GREMLIN Database
PHNI - Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI
UniProt: P16687 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10718
Length: 354 (349)
Sequences: 424 (222)
Seq/√Len: 11.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_L71_N5.8741.00
195_Q317_A5.1071.00
323_A327_S4.2241.00
89_A234_I3.6970.99
255_M285_M3.4930.98
34_V134_L3.3760.98
231_D244_N3.2610.97
65_K133_L3.2000.97
42_N68_S3.1700.97
251_T284_A3.1650.97
38_E58_E3.0760.96
222_A225_I3.0450.96
62_L65_K3.0400.96
231_D245_V2.7970.93
229_Y249_L2.7380.93
233_S242_A2.5090.89
32_L52_G2.4740.88
321_E327_S2.4370.87
94_L250_M2.3890.86
62_L133_L2.3500.85
200_D319_N2.3370.85
227_S249_L2.2800.83
252_E273_Y2.2720.83
210_S307_A2.2620.83
68_S122_Y2.2380.82
92_E235_V2.2290.82
68_S134_L2.2280.82
38_E57_R2.1680.80
284_A309_D2.1560.80
176_D190_S2.1510.80
187_C314_L2.1250.79
100_R247_E2.1160.78
176_D191_S2.0960.78
72_V327_S2.0940.78
38_E41_L2.0870.77
255_M329_L2.0140.75
131_F135_A1.9950.74
78_L321_E1.9940.74
16_H126_H1.9600.73
102_E249_L1.8620.69
183_P187_C1.8550.68
21_S27_T1.8270.67
32_L136_N1.8050.66
326_V329_L1.7520.64
208_A225_I1.7490.64
132_T135_A1.7480.63
217_R315_A1.7360.63
42_N279_M1.7360.63
154_H157_S1.7340.63
15_A122_Y1.7290.63
225_I285_M1.7130.62
344_L347_L1.6930.61
297_P310_E1.6910.61
89_A253_C1.6900.61
14_A17_A1.6720.60
94_L147_S1.6380.58
166_K295_Q1.5760.55
36_Q40_Q1.5710.55
307_A331_L1.5540.54
78_L296_A1.5490.54
35_A58_E1.5210.52
19_Q68_S1.5160.52
30_P157_S1.5070.52
109_Y285_M1.4960.51
254_E285_M1.4960.51
222_A285_M1.4820.51
227_S279_M1.4800.50
62_L129_L1.4790.50
15_A327_S1.4720.50
183_P208_A1.4610.49
40_Q52_G1.4590.49
237_E327_S1.4390.48
229_Y247_E1.4260.48
46_D126_H1.4150.47
22_R102_E1.4080.47
77_L85_L1.4030.47
162_Q185_Y1.4010.46
94_L98_G1.4010.46
72_V323_A1.3970.46
108_V256_V1.3840.46
14_A250_M1.3790.45
50_T54_I1.3700.45
231_D243_V1.3690.45
279_M323_A1.3650.45
101_L163_G1.3570.44
10_K286_A1.3480.44
199_G317_A1.3400.43
211_T307_A1.3350.43
178_I195_Q1.3270.43
235_V242_A1.3270.43
220_P329_L1.3230.43
101_L152_S1.3190.42
158_L197_M1.3180.42
248_L321_E1.3170.42
39_Q108_V1.3160.42
231_D276_V1.3140.42
46_D57_R1.3130.42
91_S126_H1.2980.41
7_G11_A1.2970.41
109_Y315_A1.2950.41
68_S305_G1.2890.41
68_S279_M1.2880.41
75_I204_L1.2680.40
286_A299_Y1.2650.40
155_V309_D1.2610.40
100_R229_Y1.2580.39
164_L339_A1.2520.39
165_A295_Q1.2440.39
223_G344_L1.2430.39
22_R247_E1.2380.39
23_R65_K1.2360.38
15_A18_L1.2330.38
15_A321_E1.2330.38
276_V280_S1.2270.38
201_E336_D1.2260.38
95_D98_G1.2140.37
211_T293_A1.2120.37
34_V206_A1.2030.37
57_R248_L1.2020.37
285_M326_V1.1920.36
225_I320_V1.1870.36
220_P326_V1.1870.36
42_N122_Y1.1760.36
19_Q162_Q1.1750.36
57_R309_D1.1480.34
13_D171_S1.1390.34
205_L212_Q1.1290.34
23_R133_L1.1280.33
