GREMLIN Database
AROP - Aromatic amino acid transport protein AroP
UniProt: P15993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10084
Length: 457 (423)
Sequences: 24764 (15871)
Seq/√Len: 771.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_N341_A4.4201.00
323_A335_N4.3741.00
383_K387_A3.5421.00
375_A410_L3.2701.00
56_G246_L3.2251.00
326_S335_N3.1141.00
232_Q236_K2.9441.00
16_K228_D2.8781.00
227_A233_S2.6951.00
96_G314_L2.6541.00
80_S317_Q2.6251.00
229_N232_Q2.5931.00
21_Q240_Q2.5791.00
315_A325_A2.5741.00
171_G255_V2.5731.00
328_D334_V2.5261.00
323_A326_S2.4721.00
132_A345_A2.4711.00
283_F287_A2.4011.00
17_N240_Q2.4001.00
225_A316_Q2.3451.00
169_I173_W2.3021.00
378_S409_C2.2611.00
431_Y435_V2.2551.00
84_Y92_G2.2531.00
68_E385_R2.1871.00
226_E309_R2.1641.00
140_A144_T2.1401.00
274_L277_H2.1261.00
338_L342_L2.1211.00
312_F316_Q2.1091.00
17_N233_S2.0861.00
147_K151_E2.0861.00
87_W383_K2.0831.00
407_W411_L2.0741.00
136_V345_A2.0651.00
435_V438_I2.0571.00
20_I227_A2.0561.00
139_N337_I2.0381.00
17_N21_Q2.0131.00
143_L334_V1.9971.00
441_G445_L1.9841.00
158_I162_I1.9821.00
236_K240_Q1.9591.00
132_A348_V1.9531.00
21_Q244_R1.9221.00
65_Q378_S1.9111.00
438_I442_I1.9111.00
131_A348_V1.8991.00
84_Y89_S1.8991.00
16_K19_H1.8981.00
87_W379_L1.8821.00
261_P264_R1.8821.00
324_L339_V1.8771.00
379_L410_L1.8671.00
57_F61_L1.8391.00
100_W340_S1.8381.00
40_V48_I1.8331.00
318_G322_K1.8231.00
11_L327_V1.8091.00
264_R278_E1.8071.00
239_N243_Y1.8051.00
274_L278_E1.7651.00
404_L408_I1.7571.00
83_A95_S1.7091.00
136_V341_A1.7091.00
47_G203_L1.7071.00
186_V189_L1.6981.00
328_D332_V1.6971.00
229_N233_S1.6951.00
411_L415_A1.6941.00
95_S376_M1.6831.00
19_H154_F1.6771.00
24_A241_V1.6571.00
330_R334_V1.6501.00
135_F344_T1.6411.00
58_I412_F1.6361.00
107_A344_T1.6321.00
143_L338_L1.6311.00
142_N301_N1.6241.00
51_G206_M1.6091.00
436_W440_L1.6081.00
126_P129_V1.6061.00
383_K386_R1.6011.00
111_L300_Y1.5971.00
15_L19_H1.5941.00
88_G91_A1.5901.00
162_I166_A1.5741.00
439_V443_G1.5551.00
243_Y247_I1.5551.00
435_V439_V1.5141.00
437_L441_G1.5011.00
335_N339_V1.5001.00
118_I130_S1.5001.00
277_H285_A1.4931.00
440_L443_G1.4851.00
163_A291_V1.4781.00
311_L336_T1.4611.00
55_A210_I1.4581.00
312_F327_V1.4521.00
307_N340_S1.4521.00
223_T305_Y1.4351.00
61_L408_I1.4291.00
135_F341_A1.4241.00
229_N236_K1.4221.00
144_T330_R1.4201.00
12_K331_G1.4161.00
83_A376_M1.4111.00
428_I431_Y1.4041.00
76_A225_A1.4021.00
63_M242_I1.3961.00
57_F408_I1.3941.00
111_L135_F1.3901.00
427_A430_V1.3841.00
379_L383_K1.3821.00
426_M429_S1.3811.00
11_L312_F1.3811.00
139_N338_L1.3781.00
114_V293_L1.3771.00
132_A136_V1.3651.00
322_K325_A1.3641.00
172_G255_V1.3591.00
