GREMLIN Database
PHNK - Putative phosphonates utilization ATP-binding protein PhnK
UniProt: P16678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10720
Length: 252 (221)
Sequences: 211506 (124199)
Seq/√Len: 8354.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E215_R3.2921.00
35_G213_A3.1441.00
7_S27_D2.9111.00
19_K22_S2.9091.00
61_E68_S2.8691.00
10_N23_D2.8221.00
138_R141_D2.8011.00
34_L217_L2.8001.00
9_N61_E2.7551.00
84_E165_K2.7331.00
215_R227_S2.6471.00
29_W32_E2.4981.00
7_S63_H2.3791.00
14_L19_K2.3311.00
22_S223_Q2.3021.00
9_N63_H2.1371.00
12_T23_D2.1231.00
12_T19_K2.1221.00
12_T59_Q2.0751.00
229_L232_R2.0441.00
8_V11_L2.0301.00
217_L227_S2.0271.00
228_G232_R2.0121.00
100_V104_G1.9961.00
13_H50_S1.9941.00
65_E165_K1.9841.00
130_E135_P1.8401.00
217_L224_V1.8101.00
126_Q139_I1.8031.00
117_H120_D1.7831.00
163_H197_L1.7821.00
48_L202_V1.7641.00
48_L168_F1.7281.00
190_G194_E1.7201.00
124_T163_H1.6921.00
30_P165_K1.6731.00
129_L139_I1.6601.00
131_E195_L1.6131.00
127_K131_E1.5911.00
15_Y20_G1.5911.00
189_R211_L1.5891.00
126_Q130_E1.5841.00
103_G107_G1.5831.00
103_G140_D1.5471.00
141_D145_T1.4711.00
102_A146_F1.4601.00
10_N25_S1.4471.00
124_T127_K1.4461.00
103_G139_I1.4351.00
32_E214_D1.4351.00
14_L58_Q1.4301.00
13_H55_L1.4291.00
13_H58_Q1.4251.00
49_K55_L1.4171.00
26_F217_L1.4131.00
28_L34_L1.4101.00
5_L65_E1.3831.00
63_H68_S1.3341.00
107_G121_I1.3181.00
12_T22_S1.3171.00
122_R126_Q1.2921.00
203_T209_A1.2851.00
131_E190_G1.2591.00
220_K225_V1.2571.00
47_L219_M1.2501.00
105_N158_R1.2471.00
15_Y46_T1.2431.00
29_W215_R1.2281.00
165_K197_L1.2181.00
8_V26_F1.2171.00
68_S71_A1.2051.00
65_E84_E1.2031.00
8_V51_I1.2011.00
192_V199_V1.1971.00
33_V201_I1.1901.00
101_S104_G1.1871.00
33_V192_V1.1841.00
191_L197_L1.1761.00
11_L57_P1.1741.00
34_L215_R1.1691.00
228_G233_V1.1671.00
103_G122_R1.1601.00
192_V214_D1.1591.00
50_S57_P1.1571.00
34_L227_S1.1531.00
21_F50_S1.1511.00
123_A127_K1.1461.00
226_E237_P1.1451.00
33_V213_A1.1421.00
52_S87_V1.1421.00
9_N27_D1.1331.00
210_R231_D1.1301.00
53_A56_T1.1141.00
163_H195_L1.0991.00
226_E236_D1.0981.00
35_G209_A1.0971.00
103_G125_A1.0961.00
182_A186_D1.0911.00
169_M188_L1.0881.00
117_H121_I1.0811.00
176_L184_L1.0811.00
185_L208_V1.0681.00
33_V199_V1.0521.00
110_L161_V1.0481.00
187_L190_G1.0481.00
181_Q205_D1.0261.00
127_K130_E1.0261.00
24_V47_L1.0201.00
181_Q208_V1.0191.00
128_W161_V1.0181.00
