HYCE - ECOLI - GREMLIN Contacts

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HYCE - Formate hydrogenlyase subunit 5

UniProt:	P16431	Sequences: MSEEKLGQHYLAALNEAFPGVVLDHAWQTKDQLTVTVKVNYLPEVVEFLYYKQGGWLSVLFGNDERKLNGHYAVYYVLSMEKGTKCWITVRVEVDANKPEYPSVTPRVPAAVWGEREVRDMYGLIPVGLPDERRLVLPDDWPDELYPLRKDSMDYRQRPAPTTDAETYEFINELGDKKNNVVPIGPLHVTSDEPGHFRLFVDGENIIDADYRLFYVHRGMEKLAETRMGYNEVTFLSDRVCGICGFAHSTAYTTSVENAMGIQVPERAQMIRAILLEVERLHSHLLNLGLACHFTGFDSGFMQFFRVRETSMKMAEILTGARKTYGLNLIGGIRRDLLKDDMIQTRQLAQQMRREVQELVDVLLSTPNMEQRTVGIGRLDPEIARDFSNVGPMVRASGHARDTRADHPFVGYGLLPMEVHSEQGCDVISRLKVRINEVYTALNMIDYGLDNLPGGPLMVEGFTYIPHRFALGFAEAPRGDDIHWSMTGDNQKLYRWRCRAATYANWPTLRYMLRGNTVSDAPLIIGSLDPCYSCTDRMTVVDVRKKKSKVVPYKELERYSIERKNSPLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10478
Length:	569 (493)
Sequences:	786 (498)
Seq/√Len:	22.4

ECOLI - HYCE HYFG NUOCD
HALSA - Q9HRL9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
353_R	446_D	6.676	1.00
422_E	436_N	4.650	1.00
218_R	533_S	4.240	1.00
424_G	429_S	4.211	1.00
389_N	508_T	3.967	1.00
267_R	336_D	3.965	1.00
400_A	405_A	3.804	1.00
182_V	518_V	3.690	1.00
100_E	127_V	3.607	1.00
350_Q	446_D	3.523	1.00
244_C	247_A	3.459	1.00
271_I	333_I	3.414	1.00
418_E	440_T	3.348	1.00
379_L	389_N	3.341	1.00
101_Y	126_P	3.259	1.00
150_K	225_E	3.138	1.00
417_M	447_Y	3.077	1.00
241_C	531_C	2.965	0.99
222_K	225_E	2.737	0.99
233_V	252_Y	2.691	0.99
400_A	419_V	2.667	0.99
357_Q	439_Y	2.637	0.99
377_G	524_I	2.615	0.99
259_A	470_A	2.553	0.98
343_I	347_Q	2.518	0.98
317_I	344_Q	2.411	0.98
349_A	446_D	2.377	0.97
265_P	268_A	2.349	0.97
173_E	176_D	2.335	0.97
512_M	528_L	2.307	0.97
129_L	132_E	2.283	0.97
346_R	450_D	2.252	0.96
61_F	74_V	2.214	0.96
43_P	106_P	2.191	0.96
175_G	178_K	2.180	0.96
173_E	177_K	2.135	0.95
270_M	453_P	2.128	0.95
39_V	98_K	2.098	0.95
266_E	414_L	2.073	0.94
405_A	419_V	2.046	0.94
195_G	506_W	2.045	0.94
47_E	51_Y	2.029	0.94
119_R	132_E	1.999	0.93
197_F	521_A	1.997	0.93
493_L	496_W	1.996	0.93
290_L	294_F	1.951	0.92
276_L	409_F	1.938	0.92
241_C	534_C	1.938	0.92
197_F	209_A	1.934	0.92
267_R	453_P	1.914	0.91
315_A	324_T	1.865	0.90
79_S	82_K	1.831	0.89
234_T	253_T	1.811	0.89
274_I	448_G	1.798	0.89
291_A	373_T	1.791	0.88
243_I	529_D	1.791	0.88
294_F	529_D	1.772	0.88
117_E	497_R	1.765	0.88
197_F	532_Y	1.762	0.88
