GREMLIN Database
SELD - Selenide, water dikinase
UniProt: P16456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10943
Length: 347 (285)
Sequences: 11898 (7583)
Seq/√Len: 449.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_R333_E3.2091.00
173_K330_A2.8861.00
251_D254_A2.8081.00
249_R335_V2.7911.00
313_A316_E2.6181.00
309_V317_V2.5701.00
170_A336_P2.5591.00
172_C223_K2.4701.00
173_K333_E2.3611.00
64_I97_G2.3201.00
173_K314_E2.2881.00
174_L308_A2.2871.00
247_Q335_V2.2471.00
241_C248_A2.2171.00
175_F318_K2.1891.00
120_E123_E2.1571.00
56_D159_T2.1491.00
314_E330_A2.1291.00
175_F328_L2.0611.00
78_F127_Y2.0571.00
170_A246_V2.0471.00
246_V334_L2.0451.00
237_L248_A2.0281.00
182_I190_K2.0271.00
310_M313_A1.9851.00
175_F330_A1.9631.00
318_K328_L1.9361.00
221_G313_A1.9331.00
78_F120_E1.9281.00
126_R130_R1.9051.00
247_Q337_A1.9051.00
78_F123_E1.8811.00
311_P333_E1.8741.00
314_E318_K1.8721.00
173_K311_P1.8451.00
237_L250_V1.8261.00
223_K310_M1.8251.00
315_N319_A1.8171.00
219_I320_T1.8051.00
174_L248_A1.7811.00
206_M209_M1.7681.00
100_I156_I1.7621.00
248_A334_L1.7561.00
168_A224_A1.7531.00
60_G160_E1.7301.00
82_R128_A1.7071.00
54_V64_I1.7061.00
60_G159_T1.6791.00
72_P75_D1.6151.00
43_L62_S1.6051.00
62_S159_T1.5961.00
316_E319_A1.5931.00
184_V187_T1.5681.00
127_Y131_Q1.5621.00
66_T153_V1.5561.00
175_F314_E1.5491.00
127_Y130_R1.5191.00
144_A148_I1.5141.00
247_Q338_R1.5011.00
92_I97_G1.4981.00
92_I153_V1.4871.00
330_A333_E1.4831.00
123_E127_Y1.4771.00
175_F309_V1.4671.00
240_M308_A1.4571.00
53_A137_A1.4391.00
106_L118_A1.4371.00
205_V209_M1.4311.00
303_G331_I1.4301.00
224_A240_M1.4221.00
182_I187_T1.4171.00
88_A153_V1.4151.00
183_G186_T1.4081.00
223_K308_A1.4081.00
319_A323_E1.4061.00
71_M75_D1.4051.00
103_I138_G1.4031.00
316_E320_T1.4001.00
79_D124_G1.3991.00
321_A328_L1.3861.00
175_F317_V1.3841.00
128_A131_Q1.3771.00
174_L306_L1.3681.00
65_S103_I1.3641.00
104_A125_G1.3581.00
215_S218_N1.3511.00
225_M307_L1.3451.00
169_Q223_K1.3441.00
52_A95_M1.3301.00
169_Q310_M1.3301.00
172_C310_M1.3111.00
168_A334_L1.2921.00
39_D98_K1.2881.00
163_K225_M1.2841.00
61_T158_P1.2841.00
114_S117_I1.2811.00
225_M305_L1.2741.00
195_K198_H1.2681.00
315_N318_K1.2371.00
69_F150_G1.2341.00
212_A215_S1.2331.00
168_A308_A1.2301.00
157_V162_V1.2261.00
320_T324_F1.2181.00
86_T128_A1.2171.00
183_G187_T1.2071.00
318_K330_A1.2071.00
183_G188_A1.1851.00
94_A225_M1.1821.00
62_S162_V1.1811.00
182_I258_L1.1781.00
108_W118_A1.1671.00
82_R131_Q1.1651.00
228_V236_H1.1651.00
66_T92_I1.1541.00
107_G144_A1.1501.00
318_K322_A1.1491.00
67_T105_I1.1461.00
251_D333_E1.1381.00
213_G216_F1.1381.00
84_A149_F1.1371.00
98_K214_A1.1331.00
129_C136_L1.1321.00
319_A322_A1.1291.00
237_L306_L1.1231.00
64_I92_I1.1061.00
67_T152_A1.1041.00
167_T223_K1.1031.00
206_M210_N1.0971.00
58_G156_I1.0941.00
42_L45_G1.0891.00
61_T156_I1.0811.00
308_A334_L1.0761.00
158_P161_R1.0741.00
57_L156_I1.0701.00
85_A102_A1.0701.00
52_A64_I1.0631.00
62_S157_V1.0631.00
65_S154_T1.0521.00
168_A240_M1.0421.00
320_T323_E1.0411.00
233_L306_L1.0301.00
265_I272_G1.0221.00
