ICLR - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ICLR - Acetate operon repressor

UniProt:	P16528	Sequences: MVAPIPAKRGRKPAVATAPATGQVQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQVGELGHWAIGAHAFMVGSSFLQSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10491
Length:	274 (247)
Sequences:	12776 (9334)
Seq/√Len:	593.9

ECOLI - ICLR ALLR YIAJ KDGR MHPR RHMR YJHI YAGI
BACSU - KIPR
HALSA - Q9HHM8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_L	30_G	3.335	1.00
115_E	258_M	3.027	1.00
123_A	161_A	2.847	1.00
108_I	262_A	2.839	1.00
28_T	70_Q	2.787	1.00
203_Q	207_R	2.561	1.00
35_E	87_H	2.538	1.00
31_L	72_F	2.398	1.00
106_H	136_D	2.390	1.00
163_K	200_D	2.379	1.00
175_T	198_K	2.377	1.00
163_K	215_E	2.343	1.00
118_E	246_R	2.265	1.00
37_I	73_V	2.117	1.00
212_D	222_C	2.089	1.00
32_K	70_Q	2.084	1.00
108_I	265_E	2.045	1.00
125_L	156_M	1.968	1.00
131_E	153_K	1.948	1.00
168_Q	228_F	1.937	1.00
213_D	221_R	1.934	1.00
110_R	138_V	1.921	1.00
169_L	173_Q	1.856	1.00
225_A	259_V	1.840	1.00
221_R	244_I	1.831	1.00
111_N	265_E	1.815	1.00
108_I	269_A	1.807	1.00
251_R	254_E	1.799	1.00
35_E	70_Q	1.791	1.00
225_A	263_A	1.774	1.00
74_R	83_A	1.712	1.00
193_S	196_H	1.705	1.00
256_G	260_I	1.688	1.00
36_W	44_V	1.678	1.00
111_N	115_E	1.678	1.00
105_V	266_V	1.671	1.00
36_W	53_A	1.662	1.00
33_L	49_L	1.658	1.00
194_P	198_K	1.655	1.00
113_M	120_V	1.654	1.00
36_W	49_L	1.638	1.00
240_I	255_F	1.604	1.00
64_L	73_V	1.603	1.00
225_A	260_I	1.586	1.00
214_E	244_I	1.585	1.00
242_G	247_I	1.562	1.00
64_L	82_W	1.549	1.00
44_V	52_Q	1.540	1.00
170_S	173_Q	1.537	1.00
49_L	60_T	1.527	1.00
214_E	219_G	1.521	1.00
187_T	190_T	1.514	1.00
200_D	203_Q	1.491	1.00
43_S	83_A	1.485	1.00
36_W	52_Q	1.480	1.00
209_Y	256_G	1.469	1.00
45_A	48_E	1.469	1.00
139_Q	145_R	1.465	1.00
108_I	111_N	1.459	1.00
174_V	198_K	1.443	1.00
37_I	43_S	1.437	1.00
132_A	156_M	1.429	1.00
116_S	258_M	1.420	1.00
102_L	136_D	1.419	1.00
37_I	44_V	1.416	1.00
112_L	258_M	1.412	1.00
132_A	165_F	1.401	1.00
228_F	267_T	1.401	1.00
43_S	81_H	1.399	1.00
204_T	210_S	1.390	1.00
87_H	90_M	1.383	1.00
55_L	60_T	1.378	1.00
258_M	261_K	1.375	1.00
35_E	72_F	1.365	1.00
175_T	194_P	1.357	1.00
113_M	138_V	1.347	1.00
31_L	70_Q	1.345	1.00
109_L	122_M	1.340	1.00
68_Q	73_V	1.312	1.00
128_S	180_R	1.311	1.00
112_L	262_A	1.290	1.00
76_V	83_A	1.285	1.00