326_S334_V1.3481.00
434_P438_I1.3401.00
161_V165_V1.3361.00
308_S337_I1.3361.00
247_I251_G1.3351.00
322_K326_S1.3341.00
114_V134_F1.3271.00
268_D274_L1.3071.00
175_L258_S1.3061.00
286_N290_I1.3011.00
87_W91_A1.3001.00
389_Q395_T1.2991.00
425_G428_I1.2971.00
19_H150_G1.2941.00
233_S236_K1.2931.00
168_I251_G1.2891.00
428_I435_V1.2851.00
425_G439_V1.2841.00
125_I129_V1.2781.00
270_S274_L1.2691.00
75_V81_H1.2691.00
63_M238_T1.2661.00
73_E85_K1.2661.00
433_I437_L1.2651.00
382_M407_W1.2551.00
62_I378_S1.2501.00
49_I254_A1.2501.00
17_N236_K1.2371.00
81_H85_K1.2341.00
15_L20_I1.2331.00
401_L405_G1.2321.00
18_R22_L1.2311.00
230_P235_P1.2301.00
90_F444_Y1.2261.00
429_S433_I1.2261.00
277_H282_T1.2251.00
415_A419_I1.2241.00
65_Q406_N1.2231.00
392_G395_T1.2171.00
35_L113_A1.2121.00
64_R239_N1.2101.00
193_G197_P1.2041.00
28_A245_I1.2011.00
86_Y380_A1.1961.00
110_E299_V1.1951.00
173_W178_G1.1951.00
75_V85_K1.1901.00
186_V190_W1.1831.00
138_I300_Y1.1831.00
47_G196_L1.1771.00
187_S190_W1.1731.00
141_I152_M1.1691.00
426_M430_V1.1681.00
15_L150_G1.1631.00
375_A414_A1.1581.00
176_F179_N1.1581.00
262_W265_V1.1571.00
20_I237_A1.1511.00
171_G259_L1.1491.00
311_L320_A1.1381.00
404_L407_W1.1361.00
172_G176_F1.1331.00
167_M171_G1.1301.00
83_A91_A1.1271.00
128_W132_A1.1251.00
100_W311_L1.1241.00
401_L404_L1.1151.00
24_A220_V1.1101.00
386_R389_Q1.1061.00
66_L79_F1.1031.00
335_N338_L1.0991.00
439_V445_L1.0931.00
23_I223_T1.0801.00
424_P427_A1.0791.00
152_M156_F1.0781.00
228_D233_S1.0771.00
425_G431_Y1.0771.00
41_I48_I1.0751.00
431_Y438_I1.0721.00
316_Q325_A1.0721.00
14_G228_D1.0681.00
85_K388_K1.0681.00
133_V137_V1.0651.00
70_V82_F1.0631.00
386_R403_P1.0621.00
93_F97_W1.0531.00
166_A170_F1.0461.00
25_L244_R1.0451.00
403_P407_W1.0431.00
327_V331_G1.0411.00
72_E395_T1.0401.00
414_A418_V1.0391.00
440_L444_Y1.0391.00
151_E155_W1.0351.00
425_G429_S1.0341.00
118_I122_Y1.0311.00
389_Q392_G1.0251.00
115_G130_S1.0201.00
25_L245_I1.0161.00
381_H406_N1.0161.00
153_E301_N1.0121.00
402_Y406_N1.0111.00
424_P428_I1.0051.00
80_S313_G1.0051.00
385_R389_Q1.0031.00
136_V140_A1.0031.00
68_E71_V0.9961.00
53_A250_I0.9951.00
342_L346_L0.9911.00
425_G438_I0.9891.00
388_K393_V0.9881.00
118_I293_L0.9881.00
261_P278_E0.9861.00
410_L414_A0.9811.00
165_V169_I0.9811.00
139_N143_L0.9811.00
146_V305_Y0.9791.00
143_L332_V0.9761.00
129_V133_V0.9731.00
204_V415_A0.9731.00
156_F298_S0.9681.00
224_A234_I0.9631.00
393_V396_R0.9501.00
215_G370_L0.9481.00
435_V440_L0.9441.00
418_V422_M0.9431.00
378_S410_L0.9381.00
168_I255_V0.9321.00
22_L154_F0.9241.00
196_L203_L0.9241.00
427_A431_Y0.9241.00
109_A212_F0.9231.00
29_I32_G0.9211.00
161_V248_F0.9181.00
