PUR9 - ECOLI - GREMLIN Contacts

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PUR9 - Bifunctional purine biosynthesis protein PurH

UniProt:	P15639	Sequences: MQQRRPVRRALLSVSDKAGIVEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEEHQIQPIDMVVVNLYPFAQTVAREGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDDNEGSLTLATRFDLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKLDMRYGENSHQQAAFYIEENVKEASVATATQVQGKALSYNNIADTDAALECVKEFAEPACVIVKHANPCGVAIGNSILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSASEEALKITAAKQNVRVLTCGQWGERVPGLDFKRVNGGLLVQDRDLGMVGAEELRVVTKRQPSEQELRDALFCWKVAKFVKSNAIVYAKNNMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSSMASDAFFPFRDGIDAAAAAGVTCVIQPGGSIRDDEVIAAADEHGIAMLFTDMRHFRH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10795
Length:	529 (502)
Sequences:	2897 (1427)
Seq/√Len:	63.7

ECOLI - PUR9
BACSU - PUR9
HALSA - Q9HS43

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
506_D	510_A	5.267	1.00
406_K	513_D	5.172	1.00
407_R	413_E	4.086	1.00
325_E	347_S	3.837	1.00
28_S	50_P	3.793	1.00
152_D	178_K	3.764	1.00
26_A	157_I	3.641	1.00
325_E	349_S	3.507	1.00
482_R	486_D	3.506	1.00
222_K	225_D	3.353	1.00
81_G	90_M	3.353	1.00
253_T	366_T	3.321	1.00
9_R	33_E	3.320	1.00
333_A	337_R	3.195	1.00
328_A	355_I	3.117	1.00
118_S	121_D	3.096	1.00
159_E	171_T	3.095	1.00
12_L	34_L	3.091	1.00
134_V	179_A	2.949	1.00
347_S	366_T	2.829	1.00
348_A	364_V	2.807	1.00
34_L	49_L	2.770	1.00
282_A	296_I	2.678	1.00
79_I	101_V	2.657	1.00
328_A	351_E	2.627	1.00
294_V	423_V	2.622	1.00
485_I	496_V	2.578	1.00
30_R	161_D	2.504	1.00
327_D	330_T	2.466	1.00
328_A	332_Q	2.368	1.00
149_K	178_K	2.364	1.00
82_R	85_Q	2.351	1.00
134_V	146_I	2.350	1.00
42_R	46_E	2.340	1.00
394_G	524_M	2.337	1.00
145_A	167_L	2.333	1.00
486_D	514_E	2.324	1.00
159_E	168_T	2.271	1.00
283_C	322_F	2.268	1.00
498_Q	519_M	2.226	1.00
88_A	92_E	2.225	1.00
12_L	24_A	2.199	1.00
482_R	507_E	2.195	1.00
83_R	99_D	2.150	1.00
265_I	382_V	2.128	1.00
455_K	459_I	2.118	1.00
299_S	302_D	2.103	1.00
224_L	259_A	2.087	1.00
420_C	435_A	2.062	1.00
64_M	90_M	2.051	1.00
445_A	448_M	2.009	1.00
26_A	161_D	1.972	1.00
54_V	75_V	1.968	1.00
147_V	156_I	1.962	1.00
220_F	386_L	1.961	1.00
43_L	47_K	1.960	1.00
22_E	25_Q	1.950	1.00
7_V	32_V	1.924	1.00
434_Y	458_G	1.910	1.00
410_S	413_E	1.902	1.00
112_V	122_A	1.899	1.00
