GREMLIN Database
PUR4 - Phosphoribosylformylglycinamidine synthase
UniProt: P15254 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10797
Length: 1295 (1209)
Sequences: 1748 (986)
Seq/√Len: 28.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_D200_N5.3301.00
512_M577_I5.1791.00
437_V555_V5.1401.00
240_M244_T5.1351.00
618_T755_E5.0761.00
712_A756_A4.4171.00
227_V613_T4.3011.00
1087_A1130_L4.2771.00
526_E529_E4.1731.00
894_L907_A4.1501.00
1075_L1116_V4.1481.00
39_H61_Y3.9771.00
596_Q599_D3.9481.00
893_T928_V3.7961.00
819_L826_L3.7441.00
719_A802_I3.7121.00
994_R1003_D3.6051.00
903_C958_A3.5871.00
167_G170_A3.5801.00
163_L166_Q3.5651.00
1003_D1007_Q3.5571.00
1161_T1200_R3.5101.00
241_I244_T3.4261.00
703_V714_L3.3991.00
564_D568_K3.3691.00
680_C726_T3.3551.00
120_T123_Q3.3531.00
413_L801_V3.3211.00
401_G408_H3.3121.00
684_T811_V3.2611.00
717_G925_L3.2381.00
894_L905_I3.2331.00
815_I874_V3.2211.00
829_I929_I3.2071.00
720_L734_I3.2031.00
173_D177_R3.1391.00
637_V891_L3.0891.00
723_I734_I3.0401.00
640_V646_V2.9911.00
723_I728_I2.9771.00
983_V1010_S2.9321.00
1131_A1254_V2.9141.00
413_L697_I2.9131.00
1081_G1119_E2.8931.00
1176_Q1186_V2.8861.00
1206_A1210_A2.8751.00
833_K862_Q2.8621.00
963_R975_S2.8551.00
731_I734_I2.8451.00
1218_V1244_I2.7941.00
1220_L1246_A2.7931.00
906_D957_Q2.7881.00
890_L928_V2.7481.00
390_R649_K2.7441.00
1213_E1218_V2.6981.00
168_R188_D2.6421.00
895_A964_F2.6320.99
584_L603_D2.6310.99
661_T664_V2.6130.99
660_V1052_S2.6130.99
237_L241_I2.5980.99
879_L929_I2.5910.99
233_Q240_M2.5870.99
642_H987_E2.5810.99
1041_K1084_D2.5720.99
560_L576_V2.5710.99
517_S606_L2.5370.99
638_K984_W2.4980.99
20_L24_Q2.4790.99
164_L200_N2.4500.99
1041_K1066_D2.4460.99
367_T992_M2.4240.99
735_K771_T2.4170.99
561_P564_D2.4150.99
233_Q758_K2.4110.99
870_I879_L2.4090.99
824_N880_L2.3830.99
943_L952_V2.3730.99
1104_E1143_N2.3710.99
1083_E1122_T2.3660.99
906_D965_V2.3650.99
1122_T1126_R2.3420.99
555_V560_L2.3280.99
236_S240_M2.3100.99
1173_E1189_Q2.3050.99
827_L954_Y2.2890.99
1174_V1220_L2.2730.98
1121_A1125_H2.2730.98
637_V895_A2.2680.98
750_D795_T2.2630.98
730_D733_R2.2530.98
39_H62_G2.2410.98
233_Q244_T2.2320.98
990_W1003_D2.2280.98
168_R172_I2.2240.98
704_A715_A2.2060.98
827_L940_E2.2060.98
719_A804_A2.1990.98
165_G200_N2.1930.98
1210_A1214_S2.1910.98
169_Q172_I2.1900.98
78_T140_F2.1820.98
1224_D1228_K2.1820.98
706_L854_P2.1790.98
562_L565_E2.1780.98
661_T1195_S2.1750.98
663_M684_T2.1750.98
638_K980_T2.1700.98
30_V114_I2.1620.98
305_W473_D2.1460.98
