GREMLIN Database
PUR2 - Phosphoribosylamine--glycine ligase
UniProt: P15640 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10792
Length: 429 (382)
Sequences: 20925 (11624)
Seq/√Len: 594.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_R161_L3.9951.00
132_L165_E3.3261.00
160_T163_E3.2811.00
121_E188_E3.2051.00
58_D62_N3.1831.00
127_E130_P3.0861.00
253_W257_K3.0251.00
250_R254_P2.8921.00
52_D55_A2.7801.00
82_D100_Q2.7241.00
140_A161_L2.6631.00
393_T396_E2.6451.00
82_D86_A2.6001.00
246_R250_R2.5261.00
391_G396_E2.4781.00
159_M163_E2.3631.00
114_R258_G2.3351.00
61_Q87_A2.2711.00
112_L255_T2.2261.00
123_Q137_E2.2231.00
27_T44_Q2.1901.00
241_D245_Q2.1421.00
77_V103_G2.1081.00
240_T243_V2.0931.00
83_T87_A2.0561.00
203_G267_T2.0461.00
110_D114_R2.0161.00
309_E313_A2.0121.00
134_Y137_E2.0021.00
234_S302_R1.9791.00
107_F110_D1.9711.00
5_V16_A1.9541.00
277_D280_G1.9421.00
161_L165_E1.9401.00
251_I282_P1.9311.00
191_D278_K1.9261.00
157_V189_F1.9001.00
392_H396_E1.8831.00
159_M191_D1.8791.00
128_V165_E1.8441.00
53_I83_T1.8301.00
19_A28_V1.8261.00
3_V92_F1.8241.00
134_Y138_K1.8081.00
304_K325_E1.7681.00
57_L87_A1.7581.00
57_L61_Q1.7421.00
128_V169_H1.7341.00
24_L309_E1.7341.00
334_V401_A1.7331.00
165_E169_H1.7311.00
100_Q107_F1.7281.00
111_F258_G1.7131.00
128_V132_L1.7011.00
55_A58_D1.7001.00
132_L161_L1.6931.00
350_V376_Q1.6921.00
110_D113_A1.6911.00
27_T45_N1.6731.00
4_L31_A1.6721.00
95_T98_A1.6541.00
115_H258_G1.6441.00
243_V246_R1.6271.00
304_K327_D1.6141.00
366_H369_T1.6041.00
101_L111_F1.6031.00
85_R96_A1.5921.00
172_L182_H1.5771.00
133_A137_E1.5761.00
200_M310_L1.5611.00
13_H42_A1.5611.00
245_Q250_R1.5521.00
166_A170_D1.5481.00
106_A124_N1.5331.00
199_V252_I1.5321.00
83_T86_A1.5191.00
68_T89_L1.5191.00
24_L312_L1.5131.00
30_V43_L1.5101.00
18_K309_E1.5071.00
245_Q248_M1.4971.00
243_V276_I1.4961.00
37_T45_N1.4961.00
34_N48_I1.4921.00
58_D61_Q1.4881.00
200_M269_F1.4831.00
106_A110_D1.4831.00
254_P257_K1.4801.00
54_P83_T1.4781.00
101_L107_F1.4661.00
132_L136_R1.4561.00
84_F89_L1.4521.00
111_F114_R1.4521.00
142_I186_I1.4521.00
147_D183_R1.4491.00
318_K321_E1.4471.00
53_I57_L1.4451.00
310_L320_D1.4431.00
370_K373_D1.4411.00
20_A44_Q1.4371.00
59_F63_E1.4291.00
197_F247_T1.4071.00
85_R95_T1.4061.00
111_F115_H1.4031.00
126_T130_P1.4021.00
123_Q134_Y1.4021.00
3_V19_A1.3951.00
200_M314_A1.3941.00
97_G101_L1.3901.00
403_A407_D1.3861.00
135_L140_A1.3841.00
