GREMLIN Database
PHNJ - Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase
UniProt: P16688 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10719
Length: 281 (272)
Sequences: 306 (111)
Seq/√Len: 6.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_A184_D4.5500.98
193_N224_S4.4090.97
103_V122_I4.0740.96
55_L59_V3.8250.94
9_F91_G3.3070.88
28_V202_L3.2790.87
244_C272_C3.1620.85
196_M203_Q3.0490.83
60_I103_V2.9820.82
266_C272_C2.9630.81
106_T205_F2.8610.79
123_F203_Q2.8530.79
198_M221_R2.7950.77
59_V103_V2.7360.76
106_T123_F2.7030.75
246_S275_Q2.6710.74
244_C266_C2.5860.71
149_E224_S2.5400.70
243_I276_S2.4710.67
106_T203_Q2.4600.67
97_R274_Q2.4470.67
24_I213_I2.4130.66
183_M216_V2.3930.65
117_E219_F2.3050.62
39_G134_I2.2350.59
113_T274_Q2.1930.58
179_G221_R2.1850.57
83_R94_T2.1180.55
167_I173_Y2.1000.54
24_I28_V2.0880.54
10_A89_V2.0290.52
138_E141_T1.9480.49
129_E141_T1.9310.48
142_R212_R1.8740.46
97_R113_T1.8480.45
60_I66_L1.8230.44
59_V122_I1.7960.43
58_S182_V1.7250.40
122_I248_H1.6480.38
212_R265_V1.6090.36
24_I59_V1.5740.35
65_V228_D1.5600.34
12_L173_Y1.5570.34
155_V160_D1.5490.34
42_M249_S1.5480.34
33_Y138_E1.5300.33
122_I179_G1.5190.33
24_I55_L1.5090.33
273_R277_E1.4870.32
132_R138_E1.4740.32
57_A76_T1.4720.32
134_I152_V1.4660.31
57_A86_F1.4620.31
121_I154_Q1.4550.31
191_F195_K1.4550.31
103_V115_L1.4450.31
158_Y249_S1.4330.30
55_L122_I1.4250.30
178_N197_D1.4190.30
155_V164_F1.3910.29
117_E200_P1.3860.29
60_I90_T1.3490.28
149_E193_N1.3410.27
62_E199_M1.3380.27
56_T66_L1.3380.27
53_I190_K1.3330.27
158_Y267_S1.3290.27
158_Y167_I1.3150.27
28_V90_T1.3110.27
9_F80_V1.2890.26
176_K182_V1.2810.26
60_I238_D1.2640.25
66_L86_F1.2520.25
48_W222_V1.2510.25
216_V250_Y1.2450.25
182_V225_L1.2400.25
81_S137_R1.2390.24
37_F48_W1.2380.24
75_D277_E1.2280.24
23_A213_I1.2270.24
175_V183_M1.2250.24
160_D167_I1.2250.24
46_Y122_I1.2250.24
121_I216_V1.2220.24
33_Y216_V1.2140.24
40_R54_Q1.2060.24
197_D221_R1.2050.24
144_M152_V1.2000.23
98_T116_T1.1990.23
34_Q61_G1.1910.23
127_I133_F1.1890.23
118_D199_M1.1850.23
144_M170_T1.1850.23
162_A190_K1.1820.23
166_H233_T1.1770.23
18_R140_E1.1770.23
12_L83_R1.1680.23
37_F175_V1.1650.22
44_M53_I1.1550.22
127_I172_A1.1500.22
23_A42_M1.1480.22
197_D242_A1.1480.22
46_Y57_A1.1400.22
169_T173_Y1.1370.22
165_G222_V1.1340.22
196_M201_A1.1310.22
12_L94_T1.1310.22
115_L201_A1.1240.21
48_W183_M1.1200.21
65_V129_E1.1170.21
48_W165_G1.1130.21
93_N100_D1.1100.21
153_M173_Y1.1060.21
158_Y173_Y1.0930.21
199_M203_Q1.0920.21
76_T86_F1.0870.21
81_S87_K1.0860.20
45_P154_Q1.0820.20
85_F151_G1.0820.20
81_S166_H1.0790.20
123_F205_F1.0730.20
153_M167_I1.0730.20
237_W249_S1.0630.20
87_K276_S1.0610.20
48_W177_V1.0570.20
133_F172_A1.0530.20
15_Q155_V1.0510.20
8_N136_P1.0470.20
140_E143_T1.0310.19
148_E180_R1.0170.19
10_A275_Q1.0150.19
205_F267_S1.0030.19
197_D223_E0.9970.18
102_T129_E0.9910.18
37_F269_T0.9880.18
250_Y275_Q0.9810.18
