GREMLIN Database
PHNN - Ribose 1,5-bisphosphate phosphokinase PhnN
UniProt: P16690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10723
Length: 185 (174)
Sequences: 5016 (3306)
Seq/√Len: 250.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_I127_Q3.4281.00
126_R130_E3.3401.00
26_R172_L2.6021.00
59_T63_Q2.5891.00
54_E58_F2.5471.00
60_R65_L2.4051.00
130_E137_A2.3931.00
37_Y80_G2.3801.00
37_Y52_L2.3171.00
58_F76_Y2.3051.00
82_E85_L2.3011.00
44_A47_E2.2471.00
56_E59_T2.2181.00
54_E76_Y2.0511.00
32_L91_F2.0241.00
71_H74_G1.9981.00
61_A69_S1.9961.00
166_Q170_T1.9531.00
53_S56_E1.9411.00
137_A141_N1.8871.00
19_L171_L1.8681.00
159_N167_S1.8671.00
81_V84_D1.8671.00
65_L82_E1.8651.00
54_E71_H1.8181.00
19_L117_C1.7911.00
73_N146_R1.7611.00
22_E168_V1.7521.00
22_E25_L1.7191.00
9_M155_C1.7171.00
163_S166_Q1.7051.00
126_R141_N1.7001.00
84_D88_H1.6841.00
54_E75_L1.6781.00
70_W100_A1.6481.00
18_S164_L1.6351.00
44_A48_N1.6141.00
72_A98_S1.5771.00
85_L89_A1.5621.00
45_G50_I1.5601.00
103_P154_D1.5581.00
71_H76_Y1.5501.00
136_N139_E1.5411.00
22_E26_R1.5131.00
58_F62_G1.4961.00
52_L60_R1.4921.00
32_L86_W1.4621.00
10_G14_S1.4331.00
106_R156_H1.4321.00
17_D96_N1.4171.00
58_F61_A1.4071.00
157_T174_L1.4001.00
121_S124_I1.3681.00
19_L168_V1.3271.00
37_Y60_R1.3221.00
8_L20_L1.3051.00
22_E165_R1.2551.00
159_N171_L1.2541.00
86_W91_F1.2521.00
56_E60_R1.2451.00
141_N145_A1.2231.00
33_V96_N1.2051.00
118_L158_L1.2041.00
169_D172_L1.1991.00
61_A76_Y1.1871.00
162_G166_Q1.1771.00
170_T176_H1.1671.00
142_A146_R1.1551.00
21_A48_N1.1441.00
127_Q131_N1.1391.00
21_A25_L1.1361.00
164_L168_V1.1351.00
52_L56_E1.1321.00
172_L176_H1.1281.00
146_R149_R1.1271.00
20_L94_L1.1141.00
86_W93_V1.1131.00
145_A148_A1.1121.00
81_V108_R1.1101.00
97_G105_A1.1061.00
118_L151_T1.1041.00
86_W89_A1.1011.00
173_T176_H1.0951.00
59_T62_G1.0911.00
26_R168_V1.0871.00
173_T177_Q1.0731.00
6_I113_L1.0721.00
4_K113_L1.0491.00
95_V105_A1.0471.00
104_Q107_A1.0381.00
106_R114_L1.0231.00
67_A83_I1.0101.00
7_W114_L1.0071.00
135_E140_I1.0001.00
55_Q58_F0.9891.00
10_G17_D0.9861.00
60_R66_L0.9821.00
128_R132_R0.9821.00
20_L96_N0.9781.00
64_N108_R0.9741.00
69_S76_Y0.9691.00
60_R80_G0.9651.00
169_D173_T0.9601.00
45_G56_E0.9551.00
8_L171_L0.9341.00
157_T170_T0.9211.00
122_P148_A0.9211.00
74_G142_A0.9171.00
159_N174_L0.9151.00
6_I175_I0.9091.00
26_R169_D0.9031.00
103_P153_Q0.8991.00
99_R153_Q0.8961.00
17_D20_L0.8961.00
149_R152_P0.8951.00
84_D109_Y0.8921.00
37_Y66_L0.8901.00
64_N81_V0.8761.00
103_P107_A0.8691.00
52_L57_F0.8630.99
23_L31_L0.8540.99
102_L114_L0.8540.99
24_R33_V0.8460.99
162_G167_S0.8370.99
139_E142_A0.8330.99
43_S46_S0.8290.99
19_L164_L0.8250.99
115_P171_L0.8230.99
43_S48_N0.8190.99
17_D48_N0.8180.99
28_Q172_L0.8170.99
113_L157_T0.8140.99
126_R144_L0.8020.99
20_L33_V0.7950.99
73_N98_S0.7870.99
130_E140_I0.7810.99
23_L168_V0.7800.99
