GREMLIN Database
PHNM - Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
UniProt: P16689 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10722
Length: 378 (336)
Sequences: 34945 (27998)
Seq/√Len: 1527.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
371_W376_R4.7331.00
346_V351_K4.5361.00
3_I42_G4.1621.00
45_G368_D3.9761.00
22_Q27_R3.7131.00
369_H376_R3.6581.00
48_L358_A3.4021.00
42_G357_L3.3291.00
323_T326_Q3.2941.00
6_V42_G3.1621.00
348_G351_K3.0461.00
287_S291_Q2.7471.00
28_A349_E2.7201.00
352_R373_Q2.6621.00
4_N39_A2.6391.00
50_G90_T2.5471.00
24_G352_R2.5061.00
48_L356_V2.4171.00
30_A33_Q2.2581.00
18_S33_Q2.1961.00
329_K333_K2.1791.00
25_E352_R2.1691.00
295_L337_Q2.1651.00
326_Q329_K2.1361.00
19_L47_L2.1291.00
347_I355_L2.1091.00
21_V355_L2.1081.00
359_H368_D2.0631.00
47_L357_L2.0581.00
344_R352_R2.0551.00
355_L371_W2.0431.00
45_G359_H1.9851.00
20_E37_P1.9581.00
47_L355_L1.9371.00
45_G357_L1.9261.00
8_L17_G1.8961.00
6_V47_L1.8931.00
4_N18_S1.8801.00
25_E344_R1.8341.00
24_G373_Q1.8331.00
258_E292_L1.7621.00
333_K346_V1.7611.00
356_V367_I1.7381.00
337_Q342_Q1.7191.00
5_N41_D1.6971.00
218_L221_A1.6891.00
297_I338_A1.6791.00
242_Q245_S1.6681.00
48_L51_L1.6631.00
329_K334_N1.6371.00
20_E28_A1.5671.00
26_I347_I1.5671.00
334_N337_Q1.5661.00
341_L344_R1.5481.00
343_D351_K1.5441.00
217_A221_A1.5211.00
328_V332_T1.5031.00
333_K337_Q1.5021.00
19_L355_L1.4961.00
19_L347_I1.4911.00
290_A326_Q1.4901.00
220_R243_L1.4811.00
189_T192_Q1.4801.00
112_E116_N1.4801.00
258_E262_K1.4721.00
176_E179_R1.4581.00
7_K16_S1.4561.00
209_Q213_E1.4561.00
18_S32_S1.4511.00
192_Q195_Q1.4441.00
254_F288_E1.4281.00
134_H137_C1.4101.00
307_L310_A1.4021.00
357_L371_W1.3931.00
29_F349_E1.3701.00
233_T236_H1.3661.00
285_A288_E1.3641.00
187_S192_Q1.3421.00
213_E217_A1.3381.00
5_N44_G1.3361.00
337_Q346_V1.3291.00
311_A314_V1.3231.00
17_G31_E1.3211.00
218_L222_R1.3041.00
242_Q246_V1.3021.00
289_L294_L1.3011.00
176_E180_E1.2861.00
179_R183_Q1.2811.00
54_L297_I1.2691.00
303_Y306_S1.2581.00
248_A251_P1.2571.00
174_N177_K1.2491.00
357_L369_H1.2481.00
20_E27_R1.2361.00
259_A263_H1.2361.00
42_G47_L1.2311.00
235_A239_E1.2271.00
189_T195_Q1.2251.00
6_V357_L1.2231.00
46_W360_R1.2201.00
359_H366_H1.2141.00
52_I335_P1.2091.00
309_D312_F1.1991.00
177_K180_E1.1991.00
18_S34_S1.1991.00
48_L328_V1.1991.00
187_S190_D1.1921.00
8_L19_L1.1901.00
297_I335_P1.1871.00
3_I21_V1.1831.00
54_L335_P1.1821.00
17_G30_A1.1751.00
297_I334_N1.1751.00
358_A367_I1.1721.00
18_S30_A1.1681.00
84_M92_V1.1681.00
190_D193_M1.1661.00
254_F257_A1.1571.00
305_A309_D1.1561.00
52_I91_T1.1541.00
260_S267_V1.1541.00
229_H301_D1.1451.00
180_E183_Q1.1441.00
5_N43_E1.1301.00
