GREMLIN Database
DGTP - Deoxyguanosinetriphosphate triphosphohydrolase
UniProt: P15723 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10225
Length: 505 (427)
Sequences: 910 (581)
Seq/√Len: 28.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
355_N358_A5.9151.00
350_Q354_D5.3431.00
5_D8_K5.3191.00
77_G114_C5.0711.00
418_L481_L5.0591.00
356_L360_F4.6721.00
410_L485_I4.4631.00
84_I263_I4.2991.00
488_M492_Y4.1821.00
135_W412_E3.9941.00
384_N388_K3.5821.00
106_F260_L3.3401.00
173_R176_I3.2401.00
176_I473_E3.2351.00
13_H249_E3.1901.00
238_S479_R3.0511.00
202_T349_A3.0201.00
210_L243_I2.8321.00
473_E476_Y2.7751.00
11_N204_A2.7631.00
364_F371_D2.7401.00
83_E349_A2.4880.99
367_A370_E2.4590.99
257_R265_E2.3450.99
446_K484_Y2.3440.99
191_R483_D2.3020.99
241_A244_A2.2450.98
184_E187_A2.2180.98
139_R143_E2.1980.98
290_Q389_H2.1080.97
119_I189_G2.0890.97
6_F9_K2.0790.97
109_I260_L2.0530.97
207_G250_L2.0320.97
190_I246_L1.9910.96
243_I252_L1.9870.96
110_V114_C1.9510.96
483_D487_G1.9500.96
285_I404_Y1.9480.96
180_L479_R1.9400.96
55_F396_V1.9350.96
264_M341_L1.9150.95
29_L79_Y1.8730.95
207_G258_F1.8670.95
209_I280_A1.8520.94
77_G110_V1.8400.94
386_A390_V1.8340.94
65_T261_T1.8330.94
240_E244_A1.8180.94
273_C383_K1.8060.94
52_T56_P1.7910.93
189_G209_I1.7890.93
55_F497_Y1.7880.93
358_A363_T1.7800.93
183_F486_S1.7620.93
216_A479_R1.7600.93
87_R350_Q1.7560.93
41_N76_V1.7210.92
77_G80_I1.7180.92
112_M205_Q1.7080.92
261_T369_L1.7000.91
87_R90_E1.6990.91
60_N282_E1.6910.91
39_I112_M1.6820.91
189_G280_A1.6680.91
64_R275_A1.6530.90
49_Q62_A1.6440.90
36_R111_E1.6170.89
88_L242_Y1.6110.89
190_I262_W1.5880.88
419_S477_R1.5880.88
176_I475_Y1.5740.88
122_P272_Y1.5710.88
409_G497_Y1.5680.88
442_R446_K1.5420.87
396_V403_G1.5330.86
313_E317_E1.5320.86
172_L176_I1.5300.86
45_I71_M1.5280.86
32_F109_I1.5250.86
140_L412_E1.5180.86
179_D216_A1.5030.85
142_P384_N1.5030.85
487_G492_Y1.5010.85
402_Q502_A1.4750.84
244_A248_K1.4690.84
188_Q196_L1.4670.84
439_I446_K1.4590.84
11_N249_E1.4580.83
178_Q217_W1.4490.83
212_Y232_K1.4440.83
37_G41_N1.4390.83
77_G131_A1.4380.83
398_R499_R1.4240.82
55_F403_G1.4160.82
119_I199_M1.4150.82
50_Q261_T1.4100.81
441_S445_H1.4020.81
4_I9_K1.3890.80
121_N259_P1.3820.80
386_A391_F1.3780.80
87_R353_I1.3770.80
357_P361_A1.3710.79
354_D361_A1.3680.79
185_G212_Y1.3680.79
257_R266_A1.3670.79
442_R448_S1.3630.79
122_P185_G1.3500.78
15_R242_Y1.3460.78
380_K384_N1.3430.78
49_Q63_V1.3270.77
263_I280_A1.3260.77
62_A197_M1.3200.77
185_G272_Y1.3150.76
180_L184_E1.3060.76
123_P407_I1.3060.76
106_F109_I1.3010.76
358_A441_S1.2980.76
347_Y360_F1.2980.76
184_E295_L1.2880.75
8_K251_N1.2870.75
76_V271_S1.2870.75
215_P235_Y1.2860.75