348_L	352_M	1.745	0.87
273_A	448_G	1.731	0.87
438_V	445_I	1.713	0.86
531_C	534_C	1.710	0.86
417_M	444_M	1.693	0.85
264_V	269_Q	1.667	0.84
218_R	245_G	1.664	0.84
190_T	532_Y	1.661	0.84
243_I	531_C	1.658	0.84
436_N	440_T	1.655	0.84
193_E	242_G	1.650	0.84
420_H	436_N	1.639	0.83
47_E	107_R	1.638	0.83
516_N	524_I	1.638	0.83
278_V	311_S	1.606	0.82
224_A	496_W	1.606	0.82
103_S	115_E	1.598	0.82
483_H	498_C	1.598	0.82
267_R	455_G	1.580	0.81
119_R	126_P	1.574	0.81
243_I	500_A	1.573	0.81
173_E	178_K	1.567	0.80
255_S	485_S	1.565	0.80
190_T	287_N	1.550	0.80
273_A	415_L	1.531	0.79
243_I	534_C	1.527	0.79
184_I	522_P	1.522	0.78
73_A	90_V	1.514	0.78
273_A	411_G	1.512	0.78
189_V	192_D	1.508	0.78
333_I	352_M	1.504	0.78
195_G	287_N	1.504	0.78
73_A	101_Y	1.500	0.77
199_L	209_A	1.500	0.77
353_R	442_L	1.491	0.77
122_Y	495_R	1.478	0.76
400_A	406_D	1.461	0.76
256_V	485_S	1.449	0.75
181_V	526_G	1.449	0.75
370_E	428_I	1.448	0.75
417_M	420_H	1.437	0.74
263_Q	269_Q	1.432	0.74
264_V	459_V	1.424	0.74
476_A	481_D	1.416	0.73
199_L	526_G	1.416	0.73
100_E	125_I	1.413	0.73
244_C	534_C	1.409	0.73
227_R	236_L	1.403	0.72
290_L	529_D	1.400	0.72
135_L	319_T	1.399	0.72
66_R	71_H	1.397	0.72
42_L	311_S	1.390	0.72
46_V	77_V	1.388	0.72
192_D	526_G	1.371	0.71
101_Y	118_V	1.366	0.70
353_R	443_N	1.363	0.70
195_G	532_Y	1.359	0.70
275_L	327_L	1.359	0.70
131_D	210_D	1.350	0.69
287_N	532_Y	1.346	0.69
48_F	51_Y	1.338	0.69
184_I	526_G	1.335	0.69
440_T	443_N	1.334	0.69
189_V	506_W	1.334	0.69
389_N	393_M	1.331	0.68
192_D	294_F	1.328	0.68
242_G	279_E	1.327	0.68
471_L	482_I	1.320	0.68
287_N	529_D	1.317	0.68
379_L	384_A	1.317	0.68
422_E	429_S	1.314	0.67
360_V	439_Y	1.297	0.66
360_V	435_I	1.290	0.66
244_C	294_F	1.288	0.66
241_C	529_D	1.287	0.66
500_A	531_C	1.283	0.65
192_D	525_I	1.281	0.65
294_F	531_C	1.279	0.65
414_L	451_N	1.276	0.65
105_T	112_V	1.275	0.65
508_T	512_M	1.272	0.65
247_A	477_P	1.270	0.65
250_T	276_L	1.268	0.64
149_R	222_K	1.251	0.63
44_E	54_G	1.247	0.63
336_D	453_P	1.247	0.63
415_L	450_D	1.245	0.63
418_E	443_N	1.244	0.63
132_E	259_A	1.243	0.63
218_R	518_V	1.242	0.63
48_F	53_Q	1.240	0.63
380_D	383_I	1.237	0.63
37_V	40_N	1.235	0.62
206_I	516_N	1.234	0.62
254_T	410_V	1.233	0.62
42_L	46_V	1.230	0.62
403_T	471_L	1.229	0.62
263_Q	347_Q	1.225	0.62
218_R	241_C	1.224	0.62
266_E	269_Q	1.220	0.61
350_Q	353_R	1.214	0.61
