CYSA - ECOLI - GREMLIN Contacts

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CYSA - Sulfate/thiosulfate import ATP-binding protein CysA

UniProt:	P16676	Sequences: MSIEIANIKKSFGRTQVLNDISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQTSGHIRFHGTDVSRLHARDRKVGFVFQHYALFRHMTVFDNIAFGLTVLPRRERPNAAAIKAKVTKLLEMVQLAHLADRYPAQLSGGQKQRVALARALAVEPQILLLDEPFGALDAQVRKELRRWLRQLHEELKFTSVFVTHDQEEATEVADRVVVMSQGNIEQADAPDQVWREPATRFVLEFMGEVNRLQGTIRGGQFHVGAHRWPLGYTPAYQGPVDLFLRPWEVDISRRTSLDSPLPVQVLEASPKGHYTQLVVQPLGWYNEPLTVVMHGDDAPQRGERLFVGLQHARLYNGDERIETRDEELALAQSA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10183
Length:	365 (306)
Sequences:	23307 (16031)
Seq/√Len:	916.4

ECOLI - CYSA FBPC MALK YCJV UGPC POTA POTG PROV YDCT METN MODC DPPF SAPD DPPD YEHX OPPD RBSA DDPD OPPF YHES YADG ARAG GSIA DDPF UUP MACB FEPC MLAF MDLB CYDC YTFR MSBA TAUB MDLA HISP NIKE FECE SAPF YECC ETTA CYDD FHUC SSUB YOJI GLNQ YHDZ LSRA LPTB PHNC ARTP GLTL YPHE THIQ ZNUC LIVG SUFC PHNK MODF ALSA XYLG PSTB LIVF FTSE LOLD NIKD BTUD MGLA YEJF FETA YBBA YDDA CCMA PHNL YNJD YBHF YBIT YHIH
BACSU - MSMX YURJ OPUAA OPUCA OPUBA YVRA OPPD METN TAGH YKFD DPPD APPD APPF YHCH YFIL YDBJ YKPA RBSA YXLF YCBN YHAQ YVFR OPPF YDIF YFMM YFMR YTRB YHEH YUSV SUNT YFIC YFIB ECFA1 YGAD FHUC BMRA YKNV YFMF TCYN YHEI YLMA YKNU YWJA CYDD YCLP ECSA YTLC ECFA2 SKFE SUFC CYDC BCEA YXDL SSUB GLNQ YXEO TCYC YVCR NATA ARTM FTSE YKOD PSTB1 MNTB ALBC YJKB EXPZ PSTB2 YHCG YVRO YTHP YKNY YYBJ ZNUC YUFO YCLH YYDI YTRE
HALSA - Q9HHQ5 Q9HR06 Q9HNZ9 BTUDA Q9HMX3 Q9HMW0 Q9HMT3 Q9HMX2 Q9HRJ6 Q9HMU8 Q9HMG1 Q9HRH8 PSTB2 Q9HSQ7 PHNC Q9HHM2 Q9HNY3 Q9HMG6 Q9HRZ9 Q9HRV7 Y2317 Y1631 PSTB1 Q9HHR7 Q9HR96 Q9HS04 Q9HQA8 Q9HT03 Q9HR21 Q9HMC1 Q9HMW1
SULSO - Q97UF2 Q97YY4 Q97UY8 Q97ZC0 Q97VC1 Q7LX64 Q97YP3 Q97VF5 Q97UH3 Q97YP7 Q97VK8 Q97VH6 Q97VF4 Q97VK9 Q97YK2 Q97X18 Q97YQ7 Q97UJ9 Q97UD4 Q97YP8 Q97Z03 Q980W0 Q97U54 Q97UH4 Y1893 Q97W42 PSTB Q7LY07 Y2030 Q97V00 Q97V01 Q7LXM4 Q97VM2 Q97VY4 Q7LX80 Q97Z56 Q97UG5 Q97Z96 Q97YP4 Q97UC2 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_D	223_Q	3.789	1.00
32_A	204_A	3.760	1.00
58_H	65_D	3.607	1.00
29_Q	206_R	3.482	1.00
7_N	20_D	3.413	1.00
4_E	24_D	3.322	1.00
6_A	58_H	3.233	1.00
122_E	127_A	3.219	1.00
294_V	310_V	3.144	1.00
16_Q	19_N	2.989	1.00
114_K	118_T	2.631	1.00
297_L	311_Q	2.610	1.00
216_E	230_T	2.558	1.00
129_L	132_R	2.479	1.00
220_A	223_Q	2.464	1.00
109_N	112_A	2.447	1.00
31_V	208_V	2.439	1.00
19_N	214_N	2.424	1.00
116_K	154_E	2.402	1.00
4_E	60_R	2.372	1.00
6_A	60_R	2.344	1.00
26_P	29_Q	2.335	1.00
5_I	8_I	2.319	1.00
9_K	16_Q	2.283	1.00