109_K187_E1.3681.00
301_L388_T1.3651.00
346_R349_D1.3631.00
129_E133_A1.3521.00
130_P133_A1.3391.00
188_E283_K1.3291.00
244_H248_M1.3291.00
301_L390_L1.3291.00
248_M253_W1.3261.00
133_A136_R1.3251.00
126_T183_R1.3231.00
199_V256_V1.3201.00
128_V168_V1.3191.00
113_A121_E1.3141.00
104_S147_D1.3091.00
90_K316_E1.3091.00
190_L285_I1.2951.00
135_L142_I1.2951.00
125_F134_Y1.2951.00
395_A399_K1.2871.00
60_A89_L1.2791.00
246_R280_G1.2751.00
45_N63_E1.2651.00
402_Y406_T1.2571.00
16_A42_A1.2511.00
169_H173_A1.2421.00
108_T112_L1.2421.00
252_I272_A1.2371.00
201_V256_V1.2291.00
319_L322_K1.2241.00
140_A160_T1.2211.00
26_E316_E1.2201.00
23_P309_E1.2201.00
396_E400_R1.2181.00
129_E132_L1.2131.00
242_D246_R1.2121.00
362_G389_A1.2111.00
110_D122_Y1.2111.00
102_E287_F1.2091.00
372_A376_Q1.2071.00
195_A276_I1.2061.00
350_V375_E1.1921.00
118_P251_I1.1901.00
201_V207_L1.1891.00
124_N183_R1.1841.00
82_D97_G1.1761.00
84_F91_I1.1741.00
112_L284_V1.1731.00
166_A169_H1.1621.00
359_V362_G1.1601.00
333_G386_C1.1591.00
361_G400_R1.1571.00
143_V157_V1.1561.00
337_A382_G1.1471.00
391_G400_R1.1461.00
71_G75_P1.1441.00
24_L313_A1.1421.00
329_R390_L1.1411.00
3_V26_E1.1401.00
333_G336_M1.1381.00
330_A333_G1.1311.00
391_G397_A1.1301.00
241_D244_H1.1271.00
199_V272_A1.1271.00
109_K119_T1.1261.00
113_A119_T1.1151.00
398_Q402_Y1.1091.00
95_T267_T1.0981.00
60_A68_T1.0951.00
163_E166_A1.0881.00
291_F307_L1.0851.00
389_A401_A1.0841.00
192_G278_K1.0811.00
305_S310_L1.0781.00
4_L60_A1.0781.00
77_V80_V1.0751.00
239_V243_V1.0741.00
156_I171_M1.0741.00
156_I170_D1.0731.00
106_A147_D1.0731.00
329_R392_H1.0691.00
313_A318_K1.0661.00
121_E138_K1.0571.00
387_V408_I1.0491.00
400_R403_A1.0471.00
3_V312_L1.0471.00
16_A28_V1.0461.00
362_G404_L1.0381.00
31_A56_L1.0371.00
32_P37_T1.0251.00
207_L253_W1.0231.00
143_V189_F1.0191.00
57_L83_T1.0141.00
387_V404_L1.0131.00
399_K403_A1.0091.00
310_L313_A1.0051.00
68_T84_F1.0001.00
156_I167_A0.9941.00
128_V172_L0.9941.00
138_K142_I0.9931.00
41_P370_K0.9901.00
168_V172_L0.9881.00
199_V270_L0.9851.00
336_M405_M0.9811.00
97_G100_Q0.9801.00
197_F252_I0.9791.00
403_A406_T0.9771.00
15_L69_I0.9771.00
32_P46_V0.9761.00
191_D277_D0.9741.00
197_F248_M0.9721.00
29_F63_E0.9671.00
16_A43_L0.9651.00
113_A122_Y0.9631.00
140_A164_A0.9581.00
238_V276_I0.9551.00
136_R165_E0.9541.00
276_I282_P0.9501.00
90_K203_G0.9501.00
208_P321_E0.9491.00
162_E166_A0.9471.00
31_A49_G0.9471.00
