SYP - ECOLI - GREMLIN Contacts

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SYP - Proline--tRNA ligase

UniProt:	P16659	Sequences: MRTSQYLLSTLKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGVRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLIRNELSSYKQLPLNFYQIQTKFRDEVRPRFGVMRSREFLMKDAYSFHTSQESLQETYDAMYAAYSKIFSRMGLDFRAVQADTGSIGGSASHEFQVLAQSGEDDVVFSDTSDYAANIELAEAIAPKEPRAAATQEMTLVDTPNAKTIAELVEQFNLPIEKTVKTLLVKAVEGSSFPQVALLVRGDHELNEVKAEKLPQVASPLTFATEEEIRAVVKAGPGSLGPVNMPIPVVIDRTVAAMSDFAAGANIDGKHYFGINWDRDVATPEVADIRNVVAGDPSPDGQGRLLIKRGIEVGHIFQLGTKYSEALKASVQGEDGRNQILTMGCYGIGVTRVVAAAIEQNYDERGIVWPDAIAPFQVAILPMNMHKSFRVQELAEKLYSELRAQGIEVLLDDRKERPGVMFADMELIGIPHTIVLGDRNLDNDDIEYKYRRNGEKQLIKTGDIVEYLVKQIKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10770
Length:	572 (560)
Sequences:	2233 (1290)
Seq/√Len:	54.5

ECOLI - SYP
BACSU - SYP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
254_L	365_I	6.741	1.00
186_S	192_F	4.066	1.00
256_D	368_K	3.547	1.00
456_I	465_I	3.407	1.00
57_V	448_V	3.232	1.00
164_H	169_S	3.169	1.00
164_H	173_T	2.970	1.00
455_A	471_I	2.925	1.00
227_S	399_G	2.907	1.00
292_P	346_P	2.875	1.00
171_Q	416_Q	2.864	1.00
256_D	367_G	2.855	1.00
82_E	119_R	2.850	1.00
227_S	396_S	2.774	1.00
495_K	499_E	2.719	1.00
224_S	227_S	2.714	1.00
97_V	103_P	2.713	1.00
487_F	491_E	2.691	1.00
179_A	183_K	2.677	1.00
62_N	133_Y	2.663	1.00
77_A	81_Q	2.655	1.00
51_K	54_E	2.605	1.00
59_E	187_R	2.596	1.00
224_S	399_G	2.562	1.00
396_S	399_G	2.513	1.00
63_N	183_K	2.424	1.00
6_Y	67_I	2.366	1.00
419_T	423_E	2.352	1.00
543_D	556_L	2.318	1.00
253_T	371_F	2.310	1.00
390_V	403_L	2.296	1.00
463_R	521_A	2.292	1.00
14_T	24_Q	2.280	1.00
264_A	268_E	2.270	1.00
224_S	396_S	2.267	1.00
2_R	494_E	2.263	1.00
280_T	295_A	2.258	1.00
52_K	506_E	2.220	1.00
555_Q	565_Y	2.150	1.00
358_D	372_G	2.146	1.00
69_V	114_I	2.127	1.00
254_L	368_K	2.127	1.00
171_Q	175_D	2.122	1.00
337_S	367_G	2.114	1.00
175_D	179_A	2.082	1.00
475_Q	506_E	2.082	1.00
392_A	404_L	2.071	1.00
323_T	326_E	2.065	1.00
302_H	352_T	2.041	1.00
282_L	295_A	2.040	1.00
476_V	505_I	2.039	1.00
88_Q	420_K	2.028	1.00
169_S	173_T	2.025	1.00
361_A	373_I	2.023	1.00
296_L	387_I	2.020	1.00
297_L	349_I	2.004	1.00
530_H	546_Y	2.001	1.00
284_K	293_Q	1.997	1.00
66_A	131_N	1.993	1.00
260_A	266_L	1.989	1.00
491_E	495_K	1.983	1.00
26_M	31_M	1.966	1.00
516_P	520_F	1.960	1.00
26_M	149_V	1.945	1.00
6_Y	474_F	1.945	1.00
53_V	452_V	1.944	1.00
548_Y	551_N	1.902	1.00
69_V	117_L	1.885	0.99
295_A	343_M	1.878	0.99
478_I	509_L	1.874	0.99
488_R	540_D	1.871	0.99
165_T	429_V	1.856	0.99
169_S	172_E	1.842	0.99
