GREMLIN Database
HYCF - Formate hydrogenlyase subunit 6
UniProt: P16432 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10479
Length: 180 (149)
Sequences: 628 (430)
Seq/√Len: 35.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_E90_I3.8241.00
155_C158_C3.5451.00
47_V55_L3.4901.00
39_Q89_A3.0461.00
35_Q90_I2.4901.00
117_C120_C2.4231.00
134_I153_E2.2600.99
131_D138_K2.1670.99
49_A84_V2.1450.99
27_K94_Q2.0290.98
151_S162_K1.9180.98
82_E92_L1.9040.98
155_C159_K1.7570.96
140_N143_S1.7350.96
97_E106_F1.7260.96
17_S20_L1.6740.95
117_C121_N1.6240.94
36_N39_Q1.6150.94
117_C155_C1.6050.94
123_P127_Q1.6040.94
119_V161_Q1.5410.92
113_A127_Q1.5320.92
49_A80_R1.5130.91
41_I87_T1.5060.91
120_C155_C1.4630.90
54_A76_I1.4530.90
159_K162_K1.4410.89
138_K148_H1.4340.89
148_H151_S1.4270.89
16_S23_I1.3960.88
14_A122_R1.3690.87
70_F92_L1.3570.86
134_I139_H1.3520.86
42_G77_F1.3480.86
120_C158_C1.3390.85
157_E161_Q1.3260.85
154_T159_K1.3110.84
102_K105_D1.3010.84
13_T20_L1.2910.83
111_R118_R1.2000.78
153_E161_Q1.1780.77
53_N105_D1.1750.77
118_R121_N1.1740.77
99_A102_K1.1600.76
142_D146_E1.1460.75
143_S146_E1.1440.75
140_N144_R1.1430.75
161_Q165_V1.1430.75
52_S76_I1.1400.75
34_E93_S1.1010.72
43_C81_C1.0990.72
43_C85_C1.0990.72
46_C50_C1.0990.72
43_C78_C1.0990.72
43_C50_C1.0990.72
46_C78_C1.0990.72
46_C81_C1.0990.72
46_C85_C1.0990.72
43_C46_C1.0990.72
50_C78_C1.0990.72
50_C81_C1.0990.72
78_C81_C1.0990.72
78_C85_C1.0990.72
81_C85_C1.0990.72
50_C85_C1.0990.72
40_C78_C1.0990.72
40_C46_C1.0990.72
40_C50_C1.0990.72
40_C43_C1.0990.72
40_C81_C1.0990.72
40_C85_C1.0990.72
144_R165_V1.0850.71
39_Q90_I1.0680.70
34_E91_K1.0630.69
132_Y140_N1.0620.69
138_K142_D1.0610.69
90_I153_E1.0590.69
75_C78_C1.0570.69
40_C75_C1.0570.69
46_C75_C1.0570.69
50_C75_C1.0570.69
43_C75_C1.0570.69
75_C85_C1.0570.69
75_C81_C1.0570.69
35_Q44_A1.0400.68
86_P89_A1.0320.67
58_E67_A1.0280.67
134_I138_K1.0270.67
146_E153_E1.0160.66
162_K165_V1.0130.66
144_R151_S1.0110.65
152_F155_C1.0020.65
122_R157_E0.9990.64
133_A151_S0.9950.64
157_E160_R0.9930.64
147_N150_E0.9900.64
145_A151_S0.9780.63
89_A92_L0.9780.63
15_T18_Y0.9760.63
154_T162_K0.9520.61
45_A49_A0.9500.60
79_G92_L0.9460.60
77_F98_L0.9390.60
54_A92_L0.9350.59
147_N151_S0.9330.59
33_P80_R0.9280.59
117_C137_L0.9250.58
119_V165_V0.9230.58
144_R149_R0.9170.58
146_E149_R0.9160.58
117_C126_V0.9150.58
131_D135_A0.9050.57
119_V127_Q0.8880.55
57_V68_W0.8850.55
114_L117_C0.8770.54
29_F83_E0.8700.54
35_Q93_S0.8630.53
151_S159_K0.8630.53
25_V96_Y0.8570.53
145_A149_R0.8570.53
