GREMLIN Database
SRLR - Glucitol operon repressor
UniProt: P15082 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10974
Length: 257 (247)
Sequences: 7681 (5642)
Seq/√Len: 359.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_D168_K3.2811.00
84_A87_S3.0551.00
106_M205_M2.9941.00
137_T144_T2.6921.00
169_L199_A2.5621.00
13_Y28_Y2.3731.00
98_D192_S2.2441.00
227_K250_I2.2181.00
108_P128_A2.2151.00
196_C220_C2.2031.00
208_S231_D2.1981.00
162_E194_A2.1231.00
90_H93_D2.1201.00
203_I227_K2.0681.00
13_Y17_Q2.0621.00
168_K203_I2.0491.00
9_A12_E2.0341.00
83_E109_L1.9961.00
79_E105_Q1.9891.00
196_C202_V1.9561.00
96_I166_F1.9501.00
218_V221_S1.9161.00
97_L103_V1.8851.00
168_K201_E1.8811.00
159_N162_E1.8711.00
234_I239_R1.8521.00
96_I195_M1.8461.00
91_D114_N1.7751.00
105_Q108_P1.7741.00
201_E227_K1.7711.00
239_R243_E1.7671.00
84_A250_I1.7471.00
119_M166_F1.7161.00
85_A170_F1.6451.00
221_S224_S1.6401.00
166_F195_M1.6351.00
159_N163_H1.6211.00
194_A197_N1.6171.00
85_A205_M1.5871.00
140_M152_F1.5801.00
126_V140_M1.5741.00
167_D200_R1.5471.00
141_P160_A1.5471.00
106_M170_F1.5371.00
74_N209_S1.4901.00
31_T36_I1.4781.00
162_E197_N1.4771.00
86_V109_L1.4771.00
182_V204_L1.4761.00
19_K57_V1.4731.00
118_V129_L1.4721.00
182_V225_V1.4621.00
25_L36_I1.4571.00
240_Q244_E1.4471.00
79_E109_L1.4361.00
157_A191_V1.4311.00
7_Q46_A1.4291.00
141_P152_F1.4221.00
74_N77_K1.4211.00
50_I59_N1.4181.00
82_A109_L1.4141.00
15_Q58_L1.4071.00
10_I25_L1.3991.00
13_Y20_C1.3941.00
9_A13_Y1.3871.00
204_L225_V1.3861.00
40_L56_V1.3851.00
194_A198_A1.3831.00
88_F229_I1.3771.00
77_K231_D1.3611.00
8_A12_E1.3591.00
93_D167_D1.3581.00
99_A151_S1.3541.00
17_Q24_E1.3501.00
208_S233_G1.3481.00
88_F203_I1.3451.00
145_F152_F1.3351.00
7_Q42_I1.3271.00
91_D113_F1.3251.00
23_E33_G1.3221.00
111_S132_L1.3171.00
235_D238_F1.3141.00
144_T188_V1.3081.00
118_V136_Q1.3071.00
75_T105_Q1.3031.00
91_D115_N1.2941.00
220_C224_S1.2941.00
52_T55_G1.2921.00
11_L48_T1.2801.00
176_I211_F1.2801.00
92_G115_N1.2641.00
21_S24_E1.2621.00
89_I110_L1.2621.00
79_E108_P1.2501.00
3_P7_Q1.2471.00
84_A88_F1.2451.00
201_E226_D1.2441.00
78_K101_S1.2381.00
9_A28_Y1.2281.00
141_P157_A1.2171.00
236_P240_Q1.2161.00
88_F250_I1.1941.00
117_T139_L1.1921.00
96_I198_A1.1881.00
14_L49_V1.1791.00
9_A29_F1.1781.00
34_T38_K1.1671.00
173_T206_A1.1661.00
75_T79_E1.1621.00
197_N224_S1.1541.00
41_V45_H1.1541.00
240_Q243_E1.1521.00
156_L160_A1.1361.00
77_K208_S1.1341.00
107_V129_L1.1331.00
211_F234_I1.1281.00
117_T137_T1.1261.00
227_K248_D1.1211.00
170_F203_I1.1161.00
17_Q28_Y1.1131.00
11_L14_L1.1101.00
14_L58_L1.1071.00
90_H168_K1.1051.00
76_H79_E1.1041.00
