GREMLIN Database
PHNF - Probable transcriptional regulator PhnF
UniProt: P16684 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10715
Length: 241 (192)
Sequences: 23852 (18294)
Seq/√Len: 1320.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_E28_H3.8501.00
30_R33_D3.7611.00
18_A58_Q3.3071.00
22_E62_K3.1651.00
24_E44_R3.1081.00
66_Q76_L2.8891.00
20_K24_E2.5471.00
17_I47_V2.5281.00
187_S190_R2.4731.00
38_E49_R2.4321.00
67_R73_V2.3851.00
68_R71_V2.3741.00
17_I45_F2.2951.00
18_A62_K2.2331.00
23_Q27_Q2.2021.00
122_G184_T2.1301.00
34_Y74_L2.0991.00
107_L192_Q2.0041.00
114_S117_V2.0041.00
18_A22_E1.9821.00
11_P19_A1.9461.00
20_K45_F1.9171.00
136_R144_C1.8891.00
71_V74_L1.8361.00
60_V67_R1.8111.00
54_R57_D1.7691.00
22_E26_R1.7031.00
192_Q195_E1.6651.00
24_E29_Y1.6651.00
39_Q43_A1.6541.00
22_E64_W1.6061.00
117_V139_N1.6011.00
40_Q44_R1.5941.00
192_Q196_C1.5921.00
100_H104_E1.5901.00
13_R16_E1.5791.00
16_E20_K1.5701.00
131_H147_D1.5241.00
60_V65_V1.5151.00
68_R74_L1.5081.00
20_K23_Q1.4931.00
37_A40_Q1.4931.00
132_L148_H1.4741.00
102_T137_R1.4721.00
14_Y58_Q1.4591.00
111_R188_A1.4481.00
93_N141_V1.4361.00
41_L52_L1.4341.00
56_I65_V1.4261.00
113_A118_A1.4161.00
190_R194_K1.3921.00
65_V73_V1.3551.00
47_V52_L1.3521.00
133_R136_R1.3501.00
104_E137_R1.3471.00
38_E53_R1.3461.00
29_Y75_V1.3291.00
11_P16_E1.3281.00
25_L75_V1.3131.00
57_D67_R1.3101.00
118_A123_I1.3091.00
66_Q74_L1.3021.00
57_D61_E1.3011.00
113_A117_V1.2841.00
182_S190_R1.2661.00
31_C77_M1.2611.00
40_Q43_A1.2571.00
58_Q61_E1.2521.00
12_T15_Q1.2491.00
132_L136_R1.2401.00
193_A197_Q1.2231.00
57_D60_V1.2191.00
111_R131_H1.2191.00
58_Q62_K1.2171.00
145_L149_Y1.2091.00
117_V149_Y1.1911.00
26_R64_W1.1841.00
169_D173_E1.1641.00
118_A121_L1.1201.00
118_A184_T1.1171.00
145_L195_E1.1111.00
126_G129_V1.0861.00
188_A192_Q1.0771.00
180_R184_T1.0751.00
15_Q19_A1.0751.00
168_H172_R1.0581.00
29_Y33_D1.0561.00
110_L152_D1.0501.00
124_T127_E1.0481.00
133_R147_D1.0391.00
177_I181_R1.0341.00
56_I73_V1.0321.00
68_R72_G1.0251.00
133_R137_R1.0201.00
110_L128_N1.0201.00
34_Y72_G1.0191.00
13_R51_T1.0051.00
155_L158_T1.0051.00
107_L131_H0.9991.00
129_V133_R0.9931.00
54_R58_Q0.9801.00
196_C200_E0.9621.00
144_C148_H0.9571.00
109_V131_H0.9441.00
21_L41_L0.9421.00
107_L188_A0.9421.00
24_E45_F0.9361.00
113_A186_I0.9331.00
19_A22_E0.9291.00
15_Q58_Q0.9231.00
181_R185_R0.9171.00
202_P205_S0.9161.00
119_D123_I0.9091.00
99_S200_E0.9031.00
122_G180_R0.8891.00
128_N152_D0.8881.00
32_G66_Q0.8871.00
48_N51_T0.8841.00
120_A133_R0.8791.00
134_T183_Q0.8791.00
178_A194_K0.8761.00
98_G102_T0.8761.00
14_Y18_A0.8761.00
125_E129_V0.8701.00
92_Q96_D0.8661.00
92_Q95_L0.8641.00
167_L170_F0.8621.00
154_T157_P0.8591.00
11_P15_Q0.8581.00
135_L147_D0.8571.00
107_L133_R0.8541.00
115_G119_D0.8521.00
99_S103_S0.8471.00
117_V120_A0.8441.00
70_G73_V0.8421.00
167_L171_L0.8401.00
106_L110_L0.8361.00
14_Y54_R0.8201.00
156_W159_L0.8191.00
191_A201_I0.8141.00
102_T140_G0.8121.00
32_G77_M0.8011.00
20_K44_R0.8001.00
120_A123_I0.7991.00
31_C76_L0.7981.00
115_G118_A0.7971.00
189_R195_E0.7911.00
34_Y37_A0.7831.00
146_I149_Y0.7781.00
114_S121_L0.7741.00
103_S196_C0.7731.00
