GREMLIN Database
HYCG - Formate hydrogenlyase subunit 7
UniProt: P16433 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10480
Length: 255 (204)
Sequences: 220 (87)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E29_S3.8910.93
22_S68_F3.4270.87
49_N128_V3.2310.84
132_T138_V3.0690.80
31_L140_V2.7630.72
21_E126_Y2.6120.68
36_R75_S2.5790.67
49_N126_Y2.4620.63
95_P148_T2.3440.59
84_F132_T2.2840.57
59_L118_S2.2340.55
37_S71_K2.2290.55
26_M83_L2.2200.54
88_V136_V2.1590.52
88_V141_Y2.0650.49
53_I122_F2.0410.48
126_Y165_Q2.0240.47
154_Y158_M1.9950.46
16_P22_S1.8630.42
45_C56_F1.8400.41
15_V22_S1.8010.40
126_Y187_M1.7940.39
32_K68_F1.7880.39
204_G207_Y1.7750.39
153_L170_R1.7700.39
18_T22_S1.7660.38
94_S136_V1.7440.38
22_S32_K1.6900.36
15_V19_V1.6740.35
53_I79_A1.6700.35
182_I207_Y1.6530.35
14_P22_S1.6300.34
29_S126_Y1.6200.34
156_F200_R1.6170.33
44_D56_F1.6130.33
23_I140_V1.6100.33
116_G135_I1.6050.33
28_A174_E1.5480.31
20_D177_E1.5390.31
28_A173_G1.5290.31
95_P98_R1.5270.31
22_S181_E1.5020.30
71_K142_I1.4950.30
98_R107_K1.4880.30
111_S179_P1.4850.29
19_V178_Q1.4420.28
41_Y93_R1.4390.28
41_Y94_S1.4330.28
63_F114_A1.3920.27
109_C118_S1.3900.27
23_I27_K1.3840.27
16_P19_V1.3840.27
37_S142_I1.3740.26
103_A150_A1.3640.26
82_L152_T1.3560.26
100_W109_C1.3550.26
114_A124_D1.3460.25
21_E49_N1.3380.25
15_V199_A1.3290.25
174_E191_L1.3150.25
28_A31_L1.2970.24
14_P28_A1.2900.24
65_A70_I1.2850.24
49_N153_L1.2820.24
21_E128_V1.2720.24
15_V68_F1.2700.23
62_L164_E1.2690.23
49_N165_Q1.2580.23
63_F124_D1.2570.23
36_R98_R1.2550.23
95_P165_Q1.2480.23
66_E71_K1.2460.23
31_L68_F1.2220.22
79_A131_G1.2180.22
193_V200_R1.2150.22
99_A108_I1.2100.22
42_R112_Y1.1980.22
189_Q210_Q1.1810.21
18_T201_R1.1780.21
183_L186_D1.1670.21
150_A159_A1.1670.21
106_P141_Y1.1560.21
75_S197_R1.1560.21
19_V189_Q1.1500.21
15_V187_M1.1490.20
58_T153_L1.1430.20
14_P18_T1.1320.20
128_V165_Q1.1310.20
97_L101_Q1.1300.20
19_V32_K1.1180.20
199_A204_G1.1120.20
39_Y163_L1.0900.19
41_Y66_E1.0880.19
204_G208_G1.0860.19
51_C113_G1.0820.19
57_A68_F1.0810.19
96_A136_V1.0570.18
52_E56_F1.0550.18
15_V186_D1.0530.18
41_Y126_Y1.0530.18
77_R147_P1.0510.18
114_A134_K1.0490.18
21_E187_M1.0450.18
16_P68_F1.0430.18
95_P142_I1.0190.18
150_A158_M1.0180.18
171_G210_Q1.0150.18
84_F96_A1.0150.18
92_M98_R1.0120.17
76_P80_D1.0040.17
101_Q114_A0.9970.17
76_P131_G0.9710.17
197_R208_G0.9640.17
19_V57_A0.9630.16
44_D66_E0.9600.16
164_E191_L0.9590.16
122_F142_I0.9590.16
194_K214_D0.9540.16
60_S66_E0.9500.16
14_P177_E0.9390.16
56_F59_L0.9390.16
80_D100_W0.9250.16
61_P155_G0.9100.15
41_Y91_A0.9070.15
15_V181_E0.9050.15
34_I78_H0.9000.15
21_E24_A0.8950.15
20_D180_A0.8930.15
21_E191_L0.8920.15
28_A215_Y0.8920.15
51_C137_P0.8920.15
44_D49_N0.8860.15
68_F95_P0.8840.15
66_E70_I0.8830.15
207_Y210_Q0.8830.15
33_K109_C0.8810.15
174_E177_E0.8740.15
27_K204_G0.8730.15
96_A132_T0.8710.15
170_R184_H0.8600.15
48_C52_E0.8580.15
22_S57_A0.8560.14
80_D139_D0.8510.14
88_V126_Y0.8480.14
14_P19_V0.8450.14
58_T66_E0.8400.14
188_V197_R0.8380.14
55_I152_T0.8380.14
16_P199_A0.8360.14
66_E73_V0.8360.14
41_Y138_V0.8340.14
39_Y103_A0.8330.14
26_M179_P0.8330.14
22_S148_T0.8330.14
51_C146_P0.8290.14
72_V118_S0.8270.14
15_V24_A0.8240.14
113_G137_P0.8230.14
173_G179_P0.8210.14
173_G204_G0.8190.14
97_L116_G0.8190.14