54_L339_L1.1271.00
266_N338_A1.1211.00
208_S211_N1.1171.00
130_E134_H1.1151.00
220_R246_V1.1141.00
11_E333_K1.1121.00
40_M371_W1.1121.00
21_V371_W1.1111.00
288_E291_Q1.1081.00
113_K116_N1.1071.00
179_R184_G1.1061.00
234_H238_A1.1051.00
257_A292_L1.1041.00
17_G29_F1.1021.00
130_E133_L1.1011.00
249_E252_T1.0951.00
307_L312_F1.0931.00
93_L339_L1.0911.00
342_Q351_K1.0901.00
129_A134_H1.0881.00
316_D327_A1.0881.00
255_E258_E1.0861.00
225_A340_N1.0801.00
178_Y181_Y1.0781.00
27_R349_E1.0771.00
30_A34_S1.0751.00
219_C226_L1.0741.00
308_L312_F1.0711.00
266_N295_L1.0661.00
214_S217_A1.0631.00
303_Y308_L1.0581.00
192_Q196_Y1.0581.00
118_I122_Q1.0551.00
9_V328_V1.0491.00
36_L39_A1.0471.00
280_H284_V1.0411.00
189_T193_M1.0391.00
26_I355_L1.0381.00
210_P213_E1.0341.00
322_F330_L1.0291.00
230_D233_T1.0261.00
120_E123_K1.0221.00
192_Q197_E1.0171.00
20_E36_L1.0161.00
303_Y310_A1.0131.00
113_K117_A1.0121.00
132_R136_R1.0111.00
259_A262_K1.0111.00
288_E292_L1.0091.00
40_M369_H1.0091.00
330_L334_N1.0071.00
3_I355_L1.0031.00
193_M196_Y1.0011.00
356_V370_V0.9981.00
116_N120_E0.9961.00
280_H283_N0.9901.00
106_D110_N0.9771.00
132_R135_L0.9721.00
52_I336_A0.9711.00
79_S82_A0.9681.00
28_A34_S0.9681.00
9_V14_V0.9671.00
115_I118_I0.9661.00
131_H134_H0.9591.00
12_N15_V0.9571.00
310_A314_V0.9541.00
109_E113_K0.9531.00
306_S309_D0.9511.00
190_D196_Y0.9491.00
119_E122_Q0.9441.00
54_L268_L0.9431.00
307_L314_V0.9431.00
20_E30_A0.9401.00
3_I47_L0.9381.00
132_R137_C0.9361.00
52_I339_L0.9301.00
186_Y192_Q0.9291.00
7_K46_W0.9271.00
187_S191_A0.9261.00
178_Y182_Y0.9251.00
268_L297_I0.9241.00
306_S310_A0.9221.00
3_I371_W0.9221.00
308_L311_A0.9221.00
180_E184_G0.9221.00
121_T124_R0.9211.00
232_A236_H0.9201.00
118_I121_T0.9181.00
193_M197_E0.9161.00
333_K351_K0.9161.00
31_E34_S0.9161.00
176_E181_Y0.9131.00
117_A120_E0.9131.00
186_Y189_T0.9111.00
306_S311_A0.9101.00
304_P310_A0.9081.00
181_Y184_G0.9061.00
118_I123_K0.9051.00
38_E376_R0.8941.00
343_D352_R0.8911.00
288_E320_N0.8911.00
191_A194_Q0.8891.00
81_D85_V0.8861.00
254_F285_A0.8821.00
331_V335_P0.8811.00
107_R110_N0.8801.00
55_H229_H0.8801.00
20_E33_Q0.8771.00
306_S312_F0.8761.00
254_F258_E0.8721.00
78_S82_A0.8711.00
187_S193_M0.8651.00
111_L115_I0.8651.00
303_Y307_L0.8651.00
312_F315_A0.8631.00
304_P307_L0.8561.00
247_I338_A0.8551.00
243_L246_V0.8551.00
137_C140_P0.8501.00
310_A313_R0.8491.00
129_A132_R0.8481.00
251_P267_V0.8471.00
144_T147_L0.8461.00
186_Y190_D0.8461.00
225_A246_V0.8461.00
185_K189_T0.8441.00
177_K181_Y0.8431.00
111_L118_I0.8411.00
175_R178_Y0.8371.00
85_V372_R0.8301.00
3_I40_M0.8301.00
307_L311_A0.8221.00
83_L86_A0.8221.00
250_F253_T0.8201.00
51_L331_V0.8201.00