92_K97_Y1.2820.75
448_S451_H1.2820.75
57_L121_N1.2790.74
10_I260_L1.2610.73
489_T492_Y1.2560.73
195_T239_E1.2520.73
5_D90_E1.2470.73
234_G280_A1.2380.72
379_L382_Y1.2340.72
50_Q61_A1.2300.71
422_L470_P1.2230.71
131_A404_Y1.2210.71
135_W188_Q1.2210.71
36_R264_M1.2180.71
252_L337_R1.2150.70
204_A261_T1.2130.70
350_Q358_A1.2100.70
52_T187_A1.2060.70
286_F385_V1.2010.70
207_G337_R1.2000.70
49_Q275_A1.1930.69
37_G337_R1.1890.69
288_V292_Y1.1860.69
207_G252_L1.1840.68
50_Q491_L1.1790.68
280_A379_L1.1760.68
348_A369_L1.1610.67
406_V493_A1.1530.66
447_L496_E1.1530.66
37_G341_L1.1500.66
447_L452_R1.1490.66
64_R271_S1.1460.66
208_G261_T1.1430.66
64_R135_W1.1390.65
46_R51_K1.1370.65
293_H297_E1.1360.65
241_A245_R1.1360.65
56_P180_L1.1350.65
190_I210_L1.1320.65
178_Q216_A1.1240.64
47_R487_G1.1240.64
177_R181_C1.1210.64
49_Q55_F1.1190.64
121_N257_R1.1190.64
121_N265_E1.1140.64
240_E412_E1.1110.63
295_L391_F1.1100.63
479_R482_Q1.1050.63
255_Y271_S1.1040.63
400_E442_R1.1000.63
131_A231_K1.0980.63
439_I500_L1.0960.62
38_R79_Y1.0960.62
208_G260_L1.0820.61
414_Y485_I1.0790.61
98_G190_I1.0770.61
291_L295_L1.0760.61
116_M283_K1.0710.61
34_S37_G1.0670.60
58_E283_K1.0660.60
49_Q497_Y1.0660.60
74_Q395_D1.0640.60
257_R269_D1.0610.60
175_K237_L1.0540.59
81_A263_I1.0530.59
284_R292_Y1.0490.59
134_D407_I1.0430.58
55_F477_R1.0380.58
111_E391_F1.0350.58
212_Y272_Y1.0280.57
31_I202_T1.0210.57
262_W266_A1.0180.57
90_E170_N1.0100.56
351_R355_N0.9990.55
16_Y116_M0.9950.55
135_W140_L0.9920.55
340_T382_Y0.9920.55
316_W325_S0.9900.54
121_N260_L0.9890.54
247_R255_Y0.9870.54
114_C264_M0.9860.54
29_L37_G0.9740.53
190_I206_V0.9710.53
47_R492_Y0.9670.53
188_Q483_D0.9640.52
478_C482_Q0.9620.52
73_V264_M0.9600.52
249_E485_I0.9590.52
32_F493_A0.9590.52
185_G232_K0.9560.52
188_Q486_S0.9530.52
49_Q68_T0.9530.52
15_R245_R0.9500.51
413_I500_L0.9490.51
112_M275_A0.9440.51
420_L440_E0.9440.51
396_V497_Y0.9430.51
175_K240_E0.9430.51
86_S90_E0.9420.51
49_Q391_F0.9390.51
187_A362_G0.9380.50
259_P265_E0.9380.50
190_I194_H0.9350.50
448_S477_R0.9320.50
333_F415_R0.9300.50
122_P212_Y0.9300.50
419_S474_Y0.9290.50
248_K363_T0.9280.50
37_G79_Y0.9270.50
41_N111_E0.9230.49
286_F291_L0.9200.49
47_R483_D0.9200.49
142_P485_I0.9190.49
392_S442_R0.9180.49
210_L481_L0.9180.49
9_K360_F0.9120.48
413_I501_M0.9100.48
37_G45_I0.9100.48
265_E269_D0.9100.48
417_L443_L0.9070.48
40_I71_M0.9060.48
416_P440_E0.9030.48
44_A481_L0.9030.48
410_L493_A0.9020.48
316_W354_D0.8990.47
366_H371_D0.8980.47
235_Y243_I0.8960.47
33_E333_F0.8860.46
184_E212_Y0.8860.46
271_S332_F0.8840.46
255_Y283_K0.8830.46
32_F42_S0.8810.46
229_L403_G0.8800.46
122_P269_D0.8800.46
51_K128_G0.8780.46
