GREMLIN Database
PANF - Sodium/pantothenate symporter
UniProt: P16256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10685
Length: 483 (460)
Sequences: 11524 (7399)
Seq/√Len: 345.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
431_V462_A6.0851.00
362_N365_R4.2031.00
265_D268_A3.9431.00
420_A463_F3.9071.00
18_G22_Y3.6531.00
357_P365_R3.4641.00
431_V458_L3.3121.00
201_I205_H3.2961.00
170_A378_G3.2161.00
421_N470_G3.2051.00
464_L468_R3.1761.00
428_A463_F3.0651.00
203_V293_L3.0421.00
212_N215_Q3.0401.00
427_S466_G3.0361.00
435_L458_L3.0141.00
462_A466_G2.9631.00
364_T368_R2.9461.00
466_G470_G2.7621.00
423_K470_G2.7441.00
368_R372_V2.7221.00
413_L463_F2.6771.00
157_P160_T2.6241.00
166_G382_L2.5811.00
115_F124_V2.5541.00
424_G467_N2.5311.00
352_Y360_M2.5111.00
372_V376_V2.3561.00
294_G307_V2.3531.00
178_F262_S2.2841.00
43_M182_V2.2781.00
11_A15_V2.2701.00
264_K268_A2.2621.00
215_Q219_T2.2181.00
427_S462_A2.1821.00
417_W420_A2.1541.00
212_N216_T2.1391.00
34_N41_R2.1311.00
423_K427_S2.1011.00
410_P425_A2.0961.00
67_G305_D2.0761.00
12_Y16_V2.0621.00
357_P360_M2.0501.00
14_V18_G2.0341.00
434_V438_V2.0091.00
113_M414_G2.0071.00
122_L426_L1.9951.00
421_N424_G1.9931.00
379_A383_L1.9761.00
163_L167_I1.9701.00
35_E40_S1.9651.00
349_K353_L1.9541.00
118_Y420_A1.9501.00
197_V201_I1.9501.00
421_N467_N1.9181.00
267_K271_R1.9041.00
424_G466_G1.9021.00
268_A271_R1.9021.00
419_R471_T1.8671.00
368_R371_A1.8671.00
47_V186_T1.8151.00
298_I314_K1.8141.00
461_L465_V1.8101.00
413_L460_L1.8061.00
59_A145_G1.8001.00
215_Q218_Q1.7951.00
38_L41_R1.7941.00
195_G327_A1.7861.00
310_T314_K1.7821.00
107_A116_A1.7651.00
353_L366_L1.7511.00
267_K270_H1.7311.00
169_I336_I1.7151.00
417_W468_R1.7131.00
352_Y369_M1.6991.00
417_W464_L1.6971.00
119_Q122_L1.6721.00
211_S215_Q1.6721.00
176_G180_A1.6621.00
6_I10_V1.6611.00
365_R368_R1.6591.00
419_R468_R1.6291.00
347_I351_L1.6281.00
424_G428_A1.6251.00
45_G268_A1.6211.00
216_T219_T1.6091.00
427_S431_V1.5801.00
167_I171_L1.5771.00
19_I187_M1.5581.00
322_G326_A1.5561.00
50_M186_T1.5541.00
431_V435_L1.5501.00
340_L378_G1.5331.00
352_Y365_R1.5261.00
218_Q221_D1.5131.00
48_L263_Y1.5061.00
147_A162_L1.4731.00
227_P230_A1.4661.00
347_I373_I1.4471.00
94_L412_V1.4321.00
207_A213_A1.4241.00
120_S422_A1.4221.00
225_V229_G1.4131.00
119_Q422_A1.4121.00
112_D349_K1.4071.00
112_D350_D1.4001.00
222_P226_T1.3951.00
343_S377_L1.3891.00
