GREMLIN Database
CYSA - Sulfate/thiosulfate import ATP-binding protein CysA
UniProt: P16676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10183
Length: 365 (306)
Sequences: 23307 (16031)
Seq/√Len: 916.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_D223_Q3.7891.00
32_A204_A3.7601.00
58_H65_D3.6071.00
29_Q206_R3.4821.00
7_N20_D3.4131.00
4_E24_D3.3221.00
6_A58_H3.2331.00
122_E127_A3.2191.00
294_V310_V3.1441.00
16_Q19_N2.9891.00
114_K118_T2.6311.00
297_L311_Q2.6101.00
216_E230_T2.5581.00
129_L132_R2.4791.00
220_A223_Q2.4641.00
109_N112_A2.4471.00
31_V208_V2.4391.00
19_N214_N2.4241.00
116_K154_E2.4021.00
4_E60_R2.3721.00
6_A60_R2.3441.00
26_P29_Q2.3351.00
5_I8_I2.3191.00
9_K16_Q2.2831.00
11_S16_Q2.2821.00
92_F96_A2.2801.00
9_K56_S2.2481.00
92_F131_D2.1951.00
10_K47_I2.1681.00
75_K156_Q2.1361.00
9_K20_D2.1031.00
7_N22_S2.0691.00
181_Q185_E2.0321.00
121_L130_A1.9911.00
47_I54_Q1.9851.00
92_F118_T1.9841.00
92_F114_K1.9801.00
125_Q174_E1.9621.00
231_R272_D1.9491.00
8_I54_Q1.9391.00
62_H156_Q1.8911.00
3_I157_I1.8711.00
60_R65_D1.8611.00
208_V215_I1.8591.00
208_V218_A1.8291.00
201_T222_D1.8141.00
211_S216_E1.8111.00
10_K55_T1.7941.00
96_A117_V1.7611.00
18_L47_I1.7571.00
116_K119_K1.7541.00
45_L193_V1.7141.00
115_A119_K1.6471.00
111_A115_A1.6421.00
112_A115_A1.6261.00
10_K52_E1.6021.00
92_F117_V1.5861.00
48_I191_V1.5731.00
120_L152_A1.5641.00
252_F256_A1.5511.00
64_T156_Q1.5501.00
65_D68_R1.5431.00
311_Q314_G1.5331.00
47_I59_I1.5201.00
11_S55_T1.4861.00
108_P112_A1.4661.00
64_T69_L1.4551.00
160_L190_S1.4551.00
231_R242_R1.4511.00
257_H260_P1.4451.00
46_R52_E1.4311.00
242_R272_D1.4261.00
124_V148_A1.4201.00
21_I44_L1.4131.00
31_V218_A1.4071.00
295_Q311_Q1.4061.00
61_F66_V1.4041.00
246_T270_P1.4021.00
66_V69_L1.3791.00
5_I23_L1.3691.00
231_R235_E1.3611.00
118_T122_E1.3601.00
90_T93_D1.3461.00
9_K19_N1.3451.00
118_T130_A1.3401.00
5_I48_I1.3351.00
45_L159_L1.3321.00
240_V274_F1.3141.00
222_D226_R1.3121.00
96_A113_I1.2911.00
23_L208_V1.2911.00
90_T133_Y1.2901.00
252_F255_G1.2841.00
112_A116_K1.2821.00
5_I44_L1.2811.00
54_Q59_I1.2791.00
235_E242_R1.2711.00
119_K122_E1.2571.00
256_A259_W1.2521.00
25_I31_V1.2511.00
93_D96_A1.2461.00
113_I117_V1.2411.00
223_Q227_E1.2411.00
31_V206_R1.2271.00
266_A269_G1.2171.00
299_A308_L1.2031.00
18_L44_L1.1931.00
89_M97_F1.1881.00
254_V257_H1.1881.00
265_P269_G1.1861.00
253_H256_A1.1811.00
108_P113_I1.1741.00
58_H67_S1.1731.00