173_W177_S0.9161.00
77_G81_H0.9151.00
246_L250_I0.9111.00
437_L440_L0.9031.00
200_F203_L0.9001.00
282_T286_N0.8961.00
137_V297_L0.8961.00
375_A413_M0.8921.00
61_L405_G0.8901.00
49_I257_L0.8881.00
240_Q244_R0.8861.00
143_L328_D0.8851.00
432_L435_V0.8841.00
280_G284_V0.8781.00
218_E222_I0.8781.00
130_S133_V0.8771.00
175_L178_G0.8751.00
191_D194_G0.8751.00
62_I413_M0.8741.00
429_S435_V0.8741.00
160_K295_A0.8741.00
254_A258_S0.8691.00
138_I301_N0.8631.00
431_Y442_I0.8621.00
18_R154_F0.8591.00
14_G147_K0.8571.00
84_Y317_Q0.8571.00
199_G202_G0.8541.00
109_A363_M0.8541.00
415_A418_V0.8531.00
115_G131_A0.8521.00
324_L335_N0.8471.00
304_V341_A0.8461.00
168_I172_G0.8411.00
431_Y434_P0.8411.00
334_V338_L0.8401.00
72_E393_V0.8381.00
119_Q123_P0.8381.00
19_H151_E0.8381.00
375_A379_L0.8371.00
11_L226_E0.8331.00
115_G127_T0.8321.00
11_L309_R0.8321.00
409_C413_M0.8311.00
60_F64_R0.8311.00
90_F94_A0.8291.00
188_N191_D0.8271.00
53_A57_F0.8261.00
441_G444_Y0.8231.00
114_V297_L0.8211.00
50_L203_L0.8201.00
382_M406_N0.8201.00
328_D331_G0.8191.00
56_G214_F0.8181.00
196_L199_G0.8181.00
388_K392_G0.8161.00
112_T362_L0.8111.00
426_M439_V0.8101.00
97_W320_A0.8101.00
91_A376_M0.8101.00
114_V296_A0.8101.00
320_A324_L0.8071.00
259_L275_I0.8071.00
205_M209_I0.8051.00
438_I441_G0.8021.00
128_W348_V0.8011.00
425_G442_I0.7991.00
151_E154_F0.7991.00
428_I438_I0.7981.00
219_L306_C0.7931.00
341_A345_A0.7931.00
77_G80_S0.7871.00
413_M416_V0.7861.00
430_V434_P0.7861.00
442_I445_L0.7851.00
60_F239_N0.7821.00
175_L179_N0.7821.00
140_A143_L0.7801.00
173_W176_F0.7771.00
382_M386_R0.7701.00
172_G251_G0.7701.00
436_W439_V0.7661.00
194_G197_P0.7661.00
69_M381_H0.7651.00
17_N237_A0.7641.00
429_S434_P0.7631.00
83_A380_A0.7591.00
439_V444_Y0.7591.00
88_G445_L0.7571.00
268_D271_P0.7541.00
61_L65_Q0.7531.00
281_D284_V0.7531.00
135_F348_V0.7521.00
189_L193_G0.7511.00
365_L369_A0.7511.00
431_Y436_W0.7471.00
425_G435_V0.7471.00
29_I34_F0.7411.00
119_Q127_T0.7411.00
14_G146_V0.7411.00
193_G196_L0.7401.00
215_G374_W0.7381.00
329_K334_V0.7381.00
429_S438_I0.7341.00
417_L420_M0.7331.00
342_L345_A0.7331.00
270_S273_V0.7331.00
69_M82_F0.7281.00
167_M276_F0.7261.00
426_M433_I0.7261.00
394_V398_P0.7251.00
168_I252_S0.7231.00
104_V343_V0.7201.00
402_Y405_G0.7171.00
144_T148_V0.7161.00
143_L330_R0.7161.00
426_M431_Y0.7151.00
29_I160_K0.7141.00
433_I436_W0.7131.00
18_R151_E0.7131.00
99_Y103_Y0.7131.00
200_F204_V0.7121.00
324_L336_T0.7101.00
176_F180_G0.7101.00
276_F279_L0.7091.00
235_P238_T0.7081.00
138_I304_V0.7081.00
50_L54_I0.7061.00
195_F198_H0.7041.00
30_G34_F0.7021.00
368_S417_L0.6991.00
59_A217_L0.6971.00
87_W380_A0.6961.00
323_A339_V0.6961.00
124_E127_T0.6931.00
