HYCC - ECOLI - GREMLIN Contacts

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HYCC - Formate hydrogenlyase subunit 3

UniProt:	P16429	Sequences: MSAISLINSGVAWFVAAAVLAFLFSFQKALSGWIAGIGGAVGSLYTAAAGFTVLTGAVGVSGALSLVSYDVQISPLNAIWLITLGLCGLFVSLYNIDWHRHAQVKCNGLQINMLMAAAVCAVIASNLGMFVVMAEIMALCAVFLTSNSKEGKLWFALGRLGTLLLAIACWLLWQRYGTLDLRLLDMRMQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIGLLGILTLSLLGGNAPLWWGIALLVLGMITAFVGGLYALVEHNIQRLLAYHTLENIGIILLGLGAGVTGIALEQPALIALGLVGGLYHLLNHSLFKSVLFLGAGSVWFRTGHRDIEKLGGIGKKMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLSNSGAFVARLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENATCAPLLMSVSVVALAICCVIGGVAAPWLLPMLSAAVPLPLEPANTTVSQPMITLLLIACPLLPFIIMAICKGDRLPSRSRGAAWVCGYDHEKSMVITAHGFAMPVKQAFAPVLKLRKWLNPVSLVPGWQCEGSALLFRRMALVELAVLVVIIVSRGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10476
Length:	608 (465)
Sequences:	14871 (8667)
Seq/√Len:	401.9

ECOLI - HYCC HYFB NUOL HYFF HYFD NUOM NUON
BACSU - MRPA MRPD NDHF
HALSA - Q9HRL3 Q9HRT0 Q9HRS9 Q9HRL2 Q9HRL1 Q9HRS8
SULSO - Q97ZA9 Q980G9 Q980G8 Q97ZA6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_A	66_L	6.279	1.00
120_C	133_M	4.458	1.00
74_S	247_T	4.403	1.00
180_D	183_L	4.207	1.00
81_L	123_I	3.504	1.00
338_V	375_G	3.449	1.00
17_A	38_G	3.258	1.00
331_N	386_N	3.203	1.00
146_S	151_G	3.173	1.00
178_T	183_L	3.009	1.00
88_G	115_M	2.965	1.00
40_A	89_L	2.787	1.00
153_L	220_Q	2.771	1.00
283_N	353_R	2.750	1.00
352_H	357_K	2.732	1.00
15_V	116_A	2.728	1.00
373_L	435_Y	2.723	1.00
282_H	356_E	2.627	1.00
287_L	355_I	2.541	1.00
267_G	304_G	2.507	1.00
354_D	357_K	2.498	1.00
328_H	390_G	2.491	1.00
43_S	86_L	2.470	1.00
81_L	119_V	2.402	1.00
376_L	431_M	2.392	1.00
84_L	122_V	2.372	1.00
301_L	420_L	2.313	1.00
95_N	108_G	2.230	1.00
275_G	294_E	2.218	1.00
288_L	343_A	2.152	1.00
456_L	460_V	2.126	1.00
222_H	230_A	2.108	1.00
168_A	200_L	2.102	1.00
271_A	423_T	2.037	1.00
279_L	429_M	1.993	1.00
85_G	119_V	1.968	1.00
211_I	300_L	1.967	1.00
127_L	248_L	1.965	1.00
83_T	333_S	1.948	1.00
222_H	238_M	1.940	1.00
124_A	129_M	1.898	1.00
246_L	303_L	1.897	1.00
212_I	269_I	1.872	1.00
127_L	184_L	1.867	1.00
268_M	419_G	1.862	1.00
282_H	354_D	1.859	1.00
368_I	453_C	1.836	1.00
202_V	263_L	1.821	1.00
238_M	292_T	1.811	1.00
414_P	418_V	1.811	1.00
61_S	66_L	1.808	1.00
365_M	368_I	1.802	1.00
355_I	438_T	1.790	1.00
40_A	44_L	1.789	1.00
263_L	304_G	1.785	1.00
291_H	430_C	1.781	1.00
467_I	471_I	1.766	1.00
171_L	197_I	1.760	1.00
372_M	434_V	1.758	1.00
481_P	484_S	1.743	1.00