27_K163_L0.8190.14
186_D214_D0.8170.14
209_R213_D0.8110.14
111_S188_V0.8080.14
175_L179_P0.8070.14
19_V188_V0.8040.14
36_R92_M0.8020.14
14_P138_V0.8000.14
111_S135_I0.7940.13
98_R165_Q0.7940.13
126_Y167_I0.7890.13
80_D133_D0.7880.13
29_S88_V0.7840.13
53_I152_T0.7740.13
200_R204_G0.7730.13
31_L209_R0.7660.13
14_P17_M0.7610.13
113_G146_P0.7610.13
41_Y142_I0.7570.13
196_D199_A0.7550.13
170_R176_D0.7550.13
192_R199_A0.7540.13
88_V92_M0.7530.13
68_F181_E0.7520.13
76_P79_A0.7520.13
125_L159_A0.7460.13
18_T168_H0.7440.13
14_P21_E0.7410.13
47_G112_Y0.7380.13
16_P32_K0.7360.12
194_K217_T0.7330.12
73_V161_G0.7270.12
28_A168_H0.7240.12
65_A81_I0.7230.12
184_H206_R0.7220.12
95_P116_G0.7220.12
85_T112_Y0.7200.12
15_V183_L0.7140.12
153_L165_Q0.7140.12
22_S192_R0.7070.12
107_K114_A0.7050.12
22_S28_A0.7050.12
110_I151_A0.7010.12
111_S117_N0.7010.12
206_R210_Q0.6960.12
39_Y92_M0.6950.12
19_V24_A0.6950.12
26_M35_K0.6890.12
42_R150_A0.6850.12
47_G92_M0.6810.12
18_T35_K0.6800.12
16_P27_K0.6790.12
48_C99_A0.6790.12
55_I105_D0.6770.12
51_C131_G0.6730.12
22_S168_H0.6730.12
20_D156_F0.6710.12
170_R173_G0.6660.11
148_T165_Q0.6640.11
37_S60_S0.6640.11
15_V18_T0.6620.11
114_A122_F0.6610.11
199_A202_L0.6590.11
14_P183_L0.6570.11
50_G102_S0.6540.11
124_D136_V0.6540.11
15_V57_A0.6510.11
39_Y56_F0.6450.11
192_R211_I0.6440.11
201_R211_I0.6430.11
26_M38_A0.6410.11
48_C117_N0.6370.11
49_N95_P0.6340.11
38_A148_T0.6290.11
111_S180_A0.6280.11
45_C116_G0.6250.11
84_F148_T0.6240.11
29_S117_N0.6210.11
60_S70_I0.6200.11
18_T109_C0.6140.11
96_A138_V0.6130.11
35_K50_G0.6130.11
29_S182_I0.6090.11
126_Y169_A0.6090.11
15_V32_K0.6080.11
113_G131_G0.6040.11
210_Q215_Y0.6010.11
183_L189_Q0.5940.10
101_Q215_Y0.5930.10
77_R146_P0.5920.10
50_G78_H0.5910.10
194_K198_E0.5890.10
94_S138_V0.5850.10
44_D126_Y0.5820.10
142_I155_G0.5810.10
107_K151_A0.5800.10
74_P126_Y0.5780.10
140_V183_L0.5770.10
60_S153_L0.5770.10
124_D149_P0.5760.10
16_P24_A0.5710.10
61_P121_I0.5670.10
107_K122_F0.5660.10
190_P196_D0.5660.10
21_E169_A0.5650.10
18_T21_E0.5650.10
34_I166_K0.5630.10
137_P146_P0.5610.10
170_R174_E0.5590.10
20_D187_M0.5580.10
19_V199_A0.5560.10
17_M29_S0.5540.10
55_I82_L0.5480.10
41_Y95_P0.5460.10
50_G91_A0.5460.10
186_D203_A0.5450.10
55_I108_I0.5440.10
84_F135_I0.5430.10
199_A208_G0.5420.10
176_D179_P0.5360.10
45_C160_L0.5360.10
45_C80_D0.5350.10
116_G138_V0.5340.10
14_P169_A0.5340.10
23_I31_L0.5300.10
23_I189_Q0.5280.10
35_K179_P0.5270.10
208_G213_D0.5270.10
80_D92_M0.5240.10
34_I159_A0.5230.10
173_G189_Q0.5190.09
121_I155_G0.5190.09
112_Y129_W0.5170.09
102_S138_V0.5170.09
38_A125_L0.5140.09
16_P20_D0.5130.09
122_F149_P0.5090.09
29_S215_Y0.5080.09
15_V201_R0.5080.09
20_D25_S0.5070.09
21_E165_Q0.5060.09
186_D210_Q0.5040.09
91_A94_S0.5010.09
79_A122_F0.5010.09
15_V20_D0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v6 1 0.5686 100 0.512 Contact Map
1h2aS 1 0.8039 100 0.66 Contact Map
4ue3S 2 0.7961 100 0.663 Contact Map
3ayxB 2 0.7451 100 0.67 Contact Map
2wpnA 1 0.7373 100 0.671 Contact Map
4iucS 1 0.7922 100 0.676 Contact Map
4uqlA 1 0.7922 100 0.676 Contact Map
3myrA 3 0.7961 100 0.677 Contact Map
4u9hS 1 0.749 100 0.678 Contact Map
4kn9S 1 0.7529 100 0.682 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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