334_G	366_D	1.836	0.99
172_E	176_A	1.827	0.99
160_A	177_M	1.811	0.99
492_L	539_L	1.808	0.99
478_I	496_L	1.806	0.99
48_R	506_E	1.801	0.99
272_L	360_A	1.793	0.99
278_V	359_F	1.780	0.99
122_L	130_L	1.777	0.99
370_Y	373_I	1.756	0.99
494_E	498_S	1.737	0.99
348_V	385_A	1.731	0.99
427_A	439_L	1.727	0.99
320_T	326_E	1.706	0.99
538_N	556_L	1.690	0.99
64_A	180_A	1.689	0.99
358_D	374_N	1.687	0.99
353_V	356_M	1.675	0.99
543_D	558_K	1.672	0.99
348_V	387_I	1.670	0.99
131_N	160_A	1.663	0.99
296_L	309_A	1.660	0.99
86_W	105_V	1.656	0.99
227_S	398_D	1.644	0.99
469_D	475_Q	1.634	0.99
428_S	436_N	1.632	0.98
92_E	95_R	1.631	0.98
285_A	319_L	1.629	0.98
365_I	368_K	1.624	0.98
170_L	416_Q	1.618	0.98
497_Y	501_R	1.616	0.98
222_V	403_L	1.613	0.98
107_G	110_H	1.608	0.98
178_Y	208_H	1.598	0.98
304_L	309_A	1.595	0.98
284_K	326_E	1.593	0.98
270_F	371_F	1.586	0.98
64_A	131_N	1.585	0.98
558_K	561_D	1.578	0.98
492_L	495_K	1.578	0.98
419_T	440_T	1.577	0.98
333_A	338_L	1.576	0.98
225_D	404_L	1.574	0.98
561_D	564_E	1.562	0.98
254_L	370_Y	1.560	0.98
260_A	269_Q	1.559	0.98
283_V	304_L	1.555	0.98
337_S	366_D	1.555	0.98
167_Q	440_T	1.547	0.98
166_S	169_S	1.546	0.98
270_F	360_A	1.540	0.98
480_P	509_L	1.536	0.98
327_I	335_P	1.535	0.98
396_S	400_Q	1.523	0.98
293_Q	330_V	1.518	0.98
250_Q	253_T	1.516	0.98
356_M	359_F	1.509	0.97
483_M	494_E	1.507	0.97
174_Y	208_H	1.495	0.97
50_L	449_T	1.494	0.97
49_V	452_V	1.493	0.97
477_A	523_M	1.488	0.97
565_Y	568_K	1.480	0.97
19_E	23_H	1.473	0.97
152_S	449_T	1.455	0.97
182_S	192_F	1.452	0.97
508_L	528_I	1.452	0.97
220_D	405_I	1.449	0.97
173_T	176_A	1.442	0.97
252_M	370_Y	1.421	0.96
429_V	437_Q	1.410	0.96
55_N	59_E	1.403	0.96
431_G	437_Q	1.402	0.96
97_V	101_E	1.400	0.96
73_V	106_L	1.400	0.96
284_K	320_T	1.378	0.96
12_K	518_V	1.377	0.96
114_I	132_F	1.376	0.96
74_V	96_F	1.375	0.96
253_T	372_G	1.368	0.95
247_A	276_K	1.367	0.95
71_M	114_I	1.365	0.95
561_D	565_Y	1.353	0.95
64_A	177_M	1.352	0.95
238_A	390_V	1.349	0.95
263_I	274_I	1.348	0.95
429_V	439_L	1.346	0.95
259_N	367_G	1.342	0.95
257_T	369_H	1.341	0.95
64_A	176_A	1.340	0.95
267_V	274_I	1.339	0.95
263_I	277_T	1.339	0.95
226_T	400_Q	1.335	0.95
178_Y	414_I	1.334	0.95
74_V	94_L	1.334	0.95
282_L	338_L	1.329	0.95
298_V	304_L	1.325	0.95
60_E	187_R	1.318	0.94
250_Q	372_G	1.314	0.94
505_I	567_V	1.306	0.94
308_K	386_D	1.302	0.94
265_E	268_E	1.301	0.94
469_D	530_H	1.300	0.94
281_L	304_L	1.290	0.94
207_S	413_H	1.278	0.93
283_V	306_E	1.273	0.93
546_Y	565_Y	1.266	0.93
428_S	438_I	1.261	0.93
359_F	375_W	1.258	0.93
227_S	400_Q	1.256	0.93
514_E	518_V	1.254	0.93
531_T	554_K	1.251	0.93