21_S142_L1.1280.33
221_F336_D1.1240.33
55_A277_F1.1230.33
157_S174_Q1.1230.33
225_I329_L1.1190.33
132_T136_N1.1120.33
220_P255_M1.1060.33
58_E134_L1.1050.32
91_S232_V1.1030.32
126_H310_E1.0970.32
246_G276_V1.0950.32
212_Q329_L1.0910.32
22_R256_V1.0820.31
131_F314_L1.0760.31
225_I243_V1.0760.31
128_L306_P1.0700.31
265_E351_Q1.0660.31
139_A178_I1.0550.30
16_H20_E1.0550.30
200_D343_L1.0530.30
95_D157_S1.0510.30
217_R321_E1.0470.30
338_Q345_K1.0430.30
34_V62_L1.0430.30
40_Q70_D1.0400.30
81_Y234_I1.0380.30
123_D330_K1.0360.30
40_Q267_P1.0320.29
19_Q122_Y1.0310.29
147_S169_E1.0300.29
220_P321_E1.0290.29
217_R327_S1.0290.29
210_S306_P1.0200.29
109_Y347_L1.0190.29
280_S310_E1.0170.29
50_T280_S1.0150.29
146_D245_V1.0120.29
169_E349_Q0.9990.28
75_I343_L0.9970.28
255_M326_V0.9970.28
121_T230_I0.9960.28
342_E346_R0.9920.28
42_N57_R0.9860.27
192_R245_V0.9850.27
20_E223_G0.9840.27
143_T174_Q0.9810.27
14_A260_I0.9810.27
207_L223_G0.9780.27
31_E237_E0.9770.27
53_G258_G0.9730.27
188_S191_S0.9710.27
137_G140_P0.9700.27
202_G277_F0.9660.27
286_A296_A0.9650.27
289_L340_E0.9650.27
107_A126_H0.9650.27
222_A288_A0.9580.26
178_I183_P0.9550.26
285_M329_L0.9480.26
154_H254_E0.9450.26
46_D249_L0.9420.26
138_E250_M0.9390.26
89_A310_E0.9350.25
210_S312_F0.9330.25
94_L108_V0.9280.25
105_I225_I0.9240.25
163_G269_F0.9210.25
21_S149_Q0.9200.25
140_P143_T0.9190.25
4_A208_A0.9160.25
199_G286_A0.9120.25
199_G207_L0.9110.25
299_Y339_A0.9110.25
32_L81_Y0.9070.24
43_L68_S0.9040.24
68_S276_V0.9040.24
15_A305_G0.9020.24
194_Q312_F0.9020.24
253_C335_V0.8960.24
71_N208_A0.8960.24
78_L234_I0.8950.24
102_E229_Y0.8950.24
194_Q311_E0.8940.24
76_F99_M0.8850.24
23_R37_I0.8850.24
161_R181_T0.8840.24
201_E221_F0.8840.24
236_P290_V0.8780.23
163_G313_V0.8750.23
16_H327_S0.8710.23
65_K76_F0.8710.23
120_P210_S0.8700.23
31_E137_G0.8680.23
36_Q61_A0.8660.23
16_H121_T0.8660.23
203_Y290_V0.8650.23
41_L44_A0.8650.23
48_V234_I0.8650.23
155_V185_Y0.8640.23
269_F273_Y0.8620.23
211_T289_L0.8580.23
276_V342_E0.8520.22
221_F289_L0.8500.22
13_D98_G0.8480.22
220_P285_M0.8470.22
176_D188_S0.8450.22
162_Q348_Q0.8420.22
50_T136_N0.8420.22
220_P320_V0.8410.22
111_D194_Q0.8380.22
97_T156_F0.8360.22
218_N257_N0.8330.22
191_S279_M0.8310.22
106_S115_G0.8310.22
20_E253_C0.8300.22
205_L292_R0.8290.22
16_H68_S0.8290.22
175_P206_A0.8290.22
274_G287_M0.8280.22
44_A227_S0.8280.22
135_A138_E0.8260.22
108_V339_A0.8260.22
297_P346_R0.8260.22
181_T208_A0.8250.22
53_G323_A0.8240.22
138_E242_A0.8210.21
49_M61_A0.8130.21
59_L64_L0.8130.21
50_T72_V0.8130.21
157_S167_F0.8120.21
279_M293_A0.8110.21
236_P241_F0.8110.21
155_V159_L0.8110.21
57_R151_P0.8110.21
105_I183_P0.8090.21
178_I222_A0.8040.21
36_Q44_A0.8020.21
185_Y312_F0.8010.21
150_Q288_A0.8000.21
215_Y258_G0.7980.21
