GREMLIN Database
TUS - DNA replication terminus site-binding protein
UniProt: P16525 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11038
Length: 309 (289)
Sequences: 218 (140)
Seq/√Len: 8.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_F128_V3.5540.95
229_K241_R3.2270.92
181_L186_V3.1090.90
152_T156_Y2.9950.88
138_A306_Y2.9560.88
61_H69_L2.8830.86
14_F88_S2.8750.86
114_I161_V2.6320.80
95_P190_L2.5310.78
187_L216_Y2.4240.74
257_T261_A2.4180.74
24_F205_R2.3400.72
110_L114_I2.2730.69
28_L113_H2.2580.69
215_E302_R2.2490.68
98_L285_V2.2250.68
157_R258_P2.1120.63
24_F28_L2.1050.63
219_I299_I2.0400.61
96_G157_R2.0150.60
96_G258_P2.0150.60
185_E188_A1.9950.59
88_S244_Y1.9300.56
64_N98_L1.9130.55
28_L148_P1.8390.52
14_F79_I1.8390.52
108_A112_S1.8180.51
265_R274_V1.8050.51
72_R113_H1.7740.50
118_N258_P1.7520.49
118_N157_R1.7520.49
242_V262_L1.7310.48
139_R198_R1.7250.48
67_Q219_I1.7210.47
215_E280_Y1.6900.46
36_A175_K1.6760.46
13_T142_W1.6640.45
285_V289_Y1.6630.45
58_V243_W1.6570.45
90_A235_K1.6560.45
63_G66_A1.6500.44
96_G118_N1.6470.44
152_T228_L1.6280.44
68_S72_R1.6210.43
216_Y306_Y1.6050.43
100_Y187_L1.5970.42
44_V212_L1.5960.42
188_A261_A1.5670.41
55_R105_L1.5480.40
9_R16_Q1.5450.40
136_T154_N1.5330.40
128_V257_T1.5120.39
87_S175_K1.4990.38
172_W258_P1.4910.38
157_R172_W1.4910.38
44_V117_I1.4780.38
279_N294_Q1.4760.37
289_Y292_Q1.4730.37
38_V210_R1.4700.37
262_L279_N1.4690.37
156_Y175_K1.4560.37
124_F240_A1.4360.36
171_G241_R1.4360.36
8_D145_R1.4280.36
159_L274_V1.4260.36
128_V262_L1.4150.35
151_I290_K1.3880.34
28_L100_Y1.3850.34
96_G172_W1.3830.34
208_W233_P1.3720.33
148_P307_V1.3670.33
18_E235_K1.3600.33
116_H260_I1.3410.32
69_L100_Y1.3370.32
170_F238_P1.3320.32
79_I88_S1.3270.32
60_Q300_I1.3250.32
114_I299_I1.3210.32
150_L302_R1.3210.32
14_F244_Y1.3140.31
24_F294_Q1.3040.31
121_K238_P1.3040.31
69_L189_Q1.2990.31
100_Y112_S1.2900.31
53_L235_K1.2850.30
98_L165_P1.2800.30
94_L173_A1.2750.30
117_I298_L1.2680.30
68_S274_V1.2540.29
77_L156_Y1.2540.29
138_A260_I1.2520.29
38_V243_W1.2430.29
184_D218_D1.2260.28
43_E209_Q1.2230.28
171_G255_C1.2230.28
30_Q126_H1.2210.28
297_R307_V1.2190.28
88_S123_T1.2170.28
142_W241_R1.2080.28
42_P238_P1.2060.28
67_Q71_L1.2040.28
86_R142_W1.1990.27
98_L145_R1.1980.27
24_F119_K1.1850.27
49_E144_H1.1840.27
125_E256_P1.1790.27
61_H98_L1.1780.27
144_H150_L1.1760.27
32_K119_K1.1740.27
27_H196_S1.1720.27
172_W277_L1.1690.26
11_N148_P1.1680.26
153_L233_P1.1680.26
169_R176_H1.1590.26
165_P168_L1.1540.26
140_F228_L1.1520.26
60_Q279_N1.1500.26
8_D12_T1.1490.26
124_F148_P1.1450.26
145_R189_Q1.1430.26
174_N280_Y1.1360.25
76_H229_K1.1320.25
45_K48_D1.1260.25
181_L189_Q1.1200.25
93_R228_L1.1190.25
217_Q264_N1.1120.25
118_N172_W1.1050.24
41_L233_P1.1030.24
97_V257_T1.1010.24
138_A246_G1.1000.24
167_T275_G1.0990.24
23_I27_H1.0980.24
10_L254_A1.0980.24
47_E234_V1.0950.24
179_K276_E1.0880.24
38_V235_K1.0850.24
152_T171_G1.0850.24
150_L232_R1.0830.24
215_E222_L1.0690.23
194_L213_E1.0630.23
88_S154_N1.0610.23
49_E87_S1.0600.23
14_F251_V1.0600.23
140_F152_T1.0600.23
73_H257_T1.0580.23