54_V162_V1.0211.00
202_A206_M1.0211.00
202_A205_V1.0181.00
161_R218_N1.0101.00
132_A208_R1.0091.00
211_I215_S1.0091.00
30_L34_Q1.0091.00
85_A129_C1.0041.00
101_M137_A1.0001.00
65_S152_A0.9991.00
203_T206_M0.9961.00
82_R127_Y0.9881.00
195_K200_G0.9871.00
213_G217_A0.9861.00
186_T190_K0.9831.00
183_G190_K0.9791.00
102_A153_V0.9741.00
252_Y272_G0.9731.00
164_K167_T0.9641.00
237_L241_C0.9591.00
176_L303_G0.9581.00
77_P117_I0.9561.00
58_G61_T0.9541.00
262_E266_K0.9521.00
56_D60_G0.9501.00
172_C334_L0.9491.00
85_A125_G0.9481.00
214_A218_N0.9471.00
50_D95_M0.9401.00
226_T306_L0.9391.00
106_L149_F0.9371.00
317_V320_T0.9361.00
215_S219_I0.9321.00
82_R86_T0.9321.00
257_K262_E0.9301.00
173_K309_V0.9241.00
182_I186_T0.9231.00
224_A308_A0.9221.00
64_I157_V0.9221.00
186_T189_E0.9171.00
183_G189_E0.9171.00
245_G337_A0.9161.00
249_R252_Y0.9151.00
216_F317_V0.9131.00
187_T190_K0.9101.00
177_T321_A0.9081.00
76_N79_D0.9041.00
102_A151_L0.9011.00
179_P327_E0.9001.00
102_A125_G0.9001.00
89_I128_A0.8991.00
101_M154_T0.8941.00
79_D82_R0.8941.00
41_N55_Y0.8931.00
278_F301_T0.8921.00
174_L334_L0.8891.00
256_P329_T0.8881.00
56_D62_S0.8861.00
50_D165_N0.8771.00
219_I316_E0.8761.00
279_A282_G0.8721.00
33_E123_E0.8711.00
317_V321_A0.8681.00
220_E320_T0.8671.00
101_M135_A0.8651.00
198_H201_L0.8621.00
161_R220_E0.8601.00
226_T239_E0.8601.00
185_L188_A0.8571.00
307_L317_V0.8531.00
241_C334_L0.8511.00
212_A321_A0.8511.00
116_E120_E0.8501.00
191_K194_L0.8461.00
220_E317_V0.8461.00
168_A244_A0.8421.00
182_I185_L0.8421.00
129_C134_I0.8401.00
41_N56_D0.8401.00
89_I153_V0.8321.00
81_G124_G0.8311.00
195_K201_L0.8301.00
211_I214_A0.8301.00
89_I134_I0.8291.00
179_P182_I0.8261.00
55_Y101_M0.8211.00
233_L237_L0.8191.00
196_P199_Q0.8081.00
215_S324_F0.8071.00
98_K133_G0.8071.00
207_C210_N0.8061.00
192_S195_K0.8001.00
263_E267_L0.7981.00
170_A173_K0.7981.00
204_E207_C0.7961.00
176_L256_P0.7951.00
212_A216_F0.7941.00
170_A335_V0.7941.00
33_E119_R0.7931.00
69_F105_I0.7891.00
54_V95_M0.7871.00
98_K218_N0.7831.00
39_D55_Y0.7791.00
43_L56_D0.7751.00
69_F107_G0.7721.00
322_A327_E0.7681.00
203_T209_M0.7681.00
215_S320_T0.7671.00
71_M74_V0.7661.00
54_V62_S0.7651.00
44_V164_K0.7641.00
115_P119_R0.7631.00
85_A128_A0.7621.00
184_V190_K0.7611.00
171_G333_E0.7591.00
185_L189_E0.7551.00
278_F281_Y0.7511.00
52_A66_T0.7481.00
42_L135_A0.7481.00
169_Q172_C0.7451.00
65_S101_M0.7411.00
113_L118_A0.7371.00
121_V149_F0.7351.00
276_R279_A0.7351.00
309_V314_E0.7341.00
119_R123_E0.7291.00
29_I119_R0.7291.00
174_L178_K0.7291.00
62_S160_E0.7271.00
103_I152_A0.7261.00
30_L33_E0.7251.00
203_T207_C0.7191.00
85_A89_I0.7171.00
98_K156_I0.7141.00
68_D91_D0.7141.00
97_G157_V0.7101.00
184_V188_A0.7091.00
41_N44_V0.7081.00
177_T305_L0.7081.00
125_G149_F0.7051.00
195_K199_Q0.7051.00
102_A129_C0.7031.00
265_I268_G0.6991.00
217_A220_E0.6931.00
212_A326_I0.6921.00
228_V304_G0.6921.00
29_I33_E0.6911.00
205_V210_N0.6911.00
212_A324_F0.6881.00
254_A329_T0.6881.00
70_F87_N0.6841.00
228_V306_L0.6821.00
193_L270_V0.6821.00
315_N330_A0.6781.00
117_I120_E0.6731.00
271_P276_R0.6731.00