367_I370_V0.8201.00
4_N41_D0.8191.00
112_E115_I0.8181.00
9_V46_W0.8141.00
176_E183_Q0.8131.00
116_N119_E0.8111.00
42_G45_G0.8071.00
190_D194_Q0.8061.00
147_L150_K0.8051.00
45_G369_H0.8051.00
194_Q197_E0.8051.00
57_D229_H0.7981.00
305_A310_A0.7951.00
133_L138_E0.7941.00
256_A259_A0.7911.00
239_E243_L0.7901.00
175_R182_Y0.7891.00
304_P308_L0.7891.00
53_E300_S0.7861.00
237_V241_H0.7831.00
129_A133_L0.7821.00
313_R317_D0.7791.00
128_R131_H0.7761.00
359_H362_D0.7741.00
194_Q198_E0.7711.00
186_Y191_A0.7711.00
235_A238_A0.7711.00
127_N130_E0.7661.00
110_N114_M0.7651.00
261_R294_L0.7651.00
56_T84_M0.7641.00
354_D373_Q0.7621.00
270_G273_N0.7611.00
107_R111_L0.7591.00
5_N42_G0.7561.00
11_E328_V0.7551.00
133_L136_R0.7551.00
59_L97_A0.7501.00
188_L192_Q0.7411.00
232_A235_A0.7381.00
18_S28_A0.7381.00
298_L330_L0.7331.00
325_P329_K0.7321.00
115_I122_Q0.7321.00
133_L137_C0.7311.00
190_D195_Q0.7301.00
76_A79_S0.7291.00
135_L138_E0.7271.00
151_L155_E0.7271.00
127_N131_H0.7271.00
230_D234_H0.7241.00
131_H135_L0.7221.00
228_S245_S0.7201.00
53_E56_T0.7201.00
130_E137_C0.7201.00
260_S263_H0.7191.00
287_S290_A0.7191.00
108_L112_E0.7191.00
7_K361_K0.7141.00
74_H78_S0.7141.00
115_I119_E0.7101.00
311_A315_A0.7081.00
312_F316_D0.7071.00
175_R179_R0.7061.00
189_T196_Y0.7061.00
270_G299_S0.7051.00
189_T194_Q0.7051.00
57_D301_D0.7041.00
130_E135_L0.7041.00
110_N113_K0.7031.00
186_Y193_M0.7021.00
120_E124_R0.7001.00
91_T354_D0.6991.00
127_N132_R0.6951.00
90_T354_D0.6941.00
85_V370_V0.6931.00
17_G347_I0.6911.00
295_L334_N0.6911.00
55_H301_D0.6901.00
19_L29_F0.6861.00
346_V349_E0.6841.00
304_P309_D0.6831.00
227_A249_E0.6831.00
258_E261_R0.6801.00
57_D250_F0.6801.00
305_A308_L0.6791.00
11_E346_V0.6771.00
111_L114_M0.6771.00
58_N80_H0.6771.00
10_L13_E0.6721.00
114_M118_I0.6701.00
114_M119_E0.6691.00
336_A345_G0.6661.00
191_A195_Q0.6661.00
58_N92_V0.6651.00
190_D197_E0.6641.00
217_A220_R0.6631.00
95_A227_A0.6631.00
238_A242_Q0.6621.00
175_R181_Y0.6621.00
128_R132_R0.6591.00
267_V294_L0.6581.00
216_A220_R0.6571.00
283_N287_S0.6491.00
333_K342_Q0.6481.00
14_V325_P0.6461.00
28_A33_Q0.6451.00
119_E123_K0.6451.00
309_D313_R0.6441.00
261_R264_G0.6431.00
6_V355_L0.6411.00
21_V27_R0.6401.00
185_K190_D0.6371.00
344_R351_K0.6341.00
26_I351_K0.6331.00
178_Y184_G0.6331.00
128_R134_H0.6331.00
150_K154_R0.6331.00
266_N297_I0.6331.00
238_A241_H0.6321.00
17_G32_S0.6301.00
143_T146_P0.6281.00
12_N348_G0.6281.00
112_E121_T0.6271.00
51_L328_V0.6271.00
119_E124_R0.6251.00
281_S284_V0.6241.00
192_Q198_E0.6231.00
277_G282_G0.6221.00
249_E253_T0.6221.00
142_H146_P0.6211.00
145_L148_F0.6201.00
134_H138_E0.6171.00
148_F151_L0.6141.00
74_H77_M0.6131.00
