GREMLIN Database
ICLR - Acetate operon repressor
UniProt: P16528 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10491
Length: 274 (247)
Sequences: 12776 (9334)
Seq/√Len: 593.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_L30_G3.3351.00
115_E258_M3.0271.00
123_A161_A2.8471.00
108_I262_A2.8391.00
28_T70_Q2.7871.00
203_Q207_R2.5611.00
35_E87_H2.5381.00
31_L72_F2.3981.00
106_H136_D2.3901.00
163_K200_D2.3791.00
175_T198_K2.3771.00
163_K215_E2.3431.00
118_E246_R2.2651.00
37_I73_V2.1171.00
212_D222_C2.0891.00
32_K70_Q2.0841.00
108_I265_E2.0451.00
125_L156_M1.9681.00
131_E153_K1.9481.00
168_Q228_F1.9371.00
213_D221_R1.9341.00
110_R138_V1.9211.00
169_L173_Q1.8561.00
225_A259_V1.8401.00
221_R244_I1.8311.00
111_N265_E1.8151.00
108_I269_A1.8071.00
251_R254_E1.7991.00
35_E70_Q1.7911.00
225_A263_A1.7741.00
74_R83_A1.7121.00
193_S196_H1.7051.00
256_G260_I1.6881.00
36_W44_V1.6781.00
111_N115_E1.6781.00
105_V266_V1.6711.00
36_W53_A1.6621.00
33_L49_L1.6581.00
194_P198_K1.6551.00
113_M120_V1.6541.00
36_W49_L1.6381.00
240_I255_F1.6041.00
64_L73_V1.6031.00
225_A260_I1.5861.00
214_E244_I1.5851.00
242_G247_I1.5621.00
64_L82_W1.5491.00
44_V52_Q1.5401.00
170_S173_Q1.5371.00
49_L60_T1.5271.00
214_E219_G1.5211.00
187_T190_T1.5141.00
200_D203_Q1.4911.00
43_S83_A1.4851.00
36_W52_Q1.4801.00
209_Y256_G1.4691.00
45_A48_E1.4691.00
139_Q145_R1.4651.00
108_I111_N1.4591.00
174_V198_K1.4431.00
37_I43_S1.4371.00
132_A156_M1.4291.00
116_S258_M1.4201.00
102_L136_D1.4191.00
37_I44_V1.4161.00
112_L258_M1.4121.00
132_A165_F1.4011.00
228_F267_T1.4011.00
43_S81_H1.3991.00
204_T210_S1.3901.00
87_H90_M1.3831.00
55_L60_T1.3781.00
258_M261_K1.3751.00
35_E72_F1.3651.00
175_T194_P1.3571.00
113_M138_V1.3471.00
31_L70_Q1.3451.00
109_L122_M1.3401.00
68_Q73_V1.3121.00
128_S180_R1.3111.00
112_L262_A1.2901.00
76_V83_A1.2851.00
56_P59_T1.2801.00
263_A267_T1.2771.00
68_Q75_Q1.2691.00
105_V122_M1.2551.00
168_Q226_C1.2491.00
61_H65_T1.2331.00
158_A190_T1.2281.00
49_L64_L1.2271.00
261_K265_E1.2261.00
40_S52_Q1.2131.00
40_S44_V1.2091.00
228_F234_P1.2081.00
171_E175_T1.2031.00
106_H110_R1.1901.00
46_L61_H1.1881.00
201_L204_T1.1871.00
179_H194_P1.1841.00
225_A256_G1.1831.00
167_A204_T1.1751.00
50_A60_T1.1701.00
158_A186_Y1.1631.00
171_E198_K1.1621.00
116_S255_F1.1611.00
260_I264_K1.1601.00
123_A132_A1.1411.00
191_L200_D1.1321.00
122_M236_A1.1301.00
174_V205_R1.1291.00
122_M227_I1.1271.00
159_S162_G1.1231.00
125_L128_S1.1231.00
110_R114_E1.1191.00
124_V236_A1.1181.00
171_E202_A1.1151.00
28_T69_Q1.1151.00
126_D153_K1.1001.00
24_V66_T1.1001.00
109_L120_V1.0931.00
47_T51_Q1.0911.00
171_E174_V1.0911.00
229_D233_E1.0891.00
189_A214_E1.0871.00