529_D	534_C	1.213	0.61
417_M	421_S	1.213	0.61
71_H	90_V	1.209	0.61
150_K	222_K	1.198	0.60
382_E	454_G	1.190	0.59
238_D	326_G	1.187	0.59
214_F	308_R	1.186	0.59
273_A	410_V	1.186	0.59
486_M	494_Y	1.184	0.59
321_A	324_T	1.177	0.59
170_F	175_G	1.176	0.59
221_E	495_R	1.170	0.58
197_F	478_R	1.159	0.57
270_M	414_L	1.149	0.57
344_Q	347_Q	1.149	0.57
199_L	525_I	1.147	0.57
113_W	135_L	1.147	0.57
383_I	511_Y	1.144	0.56
105_T	519_S	1.141	0.56
245_G	286_L	1.141	0.56
409_F	447_Y	1.134	0.56
233_V	496_W	1.133	0.56
253_T	328_N	1.129	0.55
174_L	177_K	1.127	0.55
347_Q	454_G	1.120	0.55
193_E	279_E	1.118	0.55
189_V	525_I	1.118	0.55
44_E	51_Y	1.118	0.55
279_E	325_Y	1.111	0.54
258_N	472_G	1.107	0.54
240_V	483_H	1.100	0.53
121_M	271_I	1.098	0.53
224_A	233_V	1.097	0.53
415_L	448_G	1.094	0.53
71_H	77_V	1.084	0.52
239_R	309_E	1.082	0.52
476_A	500_A	1.082	0.52
181_V	210_D	1.078	0.52
314_M	328_N	1.078	0.52
230_Y	487_T	1.073	0.52
364_L	428_I	1.073	0.52
170_F	179_N	1.072	0.51
382_E	386_D	1.071	0.51
306_R	310_T	1.070	0.51
39_V	51_Y	1.066	0.51
370_E	374_V	1.066	0.51
281_L	438_V	1.066	0.51
241_C	478_R	1.054	0.50
37_V	81_E	1.054	0.50
382_E	451_N	1.053	0.50
352_M	438_V	1.049	0.50
311_S	526_G	1.043	0.49
184_I	521_A	1.037	0.49
90_V	518_V	1.037	0.49
122_Y	420_H	1.033	0.49
90_V	363_L	1.033	0.49
314_M	348_L	1.033	0.49
308_R	323_K	1.033	0.49
42_L	81_E	1.032	0.49
72_Y	77_V	1.031	0.49
263_Q	266_E	1.029	0.49
244_C	282_H	1.029	0.49
500_A	529_D	1.026	0.48
216_V	393_M	1.023	0.48
356_V	438_V	1.020	0.48
477_P	500_A	1.019	0.48
184_I	190_T	1.018	0.48
506_W	532_Y	1.016	0.48
240_V	498_C	1.012	0.47
243_I	477_P	1.012	0.47
363_L	431_L	1.009	0.47
293_H	529_D	1.009	0.47
436_N	439_Y	1.005	0.47
243_I	535_T	1.004	0.47
112_V	129_L	1.001	0.47
150_K	494_Y	0.998	0.46
336_D	419_V	0.997	0.46
208_D	274_I	0.996	0.46
469_F	484_W	0.995	0.46
154_D	223_L	0.995	0.46
265_P	338_L	0.994	0.46
263_Q	382_E	0.992	0.46
268_A	331_G	0.992	0.46
299_S	303_Q	0.991	0.46
47_E	52_K	0.988	0.46
187_L	532_Y	0.984	0.45
406_D	419_V	0.983	0.45
184_I	199_L	0.980	0.45
428_I	432_K	0.979	0.45
506_W	535_T	0.979	0.45
60_L	73_A	0.975	0.45
120_D	146_Y	0.975	0.45
466_P	494_Y	0.975	0.45
260_M	466_P	0.971	0.45
153_M	156_R	0.968	0.44
271_I	336_D	0.968	0.44
164_D	169_E	0.966	0.44
101_Y	124_L	0.966	0.44
525_I	532_Y	0.965	0.44
289_G	434_R	0.964	0.44