33_E82_K0.8760.46
414_Y496_E0.8750.46
414_Y484_Y0.8720.45
121_N266_A0.8700.45
262_W366_H0.8690.45
176_I237_L0.8690.45
77_G473_E0.8680.45
269_D272_Y0.8680.45
355_N365_N0.8630.45
406_V494_W0.8630.45
121_N179_D0.8620.45
267_A368_L0.8610.45
62_A264_M0.8610.45
56_P187_A0.8610.45
64_R188_Q0.8600.45
44_A242_Y0.8590.44
472_W476_Y0.8570.44
185_G269_D0.8530.44
482_Q498_R0.8520.44
291_L390_V0.8510.44
82_K106_F0.8490.44
44_A489_T0.8490.44
495_D499_R0.8490.44
65_T491_L0.8470.44
33_E39_I0.8470.44
273_C379_L0.8460.43
65_T285_I0.8450.43
127_F283_K0.8430.43
121_N400_E0.8390.43
64_R334_M0.8370.43
109_I204_A0.8370.43
137_R384_N0.8360.43
212_Y269_D0.8340.43
114_C386_A0.8320.42
65_T216_A0.8290.42
62_A282_E0.8270.42
58_E64_R0.8270.42
83_E346_P0.8220.42
114_C282_E0.8210.42
473_E477_R0.8190.41
169_L363_T0.8120.41
298_A340_T0.8110.41
37_G44_A0.8100.41
395_D414_Y0.8080.41
87_R91_L0.8060.40
332_F336_L0.8030.40
34_S65_T0.8030.40
170_N414_Y0.8030.40
244_A253_A0.8020.40
43_P448_S0.8010.40
64_R196_L0.8010.40
110_V246_L0.7960.40
175_K500_L0.7950.40
239_E383_K0.7940.40
61_A65_T0.7930.39
185_G265_E0.7930.39
400_E411_L0.7910.39
246_L333_F0.7900.39
86_S380_K0.7900.39
24_T380_K0.7880.39
89_K361_A0.7860.39
184_E269_D0.7850.39
49_Q477_R0.7830.39
35_D38_R0.7800.39
109_I113_S0.7800.39
236_Y262_W0.7790.38
50_Q62_A0.7780.38
212_Y265_E0.7760.38
442_R450_R0.7740.38
172_L352_F0.7730.38
239_E266_A0.7730.38
238_S475_Y0.7730.38
407_I442_R0.7730.38
56_P121_N0.7710.38
184_E231_K0.7700.38
62_A135_W0.7670.38
55_F64_R0.7670.38
171_E419_S0.7650.37
232_K272_Y0.7640.37
136_F352_F0.7590.37
470_P484_Y0.7580.37
91_L353_I0.7570.37
280_A390_V0.7560.37
45_I74_Q0.7540.37
61_A188_Q0.7530.37
55_F62_A0.7530.37
372_A375_C0.7470.36
79_Y342_N0.7470.36
403_G409_G0.7450.36
287_T364_F0.7440.36
49_Q209_I0.7430.36
232_K269_D0.7410.36
397_E447_L0.7370.35
58_E62_A0.7330.35
58_E275_A0.7320.35
437_F446_K0.7320.35
261_T491_L0.7310.35
111_E396_V0.7310.35
196_L483_D0.7280.35
78_R269_D0.7280.35
290_Q293_H0.7280.35
81_A106_F0.7240.35
259_P266_A0.7230.34
417_L481_L0.7220.34
57_L259_P0.7200.34
410_L472_W0.7170.34
188_Q195_T0.7140.34
83_E342_N0.7130.34
277_L387_V0.7130.34
347_Y372_A0.7130.34
6_F360_F0.7130.34
49_Q58_E0.7110.34
49_Q197_M0.7100.34
81_A85_L0.7080.33
133_N479_R0.7080.33
51_K72_E0.7070.33
258_F265_E0.7060.33
359_I364_F0.7050.33
81_A213_T0.7030.33
44_A479_R0.7010.33
29_L61_A0.6990.33
241_A297_E0.6990.33
84_I363_T0.6990.33
338_V386_A0.6990.33
199_M396_V0.6970.33
29_L278_E0.6960.33
50_Q114_C0.6950.33
187_A475_Y0.6940.32
359_I362_G0.6940.32
13_H203_W0.6930.32
266_A337_R0.6930.32
184_E232_K0.6930.32
179_D265_E0.6910.32
403_G497_Y0.6870.32
114_C399_L0.6870.32
263_I352_F0.6860.32
244_A350_Q0.6850.32
