GREMLIN Database
MIAA - tRNA dimethylallyltransferase
UniProt: P16384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10595
Length: 316 (290)
Sequences: 4860 (3650)
Seq/√Len: 214.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_K64_A3.4411.00
79_Y87_D3.1601.00
219_H272_V2.9821.00
152_V175_F2.8681.00
256_S261_E2.8391.00
263_S266_E2.7581.00
227_E254_M2.6851.00
136_Q148_Q2.6431.00
132_R176_F2.6301.00
222_L268_V2.5851.00
219_H268_V2.5721.00
37_E68_R2.5421.00
228_A231_R2.4801.00
94_D98_A2.4771.00
136_Q140_Q2.4311.00
215_E272_V2.2811.00
212_Q216_Q2.1921.00
48_K74_D2.1401.00
11_K196_Q2.1021.00
270_R273_C2.0811.00
273_C277_Q1.9941.00
20_A214_I1.9741.00
274_A277_Q1.9391.00
113_K117_E1.9111.00
201_A292_V1.9041.00
147_R150_Q1.8781.00
85_R89_L1.8641.00
234_F255_W1.8561.00
59_A62_L1.8551.00
174_V182_L1.8451.00
58_N61_E1.8361.00
156_A160_I1.8231.00
148_Q151_E1.8221.00
148_Q176_F1.8111.00
104_L115_L1.8021.00
254_M267_M1.7891.00
56_K71_D1.7681.00
44_A54_T1.7211.00
113_K289_W1.7021.00
180_K188_T1.6741.00
32_K63_L1.6731.00
51_D56_K1.6691.00
140_Q144_S1.6631.00
256_S262_I1.6591.00
253_Q274_A1.6271.00
41_V104_L1.6131.00
49_G236_R1.6051.00
35_P100_R1.5741.00
218_F271_G1.5711.00
231_R235_A1.5581.00
181_T184_E1.5541.00
257_Y264_Y1.5541.00
95_I98_A1.5501.00
73_R83_D1.5431.00
227_E264_Y1.5351.00
220_Q224_S1.5261.00
27_A105_V1.5211.00
143_E147_R1.5041.00
24_T27_A1.4981.00
37_E98_A1.4951.00
91_E94_D1.4911.00
135_Q139_E1.4871.00
201_A294_W1.4731.00
14_F112_F1.4521.00
137_A165_P1.4491.00
264_Y267_M1.4471.00
68_R91_E1.4461.00
36_V103_L1.4081.00
234_F259_E1.4071.00
283_I287_R1.4041.00
264_Y268_V1.4041.00
266_E270_R1.3941.00
269_Y273_C1.3931.00
266_E269_Y1.3821.00
49_G74_D1.3781.00
40_S70_L1.3761.00
211_H276_R1.3741.00
91_E95_I1.3641.00
222_L264_Y1.3601.00
209_L212_Q1.3511.00
146_H150_Q1.3491.00
142_W165_P1.3441.00
212_Q215_E1.3251.00
41_V112_F1.3221.00
254_M258_L1.3211.00
199_Q289_W1.3201.00
155_V158_A1.3011.00
68_R98_A1.2951.00
129_V133_I1.2921.00
29_E33_I1.2881.00
216_Q220_Q1.2841.00
211_H277_Q1.2781.00
147_R151_E1.2741.00
72_I87_D1.2711.00
77_Q83_D1.2701.00
88_A115_L1.2681.00
16_M112_F1.2641.00
152_V176_F1.2601.00
240_H243_L1.2441.00
215_E276_R1.2391.00
131_A135_Q1.2281.00
227_E231_R1.2171.00
180_K184_E1.2121.00
92_M96_T1.2071.00
13_I101_I1.1941.00
148_Q152_V1.1941.00
69_L91_E1.1921.00
80_S83_D1.1871.00
83_D86_R1.1861.00
207_R211_H1.1801.00
29_E32_K1.1791.00
211_H273_C1.1731.00
89_L194_P1.1711.00
275_T278_L1.1701.00
207_R283_I1.1691.00
32_K65_A1.1531.00
21_S205_A1.1501.00
129_V176_F1.1361.00
205_A209_L1.1351.00
73_R77_Q1.1341.00
44_A248_C1.1291.00
37_E95_I1.1251.00
90_A94_D1.1231.00
152_V172_L1.1181.00
241_T259_E1.1161.00
222_L227_E1.1151.00
132_R136_Q1.1151.00
62_L71_D1.0971.00
140_Q148_Q1.0961.00
161_H164_D1.0891.00
37_E100_R1.0891.00
28_I64_A1.0871.00
11_K96_T1.0781.00
21_S202_I1.0741.00
230_V258_L1.0731.00
136_Q176_F1.0721.00
116_L197_V1.0661.00
95_I100_R1.0651.00
220_Q223_A1.0641.00
117_E291_G1.0621.00
141_G144_S1.0621.00
136_Q144_S1.0621.00
126_D177_I1.0611.00
182_L186_T1.0611.00
16_M201_A1.0591.00
10_P96_T1.0591.00