11_S	16_Q	2.282	1.00
92_F	96_A	2.280	1.00
9_K	56_S	2.248	1.00
92_F	131_D	2.195	1.00
10_K	47_I	2.168	1.00
75_K	156_Q	2.136	1.00
9_K	20_D	2.103	1.00
7_N	22_S	2.069	1.00
181_Q	185_E	2.032	1.00
121_L	130_A	1.991	1.00
47_I	54_Q	1.985	1.00
92_F	118_T	1.984	1.00
92_F	114_K	1.980	1.00
125_Q	174_E	1.962	1.00
231_R	272_D	1.949	1.00
8_I	54_Q	1.939	1.00
62_H	156_Q	1.891	1.00
3_I	157_I	1.871	1.00
60_R	65_D	1.861	1.00
208_V	215_I	1.859	1.00
208_V	218_A	1.829	1.00
201_T	222_D	1.814	1.00
211_S	216_E	1.811	1.00
10_K	55_T	1.794	1.00
96_A	117_V	1.761	1.00
18_L	47_I	1.757	1.00
116_K	119_K	1.754	1.00
45_L	193_V	1.714	1.00
115_A	119_K	1.647	1.00
111_A	115_A	1.642	1.00
112_A	115_A	1.626	1.00
10_K	52_E	1.602	1.00
92_F	117_V	1.586	1.00
48_I	191_V	1.573	1.00
120_L	152_A	1.564	1.00
252_F	256_A	1.551	1.00
64_T	156_Q	1.550	1.00
65_D	68_R	1.543	1.00
311_Q	314_G	1.533	1.00
47_I	59_I	1.520	1.00
11_S	55_T	1.486	1.00
108_P	112_A	1.466	1.00
64_T	69_L	1.455	1.00
160_L	190_S	1.455	1.00
231_R	242_R	1.451	1.00
257_H	260_P	1.445	1.00
46_R	52_E	1.431	1.00
242_R	272_D	1.426	1.00
124_V	148_A	1.420	1.00
21_I	44_L	1.413	1.00
31_V	218_A	1.407	1.00
295_Q	311_Q	1.406	1.00
61_F	66_V	1.404	1.00
246_T	270_P	1.402	1.00
66_V	69_L	1.379	1.00
5_I	23_L	1.369	1.00
231_R	235_E	1.361	1.00
118_T	122_E	1.360	1.00
90_T	93_D	1.346	1.00
9_K	19_N	1.345	1.00
118_T	130_A	1.340	1.00
5_I	48_I	1.335	1.00
45_L	159_L	1.332	1.00
240_V	274_F	1.314	1.00
222_D	226_R	1.312	1.00
96_A	113_I	1.291	1.00
23_L	208_V	1.291	1.00
90_T	133_Y	1.290	1.00
252_F	255_G	1.284	1.00
112_A	116_K	1.282	1.00
5_I	44_L	1.281	1.00
54_Q	59_I	1.279	1.00
235_E	242_R	1.271	1.00
119_K	122_E	1.257	1.00
256_A	259_W	1.252	1.00
25_I	31_V	1.251	1.00
93_D	96_A	1.246	1.00
113_I	117_V	1.241	1.00
223_Q	227_E	1.241	1.00
31_V	206_R	1.227	1.00
266_A	269_G	1.217	1.00
299_A	308_L	1.203	1.00
18_L	44_L	1.193	1.00
89_M	97_F	1.188	1.00
254_V	257_H	1.188	1.00
265_P	269_G	1.186	1.00
253_H	256_A	1.181	1.00
108_P	113_I	1.174	1.00
58_H	67_S	1.173	1.00
119_K	154_E	1.167	1.00
93_D	100_T	1.163	1.00
6_A	22_S	1.162	1.00
11_S	14_R	1.158	1.00
183_H	190_S	1.151	1.00
77_G	150_A	1.144	1.00
180_R	203_V	1.128	1.00
98_G	153_V	1.119	1.00
206_R	218_A	1.114	1.00
258_R	261_L	1.108	1.00
26_P	206_R	1.105	1.00
88_H	135_A	1.102	1.00
183_H	188_F	1.101	1.00
18_L	21_I	1.095	1.00
91_V	137_L	1.094	1.00
257_H	261_L	1.076	1.00
245_G	271_V	1.067	1.00
256_A	260_P	1.065	1.00
27_S	62_H	1.065	1.00
54_Q	67_S	1.057	1.00
240_V	243_L	1.051	1.00
253_H	257_H	1.048	1.00
164_F	179_L	1.044	1.00
119_K	123_M	1.042	1.00
209_V	224_V	1.039	1.00
244_Q	272_D	1.038	1.00
256_A	261_L	1.035	1.00
