GREMLIN Database
PEPD - Cytosol non-specific dipeptidase
UniProt: P15288 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10695
Length: 485 (471)
Sequences: 1631 (1262)
Seq/√Len: 58.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
416_Q422_T5.6761.00
97_Q108_R4.9271.00
133_V480_K3.8871.00
90_D93_K3.8431.00
99_Y108_R3.6321.00
72_V162_A3.6141.00
103_E466_E3.5921.00
43_K128_A3.5281.00
38_G42_E3.3191.00
19_I32_L3.2991.00
103_E464_H3.2891.00
477_E480_K3.2191.00
123_A139_V3.2151.00
61_A136_P2.9971.00
20_C24_H2.9411.00
225_G291_L2.7951.00
51_Q156_Q2.7671.00
453_I456_P2.7151.00
72_V444_M2.7111.00
40_A47_V2.6421.00
36_I77_L2.6241.00
122_S471_Y2.6111.00
37_V41_K2.5851.00
469_G473_T2.5851.00
30_E34_E2.5811.00
164_I407_V2.5721.00
15_I128_A2.5391.00
11_P128_A2.4541.00
45_F57_I2.4461.00
166_I449_I2.4291.00
33_A49_R2.4171.00
203_T267_A2.4081.00
341_V427_I2.3961.00
463_V468_V2.3541.00
89_H95_P2.3241.00
69_K163_D2.2911.00
27_Y144_T2.2911.00
231_L262_A2.2731.00
205_K303_D2.2291.00
144_T150_D2.2221.00
411_V478_L2.2161.00
28_H92_T2.2121.00
37_V47_V2.2121.00
37_V55_I2.2101.00
100_I465_I2.1011.00
233_R290_E2.1001.00
313_I316_S2.0991.00
231_L264_A2.0351.00
58_R161_Q2.0271.00
372_K395_A2.0061.00
179_G427_I2.0031.00
77_L141_L1.9801.00
25_P28_H1.9751.00
205_K263_F1.9521.00
380_D384_K1.9151.00
414_T477_E1.9091.00
52_V143_M1.9041.00
71_V479_L1.8951.00
75_A119_G1.8881.00
413_E417_R1.8771.00
99_Y106_K1.8611.00
18_K21_S1.8561.00
34_E38_G1.8461.00
208_L300_L1.8421.00
15_I43_K1.8371.00
46_H58_R1.8230.99
233_R370_S1.8220.99
227_A262_A1.8130.99
104_W462_Q1.7780.99
185_D255_R1.7770.99
225_G230_L1.7610.99
163_D443_E1.7530.99
52_V154_G1.7390.99
284_Q288_K1.7290.99
312_L358_V1.7230.99
20_C98_P1.6840.99
37_V49_R1.6830.99
411_V447_V1.6810.99
201_F267_A1.6620.99
84_N261_E1.6510.99
70_P162_A1.6370.99
353_M358_V1.6330.99
132_V476_T1.6300.99
84_N87_T1.6250.99
343_E371_G1.6240.99
82_Q260_R1.6100.99
204_F276_L1.5950.99
417_R481_E1.5860.99
229_K378_M1.5660.98
247_I311_A1.5520.98
89_H94_D1.5510.98
129_D132_V1.5470.98
165_L446_M1.5380.98
290_E370_S1.5350.98
118_I463_V1.5320.98
17_A21_S1.5180.98
184_I376_V1.4910.98
104_W454_T1.4890.98
412_R423_P1.4640.98
21_S95_P1.4570.97
58_R136_P1.4550.97
208_L230_L1.4460.97
127_L139_V1.4200.97
126_V137_L1.4180.97
230_L287_L1.4170.97
412_R422_T1.4160.97
176_I474_L1.4120.97
46_H50_D1.4070.97
417_R477_E1.3990.97
59_K127_L1.3990.97
48_E56_L1.3860.97
414_T418_L1.3840.97
188_S383_G1.3790.96