15_R219_I1.0580.23
12_T22_A1.0570.23
265_R297_R1.0570.23
80_Q254_A1.0560.23
61_H70_A1.0540.23
85_N260_I1.0540.23
224_Q299_I1.0530.23
32_K64_N1.0530.23
190_L291_P1.0520.23
299_I307_V1.0470.23
27_H111_V1.0430.23
44_V182_H1.0420.23
137_A167_T1.0410.22
137_A142_W1.0410.22
193_S212_L1.0370.22
74_F299_I1.0350.22
244_Y251_V1.0330.22
151_I176_H1.0270.22
220_A270_G1.0170.22
228_L238_P1.0130.22
93_R233_P1.0100.22
186_V189_Q1.0080.22
109_A188_A1.0040.21
180_N227_K1.0010.21
69_L137_A1.0000.21
151_I188_A0.9990.21
15_R28_L0.9940.21
87_S144_H0.9930.21
23_I195_K0.9900.21
156_Y302_R0.9840.21
31_H35_V0.9780.21
88_S253_H0.9730.21
179_K262_L0.9710.21
142_W197_P0.9710.21
169_R241_R0.9670.20
38_V94_L0.9600.20
41_L302_R0.9530.20
142_W148_P0.9490.20
24_F289_Y0.9460.20
204_T297_R0.9420.20
95_P277_L0.9390.20
12_T260_I0.9380.20
284_N301_P0.9320.19
22_A274_V0.9320.19
152_T302_R0.9250.19
218_D221_A0.9210.19
80_Q203_W0.9140.19
189_Q257_T0.9110.19
128_V274_V0.9110.19
93_R223_P0.9050.19
136_T289_Y0.9050.19
25_A264_N0.9040.19
20_E116_H0.9040.19
27_H113_H0.9010.19
72_R104_N0.8900.18
25_A45_K0.8890.18
147_L173_A0.8870.18
257_T263_I0.8820.18
12_T265_R0.8810.18
15_R100_Y0.8760.18
190_L242_V0.8750.18
57_E279_N0.8740.18
44_V196_S0.8740.18
227_K294_Q0.8700.18
159_L177_I0.8700.18
228_L236_V0.8690.18
234_V237_Q0.8660.18
222_L305_L0.8580.18
124_F137_A0.8570.18
212_L219_I0.8550.18
61_H188_A0.8520.17
244_Y259_L0.8520.17
168_L245_K0.8490.17
124_F261_A0.8470.17
78_F150_L0.8470.17
287_H290_K0.8470.17
185_E192_K0.8440.17
148_P197_P0.8440.17
49_E152_T0.8400.17
247_D274_V0.8390.17
121_K258_P0.8380.17
121_K157_R0.8380.17
209_Q213_E0.8370.17
60_Q271_V0.8320.17
17_M117_I0.8320.17
23_I225_N0.8290.17
67_Q100_Y0.8280.17
9_R244_Y0.8270.17
77_L223_P0.8230.17
17_M299_I0.8210.17
144_H280_Y0.8190.17
216_Y220_A0.8140.17
154_N171_G0.8130.17
236_V275_G0.8130.17
41_L228_L0.8120.17
44_V144_H0.8090.16
20_E113_H0.8090.16
89_K153_L0.8080.16
43_E244_Y0.8060.16
113_H116_H0.8060.16
44_V100_Y0.8060.16
110_L292_Q0.8030.16
36_A109_A0.8010.16
10_L307_V0.7990.16
100_Y292_Q0.7980.16
13_T124_F0.7970.16
89_K141_E0.7950.16
116_H225_N0.7950.16
84_E301_P0.7930.16
237_Q254_A0.7930.16
193_S302_R0.7880.16
97_V163_H0.7780.16
91_A237_Q0.7760.16
101_Q164_D0.7750.16
209_Q217_Q0.7750.16
39_F208_W0.7740.16
48_D51_N0.7720.16
140_F175_K0.7670.16
49_E140_F0.7670.16
140_F229_K0.7660.15
124_F216_Y0.7660.15
72_R106_S0.7650.15
143_V155_A0.7620.15
215_E303_L0.7600.15
121_K156_Y0.7600.15
10_L90_A0.7590.15
19_Q115_Q0.7590.15
11_N88_S0.7570.15
32_K60_Q0.7570.15
13_T148_P0.7530.15
89_K152_T0.7500.15
212_L282_A0.7460.15
24_F109_A0.7450.15
190_L222_L0.7410.15
235_K252_Q0.7340.15
213_E265_R0.7330.15
59_K224_Q0.7330.15
139_R239_I0.7330.15
33_L290_K0.7330.15
164_D191_E0.7320.15
117_I121_K0.7300.15
87_S156_Y0.7300.15
184_D191_E0.7280.15
286_Q307_V0.7270.15
14_F139_R0.7270.15
96_G121_K0.7260.15
78_F255_C0.7260.15
65_D247_D0.7220.15
132_S150_L0.7210.15
66_A175_K0.7180.14
110_L113_H0.7140.14
116_H119_K0.7120.14
110_L116_H0.7040.14
40_S59_K0.7000.14
93_R236_V0.7000.14
191_E218_D0.6980.14
128_V163_H0.6970.14