5_L87_L0.7670.99
45_G51_A0.7640.99
14_S117_C0.7640.99
52_L80_G0.7580.99
28_Q31_L0.7570.99
85_L88_H0.7400.98
131_N134_R0.7390.98
113_L174_L0.7370.98
164_L167_S0.7320.98
14_S17_D0.7310.98
73_N142_A0.7290.98
148_A152_P0.7250.98
58_F71_H0.7240.98
170_T173_T0.7220.98
6_I92_D0.7210.98
169_D176_H0.7200.98
168_V172_L0.7190.98
9_M102_L0.7180.98
70_W104_Q0.7100.98
60_R63_Q0.7090.98
132_R143_R0.6980.98
97_G104_Q0.6980.98
72_A146_R0.6970.98
42_A45_G0.6960.98
45_G52_L0.6950.98
123_E126_R0.6950.98
12_S140_I0.6940.98
23_L171_L0.6840.97
99_R146_R0.6820.97
72_A100_A0.6790.97
57_F69_S0.6780.97
132_R135_E0.6780.97
20_L24_R0.6770.97
24_R94_L0.6750.97
109_Y112_A0.6730.97
33_V36_R0.6650.97
67_A109_Y0.6650.97
103_P114_L0.6610.97
122_P126_R0.6570.97
22_E164_L0.6510.96
11_P14_S0.6500.96
57_F76_Y0.6490.96
166_Q169_D0.6480.96
104_Q108_R0.6420.96
32_L93_V0.6420.96
161_D167_S0.6410.96
14_S119_Q0.6400.96
31_L94_L0.6340.96
165_R169_D0.6300.96
17_D33_V0.6250.96
65_L81_V0.6230.95
87_L92_D0.6190.95
138_S141_N0.6180.95
148_A151_T0.6180.95
19_L167_S0.6160.95
28_Q176_H0.6150.95
18_S22_E0.6110.95
135_E139_E0.6090.95
9_M114_L0.6070.95
99_R103_P0.6060.95
35_H46_S0.6030.95
31_L92_D0.6030.95
36_R96_N0.6020.95
40_R51_A0.6010.94
167_S170_T0.6000.94
98_S146_R0.5990.94
4_K92_D0.5950.94
37_Y50_I0.5920.94
68_L101_H0.5920.94
5_L109_Y0.5820.93
35_H50_I0.5800.93
63_Q66_L0.5780.93
56_E63_Q0.5760.93
12_S143_R0.5700.93
144_L152_P0.5670.93
100_A104_Q0.5660.93
149_R153_Q0.5630.92
61_A78_G0.5620.92
55_Q59_T0.5620.92
7_W112_A0.5590.92
73_N99_R0.5560.92
87_L93_V0.5550.92
140_I144_L0.5540.92
157_T177_Q0.5510.91
23_L172_L0.5500.91
126_R148_A0.5500.91
41_D53_S0.5470.91
168_V171_L0.5470.91
145_A149_R0.5460.91
67_A105_A0.5450.91
3_G92_D0.5440.91
11_P151_T0.5440.91
36_R79_V0.5430.91
98_S101_H0.5430.91
117_C167_S0.5410.91
45_G48_N0.5410.91
99_R150_Y0.5370.90
53_S59_T0.5370.90
129_L132_R0.5350.90
8_L115_P0.5340.90
123_E127_Q0.5330.90
36_R101_H0.5320.90
66_L80_G0.5310.90
22_E163_S0.5310.90
43_S49_H0.5310.90
41_D75_L0.5270.90
118_L177_Q0.5250.89
120_V161_D0.5250.89
12_S125_L0.5210.89
34_A96_N0.5200.89
8_L117_C0.5200.89
14_S73_N0.5190.89
15_G18_S0.5180.89
9_M98_S0.5170.89
116_V150_Y0.5130.88
39_T54_E0.5120.88
100_A103_P0.5120.88
130_E141_N0.5120.88
115_P174_L0.5100.88
147_A150_Y0.5100.88
34_A95_V0.5030.87
143_R150_Y0.5030.87
17_D129_L0.5010.87
32_L89_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xkxA 2 0.9676 100 0.212 Contact Map
1kjwA 1 0.9676 100 0.227 Contact Map
3tvtA 1 0.9676 100 0.242 Contact Map
1s96A 4 0.9946 100 0.39 Contact Map
4deyA 1 0.8324 100 0.408 Contact Map
1lvgA 1 0.9784 100 0.473 Contact Map
3tszA 1 0.8216 100 0.474 Contact Map
3kfvA 1 0.7622 100 0.477 Contact Map
1z6gA 1 0.9784 100 0.487 Contact Map
3shwA 1 0.7676 100 0.494 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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