510_A	514_E	1.892	1.00
35_L	57_Y	1.865	1.00
504_R	507_E	1.852	1.00
416_D	435_A	1.839	1.00
119_L	141_H	1.833	1.00
449_S	460_K	1.831	1.00
57_Y	75_V	1.827	1.00
155_A	174_D	1.813	1.00
301_L	305_D	1.807	1.00
454_A	484_G	1.789	1.00
322_F	326_L	1.782	1.00
41_A	51_V	1.776	1.00
223_K	240_I	1.760	1.00
482_R	514_E	1.753	1.00
266_A	289_A	1.708	0.99
486_D	490_A	1.705	0.99
473_M	488_A	1.703	0.99
510_A	513_D	1.702	0.99
416_D	436_K	1.698	0.99
413_E	494_T	1.698	0.99
472_S	495_C	1.692	0.99
350_E	354_K	1.687	0.99
41_A	45_A	1.687	0.99
23_F	156_I	1.683	0.99
300_I	322_F	1.680	0.99
298_N	302_D	1.677	0.99
353_L	357_A	1.668	0.99
297_G	306_R	1.666	0.99
305_D	333_A	1.666	0.99
63_M	93_H	1.658	0.99
77_G	95_I	1.648	0.99
109_A	189_M	1.644	0.99
23_F	102_V	1.624	0.99
434_Y	441_I	1.621	0.99
83_R	143_D	1.619	0.99
23_F	147_V	1.605	0.99
334_I	340_V	1.605	0.99
256_Q	362_V	1.585	0.99
262_Y	378_D	1.558	0.99
119_L	194_F	1.558	0.99
45_A	53_E	1.555	0.99
266_A	380_K	1.544	0.99
149_K	152_D	1.529	0.99
397_G	400_E	1.515	0.99
30_R	160_M	1.514	0.99
64_M	89_I	1.511	0.99
281_P	300_I	1.511	0.99
452_Y	460_K	1.509	0.99
511_A	514_E	1.508	0.99
119_L	173_F	1.494	0.98
297_G	302_D	1.486	0.98
256_Q	357_A	1.478	0.98
405_T	519_M	1.471	0.98
471_S	493_V	1.469	0.98
255_V	366_T	1.453	0.98
401_L	418_L	1.445	0.98
268_T	342_V	1.443	0.98
33_E	52_T	1.424	0.98
277_E	426_F	1.415	0.98
486_D	515_H	1.413	0.98
511_A	515_H	1.413	0.98
7_V	100_M	1.411	0.98
134_V	148_V	1.406	0.98
336_S	358_A	1.393	0.97
407_R	494_T	1.380	0.97
469_K	494_T	1.380	0.97
238_F	382_V	1.361	0.97
412_Q	416_D	1.356	0.97
154_D	158_K	1.354	0.97
320_I	334_I	1.353	0.97
416_D	437_N	1.353	0.97
285_I	315_A	1.352	0.97
320_I	340_V	1.352	0.97
398_A	418_L	1.352	0.97
256_Q	356_T	1.342	0.97
235_Q	390_D	1.342	0.97
401_L	497_I	1.340	0.97
417_A	495_C	1.340	0.97
35_L	98_I	1.337	0.97
416_D	438_N	1.329	0.97
260_L	265_I	1.326	0.97
482_R	515_H	1.325	0.97
41_A	53_E	1.324	0.97
63_M	136_S	1.324	0.97
412_Q	437_N	1.323	0.97
487_A	490_A	1.319	0.96
148_V	182_H	1.316	0.96
377_L	390_D	1.313	0.96
117_C	122_A	1.307	0.96
33_E	96_Q	1.307	0.96
485_I	508_V	1.300	0.96
35_L	54_V	1.293	0.96
101_V	132_T	1.293	0.96
146_I	179_A	1.290	0.96
402_R	523_D	1.287	0.96
21_V	43_L	1.285	0.96
415_R	438_N	1.283	0.96
181_E	195_G	1.279	0.96
24_A	44_L	1.278	0.96
302_D	306_R	1.276	0.96
277_E	425_K	1.260	0.95
326_L	348_A	1.236	0.95