167_V197_L1.0181.00
26_F47_L1.0151.00
132_V157_A1.0031.00
30_P65_E1.0011.00
5_L30_P0.9921.00
128_W157_A0.9921.00
120_D123_A0.9921.00
171_E204_H0.9881.00
36_I47_L0.9721.00
14_L20_G0.9681.00
9_N25_S0.9641.00
232_R236_D0.9611.00
106_I161_V0.9611.00
86_G164_P0.9591.00
131_E194_E0.9591.00
104_G107_G0.9591.00
103_G126_Q0.9581.00
189_R192_V0.9571.00
118_Y122_R0.9501.00
107_G125_A0.9491.00
52_S168_F0.9341.00
116_R121_I0.9331.00
8_V62_I0.9321.00
5_L29_W0.9321.00
119_G123_A0.9291.00
125_A128_W0.9291.00
36_I217_L0.9231.00
124_T128_W0.9181.00
5_L27_D0.9141.00
118_Y121_I0.9121.00
8_V47_L0.9111.00
39_E220_K0.9071.00
169_M199_V0.9051.00
216_L230_T0.9021.00
28_L198_A0.8891.00
185_L211_L0.8851.00
142_L145_T0.8851.00
51_I200_V0.8841.00
120_D124_T0.8841.00
167_V199_V0.8761.00
33_V189_R0.8751.00
10_N59_Q0.8741.00
113_T162_T0.8721.00
183_R186_D0.8701.00
11_L50_S0.8691.00
86_G159_N0.8691.00
80_L83_T0.8631.00
117_H126_Q0.8631.00
28_L200_V0.8591.00
186_D189_R0.8581.00
73_S80_L0.8571.00
13_H46_T0.8491.00
88_V169_M0.8481.00
146_F154_L0.8421.00
88_V156_I0.8401.00
23_D223_Q0.8351.00
67_R84_E0.8351.00
102_A154_L0.8281.00
133_E183_R0.8231.00
226_E233_V0.8191.00
186_D190_G0.8191.00
110_L113_T0.8181.00
138_R146_F0.8161.00
231_D235_D0.8141.00
107_G122_R0.8081.00
101_S142_L0.8071.00
21_F24_V0.8021.00
116_R120_D0.8001.00
190_G195_L0.7971.00
90_Q148_G0.7941.00
110_L121_I0.7931.00
34_L200_V0.7921.00
135_P139_I0.7881.00
96_L151_Q0.7881.00
67_R72_M0.7821.00
57_P70_Y0.7821.00
138_R150_M0.7791.00
224_V227_S0.7661.00
97_R108_E0.7631.00
37_V209_A0.7621.00
50_S62_I0.7601.00
50_S55_L0.7591.00
36_I200_V0.7591.00
121_I126_Q0.7581.00
80_L84_E0.7551.00
79_R83_T0.7501.00
101_S140_D0.7481.00
152_Q175_G0.7461.00
37_V218_V0.7461.00
56_T70_Y0.7441.00
134_I137_N0.7421.00
96_L105_N0.7391.00
42_S219_M0.7391.00
99_Q144_T0.7371.00
88_V159_N0.7271.00
128_W132_V0.7201.00
6_L64_Y0.7051.00
143_P154_L0.7051.00
232_R235_D0.7041.00
40_S180_V0.7001.00
111_M121_I0.6971.00
173_T184_L0.6961.00
6_L166_L0.6951.00
182_A211_L0.6911.00
37_V206_L0.6911.00
96_L143_P0.6901.00
32_E227_S0.6901.00
63_H66_N0.6891.00
230_T234_L0.6861.00
106_I129_L0.6861.00
30_P196_N0.6831.00
15_Y55_L0.6821.00
166_L198_A0.6821.00
61_E70_Y0.6821.00
6_L51_I0.6821.00
114_G117_H0.6741.00
23_D59_Q0.6701.00
180_V183_R0.6691.00
101_S105_N0.6631.00
134_I138_R0.6601.00
188_L199_V0.6581.00
148_G153_R0.6581.00
137_N141_D0.6581.00
107_G111_M0.6551.00
