GREMLIN Database
SDHL - L-serine dehydratase 1
UniProt: P16095 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10930
Length: 454 (448)
Sequences: 1755 (987)
Seq/√Len: 46.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_A313_T4.5501.00
373_M424_V4.0901.00
189_S356_E4.0691.00
264_V404_I3.9451.00
220_I298_A3.9031.00
197_L202_K3.5951.00
426_E430_E3.5421.00
265_N405_N3.5191.00
128_Q142_T3.4281.00
71_A86_F3.2081.00
314_R356_E3.1591.00
180_Y184_T3.1411.00
197_L205_I3.0651.00
44_R112_G2.9961.00
300_Y311_I2.9941.00
182_N363_E2.9701.00
355_A360_G2.9681.00
201_S204_E2.7871.00
194_Q197_L2.7741.00
355_A407_A2.7731.00
326_Y348_S2.7611.00
180_Y191_L2.7461.00
325_L425_I2.7131.00
91_E109_R2.7031.00
122_L144_Y2.6891.00
244_R248_V2.6751.00
337_V341_G2.6371.00
193_M206_D2.6241.00
347_C372_G2.5781.00
34_V102_R2.5531.00
209_F316_F2.5121.00
94_E108_P2.4271.00
241_S245_R2.4141.00
67_I90_V2.3751.00
179_A183_E2.3711.00
95_R104_E2.2591.00
210_A309_P2.2511.00
108_P111_N2.2241.00
130_H137_V2.2191.00
44_R132_Y2.2131.00
206_D313_T2.2061.00
326_Y345_V2.1971.00
130_H140_S2.1611.00
74_E77_T2.1411.00
189_S314_R2.1381.00
48_D116_H2.1171.00
4_L320_G2.1131.00
10_V211_H2.1021.00
181_C362_P2.0891.00
202_K206_D2.0611.00
227_E245_R2.0511.00
9_K24_K2.0240.99
322_I352_A1.9840.99
133_N136_E1.9610.99
4_L209_F1.9450.99
120_L126_G1.9340.99
71_A90_V1.9300.99
67_I113_M1.8950.99
49_V66_I1.8900.99
32_D139_Y1.8790.99
27_K31_D1.8700.99
233_P387_Q1.8700.99
229_V235_R1.8520.99
48_D130_H1.8490.99
28_Q151_I1.8360.99
8_F319_A1.8260.99
5_F208_Y1.7850.99
356_E365_V1.7800.99
206_D210_A1.7700.99
43_T133_N1.7580.98
206_D309_P1.7570.98
186_Y191_L1.7290.98
309_P313_T1.7220.98
169_Y194_Q1.7180.98
200_H204_E1.7110.98
38_L41_S1.7020.98
9_K76_A1.7020.98
362_P365_V1.6980.98
63_D115_F1.6800.98
203_K207_E1.6740.98
190_G194_Q1.6720.98
347_C376_N1.6610.98
326_Y373_M1.6580.98
334_G397_A1.6580.98
45_V98_L1.6350.97
434_D439_Y1.6290.97
177_L191_L1.6260.97
419_V451_V1.6090.97
360_G411_L1.5870.97
89_D93_R1.5830.97
307_V311_I1.5800.97
5_F205_I1.5630.97
361_S364_Q1.5540.97
176_E179_A1.5450.96
141_K153_D1.5400.96
172_K328_M1.5380.96
192_A324_A1.5340.96
137_V140_S1.5320.96
200_H208_Y1.5180.96
237_P416_A1.5180.96
421_L425_I1.5120.96
308_S311_I1.5120.96
217_Q298_A1.5100.96
32_D141_K1.5090.96
33_L131_A1.5080.96
81_D222_R1.5070.96
426_E429_Y1.5040.96
310_D314_R1.4990.96
43_T134_G1.4970.96
345_V399_A1.4930.96
367_V413_R1.4910.96
318_A356_E1.4900.96
267_F303_F1.4790.95
413_R417_P1.4770.95
169_Y184_T1.4600.95
181_C191_L1.4510.95
430_E433_K1.4410.95
201_S205_I1.4320.95
108_P112_G1.4320.95
348_S373_M1.4300.94
122_L157_F1.4270.94
193_M205_I1.4270.94
40_D103_H1.4230.94
193_M202_K1.4190.94
311_I357_L1.4090.94
256_D408_R1.4090.94
218_A222_R1.4070.94
172_K176_E1.3990.94
217_Q220_I1.3960.94
73_N86_F1.3940.94