332_L398_Q0.9471.00
85_R267_T0.9431.00
80_V84_F0.9381.00
272_A287_F0.9371.00
255_T287_F0.9341.00
369_T373_D0.9331.00
204_E318_K0.9281.00
130_P134_Y0.9271.00
54_P58_D0.9271.00
252_I274_L0.9241.00
201_V206_V0.9221.00
144_I184_I0.9211.00
331_S334_V0.9191.00
113_A123_Q0.9171.00
204_E317_S0.9151.00
333_G337_A0.9131.00
331_S336_M0.9091.00
121_E137_E0.9091.00
19_A312_L0.9091.00
389_A404_L0.9081.00
201_V257_K0.9051.00
351_I369_T0.9041.00
211_T214_D0.9031.00
312_L316_E0.9031.00
209_M248_M0.9011.00
300_M388_T0.8931.00
82_D96_A0.8871.00
246_R251_I0.8861.00
242_D245_Q0.8851.00
47_A63_E0.8821.00
81_V91_I0.8811.00
206_V257_K0.8801.00
74_A78_K0.8771.00
240_T280_G0.8721.00
131_A164_A0.8671.00
148_G181_G0.8661.00
135_L164_A0.8641.00
162_E165_E0.8631.00
95_T265_T0.8591.00
131_A168_V0.8571.00
20_A42_A0.8571.00
404_L407_D0.8561.00
168_V184_I0.8531.00
329_R333_G0.8521.00
338_A341_Y0.8481.00
334_V337_A0.8471.00
5_V19_A0.8461.00
3_V25_V0.8411.00
69_I311_C0.8411.00
335_V338_A0.8381.00
251_I274_L0.8331.00
246_R282_P0.8291.00
332_L397_A0.8251.00
212_S244_H0.8251.00
364_V385_L0.8241.00
59_F65_I0.8241.00
34_N37_T0.8221.00
233_Y394_V0.8191.00
205_H257_K0.8191.00
190_L283_K0.8191.00
117_I284_V0.8141.00
82_D85_R0.8101.00
81_V85_R0.8091.00
143_V155_V0.8091.00
193_E276_I0.8041.00
20_A28_V0.8021.00
142_I158_A0.8011.00
144_I158_A0.8011.00
79_G83_T0.8001.00
106_A183_R0.7991.00
102_E259_M0.7961.00
396_E399_K0.7941.00
125_F131_A0.7941.00
56_L84_F0.7891.00
202_D206_V0.7881.00
330_A335_V0.7871.00
332_L335_V0.7871.00
352_H355_P0.7861.00
256_V270_L0.7861.00
247_T282_P0.7861.00
318_K322_K0.7851.00
170_D174_G0.7841.00
206_V256_V0.7831.00
158_A167_A0.7821.00
73_E76_L0.7801.00
92_F312_L0.7801.00
29_F59_F0.7781.00
337_A341_Y0.7741.00
19_A69_I0.7741.00
85_R97_G0.7731.00
354_L408_I0.7681.00
275_M285_I0.7671.00
78_K100_Q0.7671.00
57_L86_A0.7631.00
331_S335_V0.7631.00
29_F65_I0.7611.00
367_A370_K0.7611.00
104_S183_R0.7571.00
79_G100_Q0.7571.00
47_A59_F0.7531.00
353_G409_H0.7501.00
132_L169_H0.7441.00
84_F87_A0.7441.00
267_T314_A0.7441.00
123_Q130_P0.7401.00
79_G82_D0.7401.00
234_S298_P0.7371.00
254_P258_G0.7311.00
389_A397_A0.7281.00
179_D182_H0.7271.00
53_I80_V0.7251.00
98_A265_T0.7221.00
311_C315_C0.7211.00
135_L139_G0.7201.00
34_N47_A0.7181.00
110_D124_N0.7171.00
60_A84_F0.7161.00
328_E392_H0.7111.00
156_I174_G0.7101.00
170_D173_A0.7101.00
255_T258_G0.7091.00
395_A398_Q0.7091.00