379_F	386_L	1.233	0.95
65_D	85_Q	1.231	0.95
29_A	161_D	1.227	0.95
26_A	30_R	1.220	0.95
177_I	194_F	1.220	0.95
177_I	181_E	1.216	0.94
212_F	237_A	1.204	0.94
82_R	143_D	1.202	0.94
458_G	491_A	1.197	0.94
272_L	367_C	1.190	0.94
159_E	167_L	1.190	0.94
12_L	20_I	1.189	0.94
473_M	493_V	1.189	0.94
496_V	517_I	1.183	0.94
84_G	142_K	1.180	0.94
482_R	511_A	1.169	0.93
132_T	137_A	1.166	0.93
212_F	235_Q	1.161	0.93
158_K	161_D	1.159	0.93
109_A	182_H	1.159	0.93
169_L	173_F	1.153	0.93
171_T	175_L	1.152	0.93
15_S	125_N	1.151	0.93
490_A	515_H	1.147	0.93
77_G	93_H	1.146	0.92
32_V	100_M	1.140	0.92
141_H	173_F	1.139	0.92
15_S	107_P	1.134	0.92
26_A	29_A	1.132	0.92
434_Y	493_V	1.126	0.92
353_L	364_V	1.124	0.92
25_Q	29_A	1.123	0.92
25_Q	49_L	1.119	0.92
21_V	47_K	1.116	0.91
290_N	445_A	1.115	0.91
74_K	94_Q	1.109	0.91
156_I	171_T	1.105	0.91
119_L	122_A	1.104	0.91
462_A	468_V	1.103	0.91
238_F	250_A	1.101	0.91
145_A	175_L	1.095	0.91
403_V	520_L	1.094	0.91
434_Y	471_S	1.094	0.91
485_I	512_A	1.090	0.90
269_D	273_E	1.088	0.90
118_S	122_A	1.085	0.90
256_Q	364_V	1.078	0.90
411_E	415_R	1.077	0.90
57_Y	74_K	1.077	0.90
301_L	333_A	1.070	0.90
159_E	165_G	1.069	0.90
487_A	491_A	1.063	0.89
9_R	35_L	1.060	0.89
132_T	136_S	1.059	0.89
301_L	329_E	1.057	0.89
16_D	110_Q	1.053	0.89
413_E	518_A	1.050	0.89
84_G	143_D	1.041	0.88
275_V	321_A	1.040	0.88
351_E	354_K	1.038	0.88
503_I	506_D	1.032	0.88
310_T	440_T	1.031	0.88
332_Q	337_R	1.026	0.88
398_A	414_L	1.021	0.87
145_A	159_E	1.019	0.87
403_V	409_P	1.019	0.87
109_A	113_A	1.019	0.87
507_E	510_A	1.017	0.87
192_N	196_S	1.013	0.87
489_A	517_I	1.004	0.86
81_G	97_P	1.003	0.86
344_I	367_C	1.003	0.86
18_A	151_S	1.001	0.86
305_D	309_K	1.000	0.86
133_M	136_S	0.997	0.86
316_F	503_I	0.997	0.86
309_K	439_M	0.997	0.86
88_A	91_E	0.993	0.86
89_I	92_E	0.992	0.86
329_E	332_Q	0.990	0.86
26_A	160_M	0.990	0.86
392_D	526_H	0.989	0.86
308_Y	312_P	0.989	0.86
448_M	456_I	0.988	0.86
213_P	237_A	0.986	0.85
63_M	95_I	0.983	0.85
272_L	276_K	0.982	0.85
278_F	282_A	0.981	0.85
90_M	97_P	0.980	0.85
249_V	252_A	0.980	0.85
155_A	171_T	0.977	0.85
328_A	349_S	0.975	0.85
79_I	133_M	0.973	0.85
418_L	497_I	0.971	0.85
348_A	366_T	0.971	0.85
109_A	185_A	0.969	0.84
252_A	365_L	0.966	0.84
22_E	154_D	0.962	0.84
452_Y	455_K	0.956	0.84
440_T	443_I	0.953	0.83
148_V	152_D	0.949	0.83
445_A	456_I	0.949	0.83