121_I125_A0.6531.00
14_L59_Q0.6521.00
30_P198_A0.6501.00
29_W198_A0.6481.00
127_K163_H0.6471.00
27_D227_S0.6471.00
126_Q135_P0.6471.00
67_R80_L0.6431.00
14_L18_G0.6401.00
40_S204_H0.6391.00
122_R125_A0.6381.00
168_F200_V0.6371.00
186_D211_L0.6341.00
147_S150_M0.6321.00
203_T208_V0.6321.00
68_S72_M0.6311.00
210_R234_L0.6311.00
100_V108_E0.6301.00
21_F47_L0.6291.00
213_A230_T0.6281.00
128_W131_E0.6271.00
226_E232_R0.6251.00
177_D180_V0.6221.00
24_V224_V0.6201.00
201_I213_A0.6201.00
44_K171_E0.6191.00
146_F150_M0.6171.00
19_K23_D0.6121.00
105_N143_P0.6121.00
14_L22_S0.6091.00
10_N13_H0.6081.00
100_V105_N0.6051.00
72_M80_L0.6051.00
14_L17_P0.6031.00
210_R230_T0.5971.00
91_H151_Q0.5901.00
45_T170_D0.5881.00
209_A213_A0.5851.00
5_L64_Y0.5831.00
5_L198_A0.5831.00
218_V233_V0.5821.00
128_W160_L0.5771.00
44_K170_D0.5761.00
205_D208_V0.5751.00
85_W166_L0.5751.00
86_G162_T0.5741.00
19_K59_Q0.5731.00
50_S58_Q0.5721.00
110_L162_T0.5721.00
55_L58_Q0.5711.00
106_I120_D0.5711.00
45_T49_K0.5711.00
132_V187_L0.5691.00
7_S66_N0.5691.00
49_K54_R0.5651.00
120_D126_Q0.5601.00
81_L85_W0.5601.00
97_R100_V0.5591.00
5_L166_L0.5581.00
51_I62_I0.5571.00
26_F34_L0.5551.00
153_R183_R0.5511.00
44_K204_H0.5511.00
110_L114_G0.5481.00
123_A126_Q0.5471.00
40_S171_E0.5471.00
215_R229_L0.5461.00
51_I168_F0.5401.00
64_Y166_L0.5401.00
103_G106_I0.5401.00
97_R105_N0.5361.00
36_I202_V0.5361.00
230_T233_V0.5361.00
40_S153_R0.5351.00
192_V197_L0.5341.00
120_D129_L0.5341.00
105_N108_E0.5331.00
13_H16_A0.5331.00
220_K223_Q0.5321.00
209_A230_T0.5321.00
33_V214_D0.5271.00
65_E166_L0.5261.00
181_Q185_L0.5251.00
173_T208_V0.5241.00
191_L195_L0.5221.00
106_I157_A0.5211.00
159_N167_V0.5191.00
192_V195_L0.5111.00
156_I184_L0.5101.00
13_H20_G0.5101.00
153_R180_V0.5081.00
98_R151_Q0.5071.00
13_H21_F0.5061.00
129_L135_P0.5061.00
116_R124_T0.5061.00
22_S221_Q0.5041.00
62_I69_L0.5011.00
179_S183_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9683 100 0.059 Contact Map
1g291 4 0.9762 100 0.066 Contact Map
2it1A 1 0.9524 100 0.071 Contact Map
2yyzA 1 0.9484 100 0.071 Contact Map
1v43A 2 0.9206 100 0.072 Contact Map
3rlfA 2 0.9484 100 0.079 Contact Map
1oxxK 1 0.9722 100 0.081 Contact Map
4mkiB 2 0.9802 100 0.083 Contact Map
4huqB 1 0.9603 100 0.084 Contact Map
3fvqA 2 0.9683 100 0.084 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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