176_A	180_A	1.251	0.93
503_Q	567_V	1.242	0.92
42_W	46_G	1.241	0.92
349_I	381_T	1.236	0.92
297_L	353_V	1.233	0.92
433_D	437_Q	1.229	0.92
524_E	547_K	1.223	0.92
354_A	384_V	1.221	0.92
278_V	297_L	1.219	0.92
26_M	456_I	1.218	0.92
219_D	232_N	1.216	0.92
349_I	384_V	1.216	0.92
422_S	427_A	1.214	0.92
55_N	62_N	1.213	0.92
185_F	446_I	1.213	0.92
235_L	311_K	1.200	0.91
255_V	270_F	1.198	0.91
81_Q	103_P	1.195	0.91
118_I	132_F	1.195	0.91
21_I	460_Y	1.193	0.91
17_D	27_L	1.193	0.91
476_V	500_L	1.193	0.91
229_Y	403_L	1.192	0.91
57_V	449_T	1.189	0.91
33_R	121_E	1.179	0.90
297_L	347_V	1.178	0.90
223_F	406_K	1.169	0.90
223_F	404_L	1.166	0.90
280_T	297_L	1.162	0.90
267_V	277_T	1.162	0.90
530_H	548_Y	1.162	0.90
165_T	432_E	1.162	0.90
459_N	550_R	1.159	0.90
255_V	266_L	1.157	0.90
497_Y	509_L	1.155	0.89
58_R	68_E	1.155	0.89
63_N	501_R	1.154	0.89
82_E	425_L	1.146	0.89
336_G	369_H	1.146	0.89
81_Q	87_E	1.140	0.89
50_L	156_L	1.137	0.89
118_I	122_L	1.132	0.88
312_L	387_I	1.131	0.88
202_I	443_C	1.131	0.88
328_R	334_G	1.129	0.88
51_K	62_N	1.129	0.88
261_K	265_E	1.128	0.88
420_K	424_A	1.127	0.88
115_T	427_A	1.126	0.88
479_L	533_V	1.122	0.88
475_Q	505_I	1.119	0.88
224_S	400_Q	1.118	0.88
376_D	380_A	1.116	0.88
489_V	539_L	1.110	0.87
116_D	119_R	1.109	0.87
156_L	449_T	1.105	0.87
260_A	337_S	1.101	0.87
492_L	559_T	1.098	0.87
309_A	387_I	1.091	0.87
83_S	89_Y	1.090	0.87
324_E	328_R	1.089	0.86
564_E	568_K	1.086	0.86
52_K	55_N	1.085	0.86
285_A	313_P	1.084	0.86
333_A	366_D	1.080	0.86
256_D	365_I	1.080	0.86
480_P	490_Q	1.076	0.86
36_A	104_F	1.073	0.86
14_T	27_L	1.071	0.86
419_T	438_I	1.068	0.85
77_A	103_P	1.067	0.85
263_I	267_V	1.066	0.85
237_E	351_R	1.066	0.85
562_I	566_L	1.063	0.85
199_T	207_S	1.063	0.85
228_D	402_R	1.061	0.85
49_V	467_W	1.057	0.85
47_V	51_K	1.052	0.84
546_Y	562_I	1.051	0.84
59_E	63_N	1.048	0.84
430_Q	435_R	1.047	0.84
197_A	413_H	1.040	0.84
480_P	493_A	1.037	0.84
266_L	270_F	1.035	0.84
36_A	39_L	1.034	0.83
70_S	73_V	1.030	0.83
499_E	502_A	1.029	0.83
56_I	188_M	1.028	0.83
224_S	398_D	1.027	0.83
263_I	266_L	1.026	0.83
538_N	543_D	1.025	0.83
21_I	24_Q	1.024	0.83
164_H	170_L	1.022	0.83
182_S	186_S	1.021	0.83
538_N	541_N	1.020	0.83
483_M	490_Q	1.020	0.83
168_E	171_Q	1.020	0.83
42_W	50_L	1.014	0.82
31_M	149_V	1.010	0.82
78_D	81_Q	1.008	0.82
459_N	466_V	1.007	0.82
116_D	120_N	1.006	0.82
488_R	492_L	1.002	0.81
252_M	373_I	1.001	0.81
392_A	405_I	0.999	0.81
43_L	117_L	0.997	0.81
498_S	502_A	0.995	0.81
532_I	546_Y	0.990	0.81
537_R	540_D	0.988	0.81
222_V	405_I	0.987	0.80
199_T	208_H	0.987	0.80
363_A	368_K	0.984	0.80
74_V	106_L	0.983	0.80