119_K154_E1.1671.00
93_D100_T1.1631.00
6_A22_S1.1621.00
11_S14_R1.1581.00
183_H190_S1.1511.00
77_G150_A1.1441.00
180_R203_V1.1281.00
98_G153_V1.1191.00
206_R218_A1.1141.00
258_R261_L1.1081.00
26_P206_R1.1051.00
88_H135_A1.1021.00
183_H188_F1.1011.00
18_L21_I1.0951.00
91_V137_L1.0941.00
257_H261_L1.0761.00
245_G271_V1.0671.00
256_A260_P1.0651.00
27_S62_H1.0651.00
54_Q67_S1.0571.00
240_V243_L1.0511.00
253_H257_H1.0481.00
164_F179_L1.0441.00
119_K123_M1.0421.00
209_V224_V1.0391.00
244_Q272_D1.0381.00
256_A261_L1.0351.00
255_G259_W1.0201.00
60_R63_G1.0171.00
252_F257_H1.0171.00
100_T110_A1.0151.00
11_S17_V1.0141.00
11_S56_S1.0011.00
209_V233_V0.9991.00
221_P225_W0.9961.00
39_S210_M0.9911.00
255_G258_R0.9871.00
44_L210_M0.9861.00
244_Q270_P0.9831.00
180_R184_E0.9781.00
102_L153_V0.9751.00
123_M185_E0.9741.00
92_F130_A0.9731.00
12_F17_V0.9721.00
110_A114_K0.9711.00
302_K307_Q0.9691.00
69_L73_D0.9671.00
118_T127_A0.9631.00
30_M190_S0.9631.00
32_A200_A0.9501.00
89_M93_D0.9501.00
49_A159_L0.9481.00
7_N56_S0.9481.00
4_E63_G0.9481.00
275_L280_V0.9471.00
8_I47_I0.9421.00
77_G155_P0.9391.00
97_F101_V0.9361.00
211_S232_F0.9351.00
110_A113_I0.9291.00
219_D224_V0.9251.00
132_R136_Q0.9241.00
30_M183_H0.9231.00
119_K185_E0.9231.00
252_F260_P0.9191.00
86_F98_G0.9171.00
253_H258_R0.9151.00
194_T200_A0.9101.00
133_Y136_Q0.9101.00
299_A302_K0.9071.00
25_I189_T0.9061.00
120_L151_L0.9041.00
252_F259_W0.9031.00
28_G189_T0.9031.00
95_I148_A0.9031.00
46_R51_L0.9021.00
94_N149_R0.9001.00
70_H73_D0.8961.00
215_I218_A0.8921.00
29_Q205_D0.8901.00
27_S156_Q0.8881.00
255_G260_P0.8821.00
225_W228_P0.8801.00
95_I121_L0.8801.00
85_L134_P0.8771.00
173_K177_R0.8761.00
154_E185_E0.8741.00
83_Y166_A0.8731.00
252_F261_L0.8711.00
222_D301_P0.8701.00
180_R202_E0.8671.00
301_P306_T0.8651.00
254_V259_W0.8591.00
226_R301_P0.8571.00
265_P268_Q0.8541.00
175_L178_W0.8531.00
182_L188_F0.8501.00
61_F76_V0.8481.00
23_L218_A0.8471.00
59_I66_V0.8461.00
164_F192_F0.8431.00
154_E188_F0.8341.00
95_I152_A0.8331.00
254_V261_L0.8331.00
5_I59_I0.8261.00
294_V312_P0.8251.00
296_V308_L0.8191.00
253_H261_L0.8131.00
76_V157_I0.8131.00
96_A100_T0.8121.00
102_L108_P0.8121.00
249_G252_F0.8111.00
241_N244_Q0.8071.00
30_M203_V0.8021.00
86_F89_M0.8011.00
28_G187_K0.7931.00
192_F204_A0.7901.00
178_W181_Q0.7861.00
6_A24_D0.7831.00
158_L188_F0.7821.00
109_N113_I0.7811.00
33_L208_V0.7811.00
270_P277_P0.7791.00
8_I59_I0.7791.00