300_I	330_T	0.948	0.83
115_E	122_A	0.948	0.83
310_T	439_M	0.947	0.83
141_H	176_A	0.945	0.83
495_C	518_A	0.944	0.83
188_S	219_N	0.941	0.83
274_C	284_V	0.939	0.83
300_I	324_R	0.937	0.82
157_I	161_D	0.935	0.82
397_G	418_L	0.934	0.82
211_R	235_Q	0.934	0.82
509_I	521_F	0.932	0.82
432_I	476_D	0.931	0.82
76_H	136_S	0.931	0.82
254_Q	259_A	0.931	0.82
415_R	418_L	0.931	0.82
322_F	330_T	0.924	0.81
324_R	346_P	0.923	0.81
84_G	87_D	0.922	0.81
156_I	175_L	0.922	0.81
177_I	195_G	0.922	0.81
299_S	329_E	0.920	0.81
52_T	57_Y	0.920	0.81
330_T	334_I	0.919	0.81
409_P	520_L	0.917	0.81
101_V	146_I	0.917	0.81
268_T	344_I	0.910	0.80
20_I	24_A	0.910	0.80
401_L	414_L	0.909	0.80
403_V	408_Q	0.908	0.80
152_D	155_A	0.906	0.80
404_V	521_F	0.904	0.80
409_P	413_E	0.904	0.80
485_I	493_V	0.901	0.80
332_Q	358_A	0.898	0.80
308_Y	338_Q	0.896	0.79
19_G	22_E	0.896	0.79
485_I	489_A	0.896	0.79
441_I	468_V	0.894	0.79
451_V	484_G	0.892	0.79
427_V	433_V	0.892	0.79
59_G	74_K	0.891	0.79
275_V	282_A	0.891	0.79
142_K	169_L	0.890	0.79
64_M	82_R	0.890	0.79
486_D	511_A	0.890	0.79
167_L	172_R	0.883	0.78
141_H	169_L	0.878	0.78
433_V	440_T	0.878	0.78
286_V	321_A	0.876	0.78
268_T	365_L	0.874	0.78
28_S	34_L	0.873	0.78
347_S	368_G	0.873	0.78
109_A	221_I	0.868	0.77
313_T	452_Y	0.865	0.77
34_L	52_T	0.864	0.77
171_T	174_D	0.864	0.77
304_Y	338_Q	0.863	0.77
283_C	334_I	0.861	0.77
396_V	401_L	0.860	0.77
356_T	364_V	0.859	0.77
160_M	166_S	0.859	0.77
64_M	85_Q	0.857	0.76
407_R	516_G	0.856	0.76
313_T	449_S	0.856	0.76
65_D	89_I	0.855	0.76
484_G	508_V	0.855	0.76
336_S	362_V	0.853	0.76
168_T	171_T	0.852	0.76
181_E	185_A	0.851	0.76
334_I	343_I	0.851	0.76
420_C	472_S	0.851	0.76
448_M	452_Y	0.849	0.76
173_F	197_M	0.848	0.76
300_I	327_D	0.838	0.75
409_P	518_A	0.838	0.75
305_D	337_R	0.836	0.75
63_M	77_G	0.834	0.74
122_A	193_Y	0.834	0.74
407_R	518_A	0.832	0.74
270_A	289_A	0.830	0.74
327_D	349_S	0.830	0.74
116_G	121_D	0.828	0.74
357_A	362_V	0.828	0.74
296_I	438_N	0.828	0.74
79_I	134_V	0.825	0.74
434_Y	473_M	0.822	0.73
473_M	485_I	0.820	0.73
462_A	467_E	0.819	0.73
281_P	324_R	0.818	0.73
60_F	93_H	0.817	0.73
45_A	50_P	0.817	0.73
43_L	46_E	0.816	0.73
283_C	320_I	0.815	0.73
322_F	334_I	0.815	0.73
482_R	508_V	0.815	0.73
455_K	487_A	0.815	0.73
498_Q	521_F	0.811	0.72
222_K	237_A	0.808	0.72
145_A	156_I	0.803	0.72
494_T	516_G	0.800	0.71
238_F	265_I	0.799	0.71