341_V	370_Y	0.979	0.80
285_A	316_A	0.979	0.80
546_Y	557_I	0.979	0.80
225_D	402_R	0.976	0.80
178_Y	194_A	0.970	0.79
196_Q	235_L	0.970	0.79
178_Y	182_S	0.968	0.79
422_S	438_I	0.967	0.79
246_A	357_S	0.966	0.79
247_A	358_D	0.962	0.79
530_H	566_L	0.962	0.79
478_I	493_A	0.958	0.78
79_L	116_D	0.957	0.78
9_S	43_L	0.956	0.78
212_V	413_H	0.955	0.78
149_V	152_S	0.955	0.78
299_R	302_H	0.954	0.78
495_K	559_T	0.953	0.78
280_T	338_L	0.950	0.78
199_T	235_L	0.946	0.78
532_I	562_I	0.946	0.78
257_T	336_G	0.945	0.78
423_E	438_I	0.941	0.77
461_D	549_R	0.939	0.77
476_V	532_I	0.938	0.77
489_V	492_L	0.938	0.77
346_P	383_E	0.936	0.77
3_T	477_A	0.934	0.77
480_P	483_M	0.933	0.77
222_V	390_V	0.933	0.77
461_D	464_G	0.932	0.77
327_I	333_A	0.931	0.76
479_L	531_T	0.931	0.76
170_L	206_A	0.929	0.76
279_K	336_G	0.928	0.76
89_Y	93_L	0.926	0.76
89_Y	201_S	0.925	0.76
249_T	357_S	0.923	0.76
501_R	506_E	0.921	0.76
373_I	379_V	0.919	0.76
3_T	508_L	0.918	0.75
563_V	567_V	0.916	0.75
296_L	348_V	0.915	0.75
255_V	269_Q	0.914	0.75
175_D	178_Y	0.909	0.75
35_L	41_T	0.907	0.75
312_L	385_A	0.907	0.75
264_A	274_I	0.906	0.74
488_R	491_E	0.904	0.74
312_L	348_V	0.899	0.74
110_H	136_Q	0.892	0.73
353_V	384_V	0.891	0.73
70_S	136_Q	0.890	0.73
279_K	369_H	0.887	0.73
179_A	182_S	0.887	0.73
494_E	509_L	0.886	0.73
170_L	440_T	0.886	0.73
376_D	379_V	0.884	0.73
300_G	369_H	0.883	0.73
304_L	387_I	0.882	0.72
250_Q	371_F	0.879	0.72
293_Q	322_A	0.878	0.72
558_K	562_I	0.877	0.72
547_K	554_K	0.872	0.72
422_S	439_L	0.872	0.72
266_L	269_Q	0.872	0.72
52_K	475_Q	0.869	0.71
3_T	8_L	0.868	0.71
478_I	507_V	0.867	0.71
212_V	411_V	0.867	0.71
409_I	454_A	0.866	0.71
375_W	384_V	0.865	0.71
20_V	216_S	0.864	0.71
1_M	497_Y	0.863	0.71
266_L	360_A	0.862	0.71
353_V	359_F	0.860	0.71
252_M	377_R	0.859	0.70
302_H	388_R	0.859	0.70
183_K	186_S	0.859	0.70
423_E	428_S	0.856	0.70
498_S	501_R	0.855	0.70
479_L	519_M	0.854	0.70
283_V	321_F	0.853	0.70
53_V	451_V	0.850	0.70
252_M	341_V	0.850	0.70
287_E	292_P	0.849	0.70
131_N	177_M	0.845	0.69
379_V	382_P	0.844	0.69
487_F	490_Q	0.844	0.69
249_T	358_D	0.843	0.69
478_I	534_L	0.842	0.69
77_A	86_W	0.841	0.69
349_I	353_V	0.839	0.69
110_H	134_Q	0.839	0.69
250_Q	374_N	0.838	0.69
312_L	383_E	0.835	0.68
283_V	296_L	0.835	0.68
466_V	550_R	0.835	0.68
179_A	414_I	0.833	0.68
481_M	535_G	0.832	0.68
158_K	181_Y	0.827	0.68
334_G	337_S	0.825	0.67
150_M	216_S	0.824	0.67
258_P	336_G	0.823	0.67
48_R	52_K	0.822	0.67
456_I	459_N	0.821	0.67
73_V	136_Q	0.820	0.67
225_D	228_D	0.819	0.67
31_M	465_I	0.818	0.67
225_D	401_G	0.817	0.67
206_A	416_Q	0.814	0.66
196_Q	208_H	0.812	0.66
