GREMLIN Database
PRLF - Antitoxin PrlF
UniProt: P15373 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10955
Length: 111 (101)
Sequences: 117 (75)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V21_G3.4360.92
65_T68_A3.3030.90
20_R107_I2.3500.68
27_A47_L2.1990.62
84_T108_G2.1770.61
87_F100_D2.1640.61
19_I38_G2.1140.59
29_V80_N1.8330.48
65_T77_I1.8230.48
47_L51_Q1.7680.46
16_K38_G1.7500.45
92_G96_V1.7490.45
21_G38_G1.7480.45
80_N83_K1.7310.44
29_V46_I1.7180.44
48_P86_P1.6650.41
28_P56_R1.5630.38
21_G37_P1.5050.36
13_T65_T1.5050.36
65_T72_F1.4910.35
59_D79_N1.4870.35
101_V104_D1.4600.34
77_I84_T1.4510.34
37_P107_I1.4290.33
64_H102_N1.4070.32
25_I58_G1.3840.31
47_L109_D1.3650.31
19_I47_L1.3340.30
36_K80_N1.3050.29
34_K61_Q1.2740.28
16_K41_S1.2700.28
58_G99_M1.2510.27
27_A38_G1.2490.27
92_G110_D1.2490.27
79_N88_N1.2440.27
100_D104_D1.2360.26
36_K82_Q1.1930.25
12_T98_G1.1910.25
13_T32_A1.1760.25
75_A78_Q1.1730.25
20_R44_Y1.1700.24
102_N105_D1.1660.24
92_G97_A1.1540.24
60_E77_I1.1420.24
47_L110_D1.1350.23
85_R108_G1.1240.23
37_P41_S1.1180.23
17_V44_Y1.1180.23
53_F93_K1.0480.21
10_V110_D1.0460.21
54_M62_E1.0290.21
78_Q104_D1.0270.21
38_G53_F1.0240.20
47_L54_M1.0160.20
68_A71_R1.0150.20
37_P40_D1.0000.20
15_S32_A0.9900.20
17_V20_R0.9880.20
35_L40_D0.9620.19
66_M88_N0.9420.18
10_V56_R0.9360.18
34_K88_N0.9290.18
35_L54_M0.9260.18
84_T89_I0.9230.18
68_A96_V0.8980.17
46_I85_R0.8950.17
35_L107_I0.8890.17
62_E94_K0.8830.17
83_K94_K0.8820.17
43_H51_Q0.8680.17
17_V35_L0.8650.17
25_I65_T0.8640.17
51_Q98_G0.8640.17
47_L53_F0.8630.17
28_P108_G0.8630.17
11_L71_R0.8630.17
95_L102_N0.8580.16
31_E47_L0.8560.16
9_A92_G0.8440.16
20_R37_P0.8260.16
16_K36_K0.8140.16
21_G40_D0.8100.15
14_E41_S0.8090.15
98_G101_V0.8040.15
65_T102_N0.8010.15
25_I97_A0.7980.15
92_G98_G0.7830.15
20_R109_D0.7810.15
17_V107_I0.7720.15
67_N105_D0.7660.15
48_P87_F0.7620.15
86_P98_G0.7590.14
82_Q96_V0.7470.14
37_P66_M0.7460.14
49_G98_G0.7450.14
32_A42_I0.7440.14
64_H95_L0.7380.14
20_R48_P0.7360.14
79_N86_P0.7320.14
44_Y54_M0.7280.14
73_L100_D0.7180.14
55_C90_Q0.7180.14
34_K42_I0.7120.14
36_K83_K0.6960.13
13_T54_M0.6930.13
25_I47_L0.6930.13
14_E46_I0.6920.13
87_F99_M0.6870.13
72_F100_D0.6760.13
20_R35_L0.6740.13
51_Q54_M0.6720.13
20_R40_D0.6720.13
66_M102_N0.6690.13
36_K55_C0.6670.13
58_G61_Q0.6660.13
71_R86_P0.6650.13
43_H108_G0.6620.13
28_P110_D0.6570.13
31_E51_Q0.6540.13
15_S29_V0.6530.12
95_L103_I0.6510.12
41_S89_I0.6490.12
25_I29_V0.6470.12
84_T96_V0.6450.12
21_G57_L0.6280.12
34_K75_A0.6210.12
86_P93_K0.6180.12
12_T50_G0.6100.12
11_L90_Q0.6090.12
97_A103_I0.6090.12
33_L40_D0.6080.12
21_G44_Y0.6010.12
58_G75_A0.6000.12
28_P36_K0.5860.11
67_N102_N0.5840.11
62_E100_D0.5790.11
79_N96_V0.5710.11
12_T31_E0.5700.11
42_I97_A0.5690.11
95_L98_G0.5640.11
29_V43_H0.5590.11
89_I93_K0.5560.11
62_E97_A0.5510.11
80_N106_E0.5410.11
61_Q97_A0.5370.11
35_L106_E0.5340.11
44_Y88_N0.5300.11
38_G47_L0.5270.10
19_I40_D0.5240.10
13_T78_Q0.5140.10
71_R96_V0.5100.10
62_E92_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l66A 2 0.4685 98.1 0.813 Contact Map
2w1tA 2 0.8739 98.1 0.816 Contact Map
1yfbA 2 0.4685 98 0.82 Contact Map
3o27A 2 0.5045 97.4 0.841 Contact Map
2glwA 1 0.4324 95.1 0.874 Contact Map
1mvfD 1 0.3964 94.4 0.879 Contact Map
2mrnA 2 0.5135 93.7 0.882 Contact Map
2vb2X 1 0.4685 25.8 0.936 Contact Map
2qcpX 1 0.3964 25.1 0.936 Contact Map
4ce4c 1 0.4685 20.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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