138_V144_C0.7731.00
85_N88_A0.7721.00
93_N97_Q0.7711.00
185_R190_R0.7701.00
166_S169_D0.7631.00
190_R193_A0.7631.00
142_A154_T0.7611.00
154_T158_T0.7611.00
166_S170_F0.7561.00
154_T159_L0.7551.00
120_A124_T0.7541.00
35_L65_V0.7521.00
181_R184_T0.7521.00
41_L56_I0.7401.00
133_R194_K0.7401.00
155_L159_L0.7391.00
161_R164_S0.7381.00
24_E27_Q0.7371.00
97_Q146_I0.7361.00
116_H120_A0.7341.00
118_A122_G0.7301.00
56_I60_V0.7291.00
38_E67_R0.7241.00
17_I52_L0.7231.00
112_P128_N0.7221.00
42_A52_L0.7201.00
96_D112_P0.7181.00
118_A180_R0.7081.00
99_S196_C0.7061.00
130_I180_R0.7041.00
45_F52_L0.7041.00
103_S192_Q0.6991.00
195_E198_R0.6981.00
19_A23_Q0.6941.00
172_R178_A0.6941.00
94_L138_V0.6931.00
17_I20_K0.6931.00
131_H176_G0.6901.00
194_K197_Q0.6901.00
28_H44_R0.6891.00
36_P44_R0.6881.00
169_D172_R0.6761.00
103_S107_L0.6751.00
104_E107_L0.6681.00
189_R193_A0.6681.00
21_L29_Y0.6671.00
178_A181_R0.6631.00
43_A46_E0.6601.00
93_N98_G0.6591.00
86_A89_R0.6591.00
113_A137_R0.6551.00
201_I205_S0.6511.00
197_Q201_I0.6501.00
129_V132_L0.6411.00
189_R192_Q0.6381.00
103_S106_L0.6341.00
95_L98_G0.6331.00
10_Y16_E0.6281.00
99_S139_N0.6241.00
121_L124_T0.6241.00
41_L45_F0.6241.00
132_L151_A0.6231.00
113_A121_L0.6221.00
128_N156_W0.6221.00
107_L189_R0.6211.00
160_Q163_D0.6171.00
82_Y85_N0.6161.00
98_G101_P0.6151.00
138_V143_L0.6141.00
39_Q42_A0.6131.00
132_L144_C0.6021.00
29_Y35_L0.6021.00
191_A196_C0.6011.00
170_F173_E0.5991.00
117_V137_R0.5951.00
179_L195_E0.5941.00
106_L135_L0.5931.00
56_I67_R0.5921.00
166_S173_E0.5901.00
52_L65_V0.5891.00
120_A136_R0.5891.00
142_A145_L0.5851.00
96_D108_S0.5841.00
137_R140_G0.5801.00
51_T55_A0.5761.00
124_T129_V0.5751.00
195_E199_L0.5741.00
151_A154_T0.5731.00
97_Q101_P0.5721.00
191_A205_S0.5711.00
104_E108_S0.5691.00
107_L111_R0.5681.00
193_A196_C0.5661.00
147_D195_E0.5651.00
18_A55_A0.5641.00
178_A190_R0.5631.00
194_K198_R0.5621.00
179_L194_K0.5601.00
90_F94_L0.5581.00
114_S118_A0.5551.00
172_R177_I0.5551.00
177_I180_R0.5511.00
105_K109_V0.5511.00
124_T133_R0.5511.00
107_L110_L0.5491.00
93_N96_D0.5421.00
100_H143_L0.5401.00
60_V73_V0.5361.00
182_S187_S0.5341.00
110_L130_I0.5331.00
34_Y71_V0.5331.00
42_A45_F0.5301.00
82_Y89_R0.5281.00
95_L101_P0.5271.00
17_I55_A0.5251.00
83_P86_A0.5241.00
23_Q26_R0.5231.00
116_H119_D0.5231.00
17_I21_L0.5221.00
113_A123_I0.5211.00
50_H54_R0.5211.00
117_V136_R0.5191.00
69_Q72_G0.5181.00
111_R114_S0.5161.00
82_Y88_A0.5161.00
29_Y36_P0.5151.00
119_D122_G0.5141.00
39_Q49_R0.5091.00
113_A129_V0.5081.00
121_L133_R0.5071.00
118_A186_I0.5061.00
37_A70_G0.5041.00
83_P88_A0.5041.00
15_Q18_A0.5031.00
38_E73_V0.5021.00
95_L100_H0.5011.00
148_H151_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9917 100 0.135 Contact Map
2ra5A 2 0.5975 100 0.144 Contact Map
3f8mA 2 0.9336 100 0.158 Contact Map
3eetA 2 0.9336 100 0.191 Contact Map
3edpA 2 0.9087 100 0.194 Contact Map
3bwgA 2 0.9336 100 0.208 Contact Map
3f8lA 2 0.6639 99.9 0.447 Contact Map
1hw1A 2 0.8299 99.9 0.481 Contact Map
3sxyA 2 0.7676 99.9 0.489 Contact Map
4p96A 2 0.8838 99.9 0.492 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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