335_S340_G1.3780.96
43_K124_L1.3740.96
190_L388_A1.3640.96
218_G221_H1.3600.96
346_L379_L1.3590.96
27_Y150_D1.3560.96
28_H31_Q1.3540.96
405_S445_D1.3380.96
189_N357_N1.3380.96
320_F358_V1.3280.96
148_G180_C1.3250.96
48_E58_R1.3240.95
464_H467_S1.3150.95
38_G41_K1.3100.95
414_T481_E1.3080.95
212_K224_L1.3060.95
452_T464_H1.3050.95
477_E481_E1.3040.95
418_L474_L1.3020.95
335_S338_A1.3020.95
251_G262_A1.3010.95
84_N109_G1.2980.95
281_N284_Q1.2940.95
24_H32_L1.2900.95
48_E159_W1.2880.95
86_D109_G1.2840.95
260_R459_P1.2710.94
27_Y147_A1.2610.94
369_D372_K1.2490.94
101_D106_K1.2490.94
197_V201_F1.2480.94
312_L353_M1.2370.94
45_F50_D1.2360.93
122_S475_L1.2360.93
177_Y426_Q1.2330.93
293_E296_K1.2310.93
102_G466_E1.2250.93
87_T109_G1.2230.93
22_I35_Y1.2220.93
203_T308_D1.2100.93
204_F302_L1.2050.93
467_S470_H1.2040.93
173_E470_H1.2030.93
91_F94_D1.2020.92
293_E337_V1.2020.92
402_D445_D1.2020.92
226_N259_P1.2000.92
34_E49_R1.1890.92
211_L230_L1.1880.92
473_T476_T1.1880.92
95_P98_P1.1790.92
376_V392_A1.1770.92
14_D18_K1.1700.91
191_H316_S1.1610.91
129_D472_W1.1560.91
35_Y124_L1.1530.91
476_T480_K1.1520.91
191_H389_K1.1520.91
186_F364_I1.1460.91
404_N409_H1.1400.90
193_D313_I1.1330.90
147_A150_D1.1330.90
335_S341_V1.1310.90
184_I392_A1.1290.90
245_R317_R1.1280.90
259_P329_N1.1240.90
333_R336_D1.1170.89
24_H96_I1.1140.89
453_I463_V1.1120.89
449_I475_L1.1120.89
69_K164_I1.1090.89
234_F300_L1.1050.89
455_G462_Q1.1030.89
30_E53_G1.1020.89
272_K275_V1.0990.89
274_D277_K1.0960.89
202_E304_S1.0870.88
234_F283_Y1.0870.88
92_T95_P1.0830.88
62_T129_D1.0760.88
45_F49_R1.0750.88
75_A123_A1.0740.88
56_L159_W1.0690.87
206_L266_I1.0650.87
205_K265_T1.0640.87
225_G298_L1.0630.87
91_F111_T1.0590.87
190_L323_L1.0500.86
244_L266_I1.0490.86
219_E222_V1.0490.86
82_Q111_T1.0450.86
73_L123_A1.0430.86
322_R384_K1.0420.86
204_F304_S1.0420.86
30_E49_R1.0380.86
374_Y378_M1.0360.86
132_V472_W1.0350.85
63_A133_V1.0350.85
34_E37_V1.0240.85
224_L455_G1.0230.85
344_T371_G1.0220.85
189_N193_D1.0210.85
126_V476_T1.0210.85
248_D265_T1.0200.85
96_I99_Y1.0180.85
40_A43_K1.0050.84
255_R363_L1.0050.84
11_P14_D1.0010.84
84_N460_D1.0000.83
274_D278_S0.9990.83
273_V277_K0.9980.83
149_M363_L0.9970.83
116_N456_P0.9950.83
201_F269_A0.9920.83
60_P136_P0.9900.83
410_L478_L0.9890.83
411_V474_L0.9860.83
402_D438_K0.9830.82
39_W124_L0.9830.82
455_G460_D0.9820.82
311_A317_R0.9810.82
129_D133_V0.9790.82
332_I375_V0.9790.82
289_N400_Q0.9790.82
