GREMLIN Database
HYCC - Formate hydrogenlyase subunit 3
UniProt: P16429 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10476
Length: 608 (465)
Sequences: 14871 (8667)
Seq/√Len: 401.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_A66_L6.2791.00
120_C133_M4.4581.00
74_S247_T4.4031.00
180_D183_L4.2071.00
81_L123_I3.5041.00
338_V375_G3.4491.00
17_A38_G3.2581.00
331_N386_N3.2031.00
146_S151_G3.1731.00
178_T183_L3.0091.00
88_G115_M2.9651.00
40_A89_L2.7871.00
153_L220_Q2.7711.00
283_N353_R2.7501.00
352_H357_K2.7321.00
15_V116_A2.7281.00
373_L435_Y2.7231.00
282_H356_E2.6271.00
287_L355_I2.5411.00
267_G304_G2.5071.00
354_D357_K2.4981.00
328_H390_G2.4911.00
43_S86_L2.4701.00
81_L119_V2.4021.00
376_L431_M2.3921.00
84_L122_V2.3721.00
301_L420_L2.3131.00
95_N108_G2.2301.00
275_G294_E2.2181.00
288_L343_A2.1521.00
456_L460_V2.1261.00
222_H230_A2.1081.00
168_A200_L2.1021.00
271_A423_T2.0371.00
279_L429_M1.9931.00
85_G119_V1.9681.00
211_I300_L1.9671.00
127_L248_L1.9651.00
83_T333_S1.9481.00
222_H238_M1.9401.00
124_A129_M1.8981.00
246_L303_L1.8971.00
212_I269_I1.8721.00
127_L184_L1.8671.00
268_M419_G1.8621.00
282_H354_D1.8591.00
368_I453_C1.8361.00
202_V263_L1.8211.00
238_M292_T1.8111.00
414_P418_V1.8111.00
61_S66_L1.8081.00
365_M368_I1.8021.00
355_I438_T1.7901.00
40_A44_L1.7891.00
263_L304_G1.7851.00
291_H430_C1.7811.00
467_I471_I1.7661.00
171_L197_I1.7601.00
372_M434_V1.7581.00
481_P484_S1.7431.00
62_G65_S1.7431.00
362_G369_S1.7331.00
303_L325_G1.7291.00
79_I330_L1.7271.00
327_Y390_G1.7261.00
369_S440_L1.7221.00
305_A398_F1.7171.00
117_A136_I1.7021.00
60_V63_A1.6961.00
284_I434_V1.6941.00
202_V206_G1.6871.00
61_S64_L1.6761.00
70_D125_S1.6721.00
175_R197_I1.6611.00
44_L48_A1.6371.00
484_S488_P1.6331.00
43_S47_A1.6331.00
374_V466_A1.6281.00
264_L304_G1.6261.00
183_L186_M1.6261.00
395_Y420_L1.6111.00
77_N243_L1.6081.00
261_I265_V1.6041.00
46_T85_G1.5991.00
369_S435_Y1.5991.00
323_V484_S1.5971.00
27_Q30_L1.5971.00
372_M376_L1.5921.00
433_K437_V1.5631.00
183_L187_R1.5561.00
245_I300_L1.5391.00
157_L216_G1.5331.00
43_S85_G1.5121.00
475_A478_W1.5081.00
192_P196_D1.4991.00
125_S182_R1.4971.00
72_Q125_S1.4861.00
73_I123_I1.4791.00
42_G46_T1.4771.00
168_A204_G1.4751.00
97_D457_L1.4621.00
39_G43_S1.4621.00
130_F244_G1.4541.00
11_V116_A1.4531.00
371_A466_A1.4521.00
246_L325_G1.4511.00
324_G397_S1.4401.00
206_G211_I1.4381.00
92_S111_I1.4331.00
334_L468_C1.4331.00