232_A236_R1.0531.00
135_Q138_A1.0461.00
25_A29_E1.0401.00
130_R173_E1.0391.00
53_G251_Y1.0381.00
83_D87_D1.0341.00
34_L101_I1.0281.00
262_I266_E1.0271.00
156_A182_L1.0231.00
39_I95_I1.0171.00
87_D90_A1.0171.00
18_P21_S1.0171.00
262_I270_R1.0151.00
211_H215_E1.0021.00
109_M286_L0.9981.00
57_P62_L0.9931.00
12_A92_M0.9911.00
131_A134_E0.9901.00
200_F295_L0.9841.00
150_Q158_A0.9841.00
50_M54_T0.9821.00
87_D91_E0.9791.00
146_H157_A0.9781.00
280_K284_T0.9721.00
76_S239_L0.9681.00
227_E257_Y0.9681.00
172_L176_F0.9641.00
219_H223_A0.9621.00
127_P131_A0.9601.00
28_I67_H0.9581.00
262_I267_M0.9541.00
36_V102_P0.9541.00
249_V278_L0.9491.00
230_V254_M0.9411.00
204_P283_I0.9390.99
24_T57_P0.9390.99
146_H168_L0.9360.99
149_L171_A0.9350.99
226_F254_M0.9330.99
10_P93_A0.9310.99
133_I169_S0.9280.99
25_A220_Q0.9270.99
222_L267_M0.9270.99
134_E138_A0.9210.99
218_F272_V0.9200.99
45_L57_P0.9190.99
129_V177_I0.9180.99
136_Q145_L0.9160.99
268_V272_V0.9150.99
155_V187_Q0.9120.99
214_I279_A0.9110.99
15_L30_L0.9070.99
28_I32_K0.9060.99
281_R284_T0.9050.99
201_A286_L0.9020.99
134_E169_S0.8990.99
49_G75_P0.8980.99
137_A142_W0.8970.99
256_S270_R0.8970.99
165_P168_L0.8960.99
227_E258_L0.8940.99
28_I57_P0.8920.99
159_R164_D0.8780.99
113_K288_G0.8690.99
206_S209_L0.8680.99
155_V181_T0.8660.99
143_E162_P0.8640.99
222_L254_M0.8630.99
58_N62_L0.8570.99
75_P245_S0.8560.99
14_F116_L0.8550.99
170_R173_E0.8540.99
81_A85_R0.8530.99
25_A61_E0.8520.99
58_N224_S0.8500.99
296_D299_K0.8450.99
94_D97_A0.8420.99
85_R118_G0.8310.99
255_W259_E0.8300.99
76_S236_R0.8300.99
51_D71_D0.8290.99
51_D62_L0.8280.99
211_H283_I0.8250.99
15_L103_L0.8230.99
184_E188_T0.8220.99
129_V172_L0.8210.99
142_W168_L0.8180.99
211_H272_V0.8070.98
31_R65_A0.8070.98
265_D269_Y0.8020.98
160_I164_D0.7990.98
95_I102_P0.7990.98
35_P101_I0.7980.98
149_L168_L0.7980.98
208_E212_Q0.7980.98
146_H162_P0.7960.98
270_R274_A0.7950.98
18_P283_I0.7930.98
267_M271_G0.7890.98
116_L199_Q0.7880.98
175_F182_L0.7870.98
137_A145_L0.7860.98
74_D236_R0.7860.98
28_I65_A0.7820.98
142_W146_H0.7810.98
36_V101_I0.7810.98
50_M233_L0.7770.98
254_M271_G0.7750.98
156_A159_R0.7750.98
73_R79_Y0.7730.98
148_Q172_L0.7690.98
239_L243_L0.7690.98
41_V84_F0.7680.98
130_R141_G0.7610.98
16_M292_V0.7610.98
14_F197_V0.7600.98
209_L298_E0.7580.98
93_A96_T0.7550.98
230_V234_F0.7520.98
16_M41_V0.7490.98
133_I176_F0.7470.97
28_I38_L0.7430.97
40_S69_L0.7380.97
86_R90_A0.7360.97
269_Y272_V0.7330.97
96_T195_Y0.7330.97
156_A171_A0.7300.97
180_K185_L0.7220.97
12_A104_L0.7220.97
94_D100_R0.7210.97
122_L125_A0.7210.97
164_D168_L0.7130.97
31_R103_L0.7110.97
114_A119_L0.7110.97
138_A165_P0.7100.97
62_L65_A0.7090.97
30_L103_L0.7080.96
205_A297_S0.7070.96
254_M264_Y0.7060.96
110_L119_L0.7060.96
263_S269_Y0.7050.96
184_E187_Q0.7020.96
145_L148_Q0.7010.96
133_I172_L0.7000.96
10_P100_R0.7000.96
144_S147_R0.6940.96
253_Q271_G0.6940.96
88_A92_M0.6930.96
289_W292_V0.6920.96
69_L87_D0.6910.96
48_K71_D0.6880.96
159_R186_T0.6840.96
198_H295_L0.6800.96
61_E64_A0.6800.96
202_I297_S0.6790.96
244_P248_C0.6780.96
36_V95_I0.6780.96