140_L155_L0.9780.82
295_E298_L0.9770.82
409_H412_R0.9760.82
327_T383_G0.9750.82
189_N391_E0.9740.82
65_M68_R0.9740.82
283_Y287_L0.9730.82
183_G396_Y0.9700.82
57_I127_L0.9690.81
401_P408_M0.9660.81
180_C186_F0.9640.81
326_A382_L0.9640.81
179_G401_P0.9590.81
247_I308_D0.9560.81
209_K299_A0.9550.81
33_A37_V0.9550.81
19_I120_M0.9510.80
172_E454_T0.9510.80
190_L316_S0.9500.80
29_E144_T0.9430.80
118_I468_V0.9390.79
238_H276_L0.9380.79
362_C365_R0.9380.79
204_F273_V0.9350.79
43_K47_V0.9350.79
189_N389_K0.9350.79
408_M447_V0.9330.79
46_H49_R0.9330.79
33_A77_L0.9330.79
36_I57_I0.9320.79
249_F351_V0.9300.79
315_K319_T0.9290.79
13_W465_I0.9280.79
326_A386_A0.9280.79
203_T247_I0.9250.78
202_E268_V0.9240.78
468_V472_W0.9230.78
278_S281_N0.9170.78
325_N374_Y0.9130.77
323_L383_G0.9120.77
85_N263_F0.9110.77
196_A200_G0.9080.77
277_K281_N0.9060.77
178_M403_A0.9040.77
287_L290_E0.9030.77
351_V360_I0.8970.76
175_E426_Q0.8940.76
176_I449_I0.8930.76
198_P201_F0.8900.76
162_A167_N0.8900.76
436_L439_K0.8900.76
212_K297_N0.8890.76
275_V279_L0.8880.75
106_K462_Q0.8880.75
166_I475_L0.8870.75
95_P101_D0.8850.75
82_Q253_T0.8850.75
197_V200_G0.8820.75
338_A341_V0.8810.75
342_V430_A0.8790.75
196_A201_F0.8760.74
273_V304_S0.8710.74
61_A68_R0.8710.74
232_V325_N0.8700.74
254_L458_S0.8660.74
320_F360_I0.8650.74
354_T357_N0.8630.73
413_E481_E0.8600.73
175_E424_N0.8560.73
257_A260_R0.8560.73
243_D314_A0.8550.73
180_C436_L0.8540.73
170_S175_E0.8530.72
291_L298_L0.8490.72
162_A165_L0.8480.72
197_V267_A0.8460.72
176_I423_P0.8450.72
406_P410_L0.8430.72
170_S456_P0.8420.72
58_R138_E0.8400.71
402_D408_M0.8390.71
15_I35_Y0.8390.71
144_T147_A0.8380.71
269_A272_K0.8360.71
209_K301_L0.8340.71
191_H357_N0.8330.71
281_N285_E0.8320.71
454_T462_Q0.8320.71
242_L276_L0.8320.71
158_N441_Y0.8320.71
377_S380_D0.8270.70
408_M445_D0.8250.70
104_W455_G0.8250.70
25_P92_T0.8240.70
419_F470_H0.8240.70
335_S427_I0.8230.70
178_M182_G0.8220.70
341_V367_L0.8170.69
197_V311_A0.8150.69
17_A20_C0.8130.69
89_H96_I0.8120.69
283_Y286_I0.8080.68
452_T467_S0.8080.68
206_L302_L0.8050.68
266_I276_L0.8040.68
106_K460_D0.8040.68
333_R371_G0.8030.68
17_A105_V0.8020.68
92_T96_I0.7980.67
402_D409_H0.7980.67
120_M141_L0.7940.67
282_T285_E0.7930.67
82_Q254_L0.7920.67
87_T261_E0.7900.67
61_A133_V0.7900.67
85_N261_E0.7890.67
396_Y399_W0.7830.66
333_R344_T0.7820.66
410_L414_T0.7760.65
365_R368_I0.7760.65
39_W43_K0.7750.65
87_T97_Q0.7720.65
209_K261_E0.7720.65