279_R1066_D2.1250.98
236_S244_T2.1230.98
709_A756_A2.1180.98
634_A980_T2.1170.98
991_Q994_R2.1070.97
95_A106_L2.1040.97
435_K555_V2.0930.97
708_F752_G2.0890.97
240_M245_F2.0760.97
987_E991_Q2.0760.97
869_A943_L2.0680.97
237_L240_M2.0610.97
241_I245_F2.0450.97
564_D574_Y2.0350.97
679_N886_S2.0320.97
559_Q562_L2.0290.97
682_V814_T2.0280.97
680_C696_A2.0280.97
526_E591_R2.0270.97
870_I929_I2.0270.97
686_S689_S2.0220.97
253_L425_V2.0210.97
239_K246_E2.0150.97
1056_M1089_V2.0130.97
432_V582_E2.0100.97
642_H984_W2.0080.97
588_L598_I1.9960.96
267_E286_P1.9750.96
690_Y812_R1.9740.96
585_H599_D1.9690.96
1007_Q1010_S1.9630.96
163_L200_N1.9600.96
818_Q901_G1.9580.96
872_A876_Q1.9580.96
23_F30_V1.9530.96
238_F241_I1.9480.96
435_K579_E1.9430.96
237_L244_T1.9380.96
1004_Q1161_T1.9360.96
183_A612_M1.9280.96
869_A942_V1.9280.96
73_K124_W1.9270.96
42_D104_N1.9260.96
902_H982_R1.9250.96
1008_A1235_A1.9150.95
1231_E1243_G1.9100.95
229_D244_T1.9070.95
824_N881_A1.9060.95
1213_E1242_N1.9020.95
286_P422_A1.9000.95
174_A178_L1.8870.95
156_T541_E1.8860.95
413_L737_S1.8790.95
1181_L1286_I1.8780.95
723_I804_A1.8760.95
1184_G1285_R1.8740.95
1166_E1194_V1.8710.95
740_W743_A1.8620.95
740_W744_A1.8600.95
648_E986_A1.8590.95
15_R110_V1.8560.95
701_A801_V1.8540.95
825_A933_A1.8540.95
229_D240_M1.8530.95
827_L931_V1.8450.94
894_L928_V1.8410.94
137_E473_D1.8400.94
229_D233_Q1.8370.94
813_H875_A1.8330.94
825_A954_Y1.8320.94
928_V955_V1.8310.94
442_P573_P1.8300.94
673_W902_H1.8230.94
1165_F1195_S1.8190.94
288_H422_A1.8150.94
1011_N1226_F1.8120.94
1015_P1225_N1.8030.94
1039_R1066_D1.7880.93
625_A852_D1.7820.93
1114_D1118_D1.7810.93
128_T140_F1.7790.93
827_L952_V1.7720.93
1083_E1119_E1.7710.93
1225_N1235_A1.7660.93
895_A899_F1.7650.93
1169_F1191_P1.7640.93
707_D854_P1.7480.93
524_K579_E1.7460.93
602_L606_L1.7440.93
820_S1275_E1.7430.93
364_D368_E1.7380.92
394_E705_L1.7320.92
823_D933_A1.7250.92
737_S801_V1.7240.92
763_E767_A1.7230.92
898_A905_I1.7200.92
742_A753_L1.7180.92
272_F290_L1.7170.92
1072_M1110_I1.7120.92
517_S584_L1.7070.92
1042_V1065_F1.7020.92
72_G115_E1.6940.91
526_E589_H1.6890.91
1249_T1254_V1.6870.91
197_L601_P1.6870.91
666_R816_T1.6850.91
898_A964_F1.6810.91
225_D613_T1.6800.91
1201_V1247_V1.6780.91
89_S93_D1.6750.91
696_A803_S1.6650.91
727_Q809_E1.6650.91
828_L885_R1.6630.91
576_V579_E1.6600.91
682_V694_A1.6540.90
180_L206_L1.6540.90
650_T989_T1.6510.90
869_A946_H1.6510.90
73_K121_N1.6420.90
371_L655_I1.6410.90
81_P138_T1.6370.90
741_M744_A1.6290.90
685_A691_Y1.6250.90
