_E1.0681.00
30_D33_A1.0571.00
85_M88_A1.0531.00
52_A60_G1.0531.00
62_I79_I1.0501.00
115_L133_Y1.0461.00
64_L104_E1.0401.00
124_A128_Y1.0241.00
67_Q78_E1.0221.00
9_A51_L1.0201.00
96_K99_A1.0141.00
79_I98_L1.0121.00
76_I112_M1.0061.00
122_H125_H0.9931.00
125_H135_Q0.9731.00
8_P48_R0.9721.00
89_R123_D0.9621.00
57_E88_A0.9571.00
18_Y22_C0.9521.00
9_A49_Y0.9461.00
117_T124_A0.9351.00
20_L58_V0.9301.00
84_V93_V0.9281.00
14_T18_Y0.9271.00
35_R39_N0.9231.00
39_N42_L0.9221.00
105_A113_T0.9161.00
94_G127_F0.9041.00
34_F37_G0.8991.00
76_I114_E0.8901.00
23_E86_P0.8841.00
15_D19_A0.8831.00
54_L57_E0.8671.00
39_N43_R0.8601.00
37_G41_N0.8451.00
99_A102_E0.8421.00
98_L133_Y0.8371.00
4_C96_K0.8351.00
38_F41_N0.8331.00
15_D35_R0.8251.00
90_G123_D0.8251.00
65_H80_Q0.8211.00
8_P50_H0.8161.00
17_V61_M0.8111.00
64_L105_A0.8091.00
21_I61_M0.8021.00
115_L124_A0.8001.00
90_G130_R0.7991.00
6_L50_H0.7961.00
123_D126_R0.7951.00
24_L28_E0.7901.00
16_A85_M0.7871.00
61_M83_V0.7791.00
7_R51_L0.7781.00
78_E116_S0.7751.00
34_F38_F0.7751.00
33_A37_G0.7701.00
4_C52_A0.7671.00
98_L128_Y0.7561.00
29_F33_A0.7501.00
100_W107_Q0.7441.00
6_L96_K0.7391.00
11_Q39_N0.7361.00
67_Q76_I0.7321.00
121_R124_A0.7301.00
4_C93_V0.7171.00
24_L27_A0.7151.00
79_I82_L0.7081.00
16_A20_L0.7071.00
23_E83_V0.7071.00
23_E87_Q0.7051.00
66_L77_G0.7041.00
8_P104_E0.7011.00
127_F131_E0.7001.00
82_L128_Y0.6981.00
96_K100_W0.6961.00
78_E114_E0.6941.00
102_E131_E0.6941.00
103_E106_R0.6921.00
98_L127_F0.6871.00
37_G40_A0.6791.00
13_D53_L0.6761.00
20_L24_L0.6681.00
66_L75_W0.6631.00
49_Y63_G0.6611.00
6_L100_W0.6601.00
40_A43_R0.6551.00
38_F42_L0.6501.00
9_A14_T0.6401.00
60_G93_V0.6371.00
69_H80_Q0.6331.00
20_L83_V0.6301.00
36_V39_N0.6261.00
10_T13_D0.6171.00
127_F130_R0.6161.00
31_H35_R0.6141.00
63_G80_Q0.6131.00
79_I115_L0.6121.00
19_A22_C0.6101.00
93_V96_K0.6091.00
29_F37_G0.6071.00
99_A103_E0.6041.00
88_A93_V0.6041.00
33_A41_N0.6021.00
113_T133_Y0.5961.00
71_H74_N0.5891.00
48_R66_L0.5881.00
24_L83_V0.5871.00
78_E81_E0.5871.00
36_V40_A0.5871.00
90_G94_G0.5801.00
112_M136_S0.5791.00
34_F41_N0.5781.00
46_N75_W0.5741.00
129_L134_E0.5671.00
16_A51_L0.5611.00
52_A97_L0.5591.00
60_G97_L0.5581.00
9_A13_D0.5561.00
122_H129_L0.5561.00
52_A59_V0.5521.00
22_C31_H0.5511.00
22_C26_Q0.5491.00
32_H36_V0.5471.00
15_D38_F0.5441.00
120_K123_D0.5441.00
29_F34_F0.5361.00
19_A57_E0.5311.00
74_N111_E0.5271.00
32_H37_G0.5241.00
121_R125_H0.5191.00
75_W111_E0.5141.00
24_L80_Q0.5131.00
40_A44_D0.5131.00
75_W110_A0.5131.00
47_M81_E0.5111.00
31_H34_F0.5091.00
18_Y34_F0.5000.99
11_Q14_T0.5000.99
84_V97_L0.5000.99
21_I81_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fynA 2 0.9375 99.9 0.289 Contact Map
2b5gA 2 0.9861 99.9 0.292 Contact Map
3t9yA 2 0.9097 99.9 0.293 Contact Map
3jvnA 2 0.7847 99.9 0.295 Contact Map
1vkcA 2 0.9722 99.9 0.299 Contact Map
1z4eA 2 0.9861 99.9 0.3 Contact Map
4yfjA 2 1 99.9 0.304 Contact Map
1s3zA 2 0.9861 99.9 0.305 Contact Map
2fe7A 3 1 99.9 0.307 Contact Map
3i9sA 4 0.9931 99.8 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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