75_A120_M0.7720.65
116_N172_E0.7710.65
30_E33_A0.7700.65
94_D97_Q0.7700.65
89_H92_T0.7690.65
364_I375_V0.7690.65
209_K263_F0.7680.64
162_A169_D0.7650.64
245_R314_A0.7640.64
349_G363_L0.7640.64
170_S448_S0.7640.64
40_A44_G0.7620.64
173_E467_S0.7580.63
466_E470_H0.7550.63
233_R385_L0.7540.63
89_H111_T0.7520.63
364_I379_L0.7510.63
346_L362_C0.7500.63
284_Q299_A0.7490.62
322_R385_L0.7470.62
354_T359_E0.7450.62
202_E270_A0.7450.62
312_L316_S0.7440.62
102_G464_H0.7430.62
179_G186_F0.7360.61
268_V276_L0.7360.61
381_S385_L0.7360.61
176_I411_V0.7350.61
126_V479_L0.7340.61
373_D376_V0.7310.61
20_C32_L0.7310.61
282_T286_I0.7300.60
164_I445_D0.7290.60
267_A307_N0.7270.60
208_L211_L0.7260.60
182_G186_F0.7250.60
203_T307_N0.7250.60
9_P12_L0.7240.60
172_E175_E0.7210.60
32_L77_L0.7210.60
10_Q14_D0.7210.60
233_R236_A0.7210.60
314_A318_D0.7210.60
156_Q440_P0.7200.59
277_K304_S0.7190.59
180_C183_G0.7170.59
196_A310_A0.7140.59
140_L158_N0.7120.59
28_H81_P0.7120.59
76_H115_D0.7100.58
9_P13_W0.7100.58
31_Q93_K0.7090.58
208_L231_L0.7090.58
337_V403_A0.7080.58
69_K406_P0.7080.58
102_G106_K0.7040.58
170_S173_E0.7030.58
418_L477_E0.7030.58
106_K458_S0.7030.58
223_G336_D0.7020.57
268_V273_V0.7010.57
177_Y180_C0.7010.57
207_T263_F0.7000.57
200_G249_F0.6990.57
232_V249_F0.6960.57
305_V308_D0.6950.57
111_T459_P0.6940.57
359_E365_R0.6940.57
156_Q159_W0.6930.56
116_N218_G0.6930.56
196_A404_N0.6920.56
87_T108_R0.6910.56
33_A55_I0.6910.56
36_I124_L0.6910.56
176_I478_L0.6910.56
437_F444_M0.6900.56
83_K86_D0.6860.56
70_P136_P0.6850.56
77_L143_M0.6840.56
218_G456_P0.6840.56
20_C96_I0.6840.56
186_F392_A0.6830.55
123_A168_T0.6830.55
100_I105_V0.6820.55
62_T131_N0.6810.55
84_N260_R0.6810.55
18_K35_Y0.6800.55
40_A57_I0.6800.55
470_H474_L0.6800.55
236_A325_N0.6790.55
441_Y444_M0.6790.55
244_L321_I0.6760.55
378_M382_L0.6750.55
122_S126_V0.6720.54
170_S177_Y0.6700.54
49_R55_I0.6690.54
179_G185_D0.6680.54
403_A406_P0.6670.54
402_D405_S0.6660.54
326_A385_L0.6660.54
277_K302_L0.6650.53
382_L386_A0.6650.53
47_V50_D0.6640.53
140_L157_G0.6620.53
319_T323_L0.6590.53
86_D360_I0.6590.53
348_V360_I0.6590.53
250_N352_T0.6580.53
126_V475_L0.6570.53
383_G388_A0.6560.52
359_E362_C0.6550.52
212_K295_E0.6540.52
133_V476_T0.6530.52
326_A330_G0.6520.52
168_T171_E0.6520.52
162_A171_E0.6500.52
266_I302_L0.6490.52
13_W468_V0.6470.51
278_S282_T0.6470.51
204_F277_K0.6460.51
457_H461_E0.6460.51
25_P81_P0.6460.51
89_H98_P0.6450.51
184_I364_I0.6440.51