30_L33_W1.4291.00
264_L416_L1.4281.00
50_G54_L1.4121.00
176_Y184_L1.4091.00
74_S77_N1.4071.00
267_G301_L1.3951.00
396_Q400_K1.3881.00
376_L435_Y1.3781.00
398_F417_A1.3721.00
47_A51_F1.3621.00
377_M382_L1.3551.00
211_I266_L1.3491.00
281_E286_R1.3461.00
170_W174_Q1.3451.00
243_L247_T1.3391.00
90_F464_A1.3381.00
18_A22_F1.3301.00
461_S464_A1.3271.00
87_C235_T1.3261.00
28_K32_G1.3171.00
89_L93_L1.3161.00
13_W38_G1.3161.00
302_G394_I1.3151.00
275_G423_T1.3081.00
265_V269_I1.3031.00
168_A197_I1.3021.00
110_Q143_F1.2991.00
87_C337_S1.2981.00
456_L459_S1.2981.00
121_A240_I1.2861.00
72_Q75_P1.2771.00
62_G66_L1.2661.00
199_L203_I1.2561.00
178_T184_L1.2541.00
272_F423_T1.2461.00
18_A21_A1.2371.00
371_A463_V1.2351.00
207_L214_L1.2331.00
37_I41_V1.2281.00
418_V422_I1.2261.00
448_A451_A1.2241.00
347_W353_R1.2231.00
38_G42_G1.2191.00
65_S68_S1.2181.00
173_W179_L1.2161.00
206_G266_L1.2131.00
128_G179_L1.2131.00
171_L193_L1.2121.00
455_P458_M1.2101.00
164_L203_I1.2071.00
267_G297_G1.1991.00
46_T81_L1.1981.00
97_D455_P1.1841.00
464_A468_C1.1831.00
67_V128_G1.1791.00
36_G93_L1.1771.00
348_F452_T1.1761.00
379_M431_M1.1751.00
205_F244_G1.1651.00
33_W37_I1.1631.00
294_E427_A1.1591.00
22_F25_S1.1581.00
144_L229_A1.1541.00
349_R365_M1.1541.00
58_V61_S1.1531.00
331_N390_G1.1521.00
126_N180_D1.1491.00
367_V463_V1.1451.00
104_V107_N1.1361.00
457_L461_S1.1341.00
245_I252_G1.1321.00
477_P481_P1.1311.00
86_L90_F1.1301.00
164_L200_L1.1291.00
94_Y341_L1.1271.00
48_A52_T1.1241.00
46_T49_A1.1211.00
39_G42_G1.1191.00
11_V71_V1.1181.00
242_L300_L1.1121.00
70_D180_D1.1111.00
478_W481_P1.1111.00
186_M189_Q1.1031.00
196_D200_L1.1021.00
79_I326_L1.0981.00
299_I325_G1.0971.00
415_L418_V1.0951.00
372_M439_F1.0941.00
18_A113_M1.0931.00
481_P485_A1.0911.00
85_G89_L1.0891.00
342_G372_M1.0891.00
268_M416_L1.0861.00
355_I437_V1.0791.00
435_Y440_L1.0751.00
471_I475_A1.0741.00
463_V467_I1.0711.00
187_R190_Q1.0691.00
51_F54_L1.0671.00
399_F417_A1.0641.00
335_F378_A1.0611.00
371_A462_V1.0581.00
63_A68_S1.0571.00
248_L251_L1.0541.00
29_A32_G1.0541.00
295_N427_A1.0541.00
342_G462_V1.0521.00
35_A109_L1.0521.00
212_I273_V1.0491.00
82_I86_L1.0491.00
346_V361_I1.0451.00
181_L185_D1.0381.00
51_F55_T1.0361.00
90_F461_S1.0351.00
80_W329_L1.0351.00
173_W176_Y1.0321.00
187_R191_L1.0271.00
345_S454_A1.0271.00
50_G82_I1.0241.00
226_S229_A1.0201.00
42_G85_G1.0201.00
364_K449_E1.0201.00
137_M237_V1.0191.00