187_A212_Y0.6840.32
184_E390_V0.6830.32
133_N202_T0.6810.32
121_N135_W0.6810.32
49_Q234_G0.6800.32
235_Y410_L0.6790.31
137_R414_Y0.6760.31
273_C479_R0.6750.31
325_S409_G0.6750.31
40_I372_A0.6740.31
418_L444_F0.6710.31
475_Y496_E0.6710.31
81_A107_E0.6700.31
190_I354_D0.6650.31
50_Q64_R0.6650.31
494_W498_R0.6640.31
264_M273_C0.6630.30
406_V443_L0.6620.30
139_R142_P0.6620.30
170_N210_L0.6610.30
394_P408_S0.6600.30
123_P229_L0.6590.30
265_E272_Y0.6590.30
252_L258_F0.6580.30
5_D363_T0.6570.30
234_G494_W0.6560.30
170_N323_S0.6560.30
75_Q111_E0.6560.30
324_L328_T0.6530.30
418_L479_R0.6520.30
438_P442_R0.6510.30
110_V295_L0.6500.30
187_A269_D0.6500.30
133_N190_I0.6490.30
90_E441_S0.6490.30
171_E175_K0.6470.29
90_E350_Q0.6470.29
47_R489_T0.6460.29
409_G500_L0.6440.29
200_N271_S0.6430.29
38_R270_I0.6420.29
59_R261_T0.6400.29
88_L106_F0.6380.29
292_Y296_H0.6370.29
45_I109_I0.6350.29
288_V332_F0.6350.29
31_I391_F0.6340.29
50_Q111_E0.6330.29
55_F111_E0.6330.29
210_L247_R0.6330.29
41_N341_L0.6300.28
32_F59_R0.6270.28
37_G275_A0.6260.28
136_F485_I0.6260.28
70_S234_G0.6250.28
415_R473_E0.6250.28
57_L132_I0.6240.28
76_V341_L0.6230.28
237_L240_E0.6230.28
41_N337_R0.6230.28
185_G257_R0.6200.28
85_L103_T0.6200.28
108_S340_T0.6200.28
187_A272_Y0.6160.27
287_T290_Q0.6150.27
70_S272_Y0.6130.27
134_D320_R0.6130.27
194_H286_F0.6120.27
37_G283_K0.6120.27
44_A501_M0.6100.27
479_R491_L0.6100.27
184_E272_Y0.6090.27
58_E234_G0.6080.27
444_F452_R0.6080.27
61_A196_L0.6070.27
358_A361_A0.6070.27
212_Y257_R0.6050.27
21_G245_R0.6040.27
292_Y332_F0.6030.27
12_W17_R0.6030.27
174_R293_H0.6020.27
35_D47_R0.6020.27
179_D259_P0.6010.27
121_N258_F0.6000.27
8_K447_L0.6000.27
180_L475_Y0.5990.26
274_V337_R0.5980.26
37_G112_M0.5980.26
447_L451_H0.5970.26
55_F391_F0.5960.26
78_R337_R0.5950.26
194_H238_S0.5940.26
138_Q237_L0.5930.26
65_T195_T0.5930.26
112_M116_M0.5920.26
394_P398_R0.5910.26
21_G24_T0.5890.26
78_R111_E0.5890.26
230_M393_H0.5880.26
232_K265_E0.5880.26
66_R69_H0.5870.26
62_A65_T0.5870.26
86_S485_I0.5860.26
5_D241_A0.5860.26
295_L381_L0.5850.26
208_G287_T0.5850.26
204_A280_A0.5840.26
29_L32_F0.5820.25
112_M336_L0.5810.25
17_R20_Q0.5810.25
55_F197_M0.5800.25
50_Q282_E0.5800.25
403_G477_R0.5790.25
11_N245_R0.5780.25
143_E169_L0.5780.25
37_G116_M0.5770.25
257_R262_W0.5770.25
135_W196_L0.5760.25
8_K178_Q0.5740.25
83_E414_Y0.5740.25
358_A384_N0.5740.25
319_S443_L0.5740.25
263_I397_E0.5730.25
122_P232_K0.5720.25
173_R357_P0.5720.25
321_S359_I0.5700.25
61_A491_L0.5700.25
193_V206_V0.5690.25
42_S352_F0.5680.25
343_K347_Y0.5670.25
196_L200_N0.5670.25
262_W265_E0.5670.25
169_L481_L0.5660.25
179_D257_R0.5660.25
370_E388_K0.5650.24
