GREMLIN Database
PHNH - Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH
UniProt: P16686 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10717
Length: 194 (185)
Sequences: 609 (474)
Seq/√Len: 34.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_M184_A7.2931.00
149_I183_L6.1821.00
21_L51_V4.5001.00
25_M175_I3.8651.00
52_L96_V3.2731.00
21_L175_I3.2641.00
95_A121_A3.0451.00
23_K27_E2.9921.00
139_T146_E2.6771.00
52_L56_A2.3090.99
157_I161_L2.2970.99
45_N48_T2.2920.99
47_A179_G2.2900.99
137_R146_E2.2900.99
61_P93_T2.2860.99
175_I184_A2.2510.99
22_L26_S2.2450.99
161_L164_R2.1660.99
95_A109_L2.1140.99
27_E147_R2.0980.99
49_T76_S1.9020.97
24_A32_V1.8700.97
48_T126_Q1.8680.97
51_V175_I1.8590.97
62_V96_V1.8550.97
96_V124_I1.8100.97
33_A180_E1.7320.96
116_A119_A1.7020.95
47_A180_E1.6930.95
157_I185_I1.6640.95
19_R22_L1.6530.94
56_A96_V1.6200.94
124_I175_I1.6020.93
40_G49_T1.6010.93
44_L73_V1.5970.93
71_D75_Q1.5950.93
9_L12_Q1.5840.93
17_S50_S1.5470.92
158_L191_V1.5290.92
114_A170_L1.5230.91
113_T170_L1.5040.91
23_K26_S1.4970.91
29_G138_L1.4630.90
129_S133_G1.4490.89
30_V147_R1.4000.87
41_W76_S1.3950.87
47_A177_T1.3480.85
97_T109_L1.3260.84
136_L191_V1.3090.84
112_G117_P1.3010.83
136_L158_L1.2920.83
61_P84_P1.2900.83
69_N74_N1.2890.83
44_L96_V1.2830.82
51_V124_I1.2600.81
24_A184_A1.1730.76
158_L161_L1.1670.76
11_V15_Q1.1590.75
44_L106_L1.1430.74
71_D91_Q1.1430.74
27_E30_V1.1400.74
93_T110_S1.1360.74
161_L188_T1.1350.74
169_P187_R1.1220.73
109_L121_A1.1010.72
45_N126_Q1.0940.71
5_T158_L1.0780.70
90_E108_A1.0740.70
79_F82_N1.0670.69
63_W120_G1.0670.69
123_L174_L1.0570.68
138_L176_L1.0540.68
62_V168_F1.0460.68
48_T56_A1.0450.67
11_V97_T1.0410.67
31_I181_R1.0300.66
59_D82_N1.0280.66
62_V77_L1.0220.66
129_S132_G1.0220.66
112_G169_P1.0140.65
124_I184_A1.0100.65
142_G171_G1.0090.65
135_M183_L0.9530.60
86_V121_A0.9350.59
142_G187_R0.9330.59
29_G141_A0.9310.58
172_I192_E0.9280.58
138_L191_V0.9280.58
161_L189_T0.9250.58
133_G136_L0.9220.58
171_G187_R0.9210.58
116_A188_T0.9190.57
112_G187_R0.9180.57
143_I188_T0.9080.56
74_N78_R0.9080.56
22_L192_E0.9020.56
58_N121_A0.8920.55
118_E188_T0.8910.55
41_W116_A0.8910.55
127_V131_S0.8860.55
65_S98_D0.8850.55
135_M149_I0.8830.54
143_I189_T0.8730.54
89_P108_A0.8720.53
156_C160_E0.8680.53
118_E151_P0.8670.53
118_E164_R0.8610.52
126_Q177_T0.8600.52
48_T124_I0.8560.52
83_A124_I0.8530.52
144_A148_M0.8390.51
144_A147_R0.8370.50
17_S54_T0.8310.50
29_G191_V0.8210.49
167_P170_L0.8180.49
94_F120_G0.8180.49
71_D74_N0.8170.49
41_W49_T0.8150.49
67_P70_N0.8150.49
115_V164_R0.8140.48
77_L83_A0.8140.48
26_S124_I0.8080.48
23_K32_V0.8020.47
111_T167_P0.8000.47
100_A126_Q0.8000.47
128_A135_M0.7980.47
111_T170_L0.7950.47
39_R107_N0.7930.47
60_T84_P0.7920.47
143_I146_E0.7900.46
72_I86_V0.7890.46
56_A62_V0.7860.46
23_K30_V0.7840.46
142_G169_P0.7720.45
130_L183_L0.7540.43
52_L126_Q0.7510.43
150_A174_L0.7490.43
15_Q161_L0.7460.43
63_W109_L0.7460.43
146_E163_E0.7440.43
52_L77_L0.7420.42
94_F109_L0.7410.42
15_Q94_F0.7410.42
153_L185_I0.7410.42
34_L38_K0.7400.42