255_G	259_W	1.020	1.00
60_R	63_G	1.017	1.00
252_F	257_H	1.017	1.00
100_T	110_A	1.015	1.00
11_S	17_V	1.014	1.00
11_S	56_S	1.001	1.00
209_V	233_V	0.999	1.00
221_P	225_W	0.996	1.00
39_S	210_M	0.991	1.00
255_G	258_R	0.987	1.00
44_L	210_M	0.986	1.00
244_Q	270_P	0.983	1.00
180_R	184_E	0.978	1.00
102_L	153_V	0.975	1.00
123_M	185_E	0.974	1.00
92_F	130_A	0.973	1.00
12_F	17_V	0.972	1.00
110_A	114_K	0.971	1.00
302_K	307_Q	0.969	1.00
69_L	73_D	0.967	1.00
118_T	127_A	0.963	1.00
30_M	190_S	0.963	1.00
32_A	200_A	0.950	1.00
89_M	93_D	0.950	1.00
49_A	159_L	0.948	1.00
7_N	56_S	0.948	1.00
4_E	63_G	0.948	1.00
275_L	280_V	0.947	1.00
8_I	47_I	0.942	1.00
77_G	155_P	0.939	1.00
97_F	101_V	0.936	1.00
211_S	232_F	0.935	1.00
110_A	113_I	0.929	1.00
219_D	224_V	0.925	1.00
132_R	136_Q	0.924	1.00
30_M	183_H	0.923	1.00
119_K	185_E	0.923	1.00
252_F	260_P	0.919	1.00
86_F	98_G	0.917	1.00
253_H	258_R	0.915	1.00
194_T	200_A	0.910	1.00
133_Y	136_Q	0.910	1.00
299_A	302_K	0.907	1.00
25_I	189_T	0.906	1.00
120_L	151_L	0.904	1.00
252_F	259_W	0.903	1.00
28_G	189_T	0.903	1.00
95_I	148_A	0.903	1.00
46_R	51_L	0.902	1.00
94_N	149_R	0.900	1.00
70_H	73_D	0.896	1.00
215_I	218_A	0.892	1.00
29_Q	205_D	0.890	1.00
27_S	156_Q	0.888	1.00
255_G	260_P	0.882	1.00
225_W	228_P	0.880	1.00
95_I	121_L	0.880	1.00
85_L	134_P	0.877	1.00
173_K	177_R	0.876	1.00
154_E	185_E	0.874	1.00
83_Y	166_A	0.873	1.00
252_F	261_L	0.871	1.00
222_D	301_P	0.870	1.00
180_R	202_E	0.867	1.00
301_P	306_T	0.865	1.00
254_V	259_W	0.859	1.00
226_R	301_P	0.857	1.00
265_P	268_Q	0.854	1.00
175_L	178_W	0.853	1.00
182_L	188_F	0.850	1.00
61_F	76_V	0.848	1.00
23_L	218_A	0.847	1.00
59_I	66_V	0.846	1.00
164_F	192_F	0.843	1.00
154_E	188_F	0.834	1.00
95_I	152_A	0.833	1.00
254_V	261_L	0.833	1.00
5_I	59_I	0.826	1.00
294_V	312_P	0.825	1.00
296_V	308_L	0.819	1.00
253_H	261_L	0.813	1.00
76_V	157_I	0.813	1.00
96_A	100_T	0.812	1.00
102_L	108_P	0.812	1.00
249_G	252_F	0.811	1.00
241_N	244_Q	0.807	1.00
30_M	203_V	0.802	1.00
86_F	89_M	0.801	1.00
28_G	187_K	0.793	1.00
192_F	204_A	0.790	1.00
178_W	181_Q	0.786	1.00
6_A	24_D	0.783	1.00
158_L	188_F	0.782	1.00
109_N	113_I	0.781	1.00
33_L	208_V	0.781	1.00
270_P	277_P	0.779	1.00
8_I	59_I	0.779	1.00
11_S	19_N	0.777	1.00
173_K	198_E	0.768	1.00
206_R	217_Q	0.765	1.00
33_L	44_L	0.759	1.00
277_P	284_R	0.758	1.00
211_S	214_N	0.756	1.00
94_N	134_P	0.754	1.00
170_Q	235_E	0.753	1.00
20_D	56_S	0.750	1.00
172_R	196_D	0.750	1.00
255_G	261_L	0.749	1.00
276_R	280_V	0.747	1.00
77_G	153_V	0.745	1.00
253_H	260_P	0.743	1.00
268_Q	271_V	0.743	1.00
90_T	131_D	0.741	1.00
283_S	286_T	0.740	1.00
298_E	301_P	0.739	1.00