7_G34_Y1.6240.90
983_V1007_Q1.6220.90
659_S1193_A1.6220.90
1104_E1108_K1.6200.89
866_F927_A1.6160.89
906_D959_V1.6140.89
745_G750_D1.6130.89
709_A712_A1.6090.89
243_N761_G1.6030.89
366_M993_Q1.6010.89
528_R590_D1.6010.89
680_C814_T1.6010.89
1184_G1282_P1.5960.89
1068_I1081_G1.5900.89
600_L606_L1.5860.88
827_L929_I1.5860.88
289_I693_E1.5850.88
277_T286_P1.5810.88
367_T371_L1.5800.88
162_D165_G1.5770.88
1171_L1189_Q1.5770.88
826_L905_I1.5700.88
288_H425_V1.5640.88
285_E421_R1.5640.88
430_I434_A1.5640.88
813_H877_R1.5640.88
713_R856_D1.5630.88
326_A417_I1.5590.88
1131_A1141_M1.5540.87
236_S239_K1.5530.87
41_A106_L1.5500.87
761_G766_P1.5450.87
329_K683_T1.5410.87
732_K868_D1.5400.87
436_L512_M1.5340.87
40_F76_L1.5330.87
880_L932_R1.5310.87
873_L939_V1.5270.86
990_W994_R1.5170.86
1028_D1288_R1.5160.86
245_F252_V1.5090.86
1159_R1164_R1.5090.86
1004_Q1230_T1.5080.86
235_K762_E1.5070.86
885_R928_V1.5060.86
438_V512_M1.5060.86
76_L111_A1.4990.85
965_V975_S1.4950.85
829_I870_I1.4930.85
1169_F1270_N1.4910.85
1043_A1070_V1.4900.85
119_L124_W1.4870.85
635_D639_R1.4850.85
401_G407_Y1.4800.85
1088_L1131_A1.4770.85
238_F244_T1.4760.84
435_K557_A1.4750.84
15_R1163_D1.4740.84
225_D611_K1.4740.84
445_N541_E1.4730.84
190_L209_F1.4720.84
226_W614_R1.4710.84
162_D166_Q1.4690.84
267_E284_Q1.4680.84
676_P817_P1.4630.84
1265_F1269_S1.4630.84
942_V946_H1.4550.84
1247_V1256_I1.4540.84
342_I388_Y1.4520.83
1189_Q1227_G1.4480.83
524_K589_H1.4460.83
401_G406_G1.4450.83
192_D196_K1.4400.83
632_T635_D1.4390.83
160_S202_N1.4390.83
990_W995_L1.4370.83
1134_V1220_L1.4360.83
1058_A1265_F1.4330.83
522_G584_L1.4280.82
767_A860_V1.4220.82
1034_I1037_G1.4210.82
435_K560_L1.4190.82
51_E102_Q1.4150.82
1190_M1193_A1.4140.82
1015_P1226_F1.4120.82
1052_S1195_S1.4100.82
1175_T1221_R1.4100.82
707_D710_A1.4070.81
233_Q241_I1.4000.81
528_R591_R1.3990.81
878_K942_V1.3980.81
487_R566_L1.3950.81
821_T824_N1.3940.81
976_E981_L1.3930.81
819_L905_I1.3890.81
648_E989_T1.3880.81
720_L770_L1.3870.81
172_I176_L1.3870.81
345_F366_M1.3840.80
696_A726_T1.3830.80
566_L569_R1.3810.80
12_S1163_D1.3810.80
764_L857_V1.3810.80
811_V1267_T1.3780.80
524_K583_E1.3740.80
1190_M1278_G1.3700.80
1158_V1202_E1.3660.79
699_E704_A1.3590.79
1230_T1235_A1.3580.79
1110_I1120_F1.3580.79
982_R1009_K1.3570.79
243_N766_P1.3540.79
257_K426_Q1.3540.79
895_A905_I1.3520.79
1050_V1091_C1.3510.79
349_W988_T1.3510.79
157_P591_R1.3510.79
512_M516_V1.3500.79
1060_F1089_V1.3490.79
1205_D1208_H1.3450.78
242_K245_F1.3430.78