302_D	305_D	0.795	0.71
167_L	171_T	0.795	0.71
402_R	506_D	0.794	0.71
274_C	423_V	0.794	0.71
181_E	191_A	0.791	0.70
64_M	77_G	0.789	0.70
329_E	349_S	0.788	0.70
280_E	324_R	0.787	0.70
221_I	240_I	0.787	0.70
76_H	133_M	0.786	0.70
23_F	157_I	0.783	0.70
377_L	388_V	0.776	0.69
351_E	355_I	0.771	0.68
111_T	122_A	0.771	0.68
402_R	408_Q	0.770	0.68
79_I	146_I	0.768	0.68
506_D	513_D	0.768	0.68
278_F	423_V	0.765	0.68
76_H	132_T	0.764	0.68
111_T	125_N	0.763	0.68
12_L	21_V	0.761	0.67
332_Q	336_S	0.760	0.67
434_Y	454_A	0.760	0.67
218_L	386_L	0.754	0.67
489_A	515_H	0.753	0.67
313_T	455_K	0.752	0.66
282_A	294_V	0.749	0.66
77_G	90_M	0.747	0.66
448_M	460_K	0.745	0.66
506_D	514_E	0.743	0.66
111_T	117_C	0.738	0.65
270_A	290_N	0.738	0.65
195_G	215_T	0.737	0.65
20_I	43_L	0.736	0.65
185_A	189_M	0.735	0.65
155_A	159_E	0.734	0.65
289_A	380_K	0.732	0.64
63_M	89_I	0.731	0.64
170_A	173_F	0.730	0.64
53_E	56_D	0.730	0.64
452_Y	463_D	0.727	0.64
241_E	381_R	0.727	0.64
15_S	182_H	0.727	0.64
119_L	197_M	0.727	0.64
115_E	121_D	0.725	0.64
212_F	222_K	0.725	0.64
150_S	153_Y	0.723	0.63
42_R	45_A	0.722	0.63
290_N	448_M	0.718	0.63
21_V	25_Q	0.718	0.63
295_A	315_A	0.717	0.63
454_A	473_M	0.715	0.63
348_A	365_L	0.715	0.63
449_S	452_Y	0.712	0.62
60_F	89_I	0.710	0.62
258_K	341_E	0.709	0.62
289_A	342_V	0.709	0.62
32_V	160_M	0.707	0.62
458_G	484_G	0.707	0.62
77_G	98_I	0.706	0.62
343_I	356_T	0.706	0.62
348_A	353_L	0.705	0.61
123_V	142_K	0.705	0.61
137_A	144_V	0.704	0.61
285_I	308_Y	0.704	0.61
184_A	191_A	0.703	0.61
156_I	160_M	0.701	0.61
68_V	73_P	0.701	0.61
486_D	507_E	0.700	0.61
188_S	217_N	0.700	0.61
404_V	509_I	0.699	0.61
434_Y	468_V	0.698	0.61
85_Q	143_D	0.698	0.61
313_T	463_D	0.697	0.61
489_A	511_A	0.697	0.61
28_S	44_L	0.695	0.60
489_A	514_E	0.694	0.60
7_V	160_M	0.694	0.60
116_G	122_A	0.693	0.60
443_I	448_M	0.692	0.60
155_A	158_K	0.692	0.60
405_T	498_Q	0.692	0.60
448_M	453_S	0.691	0.60
249_V	268_T	0.690	0.60
248_S	252_A	0.690	0.60
300_I	326_L	0.690	0.60
110_Q	113_A	0.689	0.60
378_D	381_R	0.689	0.60
90_M	94_Q	0.688	0.60
452_Y	484_G	0.686	0.59
453_S	456_I	0.685	0.59
297_G	439_M	0.684	0.59
414_L	418_L	0.684	0.59
358_A	362_V	0.683	0.59
396_V	524_M	0.681	0.59
268_T	321_A	0.681	0.59
156_I	167_L	0.681	0.59
215_T	219_N	0.681	0.59
253_T	347_S	0.680	0.59
9_R	32_V	0.679	0.59
181_E	215_T	0.678	0.58
285_I	295_A	0.678	0.58