144_I168_V0.7091.00
344_D347_T0.7081.00
48_I55_A0.7071.00
144_I167_A0.7071.00
106_A185_V0.7001.00
78_K81_V0.7001.00
286_E290_R0.6971.00
329_R332_L0.6961.00
72_P76_L0.6951.00
104_S148_G0.6951.00
209_M214_D0.6941.00
13_H40_E0.6921.00
351_I354_L0.6901.00
131_A186_I0.6891.00
210_A303_M0.6881.00
190_L277_D0.6851.00
367_A372_A0.6851.00
128_V131_A0.6841.00
378_V381_G0.6821.00
310_L321_E0.6811.00
77_V81_V0.6751.00
128_V164_A0.6741.00
210_A234_S0.6731.00
6_I80_V0.6721.00
332_L337_A0.6711.00
195_A247_T0.6701.00
205_H320_D0.6691.00
72_P75_P0.6691.00
368_G371_L0.6661.00
212_S236_A0.6601.00
107_F111_F0.6601.00
359_V400_R0.6601.00
19_A26_E0.6581.00
200_M209_M0.6571.00
201_V267_T0.6571.00
116_K254_P0.6551.00
350_V353_G0.6541.00
239_V244_H0.6521.00
85_R91_I0.6511.00
211_T326_W0.6501.00
198_I269_F0.6501.00
104_S107_F0.6491.00
375_E378_V0.6481.00
193_E238_V0.6481.00
358_E361_G0.6461.00
16_A30_V0.6451.00
138_K188_E0.6451.00
352_H397_A0.6441.00
98_A267_T0.6431.00
195_A236_A0.6421.00
330_A334_V0.6421.00
276_I279_Q0.6411.00
368_G373_D0.6401.00
328_E390_L0.6401.00
90_K267_T0.6381.00
158_A164_A0.6381.00
277_D283_K0.6381.00
135_L168_V0.6361.00
252_I256_V0.6341.00
67_L315_C0.6331.00
385_L408_I0.6321.00
372_A378_V0.6311.00
369_T372_A0.6281.00
338_A349_D0.6261.00
266_Y270_L0.6231.00
355_P409_H0.6231.00
232_A298_P0.6211.00
171_M184_I0.6211.00
336_M408_I0.6201.00
323_T326_W0.6201.00
210_A214_D0.6201.00
167_A171_M0.6191.00
359_V407_D0.6181.00
211_T302_R0.6161.00
224_G229_G0.6161.00
197_F212_S0.6151.00
210_A302_R0.6141.00
212_S215_H0.6131.00
229_G232_A0.6121.00
134_Y186_I0.6121.00
81_V84_F0.6121.00
246_R254_P0.6101.00
26_E66_D0.6101.00
96_A100_Q0.6091.00
147_D185_V0.6081.00
42_A45_N0.6061.00
251_I254_P0.6061.00
352_H409_H0.6041.00
18_K24_L0.6041.00
55_A59_F0.6021.00
3_V28_V0.6001.00
30_V37_T0.6001.00
360_A363_K0.6001.00
195_A239_V0.6001.00
355_P371_L0.5991.00
197_F274_L0.5971.00
353_G371_L0.5961.00
350_V354_L0.5951.00
135_L138_K0.5951.00
90_K93_G0.5931.00
29_F46_V0.5911.00
213_Q233_Y0.5911.00
57_L89_L0.5911.00
368_G372_A0.5911.00
243_V280_G0.5891.00
279_Q283_K0.5871.00
243_V282_P0.5871.00
361_G364_V0.5861.00
321_E325_E0.5851.00
109_K120_A0.5831.00
349_D353_G0.5831.00
339_G346_R0.5821.00
330_A394_V0.5811.00
25_V308_V0.5801.00
101_L114_R0.5781.00
195_A274_L0.5781.00
300_M306_D0.5771.00
401_A405_M0.5771.00
204_E257_K0.5761.00
366_H371_L0.5761.00
259_M265_T0.5751.00
231_G334_V0.5731.00