386_N469_C1.0141.00
258_W261_I1.0141.00
178_T181_L1.0131.00
91_V341_L1.0121.00
35_A39_G1.0111.00
225_A228_P1.0111.00
29_A33_W1.0101.00
169_C201_G1.0091.00
454_A459_S1.0051.00
34_I38_G1.0041.00
131_V166_A1.0041.00
147_N223_A1.0021.00
332_H336_K0.9981.00
57_A61_S0.9911.00
370_I374_V0.9911.00
31_S35_A0.9901.00
273_V277_Y0.9881.00
45_Y49_A0.9881.00
76_L326_L0.9861.00
175_R193_L0.9831.00
185_D189_Q0.9801.00
150_E224_N0.9791.00
61_S70_D0.9791.00
168_A201_G0.9781.00
61_S65_S0.9771.00
222_H225_A0.9771.00
39_G92_S0.9751.00
83_T330_L0.9731.00
113_M140_C0.9731.00
53_V56_G0.9731.00
25_S106_C0.9711.00
267_G300_L0.9691.00
94_Y344_G0.9681.00
367_V459_S0.9631.00
220_Q286_R0.9561.00
47_A82_I0.9551.00
35_A38_G0.9551.00
264_L301_L0.9541.00
393_V396_Q0.9531.00
97_D100_R0.9531.00
459_S463_V0.9511.00
302_G325_G0.9401.00
269_I273_V0.9401.00
210_G218_V0.9391.00
127_L169_C0.9381.00
53_V78_A0.9331.00
171_L175_R0.9301.00
172_L184_L0.9291.00
468_C472_G0.9281.00
197_I201_G0.9271.00
335_F387_G0.9231.00
96_I457_L0.9231.00
423_T426_L0.9221.00
137_M240_I0.9191.00
367_V371_A0.9181.00
130_F181_L0.9171.00
460_V464_A0.9151.00
268_M301_L0.9141.00
323_V483_L0.9131.00
275_G291_H0.9121.00
295_N430_C0.9111.00
77_N247_T0.9101.00
386_N472_G0.9071.00
10_G45_Y0.9041.00
395_Y417_A0.9041.00
41_V45_Y0.9031.00
338_V465_L0.9031.00
114_L118_A0.9031.00
466_A469_C0.9021.00
42_G49_A0.9011.00
131_V169_C0.9001.00
231_A341_L0.9001.00
28_K31_S0.8991.00
125_S180_D0.8991.00
126_N129_M0.8981.00
328_H335_F0.8921.00
145_T221_A0.8891.00
43_S50_G0.8871.00
141_A237_V0.8851.00
17_A112_N0.8821.00
188_M191_L0.8791.00
274_G297_G0.8751.00
8_N11_V0.8741.00
196_D199_L0.8741.00
198_W251_L0.8711.00
84_L119_V0.8701.00
359_G444_R0.8701.00
73_I78_A0.8671.00
32_G36_G0.8641.00
373_L440_L0.8641.00
264_L268_M0.8631.00
17_A21_A0.8621.00
350_T358_L0.8621.00
185_D250_L0.8601.00
395_Y424_G0.8601.00
13_W41_V0.8601.00
52_T55_T0.8561.00
294_E430_C0.8551.00
195_S259_W0.8541.00
82_I85_G0.8521.00
369_S373_L0.8501.00
93_L460_V0.8471.00
148_S151_G0.8461.00
149_K153_L0.8441.00
374_V470_V0.8431.00
52_T56_G0.8401.00
112_N116_A0.8401.00
7_I73_I0.8401.00
49_A53_V0.8381.00
360_G441_G0.8371.00
48_A51_F0.8341.00
114_L237_V0.8341.00
342_G371_A0.8331.00
18_A116_A0.8301.00
59_G66_L0.8291.00
182_R186_M0.8291.00
71_V123_I0.8281.00
283_N354_D0.8281.00
472_G479_L0.8251.00
223_A286_R0.8251.00
345_S368_I0.8241.00
431_M434_V0.8211.00
117_A140_C0.8181.00