236_A381_S0.6440.51
183_G186_F0.6410.51
359_E367_L0.6400.51
322_R326_A0.6390.51
74_Q142_T0.6380.50
63_A318_D0.6380.50
45_F127_L0.6370.50
464_H468_V0.6370.50
33_A53_G0.6350.50
438_K446_M0.6350.50
45_F59_K0.6330.50
179_G182_G0.6320.50
223_G294_K0.6310.50
169_D172_E0.6310.50
212_K225_G0.6300.50
410_L413_E0.6300.50
82_Q459_P0.6290.49
337_V400_Q0.6290.49
476_T479_L0.6280.49
62_T133_V0.6270.49
287_L300_L0.6260.49
126_V133_V0.6260.49
108_R447_V0.6260.49
105_V206_L0.6240.49
96_I101_D0.6240.49
323_L386_A0.6220.49
257_A459_P0.6220.49
278_S304_S0.6210.49
10_Q469_G0.6210.49
12_L122_S0.6180.48
186_F197_V0.6170.48
236_A321_I0.6160.48
223_G255_R0.6150.48
178_M401_P0.6150.48
418_L473_T0.6130.48
297_N301_L0.6120.48
13_W401_P0.6120.48
104_W452_T0.6110.47
320_F324_L0.6090.47
365_R369_D0.6090.47
265_T305_V0.6090.47
419_F474_L0.6090.47
105_V465_I0.6060.47
177_Y432_L0.6050.47
54_N142_T0.6050.47
438_K443_E0.6050.47
15_I124_L0.6040.47
190_L312_L0.6040.47
166_I478_L0.6040.47
327_T362_C0.6040.47
250_N263_F0.6030.47
140_L437_F0.6030.47
111_T260_R0.6020.46
167_N171_E0.6010.46
363_L369_D0.6000.46
100_I106_K0.6000.46
54_N74_Q0.5990.46
39_W45_F0.5980.46
239_A318_D0.5970.46
189_N359_E0.5970.46
429_H433_E0.5970.46
12_L125_A0.5960.46
324_L437_F0.5960.46
76_H80_V0.5960.46
419_F473_T0.5950.46
144_T148_G0.5950.46
77_L120_M0.5930.45
247_I265_T0.5920.45
247_I267_A0.5920.45
164_I169_D0.5910.45
249_F353_M0.5910.45
126_V472_W0.5900.45
12_L468_V0.5900.45
245_R311_A0.5900.45
203_T265_T0.5890.45
414_T478_L0.5890.45
326_A381_S0.5880.45
447_V470_H0.5880.45
89_H97_Q0.5850.45
192_L353_M0.5850.45
190_L319_T0.5850.45
380_D392_A0.5840.45
412_R425_I0.5830.44
39_W55_I0.5820.44
164_I167_N0.5810.44
364_I367_L0.5810.44
172_E218_G0.5800.44
115_D457_H0.5790.44
317_R321_I0.5790.44
228_N231_L0.5790.44
180_C185_D0.5780.44
276_L279_L0.5780.44
205_K305_V0.5770.44
249_F320_F0.5770.44
84_N257_A0.5760.44
18_K39_W0.5760.44
82_Q91_F0.5760.44
363_L367_L0.5740.43
59_K134_H0.5730.43
78_D145_E0.5730.43
41_K47_V0.5730.43
14_D21_S0.5720.43
369_D398_G0.5720.43
20_C349_G0.5710.43
106_K109_G0.5710.43
218_G437_F0.5710.43
373_D395_A0.5700.43
156_Q441_Y0.5700.43
167_N217_G0.5690.43
238_H244_L0.5690.43
367_L427_I0.5670.43
356_N365_R0.5670.43
163_D441_Y0.5660.43
292_A404_N0.5650.42
168_T172_E0.5650.42
237_G283_Y0.5640.42
279_L282_T0.5640.42
188_S388_A0.5640.42
239_A244_L0.5630.42
59_K139_V0.5630.42
250_N278_S0.5620.42
275_V278_S0.5620.42
12_L471_Y0.5620.42