278_F	281_P	0.678	0.58
121_D	125_N	0.677	0.58
134_V	145_A	0.676	0.58
12_L	102_V	0.676	0.58
20_I	34_L	0.675	0.58
65_D	82_R	0.675	0.58
326_L	330_T	0.675	0.58
482_R	504_R	0.674	0.58
112_V	193_Y	0.674	0.58
222_K	239_Y	0.673	0.58
414_L	497_I	0.671	0.58
280_E	296_I	0.670	0.58
343_I	362_V	0.670	0.58
353_L	366_T	0.669	0.57
454_A	485_I	0.666	0.57
316_F	337_R	0.665	0.57
412_Q	415_R	0.664	0.57
117_C	193_Y	0.662	0.57
226_M	265_I	0.662	0.57
263_N	341_E	0.661	0.57
79_I	179_A	0.661	0.57
336_S	355_I	0.659	0.56
21_V	46_E	0.659	0.56
272_L	370_W	0.659	0.56
350_E	353_L	0.658	0.56
284_V	294_V	0.658	0.56
304_Y	333_A	0.658	0.56
360_Q	503_I	0.657	0.56
113_A	189_M	0.656	0.56
54_V	79_I	0.656	0.56
340_V	362_V	0.656	0.56
282_A	297_G	0.655	0.56
177_I	198_V	0.655	0.56
142_K	173_F	0.654	0.56
298_N	324_R	0.653	0.56
8_R	32_V	0.651	0.55
15_S	110_Q	0.651	0.55
315_A	340_V	0.650	0.55
394_G	400_E	0.649	0.55
160_M	164_E	0.648	0.55
427_V	448_M	0.647	0.55
266_A	269_D	0.647	0.55
34_L	259_A	0.647	0.55
279_A	324_R	0.646	0.55
420_C	474_A	0.646	0.55
61_P	93_H	0.643	0.55
508_V	512_A	0.638	0.54
283_C	304_Y	0.637	0.54
354_K	357_A	0.637	0.54
462_A	491_A	0.637	0.54
272_L	368_G	0.636	0.54
194_F	198_V	0.636	0.54
91_E	96_Q	0.636	0.54
353_L	356_T	0.636	0.54
123_V	136_S	0.635	0.54
390_D	393_L	0.634	0.53
434_Y	449_S	0.633	0.53
304_Y	334_I	0.632	0.53
452_Y	456_I	0.631	0.53
419_F	435_A	0.629	0.53
24_A	49_L	0.628	0.53
248_S	383_N	0.628	0.53
285_I	428_K	0.628	0.53
45_A	56_D	0.628	0.53
252_A	268_T	0.626	0.53
112_V	117_C	0.625	0.52
216_L	220_F	0.624	0.52
111_T	116_G	0.624	0.52
12_L	49_L	0.622	0.52
71_L	76_H	0.621	0.52
459_I	463_D	0.621	0.52
64_M	81_G	0.620	0.52
452_Y	458_G	0.620	0.52
488_A	493_V	0.618	0.52
407_R	513_D	0.617	0.52
35_L	52_T	0.616	0.51
83_R	98_I	0.614	0.51
269_D	385_G	0.614	0.51
462_A	469_K	0.614	0.51
297_G	330_T	0.612	0.51
86_D	91_E	0.611	0.51
79_I	138_A	0.611	0.51
436_K	494_T	0.611	0.51
75_V	136_S	0.609	0.51
445_A	460_K	0.609	0.51
472_S	518_A	0.608	0.50
473_M	496_V	0.608	0.50
117_C	121_D	0.604	0.50
266_A	315_A	0.602	0.50
274_C	528_R	0.601	0.50
54_V	136_S	0.601	0.50
318_G	340_V	0.600	0.50
462_A	471_S	0.600	0.50
174_D	177_I	0.594	0.49
468_V	471_S	0.593	0.49
77_G	136_S	0.592	0.49
332_Q	355_I	0.592	0.49
435_A	472_S	0.591	0.49
333_A	336_S	0.590	0.48
57_Y	96_Q	0.590	0.48
18_A	150_S	0.590	0.48
398_A	401_L	0.590	0.48