292_T332_H0.8181.00
271_A298_I0.8181.00
483_L486_A0.8151.00
275_G430_C0.8151.00
87_C333_S0.8141.00
485_A488_P0.8141.00
36_G40_A0.8131.00
284_I346_V0.8121.00
195_S199_L0.8111.00
227_A285_Q0.8101.00
307_V397_S0.8061.00
218_V222_H0.8051.00
9_S13_W0.8051.00
184_L187_R0.8031.00
370_I373_L0.7971.00
27_Q31_S0.7951.00
361_I365_M0.7951.00
460_V463_V0.7951.00
367_V370_I0.7951.00
345_S462_V0.7921.00
284_I438_T0.7881.00
77_N81_L0.7861.00
13_W45_Y0.7851.00
76_L246_L0.7851.00
36_G39_G0.7841.00
176_Y191_L0.7841.00
36_G89_L0.7831.00
272_F276_L0.7831.00
46_T82_I0.7811.00
134_A240_I0.7801.00
262_A265_V0.7801.00
278_A430_C0.7781.00
276_L426_L0.7731.00
339_L375_G0.7711.00
36_G96_I0.7681.00
392_W396_Q0.7671.00
271_A301_L0.7671.00
432_A436_G0.7661.00
38_G112_N0.7641.00
57_A63_A0.7631.00
364_K451_A0.7631.00
376_L380_A0.7611.00
291_H332_H0.7601.00
111_I232_L0.7601.00
161_G207_L0.7591.00
298_I423_T0.7591.00
254_N257_L0.7551.00
193_L196_D0.7541.00
194_G255_A0.7531.00
427_A430_C0.7521.00
185_D188_M0.7521.00
10_G14_F0.7501.00
59_G62_G0.7501.00
364_K443_P0.7451.00
179_L183_L0.7421.00
152_K156_A0.7411.00
70_D126_N0.7391.00
338_V462_V0.7351.00
11_V14_F0.7321.00
86_L468_C0.7311.00
384_P474_V0.7311.00
50_G78_A0.7301.00
435_Y439_F0.7291.00
348_F458_M0.7291.00
360_G443_P0.7281.00
470_V474_V0.7271.00
31_S34_I0.7261.00
7_I71_V0.7251.00
291_H336_K0.7251.00
166_A170_W0.7211.00
375_G466_A0.7211.00
381_A391_E0.7201.00
32_G96_I0.7191.00
365_M453_C0.7191.00
373_L439_F0.7181.00
8_N69_Y0.7181.00
59_G65_S0.7171.00
130_F165_L0.7171.00
284_I343_A0.7161.00
167_I200_L0.7161.00
50_G482_M0.7141.00
188_M194_G0.7121.00
298_I420_L0.7111.00
289_A292_T0.7101.00
30_L34_I0.7071.00
50_G53_V0.7061.00
222_H292_T0.7041.00
118_A237_V0.7041.00
165_L169_C0.7041.00
327_Y331_N0.7031.00
34_I37_I0.7031.00
445_T448_A0.6991.00
287_L434_V0.6981.00
489_L492_E0.6951.00
49_A52_T0.6941.00
230_A233_F0.6931.00
488_P492_E0.6931.00
295_N336_K0.6911.00
159_R162_T0.6871.00
119_V123_I0.6871.00
95_N109_L0.6851.00
222_H233_F0.6810.99
35_A112_N0.6810.99
90_F465_L0.6800.99
72_Q182_R0.6800.99
277_Y290_Y0.6800.99
242_L296_I0.6790.99
483_L487_V0.6790.99
212_I274_G0.6780.99
43_S89_L0.6770.99
492_E495_N0.6730.99
274_G293_L0.6720.99
346_V358_L0.6690.99
360_G366_P0.6670.99
218_V238_M0.6660.99
218_V221_A0.6650.99
14_F18_A0.6620.99
49_A60_V0.6600.99
46_T50_G0.6590.99
58_V63_A0.6580.99
92_S109_L0.6580.99
373_L376_L0.6570.99
282_H291_H0.6570.99