113_T142_R0.9680.18
160_D170_T0.9640.18
177_V202_L0.9600.18
142_R163_R0.9580.18
73_A186_S0.9530.17
38_G140_E0.9500.17
44_M256_L0.9490.17
42_M169_T0.9470.17
155_V170_T0.9420.17
57_A123_F0.9390.17
89_V230_H0.9360.17
46_Y86_F0.9310.17
144_M173_Y0.9250.17
102_T179_G0.9150.17
240_P247_T0.9130.17
149_E196_M0.9110.17
190_K235_Q0.9100.17
87_K196_M0.9080.16
25_L29_A0.9060.16
18_R250_Y0.9020.16
144_M159_E0.9000.16
62_E250_Y0.9000.16
181_Y232_F0.8990.16
38_G144_M0.8960.16
106_T155_V0.8910.16
46_Y76_T0.8870.16
16_T85_F0.8840.16
181_Y214_Y0.8800.16
144_M184_D0.8790.16
159_E251_L0.8750.16
33_Y182_V0.8740.16
106_T151_G0.8690.16
142_R185_P0.8680.16
153_M158_Y0.8670.16
246_S272_C0.8670.16
108_H208_G0.8660.16
123_F155_V0.8590.15
10_A175_V0.8570.15
141_T175_V0.8560.15
156_K167_I0.8540.15
183_M249_S0.8540.15
46_Y53_I0.8520.15
38_G246_S0.8510.15
221_R269_T0.8500.15
245_G260_G0.8490.15
48_W175_V0.8480.15
85_F89_V0.8440.15
73_A252_D0.8350.15
46_Y154_Q0.8310.15
73_A166_H0.8310.15
73_A89_V0.8300.15
10_A171_Y0.8290.15
138_E142_R0.8260.15
196_M235_Q0.8250.15
75_D273_R0.8180.15
11_Y76_T0.8140.15
61_G138_E0.8120.15
55_L103_V0.8110.15
39_G190_K0.8110.15
9_F199_M0.8080.14
123_F186_S0.8070.14
38_G44_M0.8050.14
132_R141_T0.8040.14
7_Y45_P0.7990.14
246_S249_S0.7980.14
160_D251_L0.7970.14
180_R222_V0.7960.14
191_F263_M0.7960.14
40_R71_Q0.7950.14
58_S149_E0.7950.14
63_S257_D0.7950.14
135_E181_Y0.7930.14
20_I178_N0.7890.14
106_T171_Y0.7880.14
248_H251_L0.7880.14
166_H169_T0.7800.14
12_L24_I0.7790.14
62_E275_Q0.7790.14
20_I252_D0.7760.14
28_V251_L0.7740.14
48_W129_E0.7710.14
98_T183_M0.7690.14
256_L259_A0.7680.14
144_M158_Y0.7670.14
250_Y276_S0.7630.14
147_L182_V0.7620.14
161_I230_H0.7610.14
53_I57_A0.7610.14
59_V83_R0.7540.14
33_Y190_K0.7500.13
66_L80_V0.7490.13
133_F184_D0.7480.13
99_D113_T0.7470.13
236_Q254_V0.7440.13
256_L261_N0.7410.13
199_M219_F0.7400.13
95_T119_Q0.7390.13
18_R116_T0.7390.13
30_I58_S0.7380.13
166_H271_Y0.7370.13
71_Q108_H0.7370.13
71_Q208_G0.7370.13
11_Y90_T0.7320.13
73_A92_V0.7320.13
77_T235_Q0.7300.13
129_E132_R0.7260.13
8_N16_T0.7260.13
175_V222_V0.7260.13
97_R223_E0.7250.13
135_E214_Y0.7220.13
123_F196_M0.7200.13
159_E224_S0.7160.13
16_T37_F0.7160.13
48_W132_R0.7130.13
177_V183_M0.7130.13
118_D257_D0.7120.13
190_K198_M0.7100.13
172_A182_V0.7070.13
62_E92_V0.7040.13
167_I249_S0.7020.13
48_W90_T0.7010.13
53_I86_F0.7000.13
44_M200_P0.6980.13
173_Y194_P0.6930.12
16_T77_T0.6930.12
19_M162_A0.6910.12
123_F236_Q0.6900.12
28_V110_I0.6860.12
41_E128_P0.6800.12
178_N236_Q0.6740.12
154_Q228_D0.6740.12
6_G114_P0.6720.12
18_R142_R0.6700.12
40_R69_I0.6690.12
151_G256_L0.6680.12
28_V200_P0.6660.12
156_K172_A0.6620.12
88_R122_I0.6610.12
30_I120_I0.6600.12
24_I65_V0.6570.12
197_D236_Q0.6520.12
160_D205_F0.6480.12
26_K185_P0.6440.12
76_T171_Y0.6420.12
73_A81_S0.6400.12
255_V262_R0.6340.12
8_N250_Y0.6320.12
190_K237_W0.6310.11
42_M225_L0.6300.11