224_L227_P1.3851.00
226_T229_G1.3811.00
148_R303_V1.3761.00
365_R369_M1.3681.00
162_L382_L1.3591.00
130_S433_G1.3581.00
10_V14_V1.3551.00
15_V19_I1.3291.00
185_D259_R1.3291.00
169_I333_M1.3221.00
352_Y357_P1.3201.00
160_T164_I1.2991.00
25_R28_S1.2991.00
16_V20_S1.2981.00
37_F370_S1.2861.00
457_L461_L1.2791.00
69_A76_W1.2691.00
210_L214_V1.2641.00
367_K371_A1.2641.00
356_R359_Q1.2531.00
360_M365_R1.2511.00
232_D235_S1.2431.00
117_R414_G1.2401.00
115_F120_S1.2291.00
16_V187_M1.2231.00
421_N471_T1.2231.00
347_I352_Y1.2221.00
452_I456_L1.2201.00
7_L11_A1.2191.00
348_I370_S1.2171.00
113_M117_R1.2161.00
160_T163_L1.2131.00
423_K466_G1.2121.00
438_V442_L1.2121.00
395_L399_A1.2121.00
163_L382_L1.2101.00
159_E386_W1.2091.00
435_L462_A1.2061.00
123_L426_L1.2061.00
159_E163_L1.2031.00
126_L426_L1.1951.00
184_N337_N1.1951.00
89_L93_I1.1941.00
95_G99_A1.1891.00
301_L304_P1.1891.00
22_Y26_K1.1841.00
146_G165_F1.1821.00
458_L462_A1.1821.00
49_A275_I1.1821.00
115_F354_N1.1771.00
166_G378_G1.1761.00
190_L194_I1.1671.00
129_L133_V1.1601.00
356_R360_M1.1571.00
15_V187_M1.1561.00
143_F166_G1.1551.00
214_V218_Q1.1541.00
457_L460_L1.1461.00
373_I376_V1.1441.00
5_V319_F1.1411.00
127_A429_M1.1401.00
151_E158_Y1.1391.00
194_I198_V1.1381.00
185_D337_N1.1381.00
216_T296_A1.1361.00
15_V18_G1.1311.00
109_T345_A1.1211.00
460_L464_L1.1181.00
39_G43_M1.1161.00
360_M366_L1.1161.00
419_R472_S1.1121.00
352_Y358_D1.1101.00
422_A426_L1.1101.00
391_M394_W1.1031.00
55_T338_A1.0971.00
312_M324_F1.0951.00
27_R35_E1.0931.00
123_L425_A1.0891.00
51_T338_A1.0891.00
143_F162_L1.0871.00
206_A297_V1.0771.00
223_Q226_T1.0741.00
39_G178_F1.0711.00
53_T279_V1.0701.00
363_E366_L1.0671.00
420_A467_N1.0671.00
124_V350_D1.0581.00
122_L126_L1.0581.00
410_P429_M1.0571.00
7_L10_V1.0561.00
174_A375_L1.0561.00
45_G49_A1.0551.00
156_I161_G1.0501.00
129_L351_L1.0491.00
12_Y20_S1.0471.00
17_F20_S1.0411.00
352_Y356_R1.0411.00
454_P457_L1.0401.00
370_S374_T1.0311.00
77_V81_M1.0281.00
348_I369_M1.0271.00
225_V228_Q1.0261.00
71_K304_P1.0191.00
18_G21_V1.0171.00
104_R266_S1.0171.00
421_N466_G1.0161.00
202_G206_A1.0121.00
211_S214_V1.0101.00
105_Y116_A1.0101.00
385_A388_P1.0101.00
420_A424_G1.0041.00
93_I97_K1.0021.00
209_G212_N0.9991.00
413_L420_A0.9981.00
428_A459_S0.9961.00
172_Y337_N0.9921.00
139_M381_L0.9901.00
419_R473_V0.9901.00
310_T313_V0.9891.00
169_I337_N0.9871.00
134_A402_G0.9841.00
214_V217_L0.9841.00