140_F232_R0.6960.14
111_V163_H0.6870.14
250_Q254_A0.6840.14
20_E40_S0.6810.14
105_L111_V0.6800.14
39_F95_P0.6780.14
17_M163_H0.6760.14
100_Y125_E0.6730.14
87_S232_R0.6730.14
91_A174_N0.6720.14
154_N237_Q0.6720.14
17_M166_A0.6710.14
52_P159_L0.6710.14
175_K228_L0.6700.14
16_Q61_H0.6700.14
154_N203_W0.6680.13
112_S242_V0.6670.13
55_R159_L0.6670.13
124_F143_V0.6660.13
20_E61_H0.6640.13
101_Q168_L0.6630.13
112_S188_A0.6600.13
153_L171_G0.6580.13
79_I89_K0.6560.13
137_A148_P0.6560.13
112_S196_S0.6540.13
140_F144_H0.6540.13
138_A244_Y0.6500.13
19_Q40_S0.6440.13
32_K123_T0.6420.13
42_P228_L0.6410.13
171_G250_Q0.6390.13
165_P191_E0.6370.13
203_W253_H0.6330.13
143_V150_L0.6320.13
53_L159_L0.6290.13
87_S152_T0.6290.13
171_G228_L0.6290.13
25_A75_R0.6280.13
128_V247_D0.6270.13
258_P277_L0.6270.13
157_R277_L0.6270.13
13_T137_A0.6260.13
135_P297_R0.6260.13
158_T301_P0.6250.13
57_E214_R0.6250.13
137_A196_S0.6240.13
97_V261_A0.6230.13
89_K232_R0.6230.13
78_F275_G0.6200.13
242_V279_N0.6180.13
50_H304_H0.6180.13
14_F123_T0.6180.13
193_S215_E0.6170.13
36_A262_L0.6150.12
79_I164_D0.6110.12
176_H285_V0.6090.12
53_L220_A0.6080.12
55_R164_D0.6040.12
214_R279_N0.6040.12
78_F241_R0.6020.12
174_N235_K0.6010.12
261_A282_A0.5990.12
168_L264_N0.5900.12
221_A306_Y0.5900.12
145_R306_Y0.5890.12
164_D210_R0.5850.12
74_F260_I0.5850.12
164_D224_Q0.5840.12
171_G240_A0.5820.12
221_A284_N0.5810.12
292_Q299_I0.5770.12
220_A274_V0.5770.12
24_F92_V0.5760.12
166_A257_T0.5730.12
138_A220_A0.5710.12
286_Q290_K0.5700.12
46_K237_Q0.5690.12
178_I254_A0.5660.12
109_A221_A0.5660.12
197_P209_Q0.5640.12
300_I304_H0.5640.12
151_I178_I0.5630.12
22_A108_A0.5620.12
32_K37_R0.5600.12
37_R108_A0.5600.12
173_A243_W0.5580.11
162_L292_Q0.5560.11
48_D138_A0.5550.11
49_E149_G0.5550.11
59_K65_D0.5530.11
121_K219_I0.5520.11
88_S242_V0.5510.11
91_A236_V0.5500.11
255_C285_V0.5460.11
241_R255_C0.5460.11
12_T112_S0.5440.11
117_I297_R0.5420.11
168_L182_H0.5420.11
251_V289_Y0.5380.11
86_R197_P0.5380.11
147_L243_W0.5380.11
16_Q115_Q0.5360.11
139_R240_A0.5340.11
9_R251_V0.5320.11
20_E283_D0.5300.11
30_Q136_T0.5300.11
16_Q20_E0.5290.11
187_L244_Y0.5280.11
140_F238_P0.5270.11
229_K255_C0.5230.11
62_L123_T0.5220.11
89_K228_L0.5220.11
87_S140_F0.5210.11
73_H192_K0.5210.11
148_P273_D0.5200.11
255_C293_A0.5180.11
16_Q62_L0.5160.11
90_A237_Q0.5160.11
76_H142_W0.5150.11
22_A119_K0.5150.11
252_Q259_L0.5140.11
97_V253_H0.5100.11
243_W252_Q0.5090.11
55_R265_R0.5090.11
173_A234_V0.5050.11
79_I219_I0.5050.11
90_A219_I0.5040.11
221_A288_R0.5040.11
106_S257_T0.5020.11
96_G277_L0.5020.11
154_N253_H0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i06A 1 0.9871 100 0.066 Contact Map
2pnvA 5 0.1262 34.5 0.962 Contact Map
3qf2A 1 0.3107 10.2 0.97 Contact Map
1g1eB 1 0.1003 7.8 0.972 Contact Map
3nmdA 2 0.1165 6.2 0.973 Contact Map
2km6A 1 0.301 6 0.973 Contact Map
1zmeC 2 0.1003 5.9 0.973 Contact Map
2hm2Q 1 0.2816 5.4 0.974 Contact Map
1e91A 1 0.1068 5.3 0.974 Contact Map
4pxvA 1 0.1392 5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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