GREMLIN Database
AROE - Shikimate dehydrogenase (NADP(+))
UniProt: P15770 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10077
Length: 272 (259)
Sequences: 6324 (4709)
Seq/√Len: 292.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_K227_E4.5331.00
9_N37_L4.0761.00
76_T99_D3.0811.00
250_L256_L2.8551.00
74_E97_L2.8501.00
85_V98_G2.8451.00
104_V247_H2.7991.00
74_E95_R2.7691.00
210_C222_F2.6121.00
247_H250_L2.5211.00
66_E132_R2.4911.00
90_R96_L2.3691.00
123_L181_F2.2281.00
221_P225_W2.1651.00
134_V213_M2.1581.00
72_A98_G2.1421.00
19_I245_A2.1111.00
72_A88_L2.1091.00
219_K224_A2.1071.00
89_M251_L2.0301.00
106_L211_Y2.0141.00
124_L135_L2.0121.00
79_A85_V1.9831.00
67_E70_A1.9381.00
59_N248_A1.9181.00
111_E141_L1.9011.00
108_S111_E1.8821.00
3_T34_G1.8551.00
210_C226_C1.8391.00
223_L234_N1.8271.00
152_V156_E1.8221.00
122_I143_C1.8011.00
58_A88_L1.7871.00
132_R161_L1.7771.00
69_F75_L1.7581.00
9_N40_I1.7551.00
5_A36_V1.7441.00
77_E80_A1.7311.00
8_G61_T1.7161.00
68_A88_L1.7111.00
106_L134_V1.7051.00
121_R182_D1.6991.00
45_N48_N1.6901.00
68_A72_A1.6711.00
156_E160_K1.6501.00
24_A31_H1.6241.00
99_D251_L1.6061.00
205_H208_I1.6051.00
64_F67_E1.6001.00
76_T97_L1.5801.00
4_Y31_H1.5801.00
108_S243_A1.5651.00
7_F58_A1.5561.00
88_L96_L1.5551.00
42_D45_N1.5531.00
4_Y24_A1.5361.00
75_L80_A1.5221.00
72_A85_V1.5141.00
130_A213_M1.4981.00
87_T101_T1.4911.00
121_R146_T1.4901.00
33_Y59_N1.4821.00
123_L148_T1.4681.00
127_A149_N1.4661.00
44_I48_N1.4531.00
82_A103_G1.4421.00
4_Y56_K1.4411.00
49_A52_S1.4361.00
146_T181_F1.4351.00
109_D211_Y1.4171.00
50_F55_G1.3961.00
73_D95_R1.3671.00
151_T154_R1.3471.00
6_V35_R1.3441.00
109_D239_G1.3411.00
10_P13_H1.3401.00
78_R99_D1.3381.00
62_V189_S1.3371.00
22_Q26_Q1.3331.00
9_N64_F1.3071.00
78_R140_S1.3041.00
9_N39_P1.3001.00
38_A46_T1.3001.00
224_A228_Q1.2991.00
6_V11_I1.2761.00
81_L140_S1.2731.00
208_I231_S1.2571.00
39_P42_D1.2571.00
227_E234_N1.2461.00
152_V172_S1.2221.00
243_A259_V1.2191.00
12_A37_L1.2111.00
120_L182_D1.2031.00
131_S187_A1.2021.00
149_N189_S1.2021.00
103_G137_P1.1941.00
135_L162_F1.1861.00
51_F90_R1.1841.00
3_T32_P1.1811.00
89_M99_D1.1721.00
75_L98_G1.1711.00
122_I138_L1.1701.00
5_A58_A1.1651.00
112_R243_A1.1561.00
146_T171_L1.1511.00
136_L140_S1.1501.00
209_Y235_A1.1481.00
51_F96_L1.1471.00
113_L235_A1.1441.00
138_L185_I1.1421.00
191_G214_F1.1421.00
75_L79_A1.1411.00
257_P262_V1.1391.00
249_F253_H1.1361.00
7_F60_V1.1331.00
50_F58_A1.1241.00
18_F22_Q1.1011.00
24_A249_F1.0911.00
121_R144_A1.0871.00
29_I253_H1.0861.00
26_Q261_P1.0831.00
89_M92_E1.0741.00
104_V108_S1.0671.00
115_F209_Y1.0641.00
106_L185_I1.0571.00
225_W228_Q1.0551.00
21_Q32_P1.0501.00
22_Q25_Q1.0501.00
81_L136_L1.0491.00
43_F68_A1.0441.00
226_C231_S1.0341.00