442_L	450_D	0.963	0.44
270_M	337_L	0.961	0.44
485_S	496_W	0.958	0.44
246_F	275_L	0.958	0.44
192_D	529_D	0.956	0.44
405_A	417_M	0.956	0.44
238_D	249_S	0.952	0.43
40_N	43_P	0.951	0.43
48_F	60_L	0.949	0.43
401_R	407_H	0.949	0.43
268_A	333_I	0.946	0.43
243_I	294_F	0.940	0.42
175_G	179_N	0.939	0.42
190_T	502_T	0.938	0.42
289_G	304_F	0.938	0.42
135_L	428_I	0.936	0.42
192_D	287_N	0.934	0.42
151_D	222_K	0.934	0.42
241_C	294_F	0.934	0.42
152_S	375_G	0.932	0.42
122_Y	148_L	0.930	0.42
444_M	448_G	0.929	0.42
421_S	461_G	0.928	0.42
206_I	350_Q	0.927	0.42
403_T	473_F	0.926	0.42
118_V	124_L	0.925	0.41
351_Q	446_D	0.925	0.41
274_I	407_H	0.924	0.41
385_R	399_H	0.924	0.41
122_Y	149_R	0.923	0.41
408_P	455_G	0.922	0.41
483_H	496_W	0.916	0.41
42_L	102_P	0.915	0.41
413_G	416_P	0.914	0.41
181_V	525_I	0.914	0.41
244_C	531_C	0.912	0.41
249_S	328_N	0.909	0.40
103_S	405_A	0.908	0.40
297_F	522_P	0.908	0.40
242_G	532_Y	0.905	0.40
44_E	47_E	0.905	0.40
214_F	294_F	0.901	0.40
279_E	532_Y	0.897	0.40
128_G	489_D	0.896	0.40
244_C	529_D	0.895	0.39
465_I	468_R	0.891	0.39
310_T	351_Q	0.887	0.39
287_N	526_G	0.887	0.39
445_I	456_P	0.886	0.39
467_H	490_N	0.884	0.39
176_D	179_N	0.884	0.39
38_K	41_Y	0.882	0.39
132_E	135_L	0.876	0.38
240_V	457_L	0.875	0.38
49_L	54_G	0.873	0.38
292_C	363_L	0.871	0.38
99_P	124_L	0.870	0.38
270_M	451_N	0.870	0.38
182_V	218_R	0.868	0.38
238_D	325_Y	0.864	0.37
245_G	325_Y	0.863	0.37
376_I	517_T	0.863	0.37
259_A	487_T	0.862	0.37
290_L	531_C	0.859	0.37
356_V	435_I	0.857	0.37
374_V	428_I	0.857	0.37
70_G	78_L	0.855	0.37
184_I	195_G	0.854	0.37
369_M	373_T	0.853	0.37
187_L	506_W	0.852	0.37
113_W	503_Y	0.850	0.37
294_F	534_C	0.850	0.37
263_Q	343_I	0.850	0.37
96_A	128_G	0.845	0.36
78_L	83_G	0.845	0.36
364_L	435_I	0.843	0.36
122_Y	150_K	0.843	0.36
39_V	74_V	0.842	0.36
46_V	104_V	0.842	0.36
113_W	214_F	0.841	0.36
432_K	436_N	0.841	0.36
420_H	447_Y	0.839	0.36
512_M	530_P	0.839	0.36
43_P	58_S	0.838	0.36
287_N	523_L	0.838	0.36
438_V	468_R	0.836	0.36
117_E	221_E	0.836	0.36
244_C	477_P	0.832	0.35
485_S	493_L	0.831	0.35
224_A	237_S	0.831	0.35
70_G	73_A	0.830	0.35
189_V	195_G	0.830	0.35
189_V	199_L	0.830	0.35
253_T	264_V	0.829	0.35
389_N	392_P	0.827	0.35
191_S	532_Y	0.826	0.35
187_L	191_S	0.826	0.35
287_N	525_I	0.825	0.35
67_K	70_G	0.825	0.35
469_F	486_M	0.823	0.35