62_G	65_S	1.743	1.00
362_G	369_S	1.733	1.00
303_L	325_G	1.729	1.00
79_I	330_L	1.727	1.00
327_Y	390_G	1.726	1.00
369_S	440_L	1.722	1.00
305_A	398_F	1.717	1.00
117_A	136_I	1.702	1.00
60_V	63_A	1.696	1.00
284_I	434_V	1.694	1.00
202_V	206_G	1.687	1.00
61_S	64_L	1.676	1.00
70_D	125_S	1.672	1.00
175_R	197_I	1.661	1.00
44_L	48_A	1.637	1.00
484_S	488_P	1.633	1.00
43_S	47_A	1.633	1.00
374_V	466_A	1.628	1.00
264_L	304_G	1.626	1.00
183_L	186_M	1.626	1.00
395_Y	420_L	1.611	1.00
77_N	243_L	1.608	1.00
261_I	265_V	1.604	1.00
46_T	85_G	1.599	1.00
369_S	435_Y	1.599	1.00
323_V	484_S	1.597	1.00
27_Q	30_L	1.597	1.00
372_M	376_L	1.592	1.00
433_K	437_V	1.563	1.00
183_L	187_R	1.556	1.00
245_I	300_L	1.539	1.00
157_L	216_G	1.533	1.00
43_S	85_G	1.512	1.00
475_A	478_W	1.508	1.00
192_P	196_D	1.499	1.00
125_S	182_R	1.497	1.00
72_Q	125_S	1.486	1.00
73_I	123_I	1.479	1.00
42_G	46_T	1.477	1.00
168_A	204_G	1.475	1.00
97_D	457_L	1.462	1.00
39_G	43_S	1.462	1.00
130_F	244_G	1.454	1.00
11_V	116_A	1.453	1.00
371_A	466_A	1.452	1.00
246_L	325_G	1.451	1.00
324_G	397_S	1.440	1.00
206_G	211_I	1.438	1.00
92_S	111_I	1.433	1.00
334_L	468_C	1.433	1.00
30_L	33_W	1.429	1.00
264_L	416_L	1.428	1.00
50_G	54_L	1.412	1.00
176_Y	184_L	1.409	1.00
74_S	77_N	1.407	1.00
267_G	301_L	1.395	1.00
396_Q	400_K	1.388	1.00
376_L	435_Y	1.378	1.00
398_F	417_A	1.372	1.00
47_A	51_F	1.362	1.00
377_M	382_L	1.355	1.00
211_I	266_L	1.349	1.00
281_E	286_R	1.346	1.00
170_W	174_Q	1.345	1.00
243_L	247_T	1.339	1.00
90_F	464_A	1.338	1.00
18_A	22_F	1.330	1.00
461_S	464_A	1.327	1.00
87_C	235_T	1.326	1.00
28_K	32_G	1.317	1.00
89_L	93_L	1.316	1.00
13_W	38_G	1.316	1.00
302_G	394_I	1.315	1.00
275_G	423_T	1.308	1.00
265_V	269_I	1.303	1.00
168_A	197_I	1.302	1.00
110_Q	143_F	1.299	1.00
87_C	337_S	1.298	1.00
456_L	459_S	1.298	1.00
121_A	240_I	1.286	1.00
72_Q	75_P	1.277	1.00
62_G	66_L	1.266	1.00
199_L	203_I	1.256	1.00
178_T	184_L	1.254	1.00
272_F	423_T	1.246	1.00
18_A	21_A	1.237	1.00
371_A	463_V	1.235	1.00
207_L	214_L	1.233	1.00
37_I	41_V	1.228	1.00
418_V	422_I	1.226	1.00
448_A	451_A	1.224	1.00
347_W	353_R	1.223	1.00
38_G	42_G	1.219	1.00
65_S	68_S	1.218	1.00
173_W	179_L	1.216	1.00
206_G	266_L	1.213	1.00
128_G	179_L	1.213	1.00
171_L	193_L	1.212	1.00
455_P	458_M	1.210	1.00
164_L	203_I	1.207	1.00
267_G	297_G	1.199	1.00
46_T	81_L	1.198	1.00
97_D	455_P	1.184	1.00
464_A	468_C	1.183	1.00
67_V	128_G	1.179	1.00
36_G	93_L	1.177	1.00
348_F	452_T	1.176	1.00
379_M	431_M	1.175	1.00
205_F	244_G	1.165	1.00
33_W	37_I	1.163	1.00