38_A41_N1.0831.00
45_A81_H1.0811.00
168_Q234_P1.0791.00
88_A95_F1.0791.00
157_H190_T1.0741.00
116_S240_I1.0721.00
48_E51_Q1.0411.00
28_T66_T1.0411.00
161_A237_A1.0381.00
125_L169_L1.0311.00
25_Q29_R1.0281.00
175_T179_H1.0271.00
178_L194_P1.0081.00
115_E261_K1.0011.00
46_L50_A0.9991.00
265_E269_A0.9981.00
186_Y190_T0.9951.00
238_I266_V0.9951.00
257_A261_K0.9951.00
123_A134_I0.9821.00
101_L236_A0.9731.00
204_T207_R0.9701.00
39_E52_Q0.9501.00
202_A206_K0.9491.00
173_Q176_K0.9461.00
188_H218_L0.9451.00
264_K268_L0.9381.00
47_T57_N0.9321.00
72_F91_V0.9291.00
34_L88_A0.9271.00
160_G222_C0.9221.00
199_E202_A0.9171.00
248_T251_R0.9091.00
199_E203_Q0.9041.00
133_I153_K0.9041.00
29_R59_T0.9031.00
33_L53_A0.9021.00
43_S76_V0.8981.00
224_A239_S0.8951.00
226_C234_P0.8951.00
111_N262_A0.8921.00
176_K180_R0.8871.00
109_L136_D0.8791.00
166_L197_L0.8741.00
185_A192_V0.8741.00
164_A168_Q0.8721.00
213_D244_I0.8701.00
106_H138_V0.8671.00
223_L256_G0.8651.00
109_L238_I0.8601.00
102_L106_H0.8581.00
23_Q69_Q0.8581.00
164_A204_T0.8561.00
121_N241_S0.8531.00
196_H200_D0.8531.00
48_E52_Q0.8521.00
58_S61_H0.8501.00
120_V240_I0.8481.00
214_E218_L0.8461.00
164_A234_P0.8451.00
253_T257_A0.8451.00
196_H199_E0.8441.00
222_C241_S0.8411.00
46_L64_L0.8411.00
198_K202_A0.8401.00
118_E142_H0.8401.00
186_Y216_H0.8341.00
53_A60_T0.8311.00
161_A239_S0.8231.00
37_I42_G0.8101.00
84_I88_A0.8101.00
33_L63_L0.8101.00
207_R256_G0.8021.00
34_L72_F0.8021.00
104_I269_A0.8021.00
203_Q206_K0.7961.00
200_D204_T0.7961.00
174_V201_L0.7951.00
259_V263_A0.7931.00
252_V257_A0.7911.00
174_V177_L0.7891.00
200_D207_R0.7881.00
243_P246_R0.7871.00
173_Q177_L0.7861.00
160_G224_A0.7851.00
222_C239_S0.7851.00
178_L182_G0.7841.00
126_D133_I0.7811.00
37_I40_S0.7801.00
165_F237_A0.7761.00
121_N148_A0.7741.00
171_E205_R0.7731.00
108_I266_V0.7661.00
68_Q82_W0.7641.00
229_D235_F0.7541.00
125_L173_Q0.7491.00
88_A91_V0.7441.00
191_L196_H0.7431.00
88_A92_G0.7421.00
26_S30_G0.7411.00
121_N137_Q0.7291.00
177_L181_K0.7291.00
142_H246_R0.7281.00
254_E258_M0.7271.00
100_N103_A0.7261.00
252_V256_G0.7261.00
33_L60_T0.7231.00
46_L57_N0.7181.00
101_L105_V0.7181.00
191_L197_L0.7181.00
23_Q28_T0.7151.00
55_L59_T0.7091.00
228_F235_F0.6971.00
158_A216_H0.6971.00
125_L165_F0.6951.00
211_F252_V0.6921.00
44_V49_L0.6911.00
262_A265_E0.6881.00
46_L60_T0.6881.00
109_L138_V0.6871.00
163_K204_T0.6871.00
167_A201_L0.6871.00
27_L63_L0.6861.00
65_T68_Q0.6841.00
50_A53_A0.6841.00
202_A205_R0.6831.00
27_L31_L0.6831.00
38_A91_V0.6791.00
159_S222_C0.6791.00
166_L201_L0.6761.00
111_N114_E0.6711.00
238_I263_A0.6701.00
46_L82_W0.6681.00
223_L252_V0.6651.00
128_S177_L0.6591.00
65_T69_Q0.6591.00