133_R	309_E	0.823	0.35
192_D	532_Y	0.822	0.35
132_E	485_S	0.822	0.35
41_Y	44_E	0.822	0.35
195_G	213_L	0.819	0.35
187_L	190_T	0.819	0.35
291_A	472_G	0.818	0.35
71_H	74_V	0.818	0.35
194_P	478_R	0.818	0.35
191_S	377_G	0.815	0.34
367_P	474_A	0.815	0.34
192_D	195_G	0.815	0.34
443_N	447_Y	0.812	0.34
136_V	214_F	0.810	0.34
41_Y	206_I	0.809	0.34
307_V	359_L	0.809	0.34
274_I	450_D	0.809	0.34
190_T	525_I	0.806	0.34
128_G	446_D	0.806	0.34
62_G	122_Y	0.806	0.34
41_Y	48_F	0.806	0.34
288_L	377_G	0.806	0.34
209_A	521_A	0.805	0.34
287_N	521_A	0.804	0.34
194_P	513_L	0.802	0.34
62_G	77_V	0.801	0.33
190_T	251_A	0.800	0.33
447_Y	451_N	0.800	0.33
121_M	399_H	0.799	0.33
81_E	85_K	0.799	0.33
289_G	478_R	0.797	0.33
44_E	48_F	0.794	0.33
195_G	209_A	0.794	0.33
187_L	195_G	0.794	0.33
57_L	60_L	0.792	0.33
502_T	534_C	0.789	0.33
194_P	198_R	0.788	0.33
242_G	531_C	0.788	0.33
336_D	455_G	0.787	0.33
378_R	490_N	0.785	0.33
165_A	169_E	0.782	0.32
168_Y	175_G	0.781	0.32
396_A	425_C	0.781	0.32
291_A	500_A	0.778	0.32
216_V	308_R	0.777	0.32
296_G	383_I	0.777	0.32
117_E	498_C	0.775	0.32
99_P	151_D	0.775	0.32
38_K	44_E	0.772	0.32
283_S	528_L	0.772	0.32
509_L	532_Y	0.769	0.32
530_P	534_C	0.769	0.32
282_H	286_L	0.765	0.31
119_R	128_G	0.764	0.31
59_V	63_N	0.763	0.31
189_V	526_G	0.759	0.31
381_P	399_H	0.759	0.31
405_A	409_F	0.759	0.31
244_C	290_L	0.756	0.31
120_D	533_S	0.756	0.31
37_V	41_Y	0.755	0.31
446_D	450_D	0.755	0.31
250_T	256_V	0.754	0.31
128_G	261_G	0.752	0.31
66_R	151_D	0.752	0.31
309_E	473_F	0.751	0.31
321_A	358_E	0.750	0.30
52_K	70_G	0.750	0.30
346_R	449_L	0.750	0.30
466_P	493_L	0.746	0.30
522_P	532_Y	0.745	0.30
477_P	529_D	0.745	0.30
129_L	248_H	0.744	0.30
192_D	290_L	0.743	0.30
194_P	532_Y	0.743	0.30
403_T	480_D	0.741	0.30
416_P	447_Y	0.741	0.30
149_R	296_G	0.740	0.30
506_W	525_I	0.739	0.30
135_L	503_Y	0.737	0.30
530_P	533_S	0.736	0.30
416_P	445_I	0.736	0.30
199_L	287_N	0.735	0.30
213_L	506_W	0.735	0.30
257_E	272_R	0.734	0.30
190_T	521_A	0.734	0.30
54_G	313_K	0.733	0.29
438_V	450_D	0.733	0.29
253_T	358_E	0.729	0.29
214_F	282_H	0.728	0.29
169_E	262_I	0.728	0.29
513_L	524_I	0.728	0.29
281_L	288_L	0.727	0.29
206_I	503_Y	0.727	0.29
308_R	315_A	0.726	0.29
409_F	499_R	0.724	0.29
221_E	445_I	0.722	0.29
225_E	494_Y	0.722	0.29
241_C	500_A	0.722	0.29
120_D	212_R	0.720	0.29
426_D	429_S	0.720	0.29