293_L297_V0.9821.00
369_M373_I0.9811.00
462_A465_V0.9811.00
172_Y333_M0.9801.00
231_D234_L0.9781.00
230_A235_S0.9751.00
34_N106_N0.9741.00
413_L464_L0.9711.00
198_V202_G0.9651.00
140_T384_A0.9641.00
409_W460_L0.9631.00
122_L422_A0.9611.00
17_F21_V0.9601.00
218_Q222_P0.9591.00
309_P312_M0.9541.00
231_D235_S0.9521.00
37_F345_A0.9501.00
132_L347_I0.9491.00
254_P342_Q0.9441.00
82_I86_A0.9431.00
198_V320_A0.9421.00
222_P227_P0.9381.00
12_Y333_M0.9371.00
406_V459_S0.9371.00
114_L127_A0.9371.00
130_S429_M0.9341.00
459_S463_F0.9341.00
188_Q337_N0.9341.00
303_V306_L0.9341.00
126_L429_M0.9301.00
96_K270_H0.9281.00
45_G271_R0.9271.00
393_I397_L0.9271.00
118_Y463_F0.9261.00
59_A332_I0.9201.00
236_P239_M0.9181.00
379_A382_L0.9141.00
51_T54_A0.9131.00
414_G425_A0.9091.00
125_W355_I0.9061.00
79_L82_I0.9061.00
398_L440_A0.9031.00
213_A217_L0.9021.00
118_Y414_G0.9021.00
423_K469_F0.8991.00
216_T220_I0.8981.00
156_I164_I0.8981.00
184_N188_Q0.8901.00
396_N400_F0.8891.00
392_I396_N0.8881.00
68_A72_Y0.8871.00
22_Y25_R0.8861.00
344_S348_I0.8831.00
249_G254_P0.8821.00
47_V182_V0.8811.00
254_P258_V0.8801.00
207_A212_N0.8801.00
245_L254_P0.8791.00
341_L344_S0.8781.00
347_I377_L0.8781.00
263_Y269_V0.8761.00
316_L320_A0.8691.00
9_L13_L0.8671.00
213_A293_L0.8641.00
453_V457_L0.8631.00
185_D338_A0.8621.00
50_M189_G0.8611.00
439_L454_P0.8611.00
222_P225_V0.8601.00
23_A27_R0.8601.00
432_G459_S0.8551.00
383_L387_K0.8541.00
430_I434_V0.8531.00
84_L281_A0.8521.00
55_T185_D0.8471.00
312_M321_A0.8471.00
219_T222_P0.8471.00
200_L286_G0.8441.00
69_A292_A0.8431.00
172_Y188_Q0.8431.00
424_G427_S0.8411.00
458_L461_L0.8401.00
206_A315_V0.8391.00
44_G268_A0.8381.00
334_S337_N0.8381.00
12_Y330_A0.8371.00
428_A432_G0.8361.00
421_N472_S0.8351.00
181_S184_N0.8351.00
84_L277_T0.8331.00
306_L310_T0.8321.00
417_W467_N0.8311.00
51_T259_R0.8301.00
294_G311_L0.8281.00
117_R417_W0.8271.00
249_G253_L0.8241.00
111_N127_A0.8221.00
99_A266_S0.8221.00
465_V469_F0.8211.00
74_L292_A0.8211.00
456_L459_S0.8201.00
445_Q448_G0.8181.00
410_P459_S0.8171.00
120_S124_V0.8161.00
13_L16_V0.8141.00
21_V25_R0.8141.00
208_G212_N0.8141.00
465_V468_R0.8131.00
147_A158_Y0.8101.00
51_T182_V0.8091.00
70_Y300_D0.8081.00
120_S123_L0.8071.00
432_G436_Y0.8061.00
11_A18_G0.8051.00
290_A311_L0.8051.00
205_H210_L0.8051.00
236_P240_T0.8031.00
426_L430_I0.8011.00
92_G274_I0.7971.00
158_Y162_L0.7941.00