264_K267_T0.6551.00
121_N222_C0.6541.00
74_R86_A0.6531.00
213_D249_D0.6511.00
123_A159_S0.6511.00
92_G95_F0.6501.00
74_R85_G0.6491.00
261_K264_K0.6491.00
257_A260_I0.6491.00
187_T191_L0.6471.00
174_V202_A0.6441.00
29_R55_L0.6391.00
260_I263_A0.6391.00
26_S63_L0.6371.00
35_E90_M0.6371.00
76_V81_H0.6371.00
169_L174_V0.6371.00
128_S131_E0.6311.00
262_A266_V0.6311.00
254_E257_A0.6301.00
192_V196_H0.6271.00
45_A57_N0.6261.00
114_E141_T0.6241.00
189_A218_L0.6241.00
165_F169_L0.6201.00
157_H183_L0.6191.00
37_I41_N0.6181.00
113_M140_C0.6181.00
75_Q82_W0.6171.00
48_E81_H0.6161.00
112_L116_S0.6161.00
118_E242_G0.6161.00
214_E221_R0.6141.00
112_L240_I0.6131.00
144_M245_S0.6131.00
72_F87_H0.6111.00
104_I107_P0.6101.00
213_D252_V0.6101.00
41_N52_Q0.6101.00
174_V178_L0.6071.00
251_R255_F0.6041.00
265_E268_L0.6021.00
165_F236_A0.6021.00
110_R136_D0.6011.00
164_A224_A0.6001.00
112_L120_V0.5951.00
225_A267_T0.5941.00
166_L174_V0.5931.00
132_A154_L0.5891.00
155_P158_A0.5891.00
117_G141_T0.5891.00
161_A222_C0.5881.00
50_A57_N0.5881.00
35_E91_V0.5861.00
137_Q150_I0.5811.00
71_G87_H0.5811.00
149_P152_G0.5801.00
124_V135_I0.5801.00
238_I262_A0.5781.00
163_K212_D0.5781.00
137_Q148_A0.5731.00
164_A226_C0.5731.00
24_V63_L0.5711.00
27_L66_T0.5711.00
29_R63_L0.5661.00
105_V109_L0.5641.00
23_Q66_T0.5611.00
132_A159_S0.5601.00
132_A161_A0.5601.00
120_V138_V0.5570.99
197_L201_L0.5560.99
258_M262_A0.5510.99
107_P269_A0.5500.99
148_A152_G0.5480.99
38_A84_I0.5470.99
195_V198_K0.5450.99
25_Q66_T0.5440.99
189_A213_D0.5440.99
195_V199_E0.5430.99
139_Q149_P0.5380.99
40_S43_S0.5380.99
32_K35_E0.5380.99
134_I148_A0.5370.99
255_F258_M0.5340.99
32_K36_W0.5310.99
208_G228_F0.5310.99
30_G63_L0.5310.99
209_Y260_I0.5280.99
225_A238_I0.5260.99
227_I236_A0.5260.99
134_I159_S0.5250.99
224_A237_A0.5230.99
31_L66_T0.5210.99
230_E267_T0.5200.99
119_T137_Q0.5200.99
228_F236_A0.5190.99
134_I161_A0.5130.99
22_G62_R0.5120.99
75_Q80_G0.5110.99
24_V27_L0.5100.99
164_A210_S0.5090.99
118_E240_I0.5090.99
238_I259_V0.5070.99
58_S62_R0.5060.99
136_D150_I0.5050.99
104_I266_V0.5050.99
78_E81_H0.5050.99
157_H177_L0.5040.99
223_L259_V0.5030.99
57_N60_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.9161 100 0.13 Contact Map
2ia2A 4 0.9051 100 0.132 Contact Map
2g7uA 6 0.9161 100 0.133 Contact Map
3r4kA 2 0.9088 100 0.134 Contact Map
1mkmA 4 0.9015 100 0.137 Contact Map
2xrnA 3 0.8796 100 0.156 Contact Map
2o0yA 4 0.9234 100 0.186 Contact Map
1ysqA 1 0.635 100 0.428 Contact Map
1tf1A 1 0.6715 100 0.431 Contact Map
2o99A 2 0.6496 100 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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