261_K	280_T	0.812	0.66
32_I	149_V	0.812	0.66
46_G	53_V	0.811	0.66
3_T	523_M	0.809	0.66
431_G	436_N	0.808	0.66
524_E	531_T	0.807	0.66
6_Y	45_T	0.805	0.65
331_V	338_L	0.804	0.65
220_D	407_R	0.803	0.65
182_S	194_A	0.802	0.65
477_A	528_I	0.801	0.65
496_L	562_I	0.801	0.65
166_S	432_E	0.800	0.65
177_M	202_I	0.799	0.65
250_Q	358_D	0.798	0.65
539_L	559_T	0.794	0.64
258_P	369_H	0.793	0.64
476_V	562_I	0.792	0.64
260_A	265_E	0.791	0.64
285_A	292_P	0.790	0.64
284_K	287_E	0.790	0.64
277_T	338_L	0.789	0.64
215_Q	406_K	0.789	0.64
214_A	409_I	0.787	0.64
114_I	443_C	0.785	0.63
307_V	311_K	0.783	0.63
61_M	158_K	0.782	0.63
269_Q	371_F	0.782	0.63
258_P	337_S	0.782	0.63
238_A	394_D	0.782	0.63
299_R	352_T	0.779	0.63
490_Q	494_E	0.779	0.63
194_A	413_H	0.779	0.63
64_A	179_A	0.779	0.63
91_P	143_V	0.777	0.63
501_R	507_V	0.777	0.63
398_D	401_G	0.777	0.63
89_Y	202_I	0.775	0.62
423_E	426_K	0.775	0.62
273_P	276_K	0.775	0.62
237_E	397_P	0.774	0.62
564_E	567_V	0.773	0.62
331_V	343_M	0.773	0.62
63_N	179_A	0.772	0.62
196_Q	398_D	0.771	0.62
483_M	509_L	0.770	0.62
212_V	458_Q	0.767	0.62
49_V	528_I	0.767	0.62
56_I	470_A	0.765	0.61
167_Q	419_T	0.762	0.61
254_L	363_A	0.761	0.61
212_V	455_A	0.760	0.61
114_I	208_H	0.759	0.61
272_L	277_T	0.759	0.61
283_V	309_A	0.759	0.61
188_M	471_I	0.759	0.61
33_R	43_L	0.758	0.61
233_I	405_I	0.752	0.60
197_A	207_S	0.752	0.60
164_H	172_E	0.752	0.60
219_D	413_H	0.751	0.60
460_Y	466_V	0.749	0.60
320_T	323_T	0.749	0.60
257_T	279_K	0.748	0.60
21_I	216_S	0.748	0.60
5_Q	176_A	0.745	0.59
79_L	93_L	0.743	0.59
128_L	429_V	0.740	0.59
267_V	270_F	0.740	0.59
286_V	316_A	0.740	0.59
33_R	117_L	0.739	0.59
341_V	373_I	0.739	0.59
9_S	33_R	0.739	0.59
35_L	76_P	0.739	0.59
557_I	565_Y	0.737	0.59
261_K	337_S	0.736	0.58
42_W	452_V	0.735	0.58
8_L	526_I	0.733	0.58
128_L	439_L	0.733	0.58
282_L	322_A	0.732	0.58
478_I	497_Y	0.731	0.58
300_G	336_G	0.731	0.58
503_Q	563_V	0.729	0.58
31_M	456_I	0.728	0.58
302_H	391_V	0.726	0.57
189_G	459_N	0.725	0.57
35_L	113_V	0.721	0.57
243_E	355_A	0.720	0.57
39_L	152_S	0.720	0.57
354_A	375_W	0.715	0.56
257_T	300_G	0.714	0.56
551_N	555_Q	0.713	0.56
349_I	354_A	0.712	0.56
57_V	446_I	0.711	0.56
96_F	106_L	0.710	0.56
56_I	471_I	0.710	0.56
381_T	384_V	0.710	0.56
303_E	391_V	0.709	0.56
74_V	105_V	0.707	0.55
328_R	333_A	0.706	0.55
5_Q	65_G	0.706	0.55
82_E	116_D	0.705	0.55
324_E	335_P	0.705	0.55
114_I	202_I	0.704	0.55
279_K	300_G	0.703	0.55
51_K	55_N	0.701	0.55
396_S	401_G	0.701	0.55
474_F	506_E	0.700	0.55
41_T	71_M	0.700	0.55
126_K	435_R	0.699	0.55
326_E	329_A	0.699	0.55
188_M	451_V	0.696	0.54
47_V	54_E	0.696	0.54