202_V262_A0.6530.99
192_P195_S0.6510.99
330_L472_G0.6510.99
47_A86_L0.6500.99
108_G228_P0.6490.99
334_L386_N0.6480.99
422_I426_L0.6480.99
355_I434_V0.6480.99
88_G111_I0.6450.99
186_M190_Q0.6430.99
26_F29_A0.6420.99
58_V66_L0.6410.99
363_K366_P0.6400.99
374_V378_A0.6400.99
261_I264_L0.6390.99
8_N62_G0.6380.99
73_I77_N0.6360.99
352_H358_L0.6350.99
441_G444_R0.6350.99
43_S49_A0.6350.99
381_A387_G0.6340.99
198_W252_G0.6330.99
291_H433_K0.6320.99
234_S332_H0.6320.99
362_G373_L0.6320.99
395_Y421_A0.6320.99
275_G426_L0.6310.99
105_K109_L0.6310.99
13_W17_A0.6310.99
291_H295_N0.6300.99
10_G49_A0.6300.99
246_L326_L0.6290.99
127_L172_L0.6270.99
171_L196_D0.6270.99
202_V245_I0.6260.99
78_A82_I0.6250.99
83_T329_L0.6230.99
88_G232_L0.6210.99
35_A92_S0.6210.99
307_V322_L0.6210.99
58_V125_S0.6200.99
219_P290_Y0.6200.99
39_G89_L0.6190.99
471_I478_W0.6190.99
419_G423_T0.6160.99
265_V268_M0.6150.99
371_A459_S0.6150.99
169_C179_L0.6140.99
295_N328_H0.6140.99
327_Y472_G0.6130.99
347_W358_L0.6120.99
16_A20_L0.6100.99
295_N298_I0.6100.99
11_V123_I0.6100.99
425_A429_M0.6090.99
33_W36_G0.6090.99
165_L201_G0.6090.99
369_S439_F0.6060.99
225_A229_A0.6060.99
118_A236_V0.6060.99
262_A266_L0.6060.99
234_S336_K0.6040.99
41_V44_L0.6040.99
332_H340_F0.6030.99
201_G205_F0.6030.99
101_H351_G0.6010.99
49_A78_A0.6000.99
121_A137_M0.6000.99
195_S258_W0.5990.99
242_L299_I0.5990.99
358_L361_I0.5980.99
95_N98_W0.5970.99
165_L244_G0.5970.99
118_A137_M0.5970.99
200_L204_G0.5970.99
342_G368_I0.5940.99
45_Y48_A0.5940.99
385_L470_V0.5910.99
199_L262_A0.5910.99
275_G427_A0.5900.99
172_L201_G0.5880.99
15_V18_A0.5870.98
195_S255_A0.5840.98
239_K296_I0.5840.98
402_S414_P0.5840.98
198_W258_W0.5840.98
110_Q385_L0.5830.98
328_H394_I0.5800.98
488_P491_L0.5800.98
368_I459_S0.5800.98
348_F455_P0.5790.98
272_F419_G0.5790.98
264_L267_G0.5790.98
58_V65_S0.5780.98
84_L88_G0.5750.98
225_A233_F0.5750.98
446_K451_A0.5750.98
176_Y187_R0.5740.98
39_G115_M0.5730.98
482_M486_A0.5730.98
39_G45_Y0.5730.98
375_G469_C0.5730.98
222_H229_A0.5730.98
453_C459_S0.5720.98
172_L197_I0.5710.98
42_G45_Y0.5710.98
489_L493_P0.5700.98
60_V64_L0.5700.98
114_L141_A0.5700.98
281_E290_Y0.5690.98
222_H231_A0.5690.98
141_A222_H0.5690.98
21_A25_S0.5690.98
378_A387_G0.5690.98
73_I81_L0.5680.98
27_Q34_I0.5680.98
219_P293_L0.5670.98
305_A401_L0.5660.98
358_L438_T0.5650.98
134_A165_L0.5650.98
355_I358_L0.5640.98
57_A62_G0.5640.98
