GREMLIN Database
PHNB - Protein PhnB
UniProt: P16681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10712
Length: 147 (126)
Sequences: 3606 (2399)
Seq/√Len: 213.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_I62_A3.1871.00
101_R105_N2.8361.00
14_S33_S2.8011.00
14_S18_A2.6551.00
100_K104_D2.3461.00
27_E65_R2.2991.00
29_L65_R2.1891.00
64_V73_M2.1751.00
31_K59_I2.1411.00
103_F126_G2.1031.00
100_K124_G2.0551.00
111_K129_T1.9941.00
93_S99_G1.9411.00
96_V100_K1.9371.00
17_I73_M1.9301.00
36_E56_D1.9051.00
18_A21_Q1.9011.00
12_N15_D1.8741.00
99_G138_I1.8191.00
85_S129_T1.8161.00
6_Y74_S1.7871.00
96_V124_G1.7781.00
63_N70_D1.7121.00
99_G116_W1.7091.00
94_Q141_V1.6991.00
95_Q98_E1.6691.00
98_E101_R1.6161.00
21_Q28_L1.6071.00
55_P58_A1.5411.00
8_S76_A1.5341.00
35_G56_D1.4621.00
65_R70_D1.4331.00
109_N131_K1.4281.00
10_A78_P1.3991.00
116_W124_G1.3981.00
110_G128_V1.3931.00
25_G67_A1.3611.00
93_S102_W1.3561.00
35_G57_T1.3421.00
14_S31_K1.3351.00
107_A112_I1.3251.00
24_L91_L1.2451.00
13_C73_M1.2451.00
64_V71_I1.2381.00
71_I89_L1.2111.00
61_H72_M1.2081.00
118_E123_H1.1671.00
103_F112_I1.1631.00
116_W140_V1.1451.00
65_R68_G1.1221.00
113_E127_K1.1051.00
113_E129_T1.1051.00
92_D139_N1.0901.00
15_D131_K1.0781.00
23_T105_N1.0661.00
19_Y23_T1.0571.00
92_D141_V1.0561.00
91_L138_I1.0471.00
67_A98_E1.0401.00
30_Y63_N1.0381.00
12_N132_F1.0361.00
62_A73_M1.0291.00
29_L63_N1.0221.00
22_R105_N1.0201.00
106_L128_V1.0171.00
97_E100_K1.0061.00
21_Q26_A1.0061.00
66_I69_S1.0011.00
129_T135_P0.9891.00
96_V123_H0.9881.00
21_Q27_E0.9841.00
9_F16_A0.9811.00
96_V140_V0.9721.00
91_L102_W0.9551.00
31_K62_A0.9471.00
33_S59_I0.9431.00
10_A58_A0.9370.99
6_Y90_V0.9310.99
121_W139_N0.9080.99
72_M90_V0.9000.99
83_S134_V0.8970.99
82_A85_S0.8860.99
5_P89_L0.8750.99
37_M41_A0.8690.99
81_K85_S0.8610.99
28_L62_A0.8500.99
5_P69_S0.8500.99
38_P41_A0.8390.99
104_D107_A0.8250.99
98_E102_W0.8180.99
11_G75_D0.8170.99
102_W138_I0.8170.99
61_H75_D0.8140.99
127_K137_M0.8130.99
5_P87_F0.8000.98
55_P78_P0.7910.98
15_D18_A0.7860.98
37_M40_S0.7860.98
114_M117_Q0.7830.98
32_I61_H0.7800.98
38_P60_A0.7800.98
116_W126_G0.7780.98
113_E135_P0.7730.98
119_T122_A0.7700.98
3_L24_L0.7670.98
19_Y131_K0.7670.98
107_A122_A0.7610.98
85_S135_P0.7600.98
99_G140_V0.7540.98
103_F115_A0.7460.97
84_Y87_F0.7440.97
103_F107_A0.7360.97
117_Q121_W0.7360.97
128_V138_I0.7330.97
17_I64_V0.7200.97
34_F60_A0.7190.97
6_Y60_A0.7150.97
100_K116_W0.7130.97
7_L20_Y0.7120.97
10_A82_A0.7120.97
4_S92_D0.7100.97
6_Y61_H0.7080.96
33_S36_E0.7050.96
18_A31_K0.7040.96
126_G138_I0.6990.96
88_T137_M0.6920.96
103_F110_G0.6910.96
8_S88_T0.6890.96
107_A128_V0.6850.96
103_F138_I0.6840.96
88_T113_E0.6830.96
118_E124_G0.6810.96
108_A131_K0.6800.96
6_Y72_M0.6700.95
78_P81_K0.6650.95
29_L70_D0.6600.95
125_F137_M0.6490.94
38_P120_F0.6490.94
96_V118_E0.6470.94
3_L89_L0.6460.94
114_M125_F0.6450.94
111_K121_W0.6440.94
19_Y132_F0.6290.93
37_M60_A0.6270.93
3_L71_I0.6150.93
118_E122_A0.6070.92
104_D108_A0.6050.92
114_M119_T0.5970.91
55_P79_S0.5930.91
41_A56_D0.5890.91
10_A79_S0.5870.91
19_Y105_N0.5860.91
4_S70_D0.5840.91
90_V139_N0.5730.90
9_F73_M0.5720.90
24_L67_A0.5700.89
12_N16_A0.5690.89
6_Y76_A0.5670.89
37_M56_D0.5630.89
10_A81_K0.5530.88
103_F128_V0.5510.88
61_H74_S0.5510.88
7_L83_S0.5510.88
60_A120_F0.5510.88
40_S56_D0.5480.88
4_S72_M0.5460.87
34_F74_S0.5430.87
106_L132_F0.5420.87
127_K135_P0.5410.87
62_A75_D0.5390.87
15_D132_F0.5390.87
88_T135_P0.5310.86
123_H141_V0.5290.86
18_A22_R0.5270.85
105_N108_A0.5260.85
18_A28_L0.5260.85
95_Q140_V0.5260.85
10_A76_A0.5230.85
5_P71_I0.5160.84
27_E131_K0.5160.84
17_I28_L0.5150.84
34_F76_A0.5140.84
110_G123_H0.5130.84
60_A75_D0.5060.83
114_M120_F0.5050.83
83_S86_G0.5050.83
8_S77_M0.5050.83
21_Q66_I0.5040.83
24_L87_F0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u69A 4 0.8367 100 0.405 Contact Map
1tsjA 2 0.7687 99.9 0.544 Contact Map
1u6lA 2 0.8912 99.8 0.568 Contact Map
3l20A 2 0.9524 99.8 0.591 Contact Map
1u7iA 2 0.8707 99.8 0.594 Contact Map
3omsA 2 0.8639 99.7 0.609 Contact Map
1xy7A 2 0.7619 99.4 0.689 Contact Map
2zw5A 2 0.7891 99.4 0.691 Contact Map
3itwA 4 0.7959 99.1 0.731 Contact Map
2a4xA 2 0.8163 98.9 0.751 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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