744_A750_D1.3410.78
760_V802_I1.3400.78
157_P595_N1.3380.78
692_G811_V1.3370.78
386_N696_A1.3370.78
1172_V1245_T1.3350.78
905_I956_G1.3350.78
587_S599_D1.3300.78
487_R569_R1.3270.77
290_L325_G1.3250.77
525_F577_I1.3250.77
530_I577_I1.3210.77
679_N883_H1.3180.77
272_F421_R1.3170.77
324_R428_G1.3170.77
1086_H1130_L1.3170.77
824_N958_A1.3130.77
371_L1164_R1.3120.77
623_G706_L1.3060.76
891_L895_A1.3030.76
327_K486_D1.3000.76
616_V755_E1.2990.76
688_D1058_A1.2960.76
275_H289_I1.2940.76
443_A532_S1.2920.75
254_S438_V1.2910.75
1022_S1188_S1.2880.75
231_E244_T1.2880.75
233_Q236_S1.2830.75
719_A738_A1.2800.75
1212_L1247_V1.2790.75
1168_R1234_P1.2740.74
740_W745_G1.2720.74
398_S401_G1.2670.74
929_I939_V1.2630.74
268_V287_A1.2590.74
236_S241_I1.2540.73
1267_T1273_H1.2540.73
1223_V1229_V1.2540.73
1270_N1281_G1.2540.73
898_A978_R1.2530.73
6_R36_E1.2510.73
132_H140_F1.2500.73
434_A498_L1.2470.73
1244_I1247_V1.2450.73
269_G688_D1.2420.73
235_K240_M1.2390.72
77_V112_Y1.2370.72
160_S595_N1.2370.72
905_I955_V1.2360.72
678_A817_P1.2350.72
865_G946_H1.2330.72
531_L575_A1.2330.72
680_C725_A1.2320.72
192_D195_T1.2300.72
52_H55_L1.2290.72
1189_Q1223_V1.2270.72
682_V726_T1.2250.71
587_S596_Q1.2240.71
266_S429_E1.2220.71
742_A750_D1.2160.71
75_L114_I1.2150.71
603_D606_L1.2130.71
634_A638_K1.2120.71
524_K587_S1.2110.71
487_R1053_H1.2080.70
168_R191_Q1.2060.70
1113_N1116_V1.2040.70
266_S499_F1.2030.70
633_I637_V1.2030.70
23_F33_I1.2030.70
1284_M1288_R1.2010.70
12_S15_R1.2010.70
902_H962_D1.1980.70
740_W750_D1.1960.70
870_I943_L1.1950.70
717_G863_L1.1950.70
229_D232_Q1.1930.69
874_V879_L1.1910.69
320_G551_Y1.1910.69
1151_S1154_W1.1900.69
243_N247_T1.1890.69
532_S537_M1.1880.69
1174_V1246_A1.1880.69
905_I964_F1.1870.69
878_K938_A1.1870.69
660_V1195_S1.1800.69
738_A802_I1.1780.68
40_F109_G1.1720.68
1211_A1214_S1.1710.68
351_E354_G1.1690.68
1118_D1122_T1.1690.68
42_D152_H1.1670.68
1056_M1091_C1.1670.68
1041_K1068_I1.1650.68
962_D978_R1.1640.67
234_P238_F1.1620.67
1159_R1163_D1.1600.67
696_A804_A1.1600.67
653_V669_M1.1590.67
741_M750_D1.1580.67
391_T643_L1.1550.67
411_I1056_M1.1550.67
1212_L1217_L1.1510.67
78_T109_G1.1500.67
1056_M1134_V1.1480.66
517_S602_L1.1470.66
937_E940_E1.1470.66
15_R1159_R1.1450.66
869_A872_A1.1440.66
431_N498_L1.1440.66
243_N762_E1.1430.66
51_E54_Q1.1420.66
1200_R1222_Y1.1420.66
561_P565_E1.1410.66
892_V896_E1.1400.66
640_V891_L1.1370.66
353_F792_R1.1340.65
1280_D1288_R1.1280.65
29_P123_Q1.1270.65
252_V443_A1.1260.65
1132_L1219_A1.1260.65
430_I473_D1.1250.65