76_F80_A0.7950.21
176_D280_S0.7890.20
263_P344_L0.7890.20
133_L136_N0.7880.20
16_H125_T0.7860.20
307_A340_E0.7830.20
34_V38_E0.7830.20
222_A327_S0.7810.20
28_D35_A0.7780.20
245_V321_E0.7770.20
11_A316_H0.7750.20
22_R41_L0.7740.20
131_F136_N0.7730.20
46_D310_E0.7630.20
192_R310_E0.7630.20
299_Y314_L0.7630.20
102_E320_V0.7600.19
17_A264_G0.7600.19
78_L303_A0.7600.19
211_T221_F0.7590.19
19_Q54_I0.7530.19
13_D16_H0.7520.19
234_I245_V0.7510.19
254_E351_Q0.7480.19
171_S175_P0.7470.19
97_T167_F0.7450.19
129_L133_L0.7440.19
19_Q53_G0.7440.19
19_Q183_P0.7440.19
45_V204_L0.7430.19
28_D132_T0.7430.19
91_S233_S0.7410.19
110_K220_P0.7400.19
185_Y199_G0.7400.19
111_D126_H0.7370.19
44_A71_N0.7350.19
88_L254_E0.7350.19
28_D31_E0.7330.19
65_K237_E0.7330.19
280_S309_D0.7320.19
294_L320_V0.7320.19
104_R226_R0.7310.19
138_E232_V0.7290.18
82_R128_L0.7280.18
57_R350_E0.7260.18
236_P239_L0.7250.18
78_L323_A0.7230.18
24_R201_E0.7230.18
165_A258_G0.7210.18
250_M303_A0.7210.18
222_A256_V0.7190.18
282_R329_L0.7180.18
206_A287_M0.7160.18
18_L225_I0.7160.18
47_R200_D0.7140.18
138_E248_L0.7140.18
64_L244_N0.7100.18
164_L286_A0.7080.18
267_P348_Q0.7080.18
145_A188_S0.7040.18
57_R152_S0.7020.18
176_D199_G0.6990.18
144_T169_E0.6990.18
282_R327_S0.6970.18
227_S317_A0.6970.18
82_R312_F0.6940.17
281_E334_Y0.6940.17
18_L50_T0.6930.17
187_C191_S0.6910.17
274_G318_D0.6900.17
32_L64_L0.6880.17
101_L254_E0.6870.17
101_L142_L0.6840.17
184_V208_A0.6810.17
297_P303_A0.6800.17
70_D180_R0.6800.17
178_I277_F0.6800.17
285_M323_A0.6800.17
61_A73_E0.6780.17
296_A320_V0.6770.17
263_P339_A0.6770.17
165_A168_E0.6770.17
211_T343_L0.6770.17
16_H253_C0.6750.17
175_P245_V0.6750.17
146_D284_A0.6750.17
215_Y307_A0.6720.17
23_R76_F0.6720.17
151_P161_R0.6710.17
186_P189_R0.6690.17
146_D169_E0.6680.17
121_T182_P0.6680.17
148_E151_P0.6650.17
104_R189_R0.6650.17
257_N340_E0.6640.17
59_L78_L0.6620.17
61_A121_T0.6610.17
175_P284_A0.6610.17
10_K22_R0.6600.16
194_Q341_L0.6590.16
90_V156_F0.6580.16
107_A222_A0.6550.16
53_G250_M0.6540.16
57_R313_V0.6540.16
47_R205_L0.6530.16
259_F270_T0.6500.16
171_S264_G0.6460.16
159_L221_F0.6440.16
45_V151_P0.6430.16
32_L37_I0.6420.16
231_D351_Q0.6420.16
35_A172_G0.6410.16
130_D133_L0.6410.16
97_T248_L0.6400.16
66_Q73_E0.6390.16
68_S126_H0.6380.16
189_R325_F0.6340.16
257_N288_A0.6330.16
57_R179_T0.6330.16
49_M77_L0.6300.16
67_A92_E0.6300.16
33_S172_G0.6280.16
178_I190_S0.6270.16
106_S220_P0.6260.16
76_F274_G0.6250.16
64_L122_Y0.6230.16
27_T173_A0.6210.15
160_A231_D0.6190.15
31_E65_K0.6190.15
178_I187_C0.6190.15
54_I245_V0.6180.15
125_T322_A0.6180.15
136_N139_A0.6170.15
274_G284_A0.6170.15
199_G227_S0.6150.15
217_R343_L0.6140.15
68_S327_S0.6130.15
50_T65_K0.6110.15
44_A336_D0.6100.15
68_S344_L0.6100.15
183_P191_S0.6090.15