56_P	59_T	1.280	1.00
263_A	267_T	1.277	1.00
68_Q	75_Q	1.269	1.00
105_V	122_M	1.255	1.00
168_Q	226_C	1.249	1.00
61_H	65_T	1.233	1.00
158_A	190_T	1.228	1.00
49_L	64_L	1.227	1.00
261_K	265_E	1.226	1.00
40_S	52_Q	1.213	1.00
40_S	44_V	1.209	1.00
228_F	234_P	1.208	1.00
171_E	175_T	1.203	1.00
106_H	110_R	1.190	1.00
46_L	61_H	1.188	1.00
201_L	204_T	1.187	1.00
179_H	194_P	1.184	1.00
225_A	256_G	1.183	1.00
167_A	204_T	1.175	1.00
50_A	60_T	1.170	1.00
158_A	186_Y	1.163	1.00
171_E	198_K	1.162	1.00
116_S	255_F	1.161	1.00
260_I	264_K	1.160	1.00
123_A	132_A	1.141	1.00
191_L	200_D	1.132	1.00
122_M	236_A	1.130	1.00
174_V	205_R	1.129	1.00
122_M	227_I	1.127	1.00
159_S	162_G	1.123	1.00
125_L	128_S	1.123	1.00
110_R	114_E	1.119	1.00
124_V	236_A	1.118	1.00
171_E	202_A	1.115	1.00
28_T	69_Q	1.115	1.00
126_D	153_K	1.100	1.00
24_V	66_T	1.100	1.00
109_L	120_V	1.093	1.00
47_T	51_Q	1.091	1.00
171_E	174_V	1.091	1.00
229_D	233_E	1.089	1.00
189_A	214_E	1.087	1.00
38_A	41_N	1.083	1.00
45_A	81_H	1.081	1.00
168_Q	234_P	1.079	1.00
88_A	95_F	1.079	1.00
157_H	190_T	1.074	1.00
116_S	240_I	1.072	1.00
48_E	51_Q	1.041	1.00
28_T	66_T	1.041	1.00
161_A	237_A	1.038	1.00
125_L	169_L	1.031	1.00
25_Q	29_R	1.028	1.00
175_T	179_H	1.027	1.00
178_L	194_P	1.008	1.00
115_E	261_K	1.001	1.00
46_L	50_A	0.999	1.00
265_E	269_A	0.998	1.00
186_Y	190_T	0.995	1.00
238_I	266_V	0.995	1.00
257_A	261_K	0.995	1.00
123_A	134_I	0.982	1.00
101_L	236_A	0.973	1.00
204_T	207_R	0.970	1.00
39_E	52_Q	0.950	1.00
202_A	206_K	0.949	1.00
173_Q	176_K	0.946	1.00
188_H	218_L	0.945	1.00
264_K	268_L	0.938	1.00
47_T	57_N	0.932	1.00
72_F	91_V	0.929	1.00
34_L	88_A	0.927	1.00
160_G	222_C	0.922	1.00
199_E	202_A	0.917	1.00
248_T	251_R	0.909	1.00
199_E	203_Q	0.904	1.00
133_I	153_K	0.904	1.00
29_R	59_T	0.903	1.00
33_L	53_A	0.902	1.00
43_S	76_V	0.898	1.00
224_A	239_S	0.895	1.00
226_C	234_P	0.895	1.00
111_N	262_A	0.892	1.00
176_K	180_R	0.887	1.00
109_L	136_D	0.879	1.00
166_L	197_L	0.874	1.00
185_A	192_V	0.874	1.00
164_A	168_Q	0.872	1.00
213_D	244_I	0.870	1.00
106_H	138_V	0.867	1.00
223_L	256_G	0.865	1.00
109_L	238_I	0.860	1.00
102_L	106_H	0.858	1.00
23_Q	69_Q	0.858	1.00
164_A	204_T	0.856	1.00
121_N	241_S	0.853	1.00
196_H	200_D	0.853	1.00
48_E	52_Q	0.852	1.00
58_S	61_H	0.850	1.00
120_V	240_I	0.848	1.00
214_E	218_L	0.846	1.00
164_A	234_P	0.845	1.00
253_T	257_A	0.845	1.00