225_W229_R1.0291.00
11_I37_L1.0071.00
40_I67_E1.0011.00
260_E264_K0.9971.00
11_I14_S0.9941.00
68_A85_V0.9921.00
44_I71_R0.9911.00
75_L85_V0.9811.00
187_A213_M0.9791.00
221_P224_A0.9791.00
41_N67_E0.9771.00
108_S247_H0.9771.00
197_P221_P0.9761.00
258_D261_P0.9741.00
157_E161_L0.9641.00
38_A64_F0.9611.00
51_F73_D0.9551.00
36_V55_G0.9551.00
172_S175_E0.9521.00
107_L111_E0.9511.00
69_F72_A0.9501.00
124_L131_S0.9481.00
89_M97_L0.9411.00
15_K18_F0.9351.00
246_A259_V0.9221.00
239_G243_A0.9201.00
27_L255_V0.9141.00
43_F71_R0.9141.00
72_A75_L0.9131.00
242_V246_A0.9131.00
49_A53_A0.9111.00
135_L145_V0.9081.00
188_T191_G0.9041.00
27_L249_F0.9021.00
184_I208_I0.9011.00
44_I67_E0.8931.00
193_S196_I0.8841.00
21_Q25_Q0.8811.00
152_V170_A0.8811.00
108_S112_R0.8751.00
23_F27_L0.8731.00
8_G11_I0.8721.00
129_G133_G0.8701.00
159_A163_A0.8691.00
107_L137_P0.8661.00
90_R94_G0.8551.00
66_E154_R0.8511.00
127_A147_I0.8481.00
109_D243_A0.8451.00
46_T49_A0.8421.00
47_L71_R0.8371.00
107_L140_S0.8371.00
60_V64_F0.8341.00
130_A187_A0.8291.00
214_F220_T0.8201.00
77_E81_L0.8141.00
92_E97_L0.8071.00
201_S225_W0.8061.00
19_I241_L0.8051.00
149_N154_R0.7950.99
153_S157_E0.7920.99
22_Q261_P0.7920.99
121_R180_E0.7920.99
219_K223_L0.7890.99
138_L143_C0.7890.99
12_A35_R0.7870.99
105_G240_M0.7870.99
74_E80_A0.7850.99
149_N155_A0.7810.99
4_Y253_H0.7800.99
175_E178_G0.7790.99
58_A68_A0.7770.99
148_T171_L0.7720.99
154_R157_E0.7720.99
23_F249_F0.7650.99
29_I249_F0.7650.99
159_A168_I0.7640.99
84_A100_N0.7610.99
247_H251_L0.7590.99
20_H245_A0.7580.99
123_L184_I0.7570.99
7_F46_T0.7560.99
92_E95_R0.7550.99
62_V192_I0.7530.99
46_T53_A0.7530.99
201_S228_Q0.7480.99
56_K92_E0.7470.99
112_R239_G0.7440.99
153_S156_E0.7410.99
43_F67_E0.7390.99
201_S229_R0.7380.99
23_F262_V0.7360.99
131_S135_L0.7360.99
194_G221_P0.7320.99
194_G197_P0.7320.99
66_E70_A0.7300.99
209_Y232_K0.7300.99
183_L209_Y0.7290.99
125_I188_T0.7280.99
82_A136_L0.7270.99
213_M240_M0.7260.99
162_F166_G0.7200.99
148_T173_M0.7190.99
72_A96_L0.7160.99
3_T53_A0.7130.99
15_K216_Q0.7100.99
125_I173_M0.7090.99
115_F183_L0.7080.99
47_L68_A0.7040.99
73_D96_L0.7040.99
117_R120_L0.7040.99
204_I210_C0.7040.99
113_L232_K0.7030.99
47_L51_F0.7000.99
7_F38_A0.6990.99
84_A133_G0.6950.99
173_M176_L0.6950.99
82_A133_G0.6930.99
186_N222_F0.6910.98
124_L147_I0.6910.98
26_Q258_D0.6900.98
210_C223_L0.6900.98
235_A239_G0.6890.98
117_R143_C0.6870.98
207_G231_S0.6860.98
200_P203_L0.6840.98
58_A90_R0.6810.98
192_I214_F0.6790.98
219_K234_N0.6780.98
20_H87_T0.6770.98
13_H62_V0.6720.98
218_G236_D0.6720.98
135_L147_I0.6710.98
157_E160_K0.6690.98
247_H256_L0.6660.98
202_S229_R0.6650.98
5_A35_R0.6630.98
68_A71_R0.6610.98
120_L144_A0.6600.98
214_F236_D0.6600.98
36_V46_T0.6570.98
48_N51_F0.6570.98