175_K215_P0.5650.24
248_K355_N0.5630.24
213_T502_A0.5620.24
55_F488_M0.5610.24
46_R72_E0.5610.24
131_A485_I0.5590.24
483_D492_Y0.5590.24
214_R218_W0.5590.24
447_L480_L0.5580.24
416_P485_I0.5580.24
489_T497_Y0.5580.24
241_A361_A0.5570.24
178_Q300_G0.5570.24
9_K258_F0.5570.24
61_A197_M0.5560.24
143_E350_Q0.5560.24
35_D53_Q0.5550.24
8_K354_D0.5550.24
361_A441_S0.5540.24
212_Y352_F0.5530.24
121_N185_G0.5530.24
477_R480_L0.5530.24
127_F396_V0.5520.24
27_E30_R0.5520.24
282_E442_R0.5520.24
8_K363_T0.5510.24
135_W242_Y0.5510.24
45_I192_L0.5500.24
377_D381_L0.5500.24
90_E354_D0.5500.24
132_I410_L0.5480.24
49_Q57_L0.5470.23
184_E207_G0.5470.23
34_S55_F0.5460.23
257_R272_Y0.5440.23
7_R90_E0.5440.23
248_K318_K0.5430.23
74_Q112_M0.5430.23
359_I486_S0.5430.23
239_E479_R0.5420.23
246_L344_L0.5420.23
194_H242_Y0.5410.23
214_R403_G0.5400.23
44_A197_M0.5400.23
398_R500_L0.5390.23
113_S502_A0.5390.23
188_Q191_R0.5380.23
376_S380_K0.5370.23
213_T233_P0.5370.23
216_A368_L0.5370.23
127_F378_L0.5360.23
297_E300_G0.5350.23
209_I234_G0.5350.23
274_V484_Y0.5350.23
381_L384_N0.5340.23
483_D488_M0.5340.23
31_I34_S0.5330.23
191_R195_T0.5330.23
262_W365_N0.5320.23
349_A447_L0.5310.23
215_P240_E0.5300.23
322_N408_S0.5300.23
182_H501_M0.5300.23
133_N214_R0.5270.22
284_R365_N0.5270.22
62_A396_V0.5270.22
43_P408_S0.5240.22
34_S264_M0.5230.22
237_L475_Y0.5230.22
357_P388_K0.5220.22
23_K361_A0.5220.22
321_S324_L0.5220.22
31_I393_H0.5220.22
271_S275_A0.5210.22
35_D46_R0.5210.22
180_L372_A0.5200.22
244_A361_A0.5200.22
135_W416_P0.5180.22
81_A110_V0.5180.22
138_Q142_P0.5180.22
373_S377_D0.5170.22
140_L441_S0.5170.22
282_E494_W0.5170.22
249_E366_H0.5170.22
317_E384_N0.5170.22
246_L385_V0.5170.22
184_E362_G0.5160.22
365_N500_L0.5160.22
7_R21_G0.5150.22
283_K338_V0.5140.22
401_L500_L0.5120.22
41_N112_M0.5110.22
64_R200_N0.5110.22
187_A265_E0.5090.21
200_N207_G0.5070.21
108_S280_A0.5070.21
64_R400_E0.5060.21
133_N233_P0.5060.21
234_G284_R0.5060.21
193_V341_L0.5050.21
184_E482_Q0.5050.21
405_R501_M0.5050.21
59_R134_D0.5040.21
353_I361_A0.5030.21
192_L386_A0.5030.21
210_L401_L0.5030.21
58_E127_F0.5020.21
122_P265_E0.5010.21
188_Q442_R0.5000.21
363_T369_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x9eA 4 0.998 100 0.265 Contact Map
3bg2A 4 0.7663 100 0.313 Contact Map
2pgsA 4 0.7545 100 0.322 Contact Map
2dqbA 4 0.6812 100 0.543 Contact Map
4mz7A 4 0.7149 100 0.839 Contact Map
4lrlA 4 0.6554 99.9 0.848 Contact Map
2q14A 4 0.5723 99.9 0.857 Contact Map
2hekA 4 0.6673 99.8 0.876 Contact Map
4n6wA 1 0.3267 96.8 0.957 Contact Map
4s1bA 2 0.4297 95.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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