196_H	199_E	0.844	1.00
222_C	241_S	0.841	1.00
46_L	64_L	0.841	1.00
198_K	202_A	0.840	1.00
118_E	142_H	0.840	1.00
186_Y	216_H	0.834	1.00
53_A	60_T	0.831	1.00
161_A	239_S	0.823	1.00
37_I	42_G	0.810	1.00
84_I	88_A	0.810	1.00
33_L	63_L	0.810	1.00
207_R	256_G	0.802	1.00
34_L	72_F	0.802	1.00
104_I	269_A	0.802	1.00
203_Q	206_K	0.796	1.00
200_D	204_T	0.796	1.00
174_V	201_L	0.795	1.00
259_V	263_A	0.793	1.00
252_V	257_A	0.791	1.00
174_V	177_L	0.789	1.00
200_D	207_R	0.788	1.00
243_P	246_R	0.787	1.00
173_Q	177_L	0.786	1.00
160_G	224_A	0.785	1.00
222_C	239_S	0.785	1.00
178_L	182_G	0.784	1.00
126_D	133_I	0.781	1.00
37_I	40_S	0.780	1.00
165_F	237_A	0.776	1.00
121_N	148_A	0.774	1.00
171_E	205_R	0.773	1.00
108_I	266_V	0.766	1.00
68_Q	82_W	0.764	1.00
229_D	235_F	0.754	1.00
125_L	173_Q	0.749	1.00
88_A	91_V	0.744	1.00
191_L	196_H	0.743	1.00
88_A	92_G	0.742	1.00
26_S	30_G	0.741	1.00
121_N	137_Q	0.729	1.00
177_L	181_K	0.729	1.00
142_H	246_R	0.728	1.00
254_E	258_M	0.727	1.00
100_N	103_A	0.726	1.00
252_V	256_G	0.726	1.00
33_L	60_T	0.723	1.00
46_L	57_N	0.718	1.00
101_L	105_V	0.718	1.00
191_L	197_L	0.718	1.00
23_Q	28_T	0.715	1.00
55_L	59_T	0.709	1.00
228_F	235_F	0.697	1.00
158_A	216_H	0.697	1.00
125_L	165_F	0.695	1.00
211_F	252_V	0.692	1.00
44_V	49_L	0.691	1.00
262_A	265_E	0.688	1.00
46_L	60_T	0.688	1.00
109_L	138_V	0.687	1.00
163_K	204_T	0.687	1.00
167_A	201_L	0.687	1.00
27_L	63_L	0.686	1.00
65_T	68_Q	0.684	1.00
50_A	53_A	0.684	1.00
202_A	205_R	0.683	1.00
27_L	31_L	0.683	1.00
38_A	91_V	0.679	1.00
159_S	222_C	0.679	1.00
166_L	201_L	0.676	1.00
111_N	114_E	0.671	1.00
238_I	263_A	0.670	1.00
46_L	82_W	0.668	1.00
223_L	252_V	0.665	1.00
128_S	177_L	0.659	1.00
65_T	69_Q	0.659	1.00
264_K	267_T	0.655	1.00
121_N	222_C	0.654	1.00
74_R	86_A	0.653	1.00
213_D	249_D	0.651	1.00
123_A	159_S	0.651	1.00
92_G	95_F	0.650	1.00
74_R	85_G	0.649	1.00
261_K	264_K	0.649	1.00
257_A	260_I	0.649	1.00
187_T	191_L	0.647	1.00
174_V	202_A	0.644	1.00
29_R	55_L	0.639	1.00
260_I	263_A	0.639	1.00
26_S	63_L	0.637	1.00
35_E	90_M	0.637	1.00
76_V	81_H	0.637	1.00
169_L	174_V	0.637	1.00
128_S	131_E	0.631	1.00
262_A	266_V	0.631	1.00
254_E	257_A	0.630	1.00
192_V	196_H	0.627	1.00
45_A	57_N	0.626	1.00
114_E	141_T	0.624	1.00
189_A	218_L	0.624	1.00
165_F	169_L	0.620	1.00
157_H	183_L	0.619	1.00
37_I	41_N	0.618	1.00
113_M	140_C	0.618	1.00
