GREMLIN Database
PHNG - Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG
UniProt: P16685 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10716
Length: 150 (143)
Sequences: 435 (304)
Seq/√Len: 25.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_A85_Q5.4791.00
22_E122_D4.6831.00
14_V116_I3.9061.00
12_M95_C3.4571.00
71_A81_Y3.4311.00
38_V72_V3.3421.00
11_W102_M3.2221.00
78_T104_Q2.9621.00
13_S17_H2.9441.00
90_Q93_E2.8131.00
84_V91_H2.6310.99
110_N114_T2.5620.99
82_S95_C2.4580.99
68_T82_S2.3240.98
128_A132_A2.3000.98
24_A90_Q2.1780.97
10_H120_D2.1690.97
50_Q59_R2.0590.96
20_P88_D1.9510.94
18_S70_A1.9290.94
39_I79_L1.9000.94
50_Q61_F1.7770.91
48_Q64_D1.7000.89
98_I115_L1.6270.87
17_H123_R1.5890.85
48_Q134_V1.5250.83
37_E73_R1.4930.82
36_Y93_E1.4570.80
90_Q94_R1.4200.78
38_V93_E1.3770.76
19_Q22_E1.3650.75
46_L70_A1.3510.75
9_Q138_R1.3440.74
25_A35_D1.3380.74
81_Y136_A1.2300.67
112_S120_D1.2240.67
51_A92_A1.2050.66
61_F95_C1.2040.66
71_A134_V1.1740.64
91_H95_C1.1440.62
125_A129_A1.1380.61
26_R98_I1.1300.61
48_Q62_A1.1040.59
18_S95_C1.1040.59
79_L137_S1.1030.59
73_R88_D1.0880.58
37_E75_T1.0750.57
30_L91_H1.0690.56
102_M108_F1.0640.56
134_V137_S1.0620.56
47_V65_A1.0240.53
144_M147_G1.0170.52
53_M58_E1.0080.52
39_I87_R1.0050.52
8_R11_W1.0010.51
64_D137_S0.9980.51
7_T73_R0.9950.51
20_P91_H0.9940.51
91_H94_R0.9760.49
46_L133_E0.9750.49
65_A70_A0.9550.48
62_A82_S0.9500.48
27_L33_T0.9430.47
53_M94_R0.9350.46
128_A140_D0.9320.46
102_M112_S0.9280.46
81_Y134_V0.9210.45
20_P24_A0.9190.45
84_V92_A0.9160.45
50_Q64_D0.9110.45
124_M128_A0.9100.45
121_A125_A0.9030.44
82_S109_Q0.9010.44
78_T105_S0.8950.44
35_D67_L0.8880.43
46_L121_A0.8830.43
117_A121_A0.8750.42
83_W87_R0.8710.42
24_A108_F0.8690.42
49_I65_A0.8550.41
13_S28_N0.8530.41
22_E25_A0.8490.40
36_Y72_V0.8440.40
11_W112_S0.8370.39
27_L127_I0.8320.39
138_R144_M0.8260.39
47_V93_E0.8190.38
22_E119_L0.8190.38
58_E67_L0.8160.38
51_A59_R0.8140.38
34_A62_A0.8070.37
140_D144_M0.7990.37
48_Q61_F0.7980.37
67_L135_N0.7950.37
54_G138_R0.7930.36
48_Q51_A0.7870.36
27_L98_I0.7800.36
14_V112_S0.7800.36
72_V132_A0.7780.35
109_Q113_E0.7770.35
31_N75_T0.7760.35
24_A94_R0.7750.35
13_S46_L0.7750.35
47_V67_L0.7750.35
84_V95_C0.7670.35
47_V112_S0.7670.35
41_A81_Y0.7660.35
64_D70_A0.7650.35
111_L137_S0.7650.35
76_D104_Q0.7620.34
16_A116_I0.7610.34
56_T81_Y0.7610.34
20_P94_R0.7550.34
53_M73_R0.7540.34