376_D	381_T	0.695	0.54
395_P	402_R	0.694	0.54
191_D	458_Q	0.693	0.54
86_W	103_P	0.692	0.54
533_V	554_K	0.690	0.54
108_P	207_S	0.689	0.54
259_N	337_S	0.689	0.54
480_P	489_V	0.687	0.53
165_T	169_S	0.687	0.53
459_N	465_I	0.686	0.53
375_W	379_V	0.686	0.53
231_A	236_A	0.685	0.53
256_D	259_N	0.684	0.53
293_Q	326_E	0.684	0.53
216_S	220_D	0.683	0.53
281_L	335_P	0.682	0.53
469_D	546_Y	0.680	0.53
171_Q	206_A	0.680	0.53
482_N	516_P	0.679	0.52
535_G	541_N	0.678	0.52
98_D	102_R	0.678	0.52
278_V	361_A	0.677	0.52
118_I	130_L	0.677	0.52
118_I	513_K	0.676	0.52
477_A	508_L	0.676	0.52
351_R	354_A	0.674	0.52
360_A	371_F	0.673	0.52
83_S	191_D	0.673	0.52
12_K	521_A	0.672	0.52
341_V	379_V	0.668	0.51
255_V	371_F	0.667	0.51
59_E	183_K	0.667	0.51
481_M	516_P	0.666	0.51
81_Q	86_W	0.666	0.51
328_R	366_D	0.665	0.51
53_V	471_I	0.663	0.51
94_L	106_L	0.663	0.51
164_H	443_C	0.662	0.51
460_Y	465_I	0.661	0.51
93_L	202_I	0.660	0.50
256_D	337_S	0.660	0.50
316_A	319_L	0.659	0.50
20_V	34_K	0.655	0.50
299_R	388_R	0.654	0.50
351_R	384_V	0.654	0.50
75_Q	113_V	0.653	0.50
71_M	113_V	0.652	0.50
149_V	449_T	0.652	0.50
64_A	173_T	0.651	0.49
415_F	445_G	0.651	0.49
495_K	502_A	0.649	0.49
413_H	451_V	0.648	0.49
94_L	105_V	0.648	0.49
99_R	141_D	0.646	0.49
67_I	130_L	0.646	0.49
493_A	509_L	0.645	0.49
263_I	279_K	0.645	0.49
15_P	23_H	0.645	0.49
532_I	566_L	0.645	0.49
262_T	265_E	0.643	0.49
262_T	300_G	0.643	0.49
463_R	552_G	0.641	0.48
455_A	459_N	0.640	0.48
548_Y	555_Q	0.640	0.48
557_I	562_I	0.639	0.48
531_T	551_N	0.638	0.48
62_N	65_G	0.636	0.48
551_N	554_K	0.636	0.48
410_E	415_F	0.636	0.48
75_Q	114_I	0.635	0.48
216_S	455_A	0.634	0.48
353_V	375_W	0.633	0.48
211_Q	233_I	0.633	0.48
74_V	139_F	0.633	0.48
73_V	137_T	0.633	0.48
541_N	556_L	0.632	0.47
540_D	543_D	0.632	0.47
430_Q	436_N	0.631	0.47
222_V	233_I	0.631	0.47
45_T	526_I	0.631	0.47
333_A	337_S	0.628	0.47
37_S	147_F	0.627	0.47
426_K	438_I	0.626	0.47
278_V	356_M	0.626	0.47
143_V	150_M	0.625	0.47
149_V	453_A	0.624	0.47
19_E	34_K	0.622	0.46
237_E	398_D	0.622	0.46
256_D	260_A	0.621	0.46
309_A	385_A	0.621	0.46
353_V	379_V	0.620	0.46
286_V	314_Q	0.620	0.46
88_Q	201_S	0.619	0.46
89_Y	95_R	0.618	0.46
64_A	160_A	0.618	0.46
281_L	295_A	0.617	0.46
89_Y	152_S	0.616	0.46
119_R	425_L	0.615	0.46
264_A	303_E	0.614	0.46
23_H	34_K	0.614	0.46
238_A	386_D	0.613	0.45
259_N	542_D	0.612	0.45
199_T	206_A	0.612	0.45
179_A	186_S	0.611	0.45
448_V	485_K	0.611	0.45
7_L	67_I	0.610	0.45
126_K	513_K	0.610	0.45
280_T	327_I	0.609	0.45
184_I	446_I	0.608	0.45
534_L	539_L	0.607	0.45
240_A	351_R	0.607	0.45
298_V	352_T	0.606	0.45
54_E	58_R	0.606	0.45