11_S19_N0.7771.00
173_K198_E0.7681.00
206_R217_Q0.7651.00
33_L44_L0.7591.00
277_P284_R0.7581.00
211_S214_N0.7561.00
94_N134_P0.7541.00
170_Q235_E0.7531.00
20_D56_S0.7501.00
172_R196_D0.7501.00
255_G261_L0.7491.00
276_R280_V0.7471.00
77_G153_V0.7451.00
253_H260_P0.7431.00
268_Q271_V0.7431.00
90_T131_D0.7411.00
283_S286_T0.7401.00
298_E301_P0.7391.00
276_R284_R0.7331.00
221_P224_V0.7321.00
42_T46_R0.7291.00
47_I55_T0.7251.00
225_W278_W0.7231.00
270_P274_F0.7221.00
234_L238_G0.7221.00
162_E195_H0.7201.00
36_P39_S0.7181.00
156_Q188_F0.7171.00
263_Y266_A0.7161.00
34_L209_V0.7121.00
241_N245_G0.7111.00
198_E202_E0.7091.00
121_L126_L0.7081.00
296_V299_A0.7071.00
273_L277_P0.7041.00
103_P109_N0.7021.00
277_P281_D0.7021.00
264_T267_Y0.6981.00
302_K305_Y0.6941.00
247_I271_V0.6901.00
39_S44_L0.6901.00
19_N212_Q0.6881.00
174_E178_W0.6871.00
120_L148_A0.6861.00
198_E302_K0.6851.00
10_K43_T0.6841.00
274_F277_P0.6841.00
33_L210_M0.6831.00
100_T113_I0.6831.00
114_K117_V0.6811.00
77_G190_S0.6801.00
177_R309_V0.6801.00
233_V237_M0.6801.00
176_R202_E0.6781.00
13_G16_Q0.6771.00
30_M192_F0.6751.00
155_P158_L0.6701.00
125_Q128_H0.6691.00
240_V244_Q0.6691.00
49_A78_F0.6691.00
250_G255_G0.6681.00
95_I98_G0.6671.00
47_I52_E0.6661.00
134_P145_V0.6651.00
75_K153_V0.6651.00
69_L72_R0.6651.00
253_H259_W0.6631.00
262_G265_P0.6611.00
147_L160_L0.6591.00
12_F52_E0.6591.00
159_L191_V0.6551.00
306_T309_V0.6531.00
177_R298_E0.6521.00
81_Q166_A0.6521.00
269_G277_P0.6511.00
266_A270_P0.6511.00
160_L192_F0.6511.00
276_R283_S0.6491.00
118_T126_L0.6481.00
296_V302_K0.6451.00
276_R282_I0.6431.00
158_L190_S0.6371.00
98_G149_R0.6371.00
294_V297_L0.6371.00
182_L186_L0.6331.00
251_Q258_R0.6331.00
108_P116_K0.6331.00
177_R181_Q0.6321.00
273_L276_R0.6301.00
296_V310_V0.6291.00
89_M94_N0.6281.00
169_A176_R0.6281.00
125_Q178_W0.6251.00
121_L127_A0.6251.00
250_G256_A0.6231.00
169_A173_K0.6231.00
204_A207_V0.6231.00
200_A204_A0.6221.00
92_F95_I0.6181.00
75_K102_L0.6171.00
116_K120_L0.6161.00
236_F239_E0.6161.00
21_I215_I0.6151.00
128_H141_Q0.6131.00
289_D293_P0.6131.00
278_W282_I0.6091.00
31_V191_V0.6081.00
291_P294_V0.6071.00
254_V258_R0.6071.00
297_L309_V0.6061.00
85_L94_N0.6041.00
275_L282_I0.6041.00
295_Q298_E0.6041.00
120_L123_M0.6041.00
222_D306_T0.6001.00
277_P280_V0.6001.00
299_A306_T0.5971.00
235_E239_E0.5971.00
210_M215_I0.5961.00
251_Q254_V0.5911.00
23_L215_I0.5901.00
251_Q255_G0.5861.00
296_V303_G0.5851.00