67_I71_A1.3890.94
429_Y433_K1.3850.93
331_S341_G1.3840.93
39_L103_H1.3610.93
213_W312_Y1.3590.93
119_N124_E1.3470.92
10_V215_T1.3460.92
27_K74_E1.3460.92
222_R274_E1.3330.92
367_V417_P1.3330.92
171_F192_A1.3330.92
67_I109_R1.3310.92
180_Y183_E1.3280.92
132_Y137_V1.3270.92
390_V418_R1.3220.92
376_N379_L1.3180.92
206_D310_D1.3100.91
95_R106_D1.3040.91
142_T154_E1.2920.91
97_L104_E1.2910.91
426_E450_K1.2750.90
88_R92_E1.2720.90
46_A130_H1.2710.90
366_C417_P1.2680.90
322_I353_G1.2610.90
178_L362_P1.2550.90
224_M266_M1.2540.90
398_I405_N1.2520.89
187_S190_G1.2460.89
211_H215_T1.2450.89
200_H205_I1.2440.89
401_V405_N1.2380.89
64_I84_P1.2370.89
66_I127_M1.2310.89
34_V99_A1.2240.88
26_G129_I1.2130.88
96_L107_F1.2100.88
73_N82_S1.2020.87
300_Y307_V1.2010.87
367_V415_S1.1880.87
42_V138_V1.1880.87
292_I334_G1.1810.86
122_L154_E1.1740.86
173_S176_E1.1660.86
246_M412_R1.1650.86
170_P180_Y1.1580.85
208_Y212_V1.1500.85
99_A102_R1.1380.84
265_N398_I1.1330.84
58_K115_F1.1310.84
214_Q218_A1.1210.83
58_K63_D1.1190.83
186_Y194_Q1.1160.83
345_V348_S1.1150.83
50_Y126_G1.1050.83
221_D225_N1.1030.82
184_T191_L1.1030.82
334_G343_V1.1020.82
127_M451_V1.0970.82
5_F212_V1.0910.82
82_S86_F1.0840.81
197_L201_S1.0840.81
219_C281_V1.0760.81
46_A114_R1.0730.81
331_S337_V1.0720.81
245_R248_V1.0700.80
94_E109_R1.0680.80
267_F302_H1.0650.80
202_K205_I1.0610.80
42_V131_A1.0570.80
292_I379_L1.0560.80
261_I401_V1.0540.79
36_K139_Y1.0510.79
217_Q221_D1.0460.79
262_D408_R1.0410.79
153_D157_F1.0400.79
437_A444_R1.0400.79
126_G129_I1.0370.78
175_T179_A1.0300.78
86_F90_V1.0260.78
310_D313_T1.0260.78
292_I400_S1.0170.77
54_S62_T1.0140.77
187_S356_E1.0000.76
54_S117_N0.9930.75
269_L397_A0.9930.75
250_S412_R0.9920.75
298_A302_H0.9900.75
171_F321_A0.9890.75
190_G314_R0.9880.75
28_Q156_H0.9870.75
427_T434_D0.9860.75
116_H119_N0.9820.74
39_L98_L0.9800.74
10_V212_V0.9760.74
311_I314_R0.9740.74
326_Y353_G0.9740.74
427_T447_L0.9720.74
347_C399_A0.9690.73
41_S133_N0.9650.73
76_A211_H0.9640.73
324_A372_G0.9630.73
430_E450_K0.9620.73
341_G405_N0.9590.73
360_G364_Q0.9550.72
331_S432_G0.9540.72
170_P195_N0.9490.72
188_L318_A0.9400.71
79_D82_S0.9380.71
68_M83_I0.9370.71
262_D412_R0.9320.70
247_L263_W0.9290.70
226_T241_S0.9280.70
213_W217_Q0.9270.70
109_R113_M0.9250.70
198_A205_I0.9250.70
30_V99_A0.9230.70
55_L345_V0.9210.70
46_A132_Y0.9210.70
24_K76_A0.9190.69
133_N138_V0.9190.69
264_V401_V0.9180.69
97_L102_R0.9170.69
128_Q140_S0.9130.69
55_L444_R0.9100.69
214_Q309_P0.9100.69
193_M197_L0.9100.69
66_I113_M0.9080.68
263_W303_F0.9070.68
301_D312_Y0.9070.68
31_D99_A0.9050.68
153_D156_H0.8990.68
265_N397_A0.8920.67
38_L42_V0.8910.67
47_V129_I0.8910.67
86_F89_D0.8890.67
324_A328_M0.8890.67
318_A322_I0.8870.67
39_L42_V0.8850.66
222_R226_T0.8840.66
337_V432_G0.8830.66
176_E183_E0.8820.66