75_Q	82_W	0.617	1.00
48_E	81_H	0.616	1.00
112_L	116_S	0.616	1.00
118_E	242_G	0.616	1.00
214_E	221_R	0.614	1.00
112_L	240_I	0.613	1.00
144_M	245_S	0.613	1.00
72_F	87_H	0.611	1.00
104_I	107_P	0.610	1.00
213_D	252_V	0.610	1.00
41_N	52_Q	0.610	1.00
174_V	178_L	0.607	1.00
251_R	255_F	0.604	1.00
265_E	268_L	0.602	1.00
165_F	236_A	0.602	1.00
110_R	136_D	0.601	1.00
164_A	224_A	0.600	1.00
112_L	120_V	0.595	1.00
225_A	267_T	0.594	1.00
166_L	174_V	0.593	1.00
132_A	154_L	0.589	1.00
155_P	158_A	0.589	1.00
117_G	141_T	0.589	1.00
161_A	222_C	0.588	1.00
50_A	57_N	0.588	1.00
35_E	91_V	0.586	1.00
137_Q	150_I	0.581	1.00
71_G	87_H	0.581	1.00
149_P	152_G	0.580	1.00
124_V	135_I	0.580	1.00
238_I	262_A	0.578	1.00
163_K	212_D	0.578	1.00
137_Q	148_A	0.573	1.00
164_A	226_C	0.573	1.00
24_V	63_L	0.571	1.00
27_L	66_T	0.571	1.00
29_R	63_L	0.566	1.00
105_V	109_L	0.564	1.00
23_Q	66_T	0.561	1.00
132_A	159_S	0.560	1.00
132_A	161_A	0.560	1.00
120_V	138_V	0.557	0.99
197_L	201_L	0.556	0.99
258_M	262_A	0.551	0.99
107_P	269_A	0.550	0.99
148_A	152_G	0.548	0.99
38_A	84_I	0.547	0.99
195_V	198_K	0.545	0.99
25_Q	66_T	0.544	0.99
189_A	213_D	0.544	0.99
195_V	199_E	0.543	0.99
139_Q	149_P	0.538	0.99
40_S	43_S	0.538	0.99
32_K	35_E	0.538	0.99
134_I	148_A	0.537	0.99
255_F	258_M	0.534	0.99
32_K	36_W	0.531	0.99
208_G	228_F	0.531	0.99
30_G	63_L	0.531	0.99
209_Y	260_I	0.528	0.99
225_A	238_I	0.526	0.99
227_I	236_A	0.526	0.99
134_I	159_S	0.525	0.99
224_A	237_A	0.523	0.99
31_L	66_T	0.521	0.99
230_E	267_T	0.520	0.99
119_T	137_Q	0.520	0.99
228_F	236_A	0.519	0.99
134_I	161_A	0.513	0.99
22_G	62_R	0.512	0.99
75_Q	80_G	0.511	0.99
24_V	27_L	0.510	0.99
164_A	210_S	0.509	0.99
118_E	240_I	0.509	0.99
238_I	259_V	0.507	0.99
58_S	62_R	0.506	0.99
136_D	150_I	0.505	0.99
104_I	266_V	0.505	0.99
78_E	81_H	0.505	0.99
157_H	177_L	0.504	0.99
223_L	259_V	0.503	0.99
57_N	60_T	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mq0A	2	0.9161	100	0.13	Contact Map
2ia2A	4	0.9051	100	0.132	Contact Map
2g7uA	6	0.9161	100	0.133	Contact Map
3r4kA	2	0.9088	100	0.134	Contact Map
1mkmA	4	0.9015	100	0.137	Contact Map
2xrnA	3	0.8796	100	0.156	Contact Map
2o0yA	4	0.9234	100	0.186	Contact Map
1ysqA	1	0.635	100	0.428	Contact Map
1tf1A	1	0.6715	100	0.431	Contact Map
2o99A	2	0.6496	100	0.433	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.