294_E	427_A	1.159	1.00
22_F	25_S	1.158	1.00
144_L	229_A	1.154	1.00
349_R	365_M	1.154	1.00
58_V	61_S	1.153	1.00
331_N	390_G	1.152	1.00
126_N	180_D	1.149	1.00
367_V	463_V	1.145	1.00
104_V	107_N	1.136	1.00
457_L	461_S	1.134	1.00
245_I	252_G	1.132	1.00
477_P	481_P	1.131	1.00
86_L	90_F	1.130	1.00
164_L	200_L	1.129	1.00
94_Y	341_L	1.127	1.00
48_A	52_T	1.124	1.00
46_T	49_A	1.121	1.00
39_G	42_G	1.119	1.00
11_V	71_V	1.118	1.00
242_L	300_L	1.112	1.00
70_D	180_D	1.111	1.00
478_W	481_P	1.111	1.00
186_M	189_Q	1.103	1.00
196_D	200_L	1.102	1.00
79_I	326_L	1.098	1.00
299_I	325_G	1.097	1.00
415_L	418_V	1.095	1.00
372_M	439_F	1.094	1.00
18_A	113_M	1.093	1.00
481_P	485_A	1.091	1.00
85_G	89_L	1.089	1.00
342_G	372_M	1.089	1.00
268_M	416_L	1.086	1.00
355_I	437_V	1.079	1.00
435_Y	440_L	1.075	1.00
471_I	475_A	1.074	1.00
463_V	467_I	1.071	1.00
187_R	190_Q	1.069	1.00
51_F	54_L	1.067	1.00
399_F	417_A	1.064	1.00
335_F	378_A	1.061	1.00
371_A	462_V	1.058	1.00
63_A	68_S	1.057	1.00
248_L	251_L	1.054	1.00
29_A	32_G	1.054	1.00
295_N	427_A	1.054	1.00
342_G	462_V	1.052	1.00
35_A	109_L	1.052	1.00
212_I	273_V	1.049	1.00
82_I	86_L	1.049	1.00
346_V	361_I	1.045	1.00
181_L	185_D	1.038	1.00
51_F	55_T	1.036	1.00
90_F	461_S	1.035	1.00
80_W	329_L	1.035	1.00
173_W	176_Y	1.032	1.00
187_R	191_L	1.027	1.00
345_S	454_A	1.027	1.00
50_G	82_I	1.024	1.00
226_S	229_A	1.020	1.00
42_G	85_G	1.020	1.00
364_K	449_E	1.020	1.00
137_M	237_V	1.019	1.00
386_N	469_C	1.014	1.00
258_W	261_I	1.014	1.00
178_T	181_L	1.013	1.00
91_V	341_L	1.012	1.00
35_A	39_G	1.011	1.00
225_A	228_P	1.011	1.00
29_A	33_W	1.010	1.00
169_C	201_G	1.009	1.00
454_A	459_S	1.005	1.00
34_I	38_G	1.004	1.00
131_V	166_A	1.004	1.00
147_N	223_A	1.002	1.00
332_H	336_K	0.998	1.00
57_A	61_S	0.991	1.00
370_I	374_V	0.991	1.00
31_S	35_A	0.990	1.00
273_V	277_Y	0.988	1.00
45_Y	49_A	0.988	1.00
76_L	326_L	0.986	1.00
175_R	193_L	0.983	1.00
185_D	189_Q	0.980	1.00
150_E	224_N	0.979	1.00
61_S	70_D	0.979	1.00
168_A	201_G	0.978	1.00
61_S	65_S	0.977	1.00
222_H	225_A	0.977	1.00
39_G	92_S	0.975	1.00
83_T	330_L	0.973	1.00
113_M	140_C	0.973	1.00
53_V	56_G	0.973	1.00
25_S	106_C	0.971	1.00
267_G	300_L	0.969	1.00
94_Y	344_G	0.968	1.00
367_V	459_S	0.963	1.00
220_Q	286_R	0.956	1.00
47_A	82_I	0.955	1.00
35_A	38_G	0.955	1.00
264_L	301_L	0.954	1.00
393_V	396_Q	0.953	1.00
97_D	100_R	0.953	1.00
459_S	463_V	0.951	1.00
302_G	325_G	0.940	1.00
269_I	273_V	0.940	1.00
210_G	218_V	0.939	1.00
127_L	169_C	0.938	1.00
53_V	78_A	0.933	1.00
171_L	175_R	0.930	1.00