215_E218_F0.6770.95
13_I198_H0.6770.95
222_L271_G0.6760.95
146_H160_I0.6740.95
134_E173_E0.6740.95
39_I91_E0.6710.95
234_F258_L0.6700.95
154_P158_A0.6700.95
57_P64_A0.6700.95
46_I79_Y0.6700.95
51_D59_A0.6690.95
62_L66_P0.6690.95
126_D129_V0.6680.95
50_M245_S0.6670.95
27_A57_P0.6640.95
205_A298_E0.6620.95
12_A96_T0.6600.95
171_A182_L0.6600.95
15_L27_A0.6600.95
241_T256_S0.6590.95
244_P247_R0.6540.95
216_Q223_A0.6530.95
125_A177_I0.6520.94
88_A91_E0.6490.94
92_M115_L0.6450.94
145_L168_L0.6420.94
132_R135_Q0.6380.94
74_D77_Q0.6350.94
55_A221_M0.6340.94
28_I63_L0.6300.93
152_V181_T0.6280.93
241_T255_W0.6240.93
38_L65_A0.6240.93
72_I79_Y0.6230.93
12_A197_V0.6230.93
256_S267_M0.6220.93
21_S204_P0.6190.93
53_G226_F0.6180.93
146_H161_H0.6150.93
272_V276_R0.6120.92
174_V186_T0.6120.92
133_I136_Q0.6070.92
117_E289_W0.6040.92
92_M104_L0.6030.92
46_I108_T0.5990.92
128_E132_R0.5980.92
49_G232_A0.5970.91
215_E268_V0.5960.91
53_G233_L0.5950.91
153_D183_T0.5940.91
68_R95_I0.5930.91
140_Q145_L0.5930.91
133_I145_L0.5930.91
122_L185_L0.5910.91
24_T28_I0.5910.91
209_L213_R0.5890.91
73_R87_D0.5870.91
231_R234_F0.5860.91
34_L103_L0.5860.91
150_Q157_A0.5850.91
39_I92_M0.5840.91
215_E269_Y0.5800.90
16_M286_L0.5790.90
175_F178_S0.5790.90
141_G165_P0.5780.90
88_A104_L0.5720.90
44_A278_L0.5700.90
89_L195_Y0.5670.89
91_E98_A0.5670.89
265_D268_V0.5650.89
193_L197_V0.5650.89
12_A115_L0.5640.89
249_V274_A0.5640.89
133_I148_Q0.5630.89
82_A86_R0.5630.89
85_R115_L0.5610.89
243_L246_I0.5580.89
113_K116_L0.5580.89
118_G123_P0.5580.89
204_P296_D0.5560.88
157_A161_H0.5520.88
52_I224_S0.5510.88
232_A235_A0.5500.88
230_V251_Y0.5480.88
84_F278_L0.5480.88
208_E211_H0.5470.88
44_A247_R0.5450.87
209_L296_D0.5410.87
231_R264_Y0.5410.87
227_E267_M0.5390.87
144_S148_Q0.5380.87
198_H293_H0.5370.87
257_Y262_I0.5370.87
81_A108_T0.5340.86
45_L278_L0.5340.86
178_S185_L0.5330.86
57_P70_L0.5330.86
199_Q291_G0.5290.86
156_A186_T0.5290.86
211_H280_K0.5290.86
30_L34_L0.5290.86
69_L72_I0.5290.86
38_L105_V0.5280.86
13_I34_L0.5270.86
254_M257_Y0.5270.86
228_A232_A0.5250.85
218_F268_V0.5220.85
297_S300_P0.5200.85
79_Y83_D0.5190.85
49_G237_G0.5190.85
15_L34_L0.5180.85
252_R256_S0.5170.84
204_P287_R0.5170.84
143_E165_P0.5150.84
114_A117_E0.5140.84
48_K72_I0.5140.84
226_F252_R0.5140.84
137_A169_S0.5140.84
99_G102_P0.5130.84
142_W163_N0.5120.84
129_V132_R0.5100.84
230_V255_W0.5100.84
146_H172_L0.5080.83
175_F183_T0.5070.83
50_M75_P0.5060.83
31_R38_L0.5050.83
153_D157_A0.5040.83
110_L285_W0.5030.83
209_L216_Q0.5020.83
89_L92_M0.5010.83
43_S46_I0.5000.82
88_A93_A0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fozA 2 0.962 100 0.194 Contact Map
3exaA 2 0.9209 100 0.206 Contact Map
3d3qA 1 0.9589 100 0.217 Contact Map
3ephA 2 0.962 100 0.225 Contact Map
3crmA 1 0.7405 100 0.287 Contact Map
3a8tA 1 0.7658 100 0.409 Contact Map
2ze6A 1 0.6551 100 0.58 Contact Map
1ckeA 1 0.6614 99.8 0.798 Contact Map
2qmhA 5 0.5316 99.7 0.834 Contact Map
3tqfA 3 0.4968 99.4 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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