110_N118_I0.6121.00
149_E153_Q0.6111.00
260_S265_M0.6101.00
185_K188_L0.6091.00
303_Y312_F0.6081.00
134_H140_P0.6021.00
108_L111_L0.6021.00
308_L314_V0.6011.00
188_L193_M0.6001.00
195_Q198_E0.5941.00
307_L313_R0.5881.00
277_G281_S0.5881.00
115_I120_E0.5841.00
112_E118_I0.5801.00
146_P149_E0.5771.00
267_V289_L0.5751.00
78_S81_D0.5741.00
177_K182_Y0.5731.00
51_L367_I0.5731.00
10_L15_V0.5721.00
174_N178_Y0.5721.00
233_T237_V0.5701.00
131_H137_C0.5681.00
236_H239_E0.5681.00
196_Y200_Q0.5671.00
77_M81_D0.5661.00
241_H296_D0.5661.00
107_R118_I0.5651.00
179_R221_A0.5651.00
185_K192_Q0.5651.00
112_E119_E0.5631.00
114_M117_A0.5621.00
183_Q222_R0.5611.00
185_K191_A0.5611.00
106_D109_E0.5611.00
282_G285_A0.5601.00
11_E325_P0.5601.00
108_L118_I0.5591.00
342_Q346_V0.5581.00
131_H136_R0.5581.00
234_H241_H0.5571.00
298_L301_D0.5561.00
18_S29_F0.5531.00
19_L26_I0.5521.00
313_R316_D0.5491.00
336_A351_K0.5471.00
11_E329_K0.5471.00
216_A226_L0.5441.00
231_D234_H0.5431.00
134_H139_L0.5431.00
254_F292_L0.5411.00
298_L331_V0.5401.00
296_D330_L0.5401.00
261_R292_L0.5381.00
246_V338_A0.5371.00
25_E343_D0.5351.00
114_M122_Q0.5341.00
9_V325_P0.5341.00
130_E136_R0.5331.00
234_H237_V0.5331.00
46_W324_L0.5311.00
231_D235_A0.5311.00
306_S314_V0.5301.00
193_M198_E0.5301.00
264_G295_L0.5291.00
109_E112_E0.5291.00
143_T147_L0.5291.00
195_Q199_E0.5291.00
6_V44_G0.5291.00
143_T148_F0.5261.00
83_L87_S0.5251.00
270_G274_I0.5251.00
4_N32_S0.5241.00
141_H144_T0.5241.00
90_T370_V0.5241.00
322_F327_A0.5231.00
11_E15_V0.5231.00
13_E16_S0.5221.00
204_A207_W0.5221.00
373_Q376_R0.5221.00
114_M123_K0.5201.00
76_A80_H0.5181.00
260_S264_G0.5171.00
50_G354_D0.5161.00
315_A327_A0.5161.00
304_P312_F0.5151.00
304_P314_V0.5141.00
127_N135_L0.5141.00
139_L143_T0.5141.00
211_N214_S0.5131.00
291_Q326_Q0.5121.00
188_L191_A0.5121.00
46_W358_A0.5111.00
129_A136_R0.5111.00
7_K360_R0.5101.00
244_G247_I0.5101.00
135_L139_L0.5101.00
179_R182_Y0.5101.00
255_E259_A0.5081.00
106_D118_I0.5081.00
211_N215_I0.5031.00
174_N181_Y0.5031.00
10_L14_V0.5031.00
248_A260_S0.5031.00
183_Q187_S0.5021.00
230_D236_H0.5011.00
269_M272_P0.5011.00
136_R140_P0.5011.00
219_C224_I0.5011.00
149_E152_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ls9A 2 0.9233 100 0.34 Contact Map
2bb0A 2 0.8968 100 0.342 Contact Map
4whbE 3 0.9444 100 0.342 Contact Map
4ub9A 4 0.9656 100 0.344 Contact Map
2p9bA 1 0.8677 100 0.347 Contact Map
3be7A 5 0.918 100 0.349 Contact Map
3lnpA 2 0.881 100 0.349 Contact Map
4dzhA 2 0.8757 100 0.351 Contact Map
4v1xA 5 0.9497 100 0.352 Contact Map
3hpaA 2 0.8677 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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