229_V233_P0.8800.66
168_P198_A0.8760.66
210_A310_D0.8740.65
345_V372_G0.8740.65
170_P173_S0.8680.65
299_Y303_F0.8590.64
20_V24_K0.8570.64
40_D102_R0.8460.63
62_T168_P0.8450.63
2_I6_D0.8420.63
256_D259_N0.8410.62
37_G40_D0.8380.62
62_T115_F0.8380.62
257_P262_D0.8370.62
384_V419_V0.8360.62
251_D259_N0.8340.62
345_V373_M0.8320.62
13_G17_S0.8290.61
141_K155_E0.8240.61
209_F320_G0.8220.61
211_H214_Q0.8210.61
379_L398_I0.8170.60
154_E158_G0.8120.60
292_I343_V0.8110.60
177_L321_A0.8110.60
168_P195_N0.8100.60
31_D34_V0.8080.59
224_M244_R0.8070.59
208_Y211_H0.8060.59
366_C415_S0.8010.59
334_G337_V0.8010.59
207_E211_H0.7990.58
300_Y304_I0.7980.58
48_D114_R0.7970.58
187_S314_R0.7950.58
199_L205_I0.7940.58
227_E241_S0.7890.57
256_D264_V0.7890.57
82_S89_D0.7860.57
120_L142_T0.7850.57
221_D298_A0.7850.57
226_T277_A0.7820.57
81_D84_P0.7810.57
87_I109_R0.7800.57
180_Y185_G0.7800.57
42_V98_L0.7770.56
28_Q32_D0.7760.56
39_L99_A0.7740.56
49_V113_M0.7720.56
348_S424_V0.7670.55
167_V199_L0.7570.54
9_K20_V0.7570.54
64_I443_S0.7570.54
189_S318_A0.7530.54
331_S334_G0.7500.54
71_A97_L0.7500.54
193_M313_T0.7410.53
150_F327_K0.7410.53
87_I91_E0.7390.53
31_D35_E0.7370.52
426_E433_K0.7360.52
2_I328_M0.7360.52
304_I311_I0.7340.52
169_Y180_Y0.7310.52
82_S85_G0.7310.52
300_Y357_L0.7310.52
89_D92_E0.7300.52
13_G18_H0.7290.52
71_A89_D0.7280.52
48_D64_I0.7270.51
84_P87_I0.7240.51
84_P88_R0.7240.51
94_E106_D0.7230.51
50_Y116_H0.7200.51
258_M408_R0.7200.51
366_C413_R0.7190.51
355_A409_M0.7190.51
141_K151_I0.7140.50
306_S311_I0.7060.49
12_I68_M0.7040.49
120_L144_Y0.7010.49
66_I124_E0.6980.49
64_I334_G0.6980.49
318_A352_A0.6970.48
364_Q371_I0.6970.48
168_P199_L0.6970.48
409_M418_R0.6950.48
152_V157_F0.6950.48
55_L117_N0.6950.48
341_G432_G0.6910.48
264_V405_N0.6900.48
265_N401_V0.6890.48
58_K423_K0.6890.48
192_A321_A0.6860.47
292_I397_A0.6860.47
376_N398_I0.6850.47
193_M310_D0.6830.47
96_L105_V0.6820.47
169_Y195_N0.6810.47
221_D302_H0.6780.47
221_D244_R0.6780.47
251_D255_N0.6780.47
345_V424_V0.6770.46
45_V122_L0.6760.46
63_D113_M0.6740.46
220_I301_D0.6740.46
301_D307_V0.6730.46
385_A390_V0.6720.46
420_S424_V0.6710.46
58_K61_H0.6710.46
106_D111_N0.6710.46
293_V319_A0.6660.45
186_Y242_A0.6660.45
173_S329_N0.6650.45
204_E208_Y0.6640.45
242_A246_M0.6630.45
267_F329_N0.6630.45
110_D114_R0.6620.45
201_S207_E0.6620.45
345_V429_Y0.6600.45
56_T59_G0.6600.45
315_Y357_L0.6590.45
61_H443_S0.6570.45
243_L267_F0.6560.44
68_M84_P0.6560.44
251_D254_S0.6550.44
13_G16_S0.6550.44
78_V83_I0.6550.44
356_E362_P0.6540.44
266_M269_L0.6500.44
317_M397_A0.6500.44
191_L361_S0.6490.44
28_Q143_Y0.6490.44
132_Y136_E0.6480.44
95_R144_Y0.6470.44
184_T194_Q0.6460.43
221_D224_M0.6450.43
262_D376_N0.6430.43
39_L102_R0.6420.43
258_M329_N0.6420.43
80_I222_R0.6410.43
14_P17_S0.6410.43