12_Q26_S0.7330.42
161_L191_V0.7300.41
99_E168_F0.7290.41
122_T175_I0.7240.41
76_S164_R0.7210.41
39_R50_S0.7190.40
54_T177_T0.7160.40
46_I77_L0.7130.40
14_A79_F0.7100.40
44_L59_D0.7070.39
26_S32_V0.7030.39
31_I135_M0.7030.39
161_L165_P0.7010.39
27_E83_A0.6990.39
155_E181_R0.6980.39
106_L160_E0.6950.38
63_W97_T0.6850.38
63_W121_A0.6780.37
99_E120_G0.6740.37
64_L73_V0.6730.37
19_R23_K0.6730.37
117_P169_P0.6710.37
130_L178_C0.6710.37
30_V184_A0.6710.37
131_S135_M0.6670.36
173_D186_P0.6670.36
130_L159_H0.6650.36
106_L158_L0.6610.36
45_N119_A0.6570.35
125_L188_T0.6560.35
48_T115_V0.6540.35
23_K34_L0.6520.35
52_L152_Q0.6510.35
56_A60_T0.6420.34
141_A188_T0.6390.34
77_L106_L0.6370.34
33_A73_V0.6370.34
81_T84_P0.6340.34
135_M148_M0.6340.34
24_A77_L0.6300.33
74_N85_L0.6290.33
9_L35_H0.6280.33
20_R139_T0.6270.33
151_P188_T0.6180.32
53_L61_P0.6180.32
5_T78_R0.6170.32
70_N74_N0.6150.32
97_T103_S0.6140.32
93_T175_I0.6120.32
14_A164_R0.6120.32
31_I134_R0.6120.32
13_D137_R0.6120.32
5_T12_Q0.6110.32
184_A191_V0.6110.32
45_N177_T0.6100.32
107_N163_E0.6080.32
53_L80_H0.6070.32
14_A54_T0.6070.32
13_D36_Q0.6060.32
33_A145_E0.6050.32
132_G137_R0.6040.31
38_K69_N0.6030.31
138_L149_I0.5990.31
52_L81_T0.5980.31
12_Q167_P0.5960.31
130_L135_M0.5950.31
140_G171_G0.5940.31
99_E126_Q0.5930.31
132_G151_P0.5920.31
21_L54_T0.5900.30
39_R91_Q0.5890.30
34_L46_I0.5880.30
11_V14_A0.5860.30
112_G141_A0.5840.30
27_E162_T0.5840.30
7_F64_L0.5830.30
117_P171_G0.5820.30
121_A181_R0.5820.30
26_S166_H0.5820.30
33_A137_R0.5800.30
114_A136_L0.5800.30
99_E107_N0.5790.30
120_G164_R0.5790.30
117_P142_G0.5780.30
132_G150_A0.5760.29
65_S109_L0.5750.29
5_T114_A0.5740.29
105_Q126_Q0.5730.29
76_S119_A0.5720.29
97_T105_Q0.5720.29
26_S163_E0.5710.29
22_L118_E0.5710.29
182_L188_T0.5690.29
60_T93_T0.5680.29
112_G171_G0.5670.29
133_G150_A0.5650.29
18_F158_L0.5640.29
112_G142_G0.5630.28
92_A191_V0.5630.28
73_V96_V0.5600.28
162_T165_P0.5590.28
111_T149_I0.5590.28
132_G149_I0.5540.28
63_W110_S0.5530.28
83_A177_T0.5480.27
24_A168_F0.5440.27
109_L157_I0.5410.27
38_K78_R0.5410.27
60_T85_L0.5400.27
172_I191_V0.5400.27
15_Q19_R0.5400.27
34_L182_L0.5380.27
139_T162_T0.5360.27
153_L181_R0.5340.27
25_M122_T0.5320.26
114_A123_L0.5300.26
14_A106_L0.5290.26
139_T190_H0.5280.26
140_G187_R0.5260.26
20_R54_T0.5250.26
19_R47_A0.5250.26
152_Q172_I0.5240.26
25_M113_T0.5220.26
13_D16_H0.5210.26
57_D82_N0.5180.25
50_S104_E0.5170.25
93_T129_S0.5150.25
150_A163_E0.5140.25
77_L92_A0.5100.25
12_Q18_F0.5090.25
64_L109_L0.5080.25
15_Q97_T0.5070.25
67_P87_S0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fsuA 2 0.8763 100 0.06 Contact Map
2fhzA 1 0.1804 19.5 0.955 Contact Map
3p9yA 1 0.4794 11.3 0.959 Contact Map
3nvsA 1 0.7371 9.8 0.961 Contact Map
1lldA 3 0.8144 7.9 0.962 Contact Map
1o7iA 1 0.433 7 0.963 Contact Map
1rf6A 1 0.768 6.4 0.964 Contact Map
2pqcA 1 0.8144 5.8 0.964 Contact Map
2k50A 1 0.4691 4.2 0.967 Contact Map
2ekiA 1 0.2062 3.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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