79_L	113_V	0.605	0.45
152_S	156_L	0.604	0.44
325_E	328_R	0.602	0.44
277_T	327_I	0.601	0.44
279_K	362_G	0.601	0.44
482_N	485_K	0.601	0.44
482_N	486_S	0.601	0.44
233_I	389_N	0.600	0.44
426_K	436_N	0.600	0.44
47_V	489_V	0.600	0.44
313_P	346_P	0.599	0.44
164_H	176_A	0.599	0.44
336_G	339_G	0.598	0.44
322_A	327_I	0.598	0.44
544_I	559_T	0.597	0.44
73_V	105_V	0.597	0.44
150_M	214_A	0.597	0.44
58_R	62_N	0.596	0.44
427_A	438_I	0.596	0.44
151_R	415_F	0.596	0.44
193_R	213_L	0.593	0.43
52_K	56_I	0.592	0.43
278_V	375_W	0.591	0.43
295_A	331_V	0.591	0.43
475_Q	528_I	0.590	0.43
282_L	331_V	0.589	0.43
258_P	300_G	0.586	0.43
7_L	152_S	0.585	0.42
241_P	355_A	0.585	0.42
436_N	524_E	0.585	0.42
160_A	443_C	0.584	0.42
53_V	57_V	0.583	0.42
245_R	357_S	0.582	0.42
82_E	426_K	0.582	0.42
35_L	137_T	0.582	0.42
49_V	456_I	0.582	0.42
7_L	132_F	0.581	0.42
295_A	345_I	0.581	0.42
166_S	440_T	0.580	0.42
46_G	452_V	0.580	0.42
331_V	334_G	0.579	0.42
83_S	95_R	0.579	0.42
168_E	172_E	0.578	0.42
390_V	393_G	0.577	0.42
246_A	276_K	0.577	0.42
499_E	503_Q	0.577	0.42
274_I	277_T	0.577	0.42
548_Y	552_G	0.576	0.42
499_E	563_V	0.576	0.42
280_T	346_P	0.576	0.42
292_P	344_P	0.572	0.41
262_T	266_L	0.572	0.41
63_N	180_A	0.572	0.41
296_L	304_L	0.572	0.41
496_L	534_L	0.572	0.41
333_A	361_A	0.571	0.41
89_Y	108_P	0.571	0.41
199_T	211_Q	0.570	0.41
456_I	460_Y	0.570	0.41
327_I	338_L	0.569	0.41
157_M	415_F	0.569	0.41
294_V	319_L	0.569	0.41
171_Q	440_T	0.567	0.41
108_P	197_A	0.566	0.40
346_P	382_P	0.565	0.40
547_K	552_G	0.564	0.40
499_E	564_E	0.562	0.40
261_K	338_L	0.562	0.40
151_R	410_E	0.562	0.40
303_E	389_N	0.561	0.40
199_T	311_K	0.561	0.40
483_M	486_S	0.561	0.40
228_D	401_G	0.561	0.40
157_M	445_G	0.560	0.40
7_L	282_L	0.559	0.40
71_M	75_Q	0.559	0.40
375_W	382_P	0.559	0.40
335_P	338_L	0.558	0.40
325_E	329_A	0.558	0.40
42_W	152_S	0.557	0.40
18_A	23_H	0.557	0.40
40_Y	409_I	0.556	0.39
419_T	422_S	0.556	0.39
257_T	263_I	0.556	0.39
474_F	508_L	0.555	0.39
201_S	307_V	0.555	0.39
326_E	330_V	0.555	0.39
354_A	381_T	0.554	0.39
416_Q	440_T	0.553	0.39
324_E	334_G	0.553	0.39
199_T	205_S	0.552	0.39
263_I	369_H	0.552	0.39
280_T	345_I	0.551	0.39
280_T	335_P	0.551	0.39
348_V	383_E	0.550	0.39
34_K	143_V	0.550	0.39
276_K	358_D	0.548	0.39
232_N	413_H	0.548	0.39
59_E	81_Q	0.547	0.39
200_G	415_F	0.547	0.39
62_N	66_A	0.547	0.39
55_N	63_N	0.546	0.38
535_G	543_D	0.546	0.38
229_Y	236_A	0.545	0.38
107_G	212_V	0.545	0.38
20_V	453_A	0.542	0.38
435_R	513_K	0.542	0.38
41_T	72_P	0.541	0.38
63_N	502_A	0.541	0.38
106_L	152_S	0.540	0.38
532_I	544_I	0.540	0.38
260_A	361_A	0.540	0.38
89_Y	449_T	0.540	0.38