276_R	284_R	0.733	1.00
221_P	224_V	0.732	1.00
42_T	46_R	0.729	1.00
47_I	55_T	0.725	1.00
225_W	278_W	0.723	1.00
270_P	274_F	0.722	1.00
234_L	238_G	0.722	1.00
162_E	195_H	0.720	1.00
36_P	39_S	0.718	1.00
156_Q	188_F	0.717	1.00
263_Y	266_A	0.716	1.00
34_L	209_V	0.712	1.00
241_N	245_G	0.711	1.00
198_E	202_E	0.709	1.00
121_L	126_L	0.708	1.00
296_V	299_A	0.707	1.00
273_L	277_P	0.704	1.00
103_P	109_N	0.702	1.00
277_P	281_D	0.702	1.00
264_T	267_Y	0.698	1.00
302_K	305_Y	0.694	1.00
247_I	271_V	0.690	1.00
39_S	44_L	0.690	1.00
19_N	212_Q	0.688	1.00
174_E	178_W	0.687	1.00
120_L	148_A	0.686	1.00
198_E	302_K	0.685	1.00
10_K	43_T	0.684	1.00
274_F	277_P	0.684	1.00
33_L	210_M	0.683	1.00
100_T	113_I	0.683	1.00
114_K	117_V	0.681	1.00
77_G	190_S	0.680	1.00
177_R	309_V	0.680	1.00
233_V	237_M	0.680	1.00
176_R	202_E	0.678	1.00
13_G	16_Q	0.677	1.00
30_M	192_F	0.675	1.00
155_P	158_L	0.670	1.00
125_Q	128_H	0.669	1.00
240_V	244_Q	0.669	1.00
49_A	78_F	0.669	1.00
250_G	255_G	0.668	1.00
95_I	98_G	0.667	1.00
47_I	52_E	0.666	1.00
134_P	145_V	0.665	1.00
75_K	153_V	0.665	1.00
69_L	72_R	0.665	1.00
253_H	259_W	0.663	1.00
262_G	265_P	0.661	1.00
147_L	160_L	0.659	1.00
12_F	52_E	0.659	1.00
159_L	191_V	0.655	1.00
306_T	309_V	0.653	1.00
177_R	298_E	0.652	1.00
81_Q	166_A	0.652	1.00
269_G	277_P	0.651	1.00
266_A	270_P	0.651	1.00
160_L	192_F	0.651	1.00
276_R	283_S	0.649	1.00
118_T	126_L	0.648	1.00
296_V	302_K	0.645	1.00
276_R	282_I	0.643	1.00
158_L	190_S	0.637	1.00
98_G	149_R	0.637	1.00
294_V	297_L	0.637	1.00
182_L	186_L	0.633	1.00
251_Q	258_R	0.633	1.00
108_P	116_K	0.633	1.00
177_R	181_Q	0.632	1.00
273_L	276_R	0.630	1.00
296_V	310_V	0.629	1.00
89_M	94_N	0.628	1.00
169_A	176_R	0.628	1.00
125_Q	178_W	0.625	1.00
121_L	127_A	0.625	1.00
250_G	256_A	0.623	1.00
169_A	173_K	0.623	1.00
204_A	207_V	0.623	1.00
200_A	204_A	0.622	1.00
92_F	95_I	0.618	1.00
75_K	102_L	0.617	1.00
116_K	120_L	0.616	1.00
236_F	239_E	0.616	1.00
21_I	215_I	0.615	1.00
128_H	141_Q	0.613	1.00
289_D	293_P	0.613	1.00
278_W	282_I	0.609	1.00
31_V	191_V	0.608	1.00
291_P	294_V	0.607	1.00
254_V	258_R	0.607	1.00
297_L	309_V	0.606	1.00
85_L	94_N	0.604	1.00
275_L	282_I	0.604	1.00
295_Q	298_E	0.604	1.00
120_L	123_M	0.604	1.00
222_D	306_T	0.600	1.00
277_P	280_V	0.600	1.00
299_A	306_T	0.597	1.00
235_E	239_E	0.597	1.00
210_M	215_I	0.596	1.00
251_Q	254_V	0.591	1.00
23_L	215_I	0.590	1.00
251_Q	255_G	0.586	1.00
296_V	303_G	0.585	1.00
111_A	114_K	0.584	1.00
262_G	266_A	0.583	1.00
27_S	187_K	0.581	1.00
277_P	283_S	0.580	1.00
193_V	197_Q	0.580	1.00
252_F	258_R	0.578	1.00
290_S	293_P	0.578	1.00