326_Y425_I0.6400.43
237_P414_T0.6380.43
124_E440_R0.6370.43
26_G66_I0.6360.42
325_L329_N0.6340.42
301_D311_I0.6340.42
357_L362_P0.6330.42
98_L105_V0.6320.42
14_P18_H0.6300.42
320_G324_A0.6300.42
124_E144_Y0.6280.42
435_M440_R0.6280.42
2_I205_I0.6270.42
348_S376_N0.6260.42
372_G409_M0.6260.42
13_G19_T0.6240.41
337_V405_N0.6240.41
427_T450_K0.6240.41
167_V198_A0.6230.41
304_I358_L0.6230.41
7_M157_F0.6220.41
37_G139_Y0.6220.41
336_E346_A0.6220.41
70_L96_L0.6180.41
38_L138_V0.6170.41
76_A451_V0.6160.41
30_V98_L0.6160.41
9_K241_S0.6160.41
256_D304_I0.6150.40
63_D405_N0.6140.40
88_R91_E0.6140.40
372_G376_N0.6140.40
103_H106_D0.6130.40
67_I86_F0.6120.40
68_M402_K0.6110.40
45_V103_H0.6110.40
329_N334_G0.6100.40
105_V117_N0.6100.40
409_M425_I0.6100.40
326_Y424_V0.6100.40
105_V112_G0.6090.40
83_I87_I0.6090.40
12_I83_I0.6090.40
129_I142_T0.6080.40
418_R423_K0.6080.40
337_V397_A0.6070.40
217_Q302_H0.6070.40
261_I345_V0.6060.40
45_V102_R0.6060.40
427_T439_Y0.6050.39
252_K255_N0.6040.39
267_F357_L0.6040.39
361_S414_T0.6020.39
23_M336_E0.6010.39
367_V427_T0.6010.39
46_A50_Y0.6010.39
261_I398_I0.6000.39
153_D376_N0.6000.39
36_K104_E0.5990.39
353_G365_V0.5980.39
142_T174_A0.5960.39
237_P242_A0.5950.39
41_S185_G0.5950.39
243_L401_V0.5930.38
326_Y352_A0.5930.38
155_E158_G0.5920.38
26_G105_V0.5920.38
77_T80_I0.5920.38
343_V346_A0.5920.38
215_T219_C0.5910.38
26_G269_L0.5900.38
31_D211_H0.5880.38
117_N399_A0.5870.38
301_D308_S0.5860.38
300_Y354_L0.5850.38
89_D137_V0.5840.38
364_Q411_L0.5840.38
304_I357_L0.5830.37
54_S63_D0.5830.37
10_V281_V0.5830.37
300_Y347_C0.5830.37
193_M314_R0.5830.37
124_E348_S0.5820.37
208_Y290_C0.5820.37
419_V427_T0.5820.37
265_N341_G0.5810.37
107_F112_G0.5810.37
50_Y120_L0.5800.37
24_K28_Q0.5790.37
77_T215_T0.5790.37
47_V113_M0.5790.37
420_S423_K0.5790.37
161_A164_E0.5780.37
29_F131_A0.5780.37
35_E84_P0.5780.37
47_V67_I0.5770.37
346_A432_G0.5770.37
14_P19_T0.5770.37
116_H355_A0.5760.37
47_V307_V0.5750.37
181_C405_N0.5750.37
224_M443_S0.5730.37
399_A409_M0.5730.37
124_E409_M0.5720.36
186_Y190_G0.5720.36
30_V34_V0.5710.36
207_E210_A0.5710.36
423_K430_E0.5710.36
126_G144_Y0.5710.36
201_S208_Y0.5700.36
345_V405_N0.5700.36
322_I355_A0.5690.36
186_Y363_E0.5680.36
41_S183_E0.5680.36
222_R279_G0.5670.36
334_G432_G0.5670.36
2_I324_A0.5660.36
146_I242_A0.5640.36
434_D438_K0.5640.36
215_T226_T0.5640.36
372_G444_R0.5630.36
33_L42_V0.5630.36
213_W301_D0.5620.36
278_G336_E0.5610.35
266_M387_Q0.5610.35
241_S244_R0.5600.35
143_Y401_V0.5600.35
85_G89_D0.5600.35
194_Q320_G0.5600.35
113_M279_G0.5600.35
220_I426_E0.5590.35
413_R440_R0.5590.35
93_R104_E0.5580.35
32_D36_K0.5580.35
373_M420_S0.5560.35
115_F260_V0.5550.35
219_C272_N0.5550.35
405_N437_A0.5550.35
305_E311_I0.5540.35
336_E432_G0.5540.35
292_I423_K0.5540.35
162_A166_S0.5540.35