15_L84_V0.7270.32
11_W103_Q0.7230.32
49_I61_F0.7220.32
7_T108_F0.7200.32
108_F122_D0.7150.31
140_D146_R0.7120.31
56_T90_Q0.7070.31
128_A131_Q0.7040.31
37_E53_M0.7040.31
98_I102_M0.7030.31
129_A133_E0.6990.30
135_N144_M0.6980.30
61_F64_D0.6960.30
64_D95_C0.6960.30
21_A113_E0.6950.30
105_S140_D0.6850.29
82_S145_V0.6800.29
40_R54_G0.6700.29
136_A147_G0.6670.28
79_L130_R0.6660.28
105_S114_T0.6650.28
41_A71_A0.6620.28
21_A25_A0.6600.28
65_A91_H0.6590.28
46_L85_Q0.6590.28
14_V23_L0.6560.28
68_T95_C0.6520.28
73_R145_V0.6470.27
42_A114_T0.6460.27
122_D125_A0.6440.27
20_P44_T0.6380.27
40_R61_F0.6380.27
49_I106_R0.6340.26
67_L83_W0.6310.26
104_Q107_H0.6310.26
47_V51_A0.6300.26
98_I103_Q0.6300.26
71_A79_L0.6300.26
59_R147_G0.6290.26
27_L30_L0.6280.26
83_W91_H0.6260.26
13_S87_R0.6240.26
17_H95_C0.6240.26
10_H59_R0.6200.26
68_T89_K0.6170.26
62_A121_A0.6140.25
25_A56_T0.6130.25
85_Q91_H0.6110.25
88_D94_R0.6100.25
54_G100_A0.6100.25
38_V56_T0.6090.25
21_A130_R0.6090.25
6_A144_M0.6090.25
117_A124_M0.6040.25
34_A101_L0.5980.24
11_W70_A0.5950.24
62_A131_Q0.5910.24
12_M148_D0.5910.24
6_A21_A0.5880.24
30_L105_S0.5860.24
9_Q81_Y0.5800.24
113_E128_A0.5780.23
17_H124_M0.5760.23
24_A28_N0.5750.23
23_L84_V0.5720.23
15_L115_L0.5710.23
108_F112_S0.5710.23
42_A70_A0.5690.23
18_S43_E0.5680.23
35_D75_T0.5650.23
75_T90_Q0.5650.23
119_L122_D0.5650.23
50_Q137_S0.5600.22
88_D138_R0.5570.22
47_V74_L0.5550.22
113_E148_D0.5500.22
36_Y119_L0.5490.22
97_L119_L0.5480.22
67_L140_D0.5460.22
10_H25_A0.5420.22
52_R77_G0.5410.22
46_L104_Q0.5360.21
66_T83_W0.5350.21
29_A65_A0.5330.21
12_M82_S0.5330.21
59_R144_M0.5310.21
30_L125_A0.5310.21
105_S117_A0.5310.21
58_E79_L0.5290.21
127_I133_E0.5290.21
35_D132_A0.5270.21
56_T142_F0.5250.21
111_L115_L0.5220.21
47_V120_D0.5210.21
65_A133_E0.5200.21
14_V44_T0.5120.20
56_T68_T0.5070.20
73_R115_L0.5070.20
23_L56_T0.5000.20
124_M140_D0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1di2A 1 0.44 31.5 0.949 Contact Map
1o0wA 2 0.5733 22.1 0.953 Contact Map
2ltrA 1 0.6333 19.6 0.954 Contact Map
3adjA 1 0.4733 18.8 0.955 Contact Map
2j0pA 1 0.88 18.5 0.955 Contact Map
2rgnB 1 0.28 18.1 0.955 Contact Map
4cdpA 1 0.9133 16.9 0.956 Contact Map
2mdrA 1 0.6067 14.9 0.957 Contact Map
3n3wA 2 0.1 10.1 0.96 Contact Map
1ekzA 1 0.5 9.9 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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