164_K168_A0.6721.00
256_P262_E0.6721.00
241_C244_A0.6701.00
265_I270_V0.6691.00
121_V125_G0.6691.00
178_K329_T0.6681.00
163_K222_V0.6651.00
217_A225_M0.6641.00
78_F124_G0.6641.00
81_G121_V0.6611.00
82_R203_T0.6561.00
29_I34_Q0.6551.00
56_D59_N0.6521.00
80_F121_V0.6521.00
216_F220_E0.6511.00
165_N243_G0.6511.00
110_I115_P0.6501.00
191_K195_K0.6450.99
262_E265_I0.6380.99
42_L137_A0.6380.99
108_W121_V0.6370.99
103_I154_T0.6340.99
117_I121_V0.6330.99
60_G158_P0.6320.99
278_F282_G0.6310.99
263_E266_K0.6300.99
185_L261_V0.6280.99
311_P314_E0.6260.99
105_I150_G0.6260.99
241_C246_V0.6220.99
40_P45_G0.6210.99
179_P258_L0.6200.99
168_A223_K0.6200.99
28_T32_S0.6160.99
163_K217_A0.6140.99
74_V147_P0.6090.99
176_L228_V0.6080.99
215_S221_G0.6080.99
89_I132_A0.6080.99
129_C151_L0.6080.99
102_A136_L0.6030.99
233_L331_I0.6030.99
110_I114_S0.6020.99
315_N322_A0.6010.99
165_N168_A0.5990.99
39_D135_A0.5990.99
32_S119_R0.5970.99
67_T150_G0.5970.99
235_G279_A0.5970.99
314_E328_L0.5930.99
70_F84_A0.5930.99
213_G307_L0.5920.99
98_K211_I0.5910.99
79_D120_E0.5890.99
67_T103_I0.5860.99
235_G238_S0.5850.99
103_I137_A0.5840.99
179_P304_G0.5800.99
131_Q211_I0.5800.99
202_A209_M0.5790.99
110_I143_D0.5780.99
84_A151_L0.5770.99
174_L250_V0.5770.99
277_N280_S0.5770.99
220_E313_A0.5760.99
107_G142_I0.5760.99
81_G125_G0.5760.99
218_N221_G0.5730.99
39_D42_L0.5720.99
55_Y65_S0.5710.99
38_V41_N0.5690.99
76_N120_E0.5680.99
311_P330_A0.5680.99
112_K115_P0.5680.99
182_I188_A0.5670.99
205_V208_R0.5670.99
88_A151_L0.5650.99
79_D208_R0.5620.99
113_L116_E0.5620.99
194_L199_Q0.5590.99
94_A305_L0.5590.99
207_C326_I0.5590.99
113_L117_I0.5570.99
110_I113_L0.5570.99
178_K327_E0.5550.99
276_R281_Y0.5540.98
211_I217_A0.5520.98
55_Y137_A0.5510.98
221_G316_E0.5510.98
177_T307_L0.5480.98
265_I277_N0.5470.98
168_A246_V0.5470.98
41_N45_G0.5430.98
258_L327_E0.5420.98
180_L233_L0.5400.98
213_G305_L0.5400.98
196_P200_G0.5380.98
116_E119_R0.5350.98
228_V233_L0.5340.98
187_T230_G0.5340.98
108_W117_I0.5320.98
259_P262_E0.5280.98
99_P134_I0.5270.98
180_L255_I0.5260.98
197_E200_G0.5260.98
174_L240_M0.5250.98
183_G191_K0.5240.98
193_L198_H0.5240.98
198_H260_G0.5230.98
236_H306_L0.5220.98
317_V328_L0.5220.98
261_V268_G0.5220.98
176_L180_L0.5210.98
301_T304_G0.5210.98
264_Y267_L0.5210.98
32_S38_V0.5210.98
31_H34_Q0.5190.98
175_F307_L0.5170.98
171_G334_L0.5130.98
44_V54_V0.5130.98
184_V189_E0.5130.98
39_D43_L0.5100.97
34_Q37_F0.5090.97
216_F219_I0.5080.97
68_D229_T0.5060.97
28_T31_H0.5040.97
194_L201_L0.5010.97
277_N281_Y0.5000.97
100_I154_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u0oA 2 0.9654 100 0.225 Contact Map
2zodA 2 0.9251 100 0.239 Contact Map
3fd5A 2 0.9193 100 0.289 Contact Map
3wjpA 2 0.8847 100 0.332 Contact Map
3viuA 1 0.8415 100 0.337 Contact Map
3m84A 2 0.902 100 0.338 Contact Map
2z1uA 2 0.8703 100 0.343 Contact Map
2z01A 2 0.8242 100 0.345 Contact Map
3p4eA 2 0.8501 100 0.347 Contact Map
2btuA 2 0.8588 100 0.349 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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