204_I225_W0.6570.98
76_T251_L0.6540.98
107_L141_L0.6530.98
108_S250_L0.6510.98
44_I70_A0.6510.98
103_G140_S0.6480.98
103_G136_L0.6460.98
109_D113_L0.6450.98
82_A100_N0.6440.98
77_E140_S0.6430.98
43_F64_F0.6430.98
151_T189_S0.6410.98
103_G107_L0.6400.98
22_Q262_V0.6380.97
139_L145_V0.6360.97
239_G263_I0.6330.97
20_H24_A0.6320.97
87_T248_A0.6320.97
238_L242_V0.6300.97
125_I184_I0.6300.97
9_N41_N0.6290.97
159_A170_A0.6260.97
3_T36_V0.6250.97
122_I183_L0.6220.97
29_I255_V0.6180.97
186_N214_F0.6140.97
33_Y87_T0.6130.97
121_R181_F0.6120.97
125_I148_T0.6110.97
204_I231_S0.6100.97
162_F165_T0.6100.97
223_L236_D0.6090.97
45_N49_A0.6080.97
127_A151_T0.6070.97
6_V59_N0.6040.97
119_G144_A0.6040.97
116_I120_L0.6020.96
139_L162_F0.6020.96
109_D235_A0.5990.96
112_R263_I0.5970.96
110_L235_A0.5960.96
110_L138_L0.5960.96
122_I185_I0.5940.96
258_D262_V0.5850.96
124_L187_A0.5840.96
185_I213_M0.5820.96
249_F257_P0.5800.96
219_K236_D0.5780.96
105_G109_D0.5760.95
7_F43_F0.5730.95
172_S176_L0.5730.95
118_P142_D0.5720.95
204_I229_R0.5700.95
7_F64_F0.5700.95
88_L98_G0.5680.95
137_P141_L0.5660.95
81_L161_L0.5660.95
5_A55_G0.5620.95
248_A252_W0.5610.95
78_R103_G0.5590.95
250_L257_P0.5580.95
190_S214_F0.5580.95
3_T54_G0.5560.95
9_N13_H0.5530.94
261_P264_K0.5500.94
193_S216_Q0.5500.94
21_Q30_E0.5460.94
181_F184_I0.5450.94
69_F79_A0.5440.94
184_I210_C0.5430.94
146_T169_Q0.5430.94
131_S149_N0.5410.94
18_F35_R0.5410.94
188_T192_I0.5410.94
246_A262_V0.5400.94
32_P35_R0.5400.94
78_R136_L0.5390.94
113_L239_G0.5390.94
192_I195_D0.5380.94
125_I199_I0.5370.93
23_F257_P0.5350.93
113_L211_Y0.5330.93
62_V214_F0.5330.93
160_K164_H0.5330.93
55_G58_A0.5330.93
90_R95_R0.5320.93
152_V155_A0.5320.93
81_L139_L0.5300.93
127_A154_R0.5300.93
134_V185_I0.5300.93
155_A159_A0.5290.93
24_A252_W0.5290.93
6_V14_S0.5270.93
218_G238_L0.5260.93
135_L158_L0.5260.93
54_G90_R0.5250.93
11_I61_T0.5240.93
103_G134_V0.5230.93
11_I216_Q0.5230.93
21_Q34_G0.5220.92
130_A133_G0.5180.92
3_T35_R0.5120.92
60_V88_L0.5120.92
124_L138_L0.5120.92
74_E77_E0.5120.92
216_Q241_L0.5120.92
111_E117_R0.5110.92
38_A49_A0.5110.92
59_N87_T0.5110.92
147_I158_L0.5100.92
259_V263_I0.5090.92
40_I64_F0.5090.92
10_P64_F0.5040.91
190_S196_I0.5040.91
110_L209_Y0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1npyA 1 0.9522 100 0.202 Contact Map
4xijA 1 0.9412 100 0.213 Contact Map
3t4eA 2 0.9853 100 0.22 Contact Map
2o7sA 2 0.9449 100 0.239 Contact Map
3phhA 1 0.9191 100 0.241 Contact Map
3pwzA 1 0.989 100 0.248 Contact Map
3tnlA 2 0.9743 100 0.249 Contact Map
3fbtA 2 0.9706 100 0.27 Contact Map
3jyoA 2 0.9853 100 0.271 Contact Map
2d5cA 2 0.9632 100 0.276 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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