28_A241_V0.6931.00
50_L53_A0.6911.00
14_G18_R0.6911.00
428_I439_V0.6901.00
406_N410_L0.6881.00
431_Y443_G0.6881.00
229_N235_P0.6871.00
40_V44_A0.6871.00
64_R405_G0.6851.00
381_H385_R0.6831.00
380_A384_F0.6831.00
399_A402_Y0.6811.00
432_L436_W0.6801.00
397_F400_L0.6781.00
142_N337_I0.6761.00
382_M403_P0.6761.00
429_S440_L0.6751.00
108_M362_L0.6711.00
49_I53_A0.6681.00
33_L252_S0.6671.00
333_P336_T0.6661.00
438_I445_L0.6641.00
106_V366_V0.6641.00
308_S336_T0.6631.00
240_Q243_Y0.6601.00
311_L339_V0.6581.00
425_G440_L0.6581.00
244_R248_F0.6581.00
428_I441_G0.6571.00
66_L377_I0.6571.00
148_V151_E0.6571.00
271_P276_F0.6571.00
142_N305_Y0.6551.00
54_I207_M0.6541.00
138_I297_L0.6521.00
21_Q237_A0.6521.00
115_G118_I0.6511.00
105_L365_L0.6501.00
427_A441_G0.6501.00
80_S84_Y0.6491.00
283_F286_N0.6491.00
202_G205_M0.6491.00
369_A373_N0.6471.00
431_Y440_L0.6461.00
48_I253_L0.6451.00
304_V308_S0.6431.00
37_S253_L0.6421.00
309_R312_F0.6411.00
128_W131_A0.6401.00
430_V433_I0.6401.00
132_A349_L0.6361.00
244_R247_I0.6361.00
65_Q409_C0.6361.00
136_V139_N0.6351.00
170_F174_L0.6341.00
46_P257_L0.6341.00
39_S360_G0.6331.00
120_F289_N0.6331.00
26_G157_A0.6321.00
175_L255_V0.6321.00
407_W410_L0.6301.00
418_V421_L0.6301.00
52_Y213_S0.6291.00
221_G238_T0.6271.00
315_A324_L0.6261.00
86_Y383_K0.6251.00
267_A270_S0.6231.00
27_G303_C0.6221.00
49_I250_I0.6221.00
18_R21_Q0.6211.00
416_V420_M0.6211.00
29_I248_F0.6191.00
399_A405_G0.6181.00
400_L404_L0.6171.00
411_L414_A0.6151.00
150_G154_F0.6151.00
435_V442_I0.6151.00
63_M217_L0.6141.00
434_P437_L0.6141.00
177_S180_G0.6141.00
295_A298_S0.6131.00
433_I438_I0.6111.00
79_F218_E0.6111.00
27_G302_S0.6101.00
36_G363_M0.6081.00
121_W290_I0.6081.00
395_T398_P0.6071.00
76_A312_F0.6071.00
21_Q24_A0.6071.00
431_Y437_L0.6061.00
439_V442_I0.6051.00
80_S96_G0.6041.00
215_G218_E0.6011.00
252_S256_L0.6011.00
425_G430_V0.6011.00
98_N373_N0.5981.00
86_Y384_F0.5981.00
55_A211_M0.5981.00
102_L370_L0.5961.00
225_A312_F0.5941.00
434_P440_L0.5921.00
61_L409_C0.5911.00
145_N148_V0.5891.00
424_P431_Y0.5881.00
430_V440_L0.5881.00
307_N311_L0.5871.00
170_F281_D0.5861.00
191_D195_F0.5861.00
69_M86_Y0.5851.00
431_Y441_G0.5851.00
159_I291_V0.5841.00
234_I238_T0.5821.00
113_A117_Y0.5821.00
70_V234_I0.5811.00
192_Q195_F0.5811.00
70_V221_G0.5801.00
72_E389_Q0.5801.00
65_Q399_A0.5781.00
67_G71_V0.5781.00
436_W444_Y0.5771.00
106_V110_E0.5751.00
106_V109_A0.5751.00
146_V223_T0.5751.00
371_V413_M0.5741.00
433_I444_Y0.5731.00
134_F300_Y0.5721.00
159_I163_A0.5721.00
436_W442_I0.5721.00
143_L337_I0.5721.00
427_A436_W0.5711.00
63_M67_G0.5711.00
110_E300_Y0.5691.00
139_N304_V0.5691.00
98_N372_I0.5691.00