289_G	308_R	0.720	0.29
120_D	519_S	0.719	0.29
309_E	468_R	0.719	0.29
517_T	522_P	0.719	0.29
284_H	437_E	0.719	0.29
283_S	481_D	0.717	0.29
286_L	529_D	0.715	0.28
275_L	362_V	0.713	0.28
412_Y	536_D	0.710	0.28
243_I	290_L	0.709	0.28
79_S	84_T	0.709	0.28
194_P	427_V	0.709	0.28
115_E	499_R	0.708	0.28
315_A	319_T	0.708	0.28
327_L	335_R	0.707	0.28
148_L	217_H	0.706	0.28
506_W	522_P	0.706	0.28
195_G	526_G	0.703	0.28
194_P	509_L	0.700	0.28
307_V	351_Q	0.700	0.28
256_V	476_A	0.698	0.28
453_P	457_L	0.698	0.28
38_K	43_P	0.698	0.28
353_R	357_Q	0.698	0.28
174_L	178_K	0.697	0.27
184_I	532_Y	0.696	0.27
56_W	61_F	0.695	0.27
209_A	525_I	0.695	0.27
224_A	528_L	0.694	0.27
248_H	483_H	0.694	0.27
188_H	192_D	0.694	0.27
190_T	506_W	0.693	0.27
190_T	522_P	0.690	0.27
348_L	442_L	0.690	0.27
287_N	290_L	0.690	0.27
168_Y	178_K	0.690	0.27
283_S	476_A	0.690	0.27
96_A	99_P	0.690	0.27
301_F	305_F	0.689	0.27
309_E	312_M	0.687	0.27
394_V	505_N	0.687	0.27
264_V	461_G	0.686	0.27
209_A	513_L	0.686	0.27
266_E	433_V	0.683	0.27
274_I	452_L	0.682	0.27
166_E	170_F	0.680	0.27
240_V	533_S	0.678	0.26
245_G	323_K	0.678	0.26
195_G	198_R	0.676	0.26
250_T	533_S	0.676	0.26
422_E	432_K	0.675	0.26
213_L	279_E	0.675	0.26
381_P	425_C	0.674	0.26
61_F	76_Y	0.674	0.26
381_P	397_S	0.672	0.26
194_P	209_A	0.672	0.26
283_S	286_L	0.671	0.26
209_A	532_Y	0.670	0.26
246_F	276_L	0.669	0.26
292_C	369_M	0.669	0.26
120_D	287_N	0.668	0.26
43_P	49_L	0.668	0.26
101_Y	523_L	0.667	0.26
521_A	525_I	0.665	0.26
241_C	244_C	0.662	0.26
216_V	509_L	0.662	0.26
292_C	431_L	0.662	0.26
48_F	52_K	0.660	0.25
227_R	230_Y	0.660	0.25
417_M	440_T	0.656	0.25
478_R	535_T	0.655	0.25
121_M	276_L	0.653	0.25
265_P	456_P	0.653	0.25
188_H	294_F	0.652	0.25
88_I	376_I	0.651	0.25
37_V	263_Q	0.651	0.25
252_Y	300_G	0.649	0.25
267_R	332_G	0.649	0.25
218_R	317_I	0.647	0.25
198_R	210_D	0.647	0.25
382_E	446_D	0.646	0.25
136_V	183_P	0.646	0.25
349_A	353_R	0.643	0.25
256_V	468_R	0.643	0.25
443_N	446_D	0.643	0.25
288_L	424_G	0.641	0.25
202_D	207_I	0.638	0.24
38_K	49_L	0.638	0.24
210_D	526_G	0.638	0.24
98_K	124_L	0.638	0.24
293_H	500_A	0.637	0.24
521_A	526_G	0.633	0.24
349_A	442_L	0.631	0.24
264_V	449_L	0.631	0.24
197_F	219_G	0.631	0.24
192_D	243_I	0.631	0.24
237_S	303_Q	0.631	0.24
525_I	529_D	0.630	0.24
192_D	506_W	0.630	0.24
181_V	478_R	0.630	0.24