1182_L1255_T1.1250.65
437_V955_V1.1240.65
1209_L1213_E1.1230.65
977_S980_T1.1220.65
357_E463_A1.1210.65
659_S1169_F1.1210.65
815_I882_Y1.1200.64
245_F771_T1.1200.64
873_L878_K1.1170.64
1150_G1154_W1.1160.64
553_L563_F1.1150.64
1052_S1134_V1.1140.64
661_T1089_V1.1130.64
32_N115_E1.1100.64
225_D232_Q1.1090.64
1086_H1128_Q1.1080.64
703_V855_A1.1080.64
694_A723_I1.1070.64
498_L556_A1.1060.63
825_A957_Q1.1060.63
461_S468_A1.1060.63
626_L849_Q1.1040.63
342_I345_F1.1030.63
1217_L1250_E1.1030.63
121_N125_Q1.1010.63
679_N884_D1.0990.63
1063_A1281_G1.0980.63
435_K576_V1.0960.63
287_A685_A1.0960.63
445_N1052_S1.0960.63
27_R30_V1.0960.63
990_W1006_H1.0950.63
529_E591_R1.0940.63
227_V615_D1.0930.63
891_L966_I1.0900.62
959_V962_D1.0890.62
633_I920_L1.0880.62
137_E463_A1.0870.62
274_D422_A1.0820.62
1065_F1284_M1.0790.61
824_N932_R1.0790.61
643_L988_T1.0780.61
679_N726_T1.0770.61
358_R1256_I1.0720.61
274_D277_T1.0710.61
744_A779_M1.0700.61
867_Y870_I1.0700.61
436_L525_F1.0700.61
1028_D1285_R1.0690.61
48_N51_E1.0680.61
240_M243_N1.0680.61
263_M289_I1.0680.61
871_Q875_A1.0650.60
565_E569_R1.0640.60
1223_V1230_T1.0640.60
430_I499_F1.0640.60
637_V974_F1.0620.60
1089_V1132_L1.0620.60
421_R438_V1.0610.60
713_R860_V1.0610.60
437_V574_Y1.0550.60
289_I685_A1.0540.60
438_V461_S1.0540.60
974_F981_L1.0530.60
565_E568_K1.0520.59
1130_L1180_L1.0520.59
302_I1140_M1.0490.59
498_L559_Q1.0470.59
1212_L1218_V1.0460.59
746_H782_K1.0450.59
430_I498_L1.0450.59
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48_N52_H0.5240.22
879_L949_A0.5240.22
865_G942_V0.5240.22
963_R971_Q0.5230.22
598_I1109_S0.5230.22
473_D712_A0.5230.22
81_P956_G0.5230.22
783_T1140_M0.5230.22
463_A990_W0.5230.22
387_G1253_R0.5220.22
1214_S1222_Y0.5220.22
290_L420_I0.5220.22
824_N966_I0.5220.22
392_Y401_G0.5220.22
234_P1004_Q0.5220.22
909_I966_I0.5220.22
260_A503_V0.5220.22
417_I486_D0.5210.22
31_H120_T0.5210.22
128_T131_L0.5210.22
717_G721_T0.5210.22
437_V637_V0.5210.22
661_T1134_V0.5200.22
1089_V1193_A0.5200.22
626_L630_G0.5200.22
998_N1161_T0.5200.22
478_E517_S0.5190.22
648_E1009_K0.5190.22
1177_S1230_T0.5190.22
424_H761_G0.5190.22
342_I991_Q0.5190.22
762_E1269_S0.5190.22
625_A849_Q0.5190.22
691_Y727_Q0.5180.22
260_A468_A0.5180.22
209_F736_L0.5180.22
574_Y1181_L0.5180.22
761_G768_L0.5170.22
663_M811_V0.5170.22
608_K612_M0.5170.22
697_I803_S0.5170.22
357_E460_Q0.5170.22
1092_G1258_M0.5170.22
831_L866_F0.5160.22
741_M748_G0.5160.22
964_F978_R0.5160.22
268_V271_Y0.5160.22
58_L95_A0.5160.22
55_L639_R0.5160.22