172_L	184_L	0.929	1.00
468_C	472_G	0.928	1.00
197_I	201_G	0.927	1.00
335_F	387_G	0.923	1.00
96_I	457_L	0.923	1.00
423_T	426_L	0.922	1.00
137_M	240_I	0.919	1.00
367_V	371_A	0.918	1.00
130_F	181_L	0.917	1.00
460_V	464_A	0.915	1.00
268_M	301_L	0.914	1.00
323_V	483_L	0.913	1.00
275_G	291_H	0.912	1.00
295_N	430_C	0.911	1.00
77_N	247_T	0.910	1.00
386_N	472_G	0.907	1.00
10_G	45_Y	0.904	1.00
395_Y	417_A	0.904	1.00
41_V	45_Y	0.903	1.00
338_V	465_L	0.903	1.00
114_L	118_A	0.903	1.00
466_A	469_C	0.902	1.00
42_G	49_A	0.901	1.00
131_V	169_C	0.900	1.00
231_A	341_L	0.900	1.00
28_K	31_S	0.899	1.00
125_S	180_D	0.899	1.00
126_N	129_M	0.898	1.00
328_H	335_F	0.892	1.00
145_T	221_A	0.889	1.00
43_S	50_G	0.887	1.00
141_A	237_V	0.885	1.00
17_A	112_N	0.882	1.00
188_M	191_L	0.879	1.00
274_G	297_G	0.875	1.00
8_N	11_V	0.874	1.00
196_D	199_L	0.874	1.00
198_W	251_L	0.871	1.00
84_L	119_V	0.870	1.00
359_G	444_R	0.870	1.00
73_I	78_A	0.867	1.00
32_G	36_G	0.864	1.00
373_L	440_L	0.864	1.00
264_L	268_M	0.863	1.00
17_A	21_A	0.862	1.00
350_T	358_L	0.862	1.00
185_D	250_L	0.860	1.00
395_Y	424_G	0.860	1.00
13_W	41_V	0.860	1.00
52_T	55_T	0.856	1.00
294_E	430_C	0.855	1.00
195_S	259_W	0.854	1.00
82_I	85_G	0.852	1.00
369_S	373_L	0.850	1.00
93_L	460_V	0.847	1.00
148_S	151_G	0.846	1.00
149_K	153_L	0.844	1.00
374_V	470_V	0.843	1.00
52_T	56_G	0.840	1.00
112_N	116_A	0.840	1.00
7_I	73_I	0.840	1.00
49_A	53_V	0.838	1.00
360_G	441_G	0.837	1.00
48_A	51_F	0.834	1.00
114_L	237_V	0.834	1.00
342_G	371_A	0.833	1.00
18_A	116_A	0.830	1.00
59_G	66_L	0.829	1.00
182_R	186_M	0.829	1.00
71_V	123_I	0.828	1.00
283_N	354_D	0.828	1.00
472_G	479_L	0.825	1.00
223_A	286_R	0.825	1.00
345_S	368_I	0.824	1.00
431_M	434_V	0.821	1.00
117_A	140_C	0.818	1.00
292_T	332_H	0.818	1.00
271_A	298_I	0.818	1.00
483_L	486_A	0.815	1.00
275_G	430_C	0.815	1.00
87_C	333_S	0.814	1.00
485_A	488_P	0.814	1.00
36_G	40_A	0.813	1.00
284_I	346_V	0.812	1.00
195_S	199_L	0.811	1.00
227_A	285_Q	0.810	1.00
307_V	397_S	0.806	1.00
218_V	222_H	0.805	1.00
9_S	13_W	0.805	1.00
184_L	187_R	0.803	1.00
370_I	373_L	0.797	1.00
27_Q	31_S	0.795	1.00
361_I	365_M	0.795	1.00
460_V	463_V	0.795	1.00
367_V	370_I	0.795	1.00
345_S	462_V	0.792	1.00
284_I	438_T	0.788	1.00
77_N	81_L	0.786	1.00
13_W	45_Y	0.785	1.00
76_L	246_L	0.785	1.00
36_G	39_G	0.784	1.00
176_Y	191_L	0.784	1.00
36_G	89_L	0.783	1.00
272_F	276_L	0.783	1.00
46_T	82_I	0.781	1.00
134_A	240_I	0.780	1.00
262_A	265_V	0.780	1.00
278_A	430_C	0.778	1.00
276_L	426_L	0.773	1.00
339_L	375_G	0.771	1.00