245_L253_L0.7931.00
274_I278_I0.7911.00
20_S24_M0.7891.00
132_L343_S0.7891.00
16_V24_M0.7881.00
203_V206_A0.7871.00
172_Y334_S0.7871.00
25_R29_T0.7851.00
460_L463_F0.7851.00
376_V380_L0.7831.00
366_L370_S0.7811.00
183_L186_T0.7811.00
374_T378_G0.7791.00
225_V230_A0.7781.00
151_E155_G0.7751.00
202_G205_H0.7751.00
196_T287_M0.7751.00
23_A183_L0.7681.00
26_K29_T0.7681.00
212_N296_A0.7681.00
17_F171_L0.7671.00
51_T55_T0.7661.00
238_F242_F0.7661.00
438_V441_T0.7651.00
45_G275_I0.7651.00
5_V321_A0.7641.00
451_P455_S0.7631.00
319_F323_I0.7631.00
95_G98_F0.7611.00
263_Y268_A0.7571.00
20_S23_A0.7521.00
204_V213_A0.7521.00
278_I282_I0.7511.00
126_L430_I0.7481.00
114_L123_L0.7471.00
21_V175_F0.7471.00
193_L197_V0.7461.00
24_M27_R0.7441.00
161_G165_F0.7441.00
79_L83_Q0.7431.00
188_Q330_A0.7411.00
207_A296_A0.7401.00
142_Q335_T0.7370.99
39_G262_S0.7370.99
230_A233_I0.7370.99
356_R365_R0.7360.99
22_Y183_L0.7360.99
435_L438_V0.7350.99
301_L310_T0.7340.99
423_K471_T0.7330.99
58_S138_A0.7300.99
413_L417_W0.7290.99
417_W421_N0.7280.99
464_L467_N0.7270.99
21_V24_M0.7270.99
112_D116_A0.7240.99
397_L400_F0.7220.99
417_W424_G0.7210.99
9_L329_M0.7200.99
352_Y355_I0.7170.99
62_F196_T0.7160.99
109_T350_D0.7160.99
148_R151_E0.7150.99
204_V209_G0.7150.99
204_V289_L0.7140.99
188_Q334_S0.7130.99
163_L379_A0.7120.99
54_A259_R0.7080.99
61_S284_M0.7070.99
70_Y301_L0.7050.99
181_S338_A0.7050.99
122_L125_W0.7050.99
146_G332_I0.7050.99
248_F408_L0.7030.99
199_L203_V0.7020.99
199_L308_I0.7020.99
399_A402_G0.7010.99
8_P322_G0.6990.99
36_Y374_T0.6990.99
188_Q335_T0.6970.99
217_L221_D0.6960.99
463_F466_G0.6930.99
466_G469_F0.6920.99
150_L161_G0.6910.99
435_L439_L0.6900.99
221_D224_L0.6890.99
8_P319_F0.6890.99
95_G269_V0.6880.99
469_F472_S0.6880.99
295_R299_P0.6870.99
125_W129_L0.6840.99
311_L315_V0.6820.99
444_I447_L0.6810.99
88_W92_G0.6810.99
433_G437_A0.6800.99
372_V375_L0.6770.99
461_L464_L0.6760.99
340_L374_T0.6750.99
148_R305_D0.6700.99
347_I369_M0.6700.99
108_V112_D0.6700.99
238_F241_S0.6700.99
62_F324_F0.6660.99
420_A428_A0.6650.99
385_A389_P0.6630.99
178_F182_V0.6630.99
197_V200_L0.6620.99
344_S374_T0.6620.99
198_V201_I0.6590.99
220_I295_R0.6590.99
162_L385_A0.6570.99
251_I254_P0.6570.99
240_T243_W0.6560.99
46_I50_M0.6560.99
217_L220_I0.6540.99
24_M175_F0.6530.99
34_N363_E0.6520.99
427_S430_I0.6500.99
44_G47_V0.6500.99
43_M48_L0.6490.99
431_V466_G0.6490.99
78_L82_I0.6490.99