193_D316_S0.5610.42
431_G434_C0.5610.42
356_N359_E0.5600.42
100_I103_E0.5590.42
415_Y421_K0.5580.42
51_Q263_F0.5580.42
157_G441_Y0.5580.42
15_I18_K0.5570.42
160_L168_T0.5560.41
192_L358_V0.5560.41
92_T98_P0.5560.41
352_T359_E0.5560.41
86_D92_T0.5560.41
226_N329_N0.5550.41
313_I317_R0.5540.41
179_G183_G0.5540.41
47_V58_R0.5530.41
228_N246_L0.5530.41
126_V132_V0.5530.41
207_T303_D0.5530.41
137_L266_I0.5530.41
250_N353_M0.5520.41
106_K455_G0.5520.41
192_L356_N0.5510.41
418_L470_H0.5510.41
416_Q423_P0.5510.41
408_M437_F0.5490.41
218_G222_V0.5490.41
39_W42_E0.5480.41
54_N429_H0.5470.41
180_C435_G0.5470.41
230_L291_L0.5440.40
43_K130_E0.5430.40
414_T474_L0.5420.40
319_T386_A0.5400.40
70_P161_Q0.5390.40
367_L371_G0.5390.40
164_I171_E0.5390.40
474_L478_L0.5380.40
418_L439_K0.5370.39
223_G334_N0.5370.39
338_A427_I0.5370.39
98_P101_D0.5360.39
287_L298_L0.5340.39
98_P254_L0.5340.39
206_L285_E0.5340.39
9_P469_G0.5330.39
23_P79_M0.5330.39
53_G143_M0.5320.39
24_H75_A0.5310.39
122_S177_Y0.5310.39
192_L196_A0.5300.39
58_R70_P0.5300.39
169_D173_E0.5300.39
243_D272_K0.5280.38
18_K42_E0.5280.38
218_G453_I0.5280.38
11_P130_E0.5270.38
33_A143_M0.5270.38
171_E174_G0.5270.38
184_I255_R0.5260.38
237_G286_I0.5260.38
241_E275_V0.5260.38
193_D197_V0.5260.38
26_S29_E0.5250.38
334_N342_V0.5250.38
344_T366_S0.5240.38
401_P405_S0.5240.38
236_A322_R0.5230.38
65_M133_V0.5230.38
171_E256_N0.5200.38
165_L169_D0.5200.38
83_K91_F0.5190.38
231_L266_I0.5170.37
207_T301_L0.5170.37
74_Q167_N0.5150.37
203_T305_V0.5150.37
454_T458_S0.5140.37
253_T350_V0.5140.37
200_G269_A0.5140.37
116_N219_E0.5130.37
334_N340_G0.5110.37
188_S323_L0.5100.37
409_H413_E0.5100.37
115_D461_E0.5100.37
39_W57_I0.5100.37
43_K57_I0.5100.37
87_T91_F0.5090.37
379_L392_A0.5080.36
237_G289_N0.5070.36
24_H346_L0.5060.36
332_I346_L0.5060.36
284_Q298_L0.5060.36
256_N431_G0.5050.36
326_A335_S0.5040.36
202_E273_V0.5020.36
293_E336_D0.5020.36
153_F440_P0.5000.36
191_H276_L0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qyvA 2 0.967 100 0.399 Contact Map
3mruA 1 1 100 0.414 Contact Map
3rzaA 2 0.7299 100 0.613 Contact Map
3pfoA 2 0.7567 100 0.613 Contact Map
3ifeA 2 0.7443 100 0.62 Contact Map
3gb0A 2 0.7299 100 0.621 Contact Map
3khxA 1 0.8 100 0.627 Contact Map
4g1pA 2 0.7546 100 0.63 Contact Map
2pokA 2 0.868 100 0.632 Contact Map
3pfeA 2 0.7505 100 0.632 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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