36_G	96_I	0.768	1.00
392_W	396_Q	0.767	1.00
271_A	301_L	0.767	1.00
432_A	436_G	0.766	1.00
38_G	112_N	0.764	1.00
57_A	63_A	0.763	1.00
364_K	451_A	0.763	1.00
376_L	380_A	0.761	1.00
291_H	332_H	0.760	1.00
111_I	232_L	0.760	1.00
161_G	207_L	0.759	1.00
298_I	423_T	0.759	1.00
254_N	257_L	0.755	1.00
193_L	196_D	0.754	1.00
194_G	255_A	0.753	1.00
427_A	430_C	0.752	1.00
185_D	188_M	0.752	1.00
10_G	14_F	0.750	1.00
59_G	62_G	0.750	1.00
364_K	443_P	0.745	1.00
179_L	183_L	0.742	1.00
152_K	156_A	0.741	1.00
70_D	126_N	0.739	1.00
338_V	462_V	0.735	1.00
11_V	14_F	0.732	1.00
86_L	468_C	0.731	1.00
384_P	474_V	0.731	1.00
50_G	78_A	0.730	1.00
435_Y	439_F	0.729	1.00
348_F	458_M	0.729	1.00
360_G	443_P	0.728	1.00
470_V	474_V	0.727	1.00
31_S	34_I	0.726	1.00
7_I	71_V	0.725	1.00
291_H	336_K	0.725	1.00
166_A	170_W	0.721	1.00
375_G	466_A	0.721	1.00
381_A	391_E	0.720	1.00
32_G	96_I	0.719	1.00
365_M	453_C	0.719	1.00
373_L	439_F	0.718	1.00
8_N	69_Y	0.718	1.00
59_G	65_S	0.717	1.00
130_F	165_L	0.717	1.00
284_I	343_A	0.716	1.00
167_I	200_L	0.716	1.00
50_G	482_M	0.714	1.00
188_M	194_G	0.712	1.00
298_I	420_L	0.711	1.00
289_A	292_T	0.710	1.00
30_L	34_I	0.707	1.00
50_G	53_V	0.706	1.00
222_H	292_T	0.704	1.00
118_A	237_V	0.704	1.00
165_L	169_C	0.704	1.00
327_Y	331_N	0.703	1.00
34_I	37_I	0.703	1.00
445_T	448_A	0.699	1.00
287_L	434_V	0.698	1.00
489_L	492_E	0.695	1.00
49_A	52_T	0.694	1.00
230_A	233_F	0.693	1.00
488_P	492_E	0.693	1.00
295_N	336_K	0.691	1.00
159_R	162_T	0.687	1.00
119_V	123_I	0.687	1.00
95_N	109_L	0.685	1.00
222_H	233_F	0.681	0.99
35_A	112_N	0.681	0.99
90_F	465_L	0.680	0.99
72_Q	182_R	0.680	0.99
277_Y	290_Y	0.680	0.99
242_L	296_I	0.679	0.99
483_L	487_V	0.679	0.99
212_I	274_G	0.678	0.99
43_S	89_L	0.677	0.99
492_E	495_N	0.673	0.99
274_G	293_L	0.672	0.99
346_V	358_L	0.669	0.99
360_G	366_P	0.667	0.99
218_V	238_M	0.666	0.99
218_V	221_A	0.665	0.99
14_F	18_A	0.662	0.99
49_A	60_V	0.660	0.99
46_T	50_G	0.659	0.99
58_V	63_A	0.658	0.99
92_S	109_L	0.658	0.99
373_L	376_L	0.657	0.99
282_H	291_H	0.657	0.99
202_V	262_A	0.653	0.99
192_P	195_S	0.651	0.99
330_L	472_G	0.651	0.99
47_A	86_L	0.650	0.99
108_G	228_P	0.649	0.99
334_L	386_N	0.648	0.99
422_I	426_L	0.648	0.99
355_I	434_V	0.648	0.99
88_G	111_I	0.645	0.99
186_M	190_Q	0.643	0.99
26_F	29_A	0.642	0.99
58_V	66_L	0.641	0.99
363_K	366_P	0.640	0.99
374_V	378_A	0.640	0.99
261_I	264_L	0.639	0.99
8_N	62_G	0.638	0.99
73_I	77_N	0.636	0.99
352_H	358_L	0.635	0.99
441_G	444_R	0.635	0.99
43_S	49_A	0.635	0.99
381_A	387_G	0.634	0.99
198_W	252_G	0.633	0.99