142_Q336_I0.6490.99
306_L309_P0.6480.99
188_Q333_M0.6470.99
449_F453_V0.6470.99
208_G211_S0.6460.99
339_Q342_Q0.6450.99
419_R422_A0.6450.99
5_V8_P0.6440.99
123_L422_A0.6440.99
170_A375_L0.6440.99
355_I358_D0.6430.99
70_Y307_V0.6430.99
359_Q365_R0.6410.99
143_F180_A0.6410.99
7_L14_V0.6390.99
213_A216_T0.6390.99
118_Y425_A0.6380.99
144_I148_R0.6370.99
97_K416_Y0.6370.99
27_R367_K0.6360.99
125_W128_S0.6360.99
48_L51_T0.6350.98
288_H292_A0.6340.98
56_Y400_F0.6340.98
277_T281_A0.6330.98
26_K179_R0.6330.98
393_I396_N0.6320.98
244_V456_L0.6310.98
352_Y359_Q0.6300.98
409_W463_F0.6300.98
335_T339_Q0.6290.98
348_I352_Y0.6280.98
172_Y180_A0.6280.98
206_A210_L0.6270.98
170_A174_A0.6270.98
96_K266_S0.6270.98
375_L379_A0.6260.98
317_P320_A0.6260.98
49_A53_T0.6240.98
24_M28_S0.6230.98
425_A432_G0.6230.98
224_L228_Q0.6210.98
295_R307_V0.6210.98
138_A253_L0.6200.98
348_I366_L0.6200.98
290_A308_I0.6190.98
357_P362_N0.6190.98
8_P326_A0.6180.98
131_L346_T0.6180.98
213_A296_A0.6170.98
229_G232_D0.6170.98
138_A339_Q0.6150.98
436_Y455_S0.6150.98
163_L386_W0.6150.98
46_I186_T0.6140.98
68_A71_K0.6130.98
111_N131_L0.6130.98
344_S373_I0.6130.98
297_V315_V0.6130.98
86_A90_S0.6120.98
437_A441_T0.6120.98
271_R275_I0.6120.98
17_F24_M0.6110.98
221_D295_R0.6110.98
440_A451_P0.6100.98
36_Y371_A0.6090.98
138_A255_H0.6040.98
353_L363_E0.6020.98
392_I395_L0.6020.98
296_A299_P0.6010.98
147_A161_G0.6010.98
344_S370_S0.6000.98
35_E179_R0.6000.98
450_H454_P0.6000.98
173_T337_N0.6000.98
318_P321_A0.5990.98
88_W273_I0.5990.98
79_L242_F0.5980.98
470_G473_V0.5980.98
54_A189_G0.5960.98
358_D362_N0.5950.98
26_K42_S0.5940.98
93_I96_K0.5940.98
33_L37_F0.5930.98
200_L289_L0.5930.98
118_Y413_L0.5930.98
90_S95_G0.5930.98
74_L77_V0.5920.98
54_A188_Q0.5920.98
67_G304_P0.5910.98
239_M242_F0.5890.98
185_D334_S0.5880.98
120_S354_N0.5880.98
88_W274_I0.5860.97
245_L249_G0.5840.97
204_V210_L0.5830.97
264_K267_K0.5830.97
137_G399_A0.5820.97
179_R183_L0.5820.97
207_A297_V0.5810.97
249_G400_F0.5810.97
390_E394_W0.5810.97
181_S341_L0.5800.97
360_M369_M0.5800.97
58_S62_F0.5790.97
16_V23_A0.5790.97
392_I397_L0.5790.97
60_S396_N0.5780.97
468_R471_T0.5770.97
95_G266_S0.5760.97
53_T283_L0.5760.97
380_L383_L0.5760.97
397_L401_G0.5760.97
455_S459_S0.5750.97
110_L411_L0.5730.97
274_I277_T0.5720.97
152_T306_L0.5710.97
207_A216_T0.5710.97
65_G69_A0.5670.97
51_T185_D0.5660.97
80_A87_V0.5660.97
139_M336_I0.5650.97