217_Q	233_V	0.577	1.00
3_I	61_F	0.577	1.00
302_K	306_T	0.576	1.00
90_T	94_N	0.575	1.00
247_I	250_G	0.575	1.00
98_G	102_L	0.574	1.00
183_H	205_D	0.571	1.00
267_Y	270_P	0.570	1.00
283_S	290_S	0.569	1.00
282_I	286_T	0.568	1.00
277_P	282_I	0.568	1.00
91_V	145_V	0.568	1.00
127_A	130_A	0.567	1.00
275_L	279_E	0.567	1.00
181_Q	298_E	0.567	1.00
281_D	284_R	0.563	1.00
51_L	80_F	0.562	1.00
299_A	303_G	0.562	1.00
180_R	183_H	0.561	1.00
242_R	274_F	0.561	1.00
126_L	129_L	0.561	1.00
232_F	235_E	0.559	1.00
251_Q	256_A	0.559	1.00
225_W	229_A	0.559	1.00
10_K	17_V	0.558	1.00
270_P	273_L	0.555	1.00
249_G	267_Y	0.554	1.00
298_E	309_V	0.554	1.00
197_Q	236_F	0.553	1.00
79_V	150_A	0.553	1.00
53_H	68_R	0.552	1.00
128_H	131_D	0.552	1.00
271_V	275_L	0.552	1.00
173_K	239_E	0.552	1.00
296_V	301_P	0.551	1.00
165_G	169_A	0.549	1.00
99_L	152_A	0.547	1.00
95_I	124_V	0.546	1.00
258_R	262_G	0.546	1.00
222_D	225_W	0.545	1.00
157_I	189_T	0.544	1.00
9_K	18_L	0.541	1.00
172_R	199_E	0.541	1.00
60_R	67_S	0.540	1.00
301_P	304_H	0.540	1.00
269_G	273_L	0.539	1.00
224_V	228_P	0.538	1.00
193_V	196_D	0.537	1.00
87_R	135_A	0.537	1.00
179_L	190_S	0.536	1.00
26_P	31_V	0.536	1.00
223_Q	226_R	0.535	1.00
209_V	228_P	0.533	1.00
250_G	257_H	0.531	1.00
235_E	238_G	0.531	1.00
250_G	253_H	0.531	1.00
92_F	113_I	0.529	1.00
280_V	283_S	0.529	1.00
248_R	253_H	0.528	1.00
269_G	276_R	0.526	1.00
263_Y	267_Y	0.525	1.00
181_Q	297_L	0.524	1.00
29_Q	218_A	0.524	1.00
303_G	306_T	0.523	1.00
275_L	278_W	0.522	1.00
67_S	71_A	0.522	1.00
180_R	205_D	0.521	1.00
58_H	68_R	0.517	1.00
12_F	43_T	0.517	1.00
115_A	122_E	0.516	1.00
46_R	98_G	0.515	1.00
233_V	236_F	0.513	1.00
245_G	273_L	0.512	1.00
248_R	251_Q	0.512	1.00
182_L	190_S	0.511	1.00
65_D	69_L	0.511	1.00
270_P	284_R	0.510	1.00
281_D	285_R	0.508	1.00
219_D	229_A	0.507	1.00
16_Q	20_D	0.506	1.00
30_M	179_L	0.506	1.00
20_D	214_N	0.505	1.00
301_P	309_V	0.504	1.00
207_V	221_P	0.503	1.00
309_V	313_L	0.503	1.00
249_G	256_A	0.502	1.00
134_P	142_K	0.502	1.00
48_I	159_L	0.501	1.00
271_V	274_F	0.501	1.00
81_Q	139_G	0.500	1.00
166_A	171_V	0.500	1.00
248_R	258_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2it1A	1	0.9644	100	0.183	Contact Map
1v43A	2	0.9288	100	0.184	Contact Map
1oxxK	1	0.9315	100	0.186	Contact Map
1g291	4	0.9589	100	0.189	Contact Map
2yyzA	1	0.9562	100	0.193	Contact Map
3rlfA	2	0.9726	100	0.198	Contact Map
3fvqA	2	0.9397	100	0.201	Contact Map
1z47A	2	0.9315	100	0.203	Contact Map
3d31A	2	0.9315	100	0.208	Contact Map
4tquS	2	0.9589	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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