83_R270_D0.6300.11
60_I204_L0.6280.11
101_A119_Q0.6280.11
63_S247_T0.6260.11
155_V251_L0.6250.11
85_F252_D0.6250.11
178_N223_E0.6240.11
60_I89_V0.6230.11
83_R155_V0.6210.11
18_R151_G0.6200.11
50_T73_A0.6190.11
212_R264_F0.6130.11
177_V222_V0.6120.11
87_K90_T0.6120.11
162_A203_Q0.6120.11
172_A233_T0.6100.11
19_M154_Q0.6080.11
50_T271_Y0.6080.11
39_G204_L0.6080.11
85_F258_D0.6080.11
141_T230_H0.6070.11
166_H184_D0.6070.11
57_A151_G0.6050.11
163_R277_E0.6040.11
178_N194_P0.6040.11
97_R123_F0.6010.11
132_R171_Y0.6000.11
153_M184_D0.6000.11
214_Y232_F0.5980.11
155_V159_E0.5970.11
100_D246_S0.5940.11
162_A199_M0.5940.11
144_M178_N0.5930.11
141_T164_F0.5910.11
200_P212_R0.5900.11
102_T118_D0.5880.11
106_T170_T0.5880.11
63_S238_D0.5870.11
141_T183_M0.5860.11
12_L231_P0.5840.11
242_A257_D0.5830.11
37_F85_F0.5830.11
29_A136_P0.5830.11
179_G182_V0.5810.11
230_H256_L0.5810.11
26_K119_Q0.5780.11
75_D276_S0.5750.11
8_N75_D0.5740.11
246_S273_R0.5740.11
123_F171_Y0.5720.11
39_G152_V0.5720.11
99_D221_R0.5710.11
193_N219_F0.5710.11
254_V262_R0.5710.11
158_Y193_N0.5710.11
87_K146_A0.5700.11
238_D246_S0.5700.11
38_G53_I0.5700.11
19_M45_P0.5690.11
35_V198_M0.5690.11
53_I235_Q0.5690.11
100_D275_Q0.5640.11
55_L186_S0.5600.10
207_A210_E0.5590.10
169_T224_S0.5580.10
213_I259_A0.5570.10
201_A252_D0.5550.10
200_P270_D0.5550.10
117_E197_D0.5540.10
19_M77_T0.5520.10
132_R222_V0.5520.10
69_I108_H0.5520.10
69_I208_G0.5520.10
121_I196_M0.5510.10
73_A96_E0.5500.10
252_D255_V0.5500.10
12_L267_S0.5480.10
200_P249_S0.5480.10
10_A90_T0.5480.10
116_T221_R0.5470.10
118_D155_V0.5460.10
270_D276_S0.5450.10
224_S274_Q0.5440.10
200_P219_F0.5430.10
53_I82_I0.5420.10
18_R62_E0.5410.10
58_S237_W0.5400.10
81_S133_F0.5400.10
18_R130_P0.5390.10
15_Q27_A0.5380.10
86_F140_E0.5360.10
248_H271_Y0.5360.10
128_P157_L0.5350.10
94_T137_R0.5330.10
91_G213_I0.5310.10
57_A235_Q0.5310.10
33_Y142_R0.5300.10
183_M222_V0.5300.10
11_Y26_K0.5290.10
135_E211_K0.5280.10
55_L171_Y0.5270.10
48_W141_T0.5260.10
138_E237_W0.5260.10
23_A110_I0.5260.10
19_M76_T0.5250.10
26_K104_I0.5250.10
33_Y121_I0.5220.10
169_T244_C0.5210.10
25_L159_E0.5210.10
100_D273_R0.5200.10
89_V240_P0.5160.10
249_S267_S0.5160.10
81_S118_D0.5160.10
63_S273_R0.5140.10
102_T120_I0.5110.10
121_I203_Q0.5100.10
45_P76_T0.5090.10
190_K233_T0.5080.10
9_F255_V0.5080.10
11_Y19_M0.5030.10
169_T172_A0.5010.10
178_N274_Q0.5000.10
121_I200_P0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fqhA 1 0.1744 53.1 0.976 Contact Map
1vd4A 1 0.1922 20.1 0.981 Contact Map
3efoB 1 0.3132 19.6 0.981 Contact Map
2fsuA 2 0.5552 19.1 0.981 Contact Map
4lkbF 4 0.1993 16.8 0.982 Contact Map
3pfqA 1 0 13.8 0.982 Contact Map
3n2bA 2 0.4057 13.3 0.982 Contact Map
4x33A 1 0.2064 13.2 0.982 Contact Map
1bboA 1 0.1423 12.2 0.983 Contact Map
2epxA 1 0.153 12.1 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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