237_E290_V0.6080.15
100_R129_L0.6080.15
257_N289_L0.6080.15
148_E247_E0.6040.15
64_L161_R0.6040.15
65_K162_Q0.6030.15
189_R214_G0.6000.15
57_R92_E0.5980.15
66_Q127_R0.5970.15
70_D267_P0.5970.15
188_S237_E0.5930.15
88_L234_I0.5930.15
206_A225_I0.5920.15
14_A88_L0.5900.15
85_L245_V0.5900.15
29_L157_S0.5880.15
237_E314_L0.5870.15
15_A288_A0.5860.15
107_A204_L0.5850.15
270_T292_R0.5820.14
136_N248_L0.5810.14
75_I320_V0.5800.14
10_K46_D0.5790.14
121_T288_A0.5790.14
109_Y112_I0.5790.14
16_H271_R0.5780.14
22_R249_L0.5770.14
29_L351_Q0.5760.14
91_S249_L0.5750.14
286_A349_Q0.5750.14
78_L91_S0.5750.14
98_G174_Q0.5750.14
167_F176_D0.5740.14
10_K195_Q0.5730.14
264_G344_L0.5730.14
262_P266_P0.5730.14
101_L144_T0.5720.14
296_A301_E0.5710.14
155_V289_L0.5710.14
57_R147_S0.5700.14
28_D163_G0.5690.14
240_G248_L0.5680.14
284_A303_A0.5670.14
36_Q275_L0.5650.14
44_A187_C0.5640.14
15_A121_T0.5640.14
102_E242_A0.5640.14
22_R254_E0.5630.14
29_L167_F0.5620.14
282_R336_D0.5620.14
65_K287_M0.5620.14
13_D22_R0.5620.14
149_Q248_L0.5620.14
213_R316_H0.5600.14
70_D200_D0.5590.14
120_P307_A0.5580.14
317_A327_S0.5580.14
252_E274_G0.5580.14
43_L348_Q0.5580.14
340_E343_L0.5570.14
157_S227_S0.5570.14
90_V151_P0.5530.14
115_G220_P0.5530.14
111_D338_Q0.5530.14
26_D31_E0.5510.14
188_S302_H0.5510.14
218_N289_L0.5500.14
149_Q181_T0.5500.14
50_T64_L0.5500.14
199_G275_L0.5480.14
197_M351_Q0.5470.14
261_D295_Q0.5460.14
73_E127_R0.5460.14
217_R323_A0.5450.14
165_A286_A0.5440.14
162_Q345_K0.5370.13
225_I237_E0.5360.13
195_Q262_P0.5360.13
275_L293_A0.5350.13
83_T239_L0.5350.13
109_Y155_V0.5350.13
105_I339_A0.5350.13
43_L70_D0.5340.13
259_F275_L0.5340.13
24_R47_R0.5330.13
15_A93_P0.5330.13
263_P268_H0.5320.13
296_A303_A0.5310.13
114_G202_G0.5310.13
190_S347_L0.5270.13
29_L94_L0.5270.13
22_R349_Q0.5270.13
85_L329_L0.5270.13
160_A165_A0.5260.13
139_A181_T0.5240.13
246_G294_L0.5210.13
29_L174_Q0.5190.13
106_S213_R0.5190.13
14_A175_P0.5180.13
14_A225_I0.5180.13
98_G144_T0.5170.13
195_Q227_S0.5170.13
28_D98_G0.5130.13
133_L247_E0.5130.13
160_A167_F0.5130.13
171_S174_Q0.5110.13
35_A147_S0.5100.13
248_L302_H0.5090.13
183_P231_D0.5070.13
50_T254_E0.5060.13
33_S167_F0.5020.13
142_L250_M0.5010.13
141_T146_D0.5010.13
72_V120_P0.5000.13
234_I275_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ooaA 1 0.1186 80 0.973 Contact Map
4dbgB 1 0.2401 76.8 0.974 Contact Map
2oo9A 2 0.1299 65.7 0.976 Contact Map
2jujA 1 0.1582 64.3 0.976 Contact Map
2mr9A 1 0.1243 46.9 0.979 Contact Map
2d9sA 2 0.1497 46.8 0.979 Contact Map
2g3qA 1 0.1215 34.5 0.98 Contact Map
1z96A 1 0.1073 33.7 0.98 Contact Map
2knzA 1 0.1497 31.3 0.981 Contact Map
2xijA 2 0.5819 30.7 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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