183_A611_K0.5160.22
324_R731_I0.5160.22
1075_L1080_T0.5160.22
660_V1089_V0.5150.22
685_A994_R0.5150.22
827_L908_D0.5150.22
751_A804_A0.5150.22
27_R660_V0.5150.22
36_E70_P0.5150.22
239_K754_Y0.5140.22
22_R128_T0.5140.22
718_E997_D0.5140.22
1264_V1277_W0.5140.22
885_R888_G0.5140.22
349_W1163_D0.5130.22
354_G792_R0.5130.22
443_A1158_V0.5130.22
119_L559_Q0.5130.22
733_R1052_S0.5130.22
861_A1077_T0.5120.22
869_A1088_L0.5120.22
1161_T1230_T0.5120.22
42_D387_G0.5120.22
319_E551_Y0.5120.22
398_S406_G0.5120.22
350_E538_S0.5110.22
241_I246_E0.5110.22
560_L564_D0.5110.22
288_H326_A0.5110.22
734_I883_H0.5100.22
694_A737_S0.5100.22
431_N582_E0.5100.22
267_E938_A0.5100.22
694_A890_L0.5100.22
417_I732_K0.5100.22
189_Y899_F0.5090.22
1141_M1246_A0.5090.22
574_Y868_D0.5090.22
680_C744_A0.5090.22
346_E796_S0.5090.22
88_S342_I0.5080.21
437_V1125_H0.5080.21
392_Y697_I0.5080.21
306_P485_I0.5080.21
892_V958_A0.5080.21
983_V1008_A0.5070.21
26_A29_P0.5070.21
227_V602_L0.5070.21
208_M882_Y0.5070.21
302_I783_T0.5070.21
236_S245_F0.5070.21
117_G198_G0.5060.21
473_D584_L0.5060.21
282_F686_S0.5060.21
267_E659_S0.5060.21
39_H1286_I0.5060.21
588_L973_V0.5060.21
33_I558_D0.5060.21
388_Y649_K0.5050.21
34_Y70_P0.5050.21
731_I1182_L0.5050.21
817_P882_Y0.5050.21
475_P496_P0.5050.21
1043_A1283_W0.5050.21
1186_V1190_M0.5050.21
399_H534_E0.5050.21
1043_A1081_G0.5050.21
737_S1194_V0.5050.21
437_V475_P0.5040.21
24_Q732_K0.5040.21
20_L33_I0.5040.21
418_G496_P0.5040.21
585_H796_S0.5030.21
939_V942_V0.5030.21
740_W896_E0.5030.21
860_V864_K0.5030.21
347_Q798_L0.5030.21
872_A944_A0.5030.21
1092_G1196_H0.5030.21
826_L955_V0.5030.21
908_D963_R0.5030.21
229_D236_S0.5030.21
235_K239_K0.5030.21
418_G732_K0.5030.21
97_N1229_V0.5030.21
349_W991_Q0.5020.21
292_K547_S0.5020.21
350_E1126_R0.5020.21
253_L286_P0.5020.21
206_L209_F0.5020.21
31_H118_T0.5010.21
1000_E1183_Q0.5010.21
647_A745_G0.5010.21
681_A695_M0.5010.21
161_V481_C0.5010.21
892_V1054_V0.5010.21
51_E929_I0.5010.21
873_L876_Q0.5000.21
661_T761_G0.5000.21
1232_T1235_A0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3viuA 1 0.5382 100 0.716 Contact Map
1vk3A 1 0.4486 100 0.775 Contact Map
3fd5A 2 0.2394 100 0.947 Contact Map
3d54D 1 0.1629 100 0.948 Contact Map
3u0oA 2 0.2247 100 0.949 Contact Map
2zodA 2 0.2263 100 0.95 Contact Map
2v9yA 2 0.2154 99.9 0.95 Contact Map
3vtiC 2 0.2263 99.9 0.951 Contact Map
2rb9A 2 0.2324 99.9 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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