112_V	118_S	0.590	0.48
435_A	474_A	0.589	0.48
295_A	416_D	0.589	0.48
44_L	49_L	0.587	0.48
253_T	353_L	0.585	0.48
247_A	272_L	0.584	0.48
272_L	383_N	0.582	0.47
306_R	437_N	0.582	0.47
423_V	440_T	0.582	0.47
100_M	145_A	0.581	0.47
274_C	294_V	0.581	0.47
173_F	177_I	0.581	0.47
249_V	265_I	0.581	0.47
460_K	484_G	0.579	0.47
458_G	487_A	0.579	0.47
9_R	96_Q	0.578	0.47
304_Y	340_V	0.578	0.47
132_T	173_F	0.578	0.47
104_N	150_S	0.577	0.47
262_Y	381_R	0.574	0.47
482_R	510_A	0.574	0.47
53_E	57_Y	0.573	0.46
398_A	415_R	0.572	0.46
416_D	472_S	0.571	0.46
249_V	344_I	0.571	0.46
238_F	260_L	0.571	0.46
427_V	443_I	0.571	0.46
142_K	172_R	0.571	0.46
107_P	110_Q	0.570	0.46
34_L	47_K	0.569	0.46
20_I	49_L	0.569	0.46
220_F	241_E	0.569	0.46
79_I	136_S	0.568	0.46
268_T	272_L	0.568	0.46
198_V	210_G	0.568	0.46
73_P	77_G	0.567	0.46
274_C	277_E	0.564	0.45
484_G	512_A	0.564	0.45
396_V	418_L	0.563	0.45
435_A	438_N	0.563	0.45
214_R	221_I	0.562	0.45
326_L	334_I	0.562	0.45
45_A	51_V	0.561	0.45
82_R	86_D	0.561	0.45
382_V	385_G	0.561	0.45
45_A	226_M	0.560	0.45
256_Q	353_L	0.559	0.45
195_G	268_T	0.559	0.45
327_D	351_E	0.558	0.45
119_L	493_V	0.557	0.45
181_E	219_N	0.557	0.45
119_L	193_Y	0.557	0.45
281_P	323_N	0.556	0.44
308_Y	315_A	0.556	0.44
289_A	481_F	0.556	0.44
216_L	388_V	0.553	0.44
439_M	467_E	0.553	0.44
220_F	379_F	0.553	0.44
301_L	327_D	0.552	0.44
378_D	391_R	0.552	0.44
79_I	95_I	0.551	0.44
417_A	472_S	0.551	0.44
37_T	65_D	0.551	0.44
431_A	476_D	0.551	0.44
251_T	368_G	0.551	0.44
52_T	56_D	0.551	0.44
37_T	238_F	0.550	0.44
316_F	479_F	0.550	0.44
285_I	342_V	0.550	0.44
271_A	321_A	0.549	0.44
406_K	516_G	0.549	0.44
240_I	251_T	0.548	0.44
519_M	522_T	0.548	0.44
181_E	194_F	0.547	0.43
145_A	171_T	0.546	0.43
479_F	484_G	0.546	0.43
306_R	438_N	0.541	0.43
7_V	28_S	0.541	0.43
145_A	172_R	0.540	0.43
310_T	452_Y	0.540	0.43
224_L	260_L	0.540	0.43
79_I	132_T	0.539	0.43
415_R	437_N	0.539	0.43
66_G	69_K	0.537	0.42
24_A	28_S	0.537	0.42
278_F	422_K	0.536	0.42
68_V	71_L	0.536	0.42
304_Y	308_Y	0.536	0.42
331_A	355_I	0.536	0.42
247_A	251_T	0.535	0.42
405_T	409_P	0.535	0.42
294_V	440_T	0.535	0.42
212_F	377_L	0.535	0.42
449_S	459_I	0.535	0.42
224_L	265_I	0.534	0.42
357_A	364_V	0.534	0.42
35_L	96_Q	0.534	0.42
320_I	338_Q	0.534	0.42
301_L	330_T	0.534	0.42
115_E	118_S	0.533	0.42
423_V	448_M	0.533	0.42
461_A	468_V	0.532	0.42