291_H	433_K	0.632	0.99
234_S	332_H	0.632	0.99
362_G	373_L	0.632	0.99
395_Y	421_A	0.632	0.99
275_G	426_L	0.631	0.99
105_K	109_L	0.631	0.99
13_W	17_A	0.631	0.99
291_H	295_N	0.630	0.99
10_G	49_A	0.630	0.99
246_L	326_L	0.629	0.99
127_L	172_L	0.627	0.99
171_L	196_D	0.627	0.99
202_V	245_I	0.626	0.99
78_A	82_I	0.625	0.99
83_T	329_L	0.623	0.99
88_G	232_L	0.621	0.99
35_A	92_S	0.621	0.99
307_V	322_L	0.621	0.99
58_V	125_S	0.620	0.99
219_P	290_Y	0.620	0.99
39_G	89_L	0.619	0.99
471_I	478_W	0.619	0.99
419_G	423_T	0.616	0.99
265_V	268_M	0.615	0.99
371_A	459_S	0.615	0.99
169_C	179_L	0.614	0.99
295_N	328_H	0.614	0.99
327_Y	472_G	0.613	0.99
347_W	358_L	0.612	0.99
16_A	20_L	0.610	0.99
295_N	298_I	0.610	0.99
11_V	123_I	0.610	0.99
425_A	429_M	0.609	0.99
33_W	36_G	0.609	0.99
165_L	201_G	0.609	0.99
369_S	439_F	0.606	0.99
225_A	229_A	0.606	0.99
118_A	236_V	0.606	0.99
262_A	266_L	0.606	0.99
234_S	336_K	0.604	0.99
41_V	44_L	0.604	0.99
332_H	340_F	0.603	0.99
201_G	205_F	0.603	0.99
101_H	351_G	0.601	0.99
49_A	78_A	0.600	0.99
121_A	137_M	0.600	0.99
195_S	258_W	0.599	0.99
242_L	299_I	0.599	0.99
358_L	361_I	0.598	0.99
95_N	98_W	0.597	0.99
165_L	244_G	0.597	0.99
118_A	137_M	0.597	0.99
200_L	204_G	0.597	0.99
342_G	368_I	0.594	0.99
45_Y	48_A	0.594	0.99
385_L	470_V	0.591	0.99
199_L	262_A	0.591	0.99
275_G	427_A	0.590	0.99
172_L	201_G	0.588	0.99
15_V	18_A	0.587	0.98
195_S	255_A	0.584	0.98
239_K	296_I	0.584	0.98
402_S	414_P	0.584	0.98
198_W	258_W	0.584	0.98
110_Q	385_L	0.583	0.98
328_H	394_I	0.580	0.98
488_P	491_L	0.580	0.98
368_I	459_S	0.580	0.98
348_F	455_P	0.579	0.98
272_F	419_G	0.579	0.98
264_L	267_G	0.579	0.98
58_V	65_S	0.578	0.98
84_L	88_G	0.575	0.98
225_A	233_F	0.575	0.98
446_K	451_A	0.575	0.98
176_Y	187_R	0.574	0.98
39_G	115_M	0.573	0.98
482_M	486_A	0.573	0.98
39_G	45_Y	0.573	0.98
375_G	469_C	0.573	0.98
222_H	229_A	0.573	0.98
453_C	459_S	0.572	0.98
172_L	197_I	0.571	0.98
42_G	45_Y	0.571	0.98
489_L	493_P	0.570	0.98
60_V	64_L	0.570	0.98
114_L	141_A	0.570	0.98
281_E	290_Y	0.569	0.98
222_H	231_A	0.569	0.98
141_A	222_H	0.569	0.98
21_A	25_S	0.569	0.98
378_A	387_G	0.569	0.98
73_I	81_L	0.568	0.98
27_Q	34_I	0.568	0.98
219_P	293_L	0.567	0.98
305_A	401_L	0.566	0.98
358_L	438_T	0.565	0.98
134_A	165_L	0.565	0.98
355_I	358_L	0.564	0.98
57_A	62_G	0.564	0.98
54_L	59_G	0.563	0.98
39_G	49_A	0.563	0.98
398_F	420_L	0.560	0.98
292_T	336_K	0.560	0.98
169_C	204_G	0.560	0.98
241_G	329_L	0.558	0.98
222_H	285_Q	0.556	0.98
57_A	65_S	0.555	0.98
324_G	393_V	0.555	0.98