47_V57_V0.8490.52
117_C158_C0.8450.52
146_E152_F0.8450.52
144_R153_E0.8430.51
138_K147_N0.8390.51
45_A76_I0.8360.51
116_N123_P0.8330.51
148_H154_T0.8320.50
37_P89_A0.8290.50
38_Q91_K0.8280.50
154_T158_C0.8270.50
117_C124_F0.8210.50
72_L77_F0.8090.49
21_E24_A0.8080.48
84_V89_A0.8070.48
29_F33_P0.8030.48
52_S74_H0.7950.47
32_K95_E0.7740.46
76_I80_R0.7720.45
77_F92_L0.7720.45
124_F128_K0.7620.44
120_C123_P0.7490.43
145_A152_F0.7480.43
118_R131_D0.7460.43
77_F87_T0.7380.42
38_Q70_F0.7330.42
54_A155_C0.7250.41
148_H162_K0.7190.41
22_P88_A0.7150.41
131_D134_I0.7130.40
16_S21_E0.7120.40
15_T19_P0.7090.40
160_R164_L0.7080.40
127_Q131_D0.7080.40
73_G77_F0.7070.40
59_T72_L0.7050.40
67_A111_R0.6940.39
51_P76_I0.6930.39
144_R147_N0.6920.39
148_H152_F0.6920.39
138_K149_R0.6910.39
88_A93_S0.6880.38
150_E153_E0.6830.38
159_K163_C0.6800.38
31_G36_N0.6790.38
149_R153_E0.6790.38
41_I80_R0.6770.37
119_V162_K0.6760.37
41_I44_A0.6710.37
20_L103_K0.6690.37
154_T157_E0.6540.36
126_V129_E0.6500.35
150_E165_V0.6470.35
115_C120_C0.6460.35
18_Y97_E0.6380.34
160_R163_C0.6370.34
120_C124_F0.6320.34
49_A128_K0.6300.34
157_E165_V0.6300.34
117_C130_I0.6290.34
17_S22_P0.6280.34
38_Q104_E0.6280.34
120_C126_V0.6250.33
59_T73_G0.6240.33
74_H84_V0.6220.33
55_L70_F0.6210.33
44_A98_L0.6210.33
120_C137_L0.6200.33
121_N125_A0.6190.33
122_R126_V0.6180.33
135_A147_N0.6140.32
147_N161_Q0.6120.32
92_L120_C0.6120.32
33_P83_E0.6110.32
53_N97_E0.6080.32
45_A87_T0.5980.31
76_I92_L0.5960.31
68_W76_I0.5960.31
146_E164_L0.5920.31
79_G82_E0.5880.31
122_R135_A0.5760.30
45_A120_C0.5730.29
157_E163_C0.5730.29
134_I146_E0.5650.29
70_F108_Q0.5630.29
135_A150_E0.5600.29
146_E150_E0.5570.28
15_T30_R0.5490.28
53_N107_L0.5450.28
127_Q135_A0.5380.27
108_Q113_A0.5370.27
44_A48_N0.5290.26
111_R117_C0.5270.26
152_F157_E0.5260.26
150_E156_P0.5250.26
33_P68_W0.5240.26
24_A94_Q0.5240.26
137_L155_C0.5120.25
134_I141_G0.5120.25
121_N135_A0.5080.25
27_K138_K0.5060.25
38_Q164_L0.5060.25
60_D84_V0.5050.25
118_R150_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v9 1 0.7611 99.9 0.554 Contact Map
1gteA 4 0.5556 99.6 0.679 Contact Map
5c4iB 1 0.5111 99.6 0.679 Contact Map
4omfG 2 0.5278 99.5 0.693 Contact Map
1hfeL 2 0.9056 99.5 0.697 Contact Map
1xerA 2 0.5222 99.5 0.701 Contact Map
2gmhA 1 0.5889 99.5 0.702 Contact Map
3i9v3 1 0.9 99.4 0.708 Contact Map
1rgvA 1 0.4111 99.4 0.709 Contact Map
1jb0C 1 0.4333 99.4 0.711 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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