110_A	480_D	0.627	0.24
187_L	522_P	0.626	0.24
135_L	238_D	0.626	0.24
361_D	365_S	0.625	0.24
314_M	317_I	0.624	0.24
422_E	433_V	0.623	0.24
164_D	168_Y	0.623	0.24
77_V	83_G	0.621	0.24
208_D	510_R	0.620	0.23
296_G	374_V	0.619	0.23
254_T	472_G	0.617	0.23
369_M	518_V	0.617	0.23
147_P	495_R	0.616	0.23
407_H	498_C	0.616	0.23
395_R	475_E	0.616	0.23
372_R	520_D	0.615	0.23
450_D	454_G	0.614	0.23
128_G	172_N	0.613	0.23
127_V	433_V	0.612	0.23
61_F	65_E	0.612	0.23
170_F	178_K	0.612	0.23
149_R	225_E	0.611	0.23
287_N	506_W	0.610	0.23
339_K	490_N	0.610	0.23
244_C	500_A	0.609	0.23
45_V	48_F	0.609	0.23
77_V	128_G	0.609	0.23
195_G	521_A	0.609	0.23
464_Y	467_H	0.604	0.23
121_M	137_L	0.604	0.23
188_H	529_D	0.603	0.23
282_H	312_M	0.603	0.23
62_G	73_A	0.603	0.23
394_V	401_R	0.602	0.23
412_Y	495_R	0.601	0.23
105_T	497_R	0.600	0.22
189_V	287_N	0.600	0.22
526_G	529_D	0.598	0.22
128_G	380_D	0.598	0.22
113_W	510_R	0.598	0.22
326_G	411_G	0.597	0.22
279_E	534_C	0.597	0.22
379_L	397_S	0.597	0.22
387_F	511_Y	0.596	0.22
300_G	394_V	0.592	0.22
524_I	530_P	0.592	0.22
73_A	501_A	0.592	0.22
146_Y	419_V	0.589	0.22
198_R	526_G	0.589	0.22
191_S	195_G	0.588	0.22
294_F	526_G	0.587	0.22
473_F	480_D	0.586	0.22
435_I	440_T	0.586	0.22
328_N	515_G	0.585	0.22
401_R	406_D	0.585	0.22
477_P	530_P	0.584	0.22
188_H	196_H	0.584	0.22
78_L	434_R	0.584	0.22
205_N	376_I	0.583	0.22
134_R	528_L	0.582	0.22
275_L	296_G	0.581	0.22
50_Y	54_G	0.580	0.22
405_A	440_T	0.580	0.22
137_L	529_D	0.580	0.22
384_A	394_V	0.579	0.21
133_R	210_D	0.576	0.21
197_F	506_W	0.575	0.21
152_S	155_Y	0.575	0.21
526_G	532_Y	0.574	0.21
39_V	66_R	0.574	0.21
290_L	477_P	0.573	0.21
212_R	236_L	0.572	0.21
350_Q	445_I	0.571	0.21
299_S	480_D	0.571	0.21
89_T	92_V	0.569	0.21
287_N	522_P	0.569	0.21
252_Y	412_Y	0.569	0.21
282_H	319_T	0.569	0.21
187_L	531_C	0.568	0.21
191_S	194_P	0.568	0.21
73_A	476_A	0.568	0.21
189_V	532_Y	0.568	0.21
281_L	361_D	0.567	0.21
187_L	530_P	0.566	0.21
394_V	410_V	0.566	0.21
66_R	101_Y	0.564	0.21
267_R	271_I	0.564	0.21
394_V	399_H	0.563	0.21
276_L	427_V	0.562	0.21
384_A	425_C	0.562	0.21
171_I	178_K	0.560	0.21
319_T	325_Y	0.560	0.21
339_K	423_Q	0.559	0.21
311_S	326_G	0.559	0.21
114_G	504_A	0.558	0.21
227_R	232_E	0.557	0.20
105_T	445_I	0.557	0.20
39_V	44_E	0.556	0.20
420_H	440_T	0.555	0.20
403_T	490_N	0.555	0.20
204_E	294_F	0.555	0.20