337_A340_G0.5731.00
105_K145_K0.5731.00
61_Q86_A0.5711.00
297_Q300_M0.5711.00
136_R140_A0.5711.00
60_A65_I0.5701.00
157_V227_T0.5691.00
49_G52_D0.5681.00
172_L184_I0.5671.00
214_D236_A0.5671.00
92_F315_C0.5671.00
48_I59_F0.5641.00
397_A401_A0.5631.00
301_L363_K0.5611.00
167_A170_D0.5580.99
202_D317_S0.5560.99
324_S327_D0.5530.99
276_I280_G0.5520.99
211_T215_H0.5510.99
117_I251_I0.5500.99
153_K174_G0.5490.99
354_L377_V0.5480.99
58_D87_A0.5470.99
159_M189_F0.5460.99
112_L117_I0.5430.99
25_V28_V0.5410.99
109_K113_A0.5410.99
364_V408_I0.5400.99
406_T409_H0.5390.99
118_P283_K0.5380.99
188_E277_D0.5370.99
4_L65_I0.5360.99
333_G338_A0.5350.99
307_L311_C0.5340.99
68_T91_I0.5330.99
332_L336_M0.5330.99
272_A284_V0.5330.99
210_A213_Q0.5330.99
359_V363_K0.5330.99
329_R335_V0.5310.99
329_R334_V0.5300.99
35_A377_V0.5300.99
345_Y348_G0.5290.99
144_I164_A0.5290.99
202_D319_L0.5290.99
240_T276_I0.5280.99
209_M253_W0.5280.99
370_K378_V0.5270.99
250_R253_W0.5260.99
255_T284_V0.5260.99
364_V367_A0.5250.99
394_V398_Q0.5250.99
312_L315_C0.5240.99
74_A77_V0.5230.99
213_Q236_A0.5220.99
330_A393_T0.5220.99
310_L322_K0.5220.99
97_G107_F0.5210.99
139_G161_L0.5200.99
373_D376_Q0.5190.99
71_G76_L0.5190.99
198_I212_S0.5190.99
310_L314_A0.5180.99
144_I186_I0.5180.99
204_E267_T0.5180.99
163_E167_A0.5170.99
56_L68_T0.5160.99
347_T350_V0.5160.99
17_W23_P0.5150.99
132_L164_A0.5150.99
120_A285_I0.5150.99
208_P248_M0.5150.99
41_P44_Q0.5140.99
366_H373_D0.5140.99
269_F291_F0.5140.99
46_V59_F0.5130.99
18_K306_D0.5130.99
5_V30_V0.5130.99
226_N229_G0.5130.99
120_A190_L0.5130.99
158_A163_E0.5120.99
19_A308_V0.5120.99
247_T274_L0.5110.99
328_E331_S0.5090.99
49_G55_A0.5090.99
129_E165_E0.5090.99
198_I271_Y0.5080.99
297_Q333_G0.5060.99
117_I254_P0.5060.99
266_Y289_C0.5060.99
40_E370_K0.5060.99
313_A320_D0.5060.99
225_P230_M0.5040.99
99_A289_C0.5030.99
366_H372_A0.5030.99
298_P301_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mjfA 1 0.9837 100 0.295 Contact Map
3lp8A 1 0.965 100 0.299 Contact Map
2ip4A 1 0.9627 100 0.301 Contact Map
2yw2A 2 0.9837 100 0.307 Contact Map
2qk4A 1 0.972 100 0.308 Contact Map
2yrxA 1 0.9557 100 0.316 Contact Map
2xclA 1 0.9744 100 0.318 Contact Map
3n6rA 1 0.8019 100 0.346 Contact Map
4rcnA 6 0.8741 100 0.347 Contact Map
3u9tA 3 0.9277 100 0.348 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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