54_L59_G0.5630.98
39_G49_A0.5630.98
398_F420_L0.5600.98
292_T336_K0.5600.98
169_C204_G0.5600.98
241_G329_L0.5580.98
222_H285_Q0.5560.98
57_A65_S0.5550.98
324_G393_V0.5550.98
476_A480_L0.5540.98
298_I394_I0.5530.98
49_A73_I0.5520.98
335_F469_C0.5520.98
359_G441_G0.5510.98
47_A50_G0.5500.98
42_G119_V0.5490.98
356_E437_V0.5490.98
331_N469_C0.5480.98
347_W351_G0.5440.98
305_A397_S0.5430.98
338_V466_A0.5430.98
121_A134_A0.5430.98
238_M296_I0.5400.97
150_E220_Q0.5390.97
377_M432_A0.5390.97
222_H226_S0.5380.97
335_F379_M0.5360.97
477_P484_S0.5360.97
221_A289_A0.5350.97
181_L251_L0.5350.97
299_I329_L0.5330.97
94_Y98_W0.5320.97
234_S340_F0.5320.97
21_A35_A0.5310.97
227_A231_A0.5300.97
8_N12_A0.5290.97
14_F42_G0.5280.97
301_L398_F0.5280.97
246_L322_L0.5270.97
226_S230_A0.5270.97
97_D458_M0.5260.97
385_L389_A0.5260.97
114_L232_L0.5260.97
368_I454_A0.5240.97
93_L457_L0.5240.97
349_R454_A0.5220.97
384_P389_A0.5220.97
14_F22_F0.5210.97
380_A428_V0.5210.97
9_S16_A0.5200.97
60_V66_L0.5200.97
426_L430_C0.5200.97
194_G197_I0.5200.97
322_L491_L0.5190.97
95_N111_I0.5180.97
11_V18_A0.5180.97
487_V491_L0.5180.97
168_A248_L0.5170.97
209_A241_G0.5170.97
209_A242_L0.5160.97
421_A424_G0.5160.97
252_G255_A0.5140.97
91_V228_P0.5140.97
277_Y280_V0.5130.97
30_L35_A0.5130.97
17_A34_I0.5130.97
216_G219_P0.5130.97
326_L483_L0.5120.96
362_G366_P0.5110.96
32_G39_G0.5110.96
44_L47_A0.5100.96
327_Y393_V0.5090.96
145_T233_F0.5090.96
225_A231_A0.5090.96
446_K449_E0.5090.96
466_A470_V0.5080.96
491_L494_A0.5080.96
59_G64_L0.5080.96
334_L469_C0.5070.96
327_Y389_A0.5070.96
426_L429_M0.5060.96
164_L167_I0.5060.96
428_V432_A0.5050.96
222_H227_A0.5050.96
85_G115_M0.5050.96
42_G48_A0.5050.96
338_V469_C0.5040.96
399_F402_S0.5030.96
91_V111_I0.5020.96
101_H105_K0.5020.96
126_N179_L0.5020.96
290_Y293_L0.5020.96
191_L194_G0.5020.96
486_A490_P0.5020.96
37_I40_A0.5010.96
260_G264_L0.5010.96
323_V480_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoL 1 0.9391 100 0.232 Contact Map
4he8L 1 0.9424 100 0.237 Contact Map
3rkoM 1 0.773 100 0.316 Contact Map
4he8M 1 0.7418 100 0.349 Contact Map
3rkoN 1 0.7434 100 0.365 Contact Map
4he8N 1 0.6891 100 0.404 Contact Map
4he8K 1 0.1414 22 0.975 Contact Map
3rkoK 1 0.148 15.7 0.977 Contact Map
2m20A 2 0.0987 7.4 0.98 Contact Map
3b5xA 2 0.3914 4.8 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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