331_S336_E0.5530.35
312_Y316_F0.5530.35
214_Q237_P0.5520.35
158_G163_N0.5520.35
89_D97_L0.5510.35
325_L409_M0.5500.34
175_T180_Y0.5500.34
54_S66_I0.5500.34
414_T417_P0.5500.34
93_R106_D0.5490.34
236_V279_G0.5480.34
46_A140_S0.5470.34
43_T186_Y0.5470.34
110_D202_K0.5460.34
264_V299_Y0.5460.34
287_N327_K0.5460.34
254_S267_F0.5450.34
11_G22_P0.5450.34
50_Y373_M0.5440.34
413_R416_A0.5440.34
122_L409_M0.5440.34
337_V429_Y0.5420.34
187_S191_L0.5420.34
35_E108_P0.5410.34
133_N137_V0.5400.34
15_S18_H0.5390.33
347_C379_L0.5380.33
126_G142_T0.5370.33
215_T313_T0.5370.33
88_R203_K0.5360.33
10_V218_A0.5360.33
92_E182_N0.5350.33
438_K445_G0.5350.33
280_R295_A0.5340.33
179_A203_K0.5340.33
169_Y191_L0.5340.33
46_A112_G0.5340.33
154_E157_F0.5340.33
113_M161_A0.5330.33
55_L399_A0.5330.33
56_T335_A0.5330.33
186_Y235_R0.5330.33
35_E40_D0.5330.33
30_V38_L0.5320.33
73_N113_M0.5320.33
260_V401_V0.5310.33
143_Y402_K0.5310.33
319_A353_G0.5300.33
94_E110_D0.5300.33
55_L267_F0.5300.33
171_F324_A0.5300.33
256_D305_E0.5300.33
320_G328_M0.5290.33
348_S420_S0.5290.33
28_Q158_G0.5280.32
188_L356_E0.5280.32
79_D372_G0.5280.32
181_C184_T0.5280.32
79_D347_C0.5270.32
374_E394_E0.5270.32
307_V312_Y0.5260.32
353_G364_Q0.5260.32
423_K444_R0.5260.32
258_M262_D0.5250.32
15_S21_G0.5250.32
24_K259_N0.5250.32
335_A441_E0.5240.32
348_S408_R0.5230.32
146_I379_L0.5220.32
24_K158_G0.5220.32
174_A390_V0.5220.32
98_L102_R0.5220.32
376_N402_K0.5220.32
290_C417_P0.5220.32
49_V60_H0.5210.32
192_A400_S0.5210.32
410_A424_V0.5200.32
23_M341_G0.5200.32
35_E229_V0.5200.32
114_R308_S0.5180.32
184_T190_G0.5180.32
239_R287_N0.5180.32
80_I357_L0.5170.32
375_H394_E0.5170.32
146_I152_V0.5160.31
197_L255_N0.5160.31
48_D118_G0.5150.31
134_G204_E0.5140.31
134_G183_E0.5140.31
27_K34_V0.5140.31
175_T182_N0.5140.31
11_G18_H0.5120.31
297_L315_Y0.5120.31
265_N269_L0.5120.31
20_V75_P0.5120.31
43_T103_H0.5110.31
277_A293_V0.5110.31
43_T106_D0.5100.31
263_W364_Q0.5100.31
217_Q309_P0.5100.31
187_S310_D0.5090.31
45_V96_L0.5080.31
172_K180_Y0.5080.31
37_G203_K0.5070.31
371_I413_R0.5060.31
373_M451_V0.5050.31
106_D110_D0.5050.31
191_L197_L0.5040.30
52_S125_N0.5040.30
256_D262_D0.5040.30
256_D326_Y0.5040.30
24_K74_E0.5030.30
231_P272_N0.5020.30
387_Q440_R0.5020.30
24_K153_D0.5000.30
251_D302_H0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rqoA 2 0.9868 100 0.182 Contact Map
2iafA 1 0.304 100 0.741 Contact Map
1ygyA 4 0.4405 99.6 0.914 Contact Map
2hp0A 2 0.4471 73.3 0.977 Contact Map
1szqA 2 0.5132 63.2 0.979 Contact Map
2nptA 1 0.2115 26.2 0.983 Contact Map
4d0gC 1 0.0991 24.7 0.983 Contact Map
3tsoC 2 0.1167 23.1 0.983 Contact Map
1owfB 1 0.1982 17.6 0.984 Contact Map
4n1vA 2 0.1938 16.6 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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