476_A	480_L	0.554	0.98
298_I	394_I	0.553	0.98
49_A	73_I	0.552	0.98
335_F	469_C	0.552	0.98
359_G	441_G	0.551	0.98
47_A	50_G	0.550	0.98
42_G	119_V	0.549	0.98
356_E	437_V	0.549	0.98
331_N	469_C	0.548	0.98
347_W	351_G	0.544	0.98
305_A	397_S	0.543	0.98
338_V	466_A	0.543	0.98
121_A	134_A	0.543	0.98
238_M	296_I	0.540	0.97
150_E	220_Q	0.539	0.97
377_M	432_A	0.539	0.97
222_H	226_S	0.538	0.97
335_F	379_M	0.536	0.97
477_P	484_S	0.536	0.97
221_A	289_A	0.535	0.97
181_L	251_L	0.535	0.97
299_I	329_L	0.533	0.97
94_Y	98_W	0.532	0.97
234_S	340_F	0.532	0.97
21_A	35_A	0.531	0.97
227_A	231_A	0.530	0.97
8_N	12_A	0.529	0.97
14_F	42_G	0.528	0.97
301_L	398_F	0.528	0.97
246_L	322_L	0.527	0.97
226_S	230_A	0.527	0.97
97_D	458_M	0.526	0.97
385_L	389_A	0.526	0.97
114_L	232_L	0.526	0.97
368_I	454_A	0.524	0.97
93_L	457_L	0.524	0.97
349_R	454_A	0.522	0.97
384_P	389_A	0.522	0.97
14_F	22_F	0.521	0.97
380_A	428_V	0.521	0.97
9_S	16_A	0.520	0.97
60_V	66_L	0.520	0.97
426_L	430_C	0.520	0.97
194_G	197_I	0.520	0.97
322_L	491_L	0.519	0.97
95_N	111_I	0.518	0.97
11_V	18_A	0.518	0.97
487_V	491_L	0.518	0.97
168_A	248_L	0.517	0.97
209_A	241_G	0.517	0.97
209_A	242_L	0.516	0.97
421_A	424_G	0.516	0.97
252_G	255_A	0.514	0.97
91_V	228_P	0.514	0.97
277_Y	280_V	0.513	0.97
30_L	35_A	0.513	0.97
17_A	34_I	0.513	0.97
216_G	219_P	0.513	0.97
326_L	483_L	0.512	0.96
362_G	366_P	0.511	0.96
32_G	39_G	0.511	0.96
44_L	47_A	0.510	0.96
327_Y	393_V	0.509	0.96
145_T	233_F	0.509	0.96
225_A	231_A	0.509	0.96
446_K	449_E	0.509	0.96
466_A	470_V	0.508	0.96
491_L	494_A	0.508	0.96
59_G	64_L	0.508	0.96
334_L	469_C	0.507	0.96
327_Y	389_A	0.507	0.96
426_L	429_M	0.506	0.96
164_L	167_I	0.506	0.96
428_V	432_A	0.505	0.96
222_H	227_A	0.505	0.96
85_G	115_M	0.505	0.96
42_G	48_A	0.505	0.96
338_V	469_C	0.504	0.96
399_F	402_S	0.503	0.96
91_V	111_I	0.502	0.96
101_H	105_K	0.502	0.96
126_N	179_L	0.502	0.96
290_Y	293_L	0.502	0.96
191_L	194_G	0.502	0.96
486_A	490_P	0.502	0.96
37_I	40_A	0.501	0.96
260_G	264_L	0.501	0.96
323_V	480_L	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rkoL	1	0.9391	100	0.232	Contact Map
4he8L	1	0.9424	100	0.237	Contact Map
3rkoM	1	0.773	100	0.316	Contact Map
4he8M	1	0.7418	100	0.349	Contact Map
3rkoN	1	0.7434	100	0.365	Contact Map
4he8N	1	0.6891	100	0.404	Contact Map
4he8K	1	0.1414	22	0.975	Contact Map
3rkoK	1	0.148	15.7	0.977	Contact Map
2m20A	2	0.0987	7.4	0.98	Contact Map
3b5xA	2	0.3914	4.8	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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