403_P406_N0.5671.00
118_I134_F0.5671.00
227_A234_I0.5661.00
222_I306_C0.5651.00
135_F345_A0.5651.00
187_S191_D0.5641.00
108_M347_C0.5641.00
231_E394_V0.5641.00
117_Y292_V0.5631.00
428_I433_I0.5631.00
267_A271_P0.5631.00
157_A160_K0.5621.00
149_F305_Y0.5621.00
251_G255_V0.5601.00
427_A438_I0.5591.00
148_V152_M0.5591.00
427_A445_L0.5591.00
272_F276_F0.5591.00
425_G436_W0.5581.00
83_A92_G0.5581.00
78_S221_G0.5571.00
426_M436_W0.5571.00
162_I165_V0.5571.00
428_I437_L0.5561.00
55_A214_F0.5551.00
24_A28_A0.5541.00
103_Y303_C0.5541.00
110_E113_A0.5541.00
401_L406_N0.5541.00
110_E296_A0.5501.00
409_C412_F0.5491.00
290_I294_T0.5491.00
419_I423_T0.5491.00
215_G366_V0.5481.00
31_T212_F0.5471.00
266_T270_S0.5451.00
134_F297_L0.5451.00
431_Y439_V0.5441.00
384_F388_K0.5441.00
163_A287_A0.5421.00
255_V258_S0.5421.00
430_V435_V0.5421.00
111_L115_G0.5421.00
27_G219_L0.5421.00
385_R402_Y0.5401.00
287_A291_V0.5391.00
204_V419_I0.5391.00
426_M435_V0.5391.00
116_K127_T0.5391.00
271_P279_L0.5381.00
345_A348_V0.5381.00
155_W159_I0.5371.00
428_I432_L0.5361.00
40_V206_M0.5361.00
276_F281_D0.5351.00
137_V141_I0.5341.00
80_S92_G0.5321.00
25_L157_A0.5321.00
360_G363_M0.5321.00
95_S373_N0.5311.00
226_E333_P0.5311.00
308_S340_S0.5301.00
190_W193_G0.5291.00
150_G301_N0.5291.00
429_S432_L0.5291.00
327_V330_R0.5281.00
72_E384_F0.5271.00
323_A327_V0.5271.00
72_E396_R0.5261.00
79_F222_I0.5261.00
375_A417_L0.5261.00
426_M444_Y0.5261.00
13_R228_D0.5241.00
121_W289_N0.5241.00
155_W158_I0.5241.00
97_W435_V0.5231.00
413_M417_L0.5211.00
384_F389_Q0.5201.00
23_I26_G0.5201.00
16_K147_K0.5171.00
29_I36_G0.5161.00
114_V118_I0.5161.00
71_V396_R0.5151.00
244_R251_G0.5141.00
230_P233_S0.5141.00
433_I440_L0.5141.00
231_E236_K0.5141.00
40_V210_I0.5131.00
392_G396_R0.5121.00
256_L272_F0.5121.00
52_Y253_L0.5111.00
39_S42_Q0.5111.00
334_V337_I0.5111.00
220_V234_I0.5101.00
218_E374_W0.5091.00
174_L177_S0.5081.00
52_Y249_Y0.5081.00
104_V340_S0.5081.00
49_I52_Y0.5071.00
175_L259_L0.5071.00
20_I220_V0.5071.00
188_N192_Q0.5061.00
438_I443_G0.5051.00
133_V136_V0.5041.00
102_L369_A0.5031.00
189_L192_Q0.5011.00
227_A237_A0.5001.00
406_N420_M0.5001.00
430_V439_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9059 100 0.294 Contact Map
4djkA 2 0.8972 100 0.349 Contact Map
3giaA 1 0.9212 100 0.35 Contact Map
3dh4A 3 0.9212 99.2 0.841 Contact Map
2xq2A 2 0.9278 99.1 0.847 Contact Map
2jlnA 1 0.9103 98.8 0.864 Contact Map
4wgvA 2 0.8118 97.7 0.899 Contact Map
2a65A 2 0.9344 97.3 0.907 Contact Map
4xp4A 1 0.9409 97.1 0.91 Contact Map
4us3A 1 0.8731 96.9 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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