304_P307_V0.5650.97
282_I286_G0.5650.97
55_T255_H0.5650.97
19_I23_A0.5630.97
114_L410_P0.5630.97
396_N404_E0.5630.97
29_T35_E0.5610.97
90_S99_A0.5610.97
359_Q362_N0.5610.97
136_V384_A0.5610.97
130_S406_V0.5590.97
456_L460_L0.5590.97
226_T230_A0.5580.97
148_R152_T0.5580.97
91_L95_G0.5580.97
163_L166_G0.5580.97
64_G138_A0.5560.97
194_I197_V0.5560.97
442_L446_Y0.5560.97
33_L366_L0.5550.97
199_L324_F0.5540.96
56_Y83_Q0.5530.96
80_A83_Q0.5520.96
47_V183_L0.5520.96
239_M243_W0.5520.96
382_L385_A0.5510.96
5_V322_G0.5490.96
353_L356_R0.5490.96
13_L20_S0.5490.96
271_R274_I0.5490.96
280_V284_M0.5490.96
196_T286_G0.5460.96
62_F67_G0.5460.96
408_L412_V0.5460.96
27_R179_R0.5450.96
151_E157_P0.5450.96
421_N425_A0.5450.96
405_A409_W0.5430.96
82_I85_P0.5420.96
55_T173_T0.5420.96
162_L166_G0.5420.96
223_Q233_I0.5420.96
435_L455_S0.5410.96
260_C273_I0.5380.96
108_V349_K0.5370.96
223_Q227_P0.5360.96
283_L287_M0.5350.96
119_Q123_L0.5300.95
157_P161_G0.5300.95
429_M432_G0.5280.95
43_M262_S0.5280.95
53_T189_G0.5280.95
348_I373_I0.5280.95
90_S93_I0.5280.95
98_F257_A0.5280.95
371_A374_T0.5270.95
75_G78_L0.5260.95
419_R464_L0.5260.95
326_A330_A0.5260.95
298_I310_T0.5260.95
413_L467_N0.5250.95
333_M337_N0.5240.95
124_V354_N0.5240.95
424_G470_G0.5230.95
247_C254_P0.5220.95
23_A179_R0.5210.95
225_V235_S0.5210.95
228_Q231_D0.5200.95
79_L86_A0.5200.95
386_W389_P0.5190.95
131_L407_F0.5170.95
182_V185_D0.5170.95
152_T310_T0.5130.95
144_I158_Y0.5130.95
266_S270_H0.5120.95
211_S218_Q0.5120.95
294_G298_I0.5110.95
259_R338_A0.5100.94
34_N108_V0.5090.94
107_A113_M0.5090.94
316_L324_F0.5070.94
353_L358_D0.5070.94
138_A142_Q0.5070.94
424_G462_A0.5060.94
224_L229_G0.5060.94
13_L17_F0.5050.94
205_H208_G0.5050.94
156_I160_T0.5040.94
222_P229_G0.5030.94
401_G436_Y0.5030.94
222_P228_Q0.5020.94
53_T57_I0.5020.94
419_R467_N0.5020.94
162_L165_F0.5020.94
196_T283_L0.5000.94
339_Q407_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.94 100 0.187 Contact Map
3dh4A 3 0.8944 100 0.227 Contact Map
3l1lA 2 0.8364 99.4 0.84 Contact Map
3giaA 1 0.8613 99.2 0.856 Contact Map
4wgvA 2 0.7557 99.1 0.865 Contact Map
2jlnA 1 0.8571 98.9 0.874 Contact Map
4djkA 2 0.8116 98.6 0.888 Contact Map
4c7rA 3 0.882 97 0.92 Contact Map
2wswA 3 0.8157 96.5 0.926 Contact Map
4us3A 1 0.8095 93 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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