127_Q	477_A	0.539	0.38
277_T	360_A	0.539	0.38
501_R	505_I	0.538	0.38
151_R	200_G	0.538	0.38
107_G	134_Q	0.538	0.38
431_G	435_R	0.537	0.38
188_M	211_Q	0.537	0.38
435_R	524_E	0.536	0.37
19_E	102_R	0.536	0.37
202_I	422_S	0.536	0.37
263_I	336_G	0.536	0.37
310_E	318_P	0.536	0.37
198_D	311_K	0.535	0.37
180_A	184_I	0.534	0.37
75_Q	202_I	0.534	0.37
143_V	214_A	0.534	0.37
126_K	429_V	0.533	0.37
239_I	400_Q	0.533	0.37
313_P	348_V	0.532	0.37
67_I	519_M	0.532	0.37
46_G	156_L	0.532	0.37
339_G	364_N	0.531	0.37
362_G	369_H	0.531	0.37
11_L	514_E	0.531	0.37
137_T	219_D	0.530	0.37
192_F	411_V	0.529	0.37
250_Q	276_K	0.528	0.37
122_L	128_L	0.528	0.37
89_Y	143_V	0.528	0.37
238_A	351_R	0.528	0.37
285_A	294_V	0.527	0.37
149_V	456_I	0.527	0.37
463_R	524_E	0.527	0.37
306_E	403_L	0.527	0.37
21_I	459_N	0.526	0.36
280_T	333_A	0.526	0.36
211_Q	440_T	0.526	0.36
48_R	62_N	0.525	0.36
35_L	116_D	0.523	0.36
475_Q	501_R	0.523	0.36
562_I	567_V	0.522	0.36
336_G	340_P	0.522	0.36
185_F	534_L	0.522	0.36
107_G	136_Q	0.522	0.36
80_W	84_G	0.521	0.36
202_I	439_L	0.521	0.36
9_S	45_T	0.520	0.36
126_K	433_D	0.520	0.36
269_Q	360_A	0.520	0.36
190_L	454_A	0.519	0.36
375_W	381_T	0.519	0.36
27_L	221_V	0.518	0.36
20_V	212_V	0.518	0.36
421_Y	445_G	0.517	0.36
222_V	235_L	0.517	0.36
246_A	249_T	0.517	0.36
50_L	70_S	0.516	0.35
364_N	369_H	0.516	0.35
92_E	100_G	0.516	0.35
266_L	369_H	0.515	0.35
89_Y	92_E	0.514	0.35
15_P	18_A	0.514	0.35
31_M	303_E	0.513	0.35
248_A	372_G	0.513	0.35
383_E	387_I	0.513	0.35
147_F	408_G	0.512	0.35
339_G	362_G	0.512	0.35
469_D	550_R	0.511	0.35
176_A	179_A	0.511	0.35
73_V	219_D	0.510	0.35
115_T	443_C	0.509	0.35
464_G	549_R	0.509	0.35
425_L	439_L	0.508	0.35
6_Y	31_M	0.507	0.35
267_V	272_L	0.507	0.35
282_L	333_A	0.507	0.35
532_I	557_I	0.507	0.35
510_D	519_M	0.506	0.34
182_S	414_I	0.505	0.34
293_Q	524_E	0.505	0.34
84_G	180_A	0.504	0.34
228_D	400_Q	0.504	0.34
13_E	459_N	0.504	0.34
147_F	214_A	0.503	0.34
92_E	104_F	0.502	0.34
66_A	133_Y	0.502	0.34
167_Q	171_Q	0.502	0.34
397_P	400_Q	0.501	0.34
26_M	51_K	0.500	0.34
93_L	443_C	0.500	0.34
41_T	449_T	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j3lA	2	0.9878	100	0.45	Contact Map
2i4lA	2	0.7657	100	0.537	Contact Map
4phcA	2	0.7762	100	0.65	Contact Map
4hvcA	2	0.6573	100	0.674	Contact Map
2zt5A	2	0.7238	100	0.677	Contact Map
1qf6A	1	0.7028	100	0.685	Contact Map
1nj8A	2	0.6434	100	0.691	Contact Map
3ialA	2	0.6538	100	0.692	Contact Map
1nj1A	2	0.6399	100	0.699	Contact Map
4ncxA	2	0.6084	100	0.702	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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