46_V	50_Y	0.554	0.20
294_F	500_A	0.552	0.20
409_F	412_Y	0.552	0.20
342_M	352_M	0.551	0.20
365_S	423_Q	0.550	0.20
290_L	534_C	0.549	0.20
242_G	522_P	0.549	0.20
268_A	332_G	0.548	0.20
174_L	179_N	0.547	0.20
72_Y	76_Y	0.546	0.20
74_V	77_V	0.546	0.20
380_D	443_N	0.546	0.20
409_F	440_T	0.546	0.20
379_L	512_M	0.545	0.20
464_Y	468_R	0.545	0.20
294_F	308_R	0.543	0.20
188_H	525_I	0.542	0.20
517_T	525_I	0.540	0.20
190_T	523_L	0.539	0.20
190_T	195_G	0.537	0.20
339_K	365_S	0.536	0.20
415_L	444_M	0.536	0.20
380_D	459_V	0.536	0.20
194_P	377_G	0.536	0.20
133_R	198_R	0.534	0.19
209_A	517_T	0.534	0.19
187_L	394_V	0.532	0.19
505_N	530_P	0.532	0.19
196_H	215_Y	0.532	0.19
189_V	478_R	0.530	0.19
88_I	347_Q	0.529	0.19
306_R	355_E	0.527	0.19
500_A	534_C	0.526	0.19
216_V	530_P	0.525	0.19
97_N	459_V	0.525	0.19
121_M	141_W	0.525	0.19
343_I	354_R	0.524	0.19
488_G	492_K	0.524	0.19
444_M	447_Y	0.524	0.19
131_D	191_S	0.524	0.19
340_D	446_D	0.522	0.19
49_L	62_G	0.521	0.19
182_V	427_V	0.521	0.19
249_S	453_P	0.519	0.19
522_P	525_I	0.519	0.19
274_I	418_E	0.518	0.19
163_T	438_V	0.518	0.19
248_H	390_V	0.518	0.19
162_T	167_T	0.518	0.19
369_M	415_L	0.517	0.19
113_W	293_H	0.515	0.19
460_E	464_Y	0.515	0.19
247_A	481_D	0.514	0.19
90_V	98_K	0.514	0.19
190_T	509_L	0.514	0.19
321_A	325_Y	0.513	0.19
81_E	92_V	0.513	0.19
384_A	512_M	0.513	0.19
184_I	506_W	0.513	0.19
243_I	506_W	0.512	0.19
241_C	323_K	0.512	0.19
216_V	534_C	0.510	0.18
117_E	496_W	0.509	0.18
339_K	350_Q	0.508	0.18
41_Y	51_Y	0.506	0.18
101_Y	117_E	0.505	0.18
270_M	491_Q	0.505	0.18
389_N	399_H	0.505	0.18
176_D	312_M	0.504	0.18
266_E	451_N	0.504	0.18
36_T	79_S	0.504	0.18
40_N	44_E	0.504	0.18
39_V	53_Q	0.504	0.18
122_Y	494_Y	0.504	0.18
119_R	183_P	0.503	0.18
270_M	448_G	0.503	0.18
293_H	359_L	0.501	0.18
136_V	282_H	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3i9v4	1	0.6151	100	0.494	Contact Map
4omfA	1	0.6116	100	0.581	Contact Map
3ze9B	1	0.6221	100	0.595	Contact Map
4kn9L	2	0.6186	100	0.596	Contact Map
4u9hL	1	0.6274	100	0.608	Contact Map
4uqlQ	1	0.6362	100	0.609	Contact Map
1e3dB	1	0.6344	100	0.62	Contact Map
1yq9H	1	0.6221	100	0.622	Contact Map
4ue3L	2	0.6485	100	0.63	Contact Map
3myrB	2	0.6239	100	0.64	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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