111_A114_K0.5841.00
262_G266_A0.5831.00
27_S187_K0.5811.00
277_P283_S0.5801.00
193_V197_Q0.5801.00
252_F258_R0.5781.00
290_S293_P0.5781.00
217_Q233_V0.5771.00
3_I61_F0.5771.00
302_K306_T0.5761.00
90_T94_N0.5751.00
247_I250_G0.5751.00
98_G102_L0.5741.00
183_H205_D0.5711.00
267_Y270_P0.5701.00
283_S290_S0.5691.00
282_I286_T0.5681.00
277_P282_I0.5681.00
91_V145_V0.5681.00
127_A130_A0.5671.00
275_L279_E0.5671.00
181_Q298_E0.5671.00
281_D284_R0.5631.00
51_L80_F0.5621.00
299_A303_G0.5621.00
180_R183_H0.5611.00
242_R274_F0.5611.00
126_L129_L0.5611.00
232_F235_E0.5591.00
251_Q256_A0.5591.00
225_W229_A0.5591.00
10_K17_V0.5581.00
270_P273_L0.5551.00
249_G267_Y0.5541.00
298_E309_V0.5541.00
197_Q236_F0.5531.00
79_V150_A0.5531.00
53_H68_R0.5521.00
128_H131_D0.5521.00
271_V275_L0.5521.00
173_K239_E0.5521.00
296_V301_P0.5511.00
165_G169_A0.5491.00
99_L152_A0.5471.00
95_I124_V0.5461.00
258_R262_G0.5461.00
222_D225_W0.5451.00
157_I189_T0.5441.00
9_K18_L0.5411.00
172_R199_E0.5411.00
60_R67_S0.5401.00
301_P304_H0.5401.00
269_G273_L0.5391.00
224_V228_P0.5381.00
193_V196_D0.5371.00
87_R135_A0.5371.00
179_L190_S0.5361.00
26_P31_V0.5361.00
223_Q226_R0.5351.00
209_V228_P0.5331.00
250_G257_H0.5311.00
235_E238_G0.5311.00
250_G253_H0.5311.00
92_F113_I0.5291.00
280_V283_S0.5291.00
248_R253_H0.5281.00
269_G276_R0.5261.00
263_Y267_Y0.5251.00
181_Q297_L0.5241.00
29_Q218_A0.5241.00
303_G306_T0.5231.00
275_L278_W0.5221.00
67_S71_A0.5221.00
180_R205_D0.5211.00
58_H68_R0.5171.00
12_F43_T0.5171.00
115_A122_E0.5161.00
46_R98_G0.5151.00
233_V236_F0.5131.00
245_G273_L0.5121.00
248_R251_Q0.5121.00
182_L190_S0.5111.00
65_D69_L0.5111.00
270_P284_R0.5101.00
281_D285_R0.5081.00
219_D229_A0.5071.00
16_Q20_D0.5061.00
30_M179_L0.5061.00
20_D214_N0.5051.00
301_P309_V0.5041.00
207_V221_P0.5031.00
309_V313_L0.5031.00
249_G256_A0.5021.00
134_P142_K0.5021.00
48_I159_L0.5011.00
271_V274_F0.5011.00
81_Q139_G0.5001.00
166_A171_V0.5001.00
248_R258_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2it1A 1 0.9644 100 0.183 Contact Map
1v43A 2 0.9288 100 0.184 Contact Map
1oxxK 1 0.9315 100 0.186 Contact Map
1g291 4 0.9589 100 0.189 Contact Map
2yyzA 1 0.9562 100 0.193 Contact Map
3rlfA 2 0.9726 100 0.198 Contact Map
3fvqA 2 0.9397 100 0.201 Contact Map
1z47A 2 0.9315 100 0.203 Contact Map
3d31A 2 0.9315 100 0.208 Contact Map
4tquS 2 0.9589 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0132 seconds.