398_A	411_E	0.532	0.42
285_I	340_V	0.531	0.42
433_V	443_I	0.531	0.42
262_Y	388_V	0.531	0.42
473_M	484_G	0.531	0.42
27_L	32_V	0.531	0.42
102_V	153_Y	0.530	0.42
485_I	517_I	0.529	0.41
512_A	515_H	0.529	0.41
367_C	370_W	0.529	0.41
266_A	285_I	0.529	0.41
218_L	379_F	0.528	0.41
447_Q	456_I	0.528	0.41
427_V	431_A	0.528	0.41
433_V	445_A	0.528	0.41
235_Q	400_E	0.527	0.41
42_R	53_E	0.527	0.41
274_C	426_F	0.527	0.41
403_V	414_L	0.527	0.41
38_G	131_P	0.527	0.41
253_T	368_G	0.527	0.41
199_P	210_G	0.526	0.41
417_A	421_W	0.526	0.41
194_F	225_D	0.525	0.41
36_S	39_G	0.524	0.41
283_C	419_F	0.524	0.41
34_L	51_V	0.524	0.41
90_M	136_S	0.524	0.41
508_V	511_A	0.523	0.41
9_R	57_Y	0.523	0.41
275_V	286_V	0.523	0.41
405_T	513_D	0.522	0.41
230_E	263_N	0.522	0.41
44_L	47_K	0.522	0.41
417_A	520_L	0.521	0.41
87_D	90_M	0.520	0.40
54_V	132_T	0.520	0.40
305_D	329_E	0.520	0.40
117_C	125_N	0.520	0.40
36_S	131_P	0.520	0.40
14_V	153_Y	0.519	0.40
496_V	508_V	0.519	0.40
105_L	134_V	0.519	0.40
405_T	521_F	0.518	0.40
417_A	420_C	0.517	0.40
191_A	215_T	0.517	0.40
379_F	388_V	0.516	0.40
112_V	189_M	0.516	0.40
278_F	323_N	0.516	0.40
441_I	471_S	0.515	0.40
232_S	420_C	0.514	0.40
122_A	194_F	0.514	0.40
221_I	242_E	0.514	0.40
89_I	93_H	0.514	0.40
81_G	132_T	0.513	0.40
409_P	513_D	0.513	0.40
102_V	247_A	0.512	0.40
63_M	83_R	0.511	0.39
273_E	380_K	0.511	0.39
394_G	397_G	0.510	0.39
152_D	443_I	0.510	0.39
441_I	467_E	0.509	0.39
166_S	344_I	0.508	0.39
452_Y	487_A	0.506	0.39
111_T	270_A	0.506	0.39
308_Y	333_A	0.506	0.39
281_P	330_T	0.506	0.39
256_Q	360_Q	0.506	0.39
278_F	426_F	0.506	0.39
84_G	120_E	0.505	0.39
308_Y	313_T	0.505	0.39
421_W	522_T	0.504	0.39
32_V	102_V	0.504	0.39
491_A	512_A	0.504	0.39
181_E	214_R	0.504	0.39
294_V	310_T	0.503	0.39
442_G	448_M	0.503	0.39
252_A	284_V	0.502	0.38
322_F	346_P	0.502	0.38
64_M	86_D	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ehiA	2	0.9433	100	0.094	Contact Map
3zzmA	2	0.9679	100	0.096	Contact Map
1g8mA	2	0.9395	100	0.139	Contact Map
1zczA	2	0.8563	100	0.145	Contact Map
4j6eA	2	0.4102	100	0.843	Contact Map
1a9xA	3	0.2552	99.3	0.941	Contact Map
2yvqA	2	0.225	99.2	0.943	Contact Map
2xw6A	5	0.2344	98.8	0.952	Contact Map
1b93A	5	0.2609	98.4	0.958	Contact Map
1vmdA	5	0.2684	98.3	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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