158_E191_V1.1041.00
12_E16_K1.0931.00
173_T219_V1.0921.00
202_V225_V1.0691.00
50_I57_V1.0661.00
49_V56_V1.0421.00
203_I229_I1.0411.00
42_I46_A1.0401.00
139_L144_T1.0361.00
119_M164_F1.0331.00
86_V89_I1.0291.00
85_A106_M1.0261.00
82_A86_V1.0251.00
176_I206_A1.0231.00
22_V40_L1.0191.00
175_G183_T1.0151.00
141_P161_F1.0101.00
67_I101_S1.0041.00
238_F241_A0.9981.00
26_A33_G0.9951.00
89_I170_F0.9901.00
88_F227_K0.9881.00
211_F228_L0.9861.00
77_K81_I0.9791.00
158_E194_A0.9781.00
5_Q9_A0.9701.00
97_L106_M0.9681.00
100_G103_V0.9661.00
156_L164_F0.9571.00
13_Y16_K0.9561.00
86_V106_M0.9451.00
3_P42_I0.9441.00
103_V125_I0.9281.00
173_T204_L0.9251.00
177_D180_A0.9231.00
107_V128_A0.9211.00
169_L195_M0.9211.00
74_N207_D0.9211.00
223_E245_K0.9181.00
124_H150_A0.9111.00
79_E83_E0.9091.00
138_I145_F0.9081.00
41_V44_E0.9071.00
177_D214_K0.9061.00
174_D184_T0.9061.00
81_I102_T0.9041.00
106_M109_L0.9031.00
163_H193_K0.8971.00
20_C56_V0.8961.00
239_R249_V0.8921.00
102_T207_D0.8901.00
20_C25_L0.8901.00
42_I45_H0.8841.00
184_T190_T0.8811.00
78_K210_K0.8781.00
103_V106_M0.8771.00
24_E28_Y0.8741.00
190_T217_N0.8671.00
26_A36_I0.8641.00
156_L163_H0.8631.00
130_S150_A0.8611.00
82_A106_M0.8611.00
82_A105_Q0.8591.00
11_L15_Q0.8541.00
78_K102_T0.8531.00
241_A244_E0.8501.00
122_S125_I0.8491.00
107_V125_I0.8451.00
149_S174_D0.8451.00
165_T200_R0.8431.00
170_F205_M0.8431.00
43_L48_T0.8381.00
200_R214_K0.8291.00
111_S128_A0.8241.00
161_F194_A0.8161.00
164_F187_E0.8071.00
102_T210_K0.8051.00
80_L83_E0.8041.00
5_Q8_A0.8041.00
165_T180_A0.8041.00
187_E217_N0.7971.00
161_F195_M0.7971.00
202_V226_D0.7961.00
165_T218_V0.7921.00
12_E15_Q0.7911.00
103_V205_M0.7861.00
165_T214_K0.7831.00
178_L181_G0.7771.00
85_A229_I0.7761.00
128_A131_E0.7721.00
41_V51_R0.7651.00
127_N150_A0.7611.00
132_L136_Q0.7541.00
180_A214_K0.7531.00
96_I161_F0.7501.00
104_L128_A0.7501.00
24_E27_Q0.7491.00
178_L241_A0.7471.00
183_T214_K0.7471.00
97_L107_V0.7451.00
173_T182_V0.7431.00
165_T198_A0.7411.00
163_H218_V0.7411.00
5_Q19_K0.7391.00
146_R153_H0.7381.00
18_G58_L0.7371.00
70_K174_D0.7361.00
74_N208_S0.7341.00
66_P69_H0.7311.00
196_C219_V0.7261.00
40_L51_R0.7230.99
234_I249_V0.7230.99
76_H80_L0.7190.99
166_F199_A0.7170.99
111_S114_N0.7160.99
7_Q11_L0.7120.99
234_I238_F0.7070.99
182_V219_V0.7050.99
105_Q109_L0.7040.99
101_S210_K0.7040.99
176_I182_V0.7010.99
97_L118_V0.7000.99
206_A228_L0.6990.99
146_R189_Y0.6990.99
126_V145_F0.6970.99
131_E150_A0.6880.99
176_I222_L0.6860.99
95_I118_V0.6860.99
11_L43_L0.6850.99
193_K197_N0.6840.99
99_A149_S0.6810.99
94_S119_M0.6810.99
142_G160_A0.6810.99
23_E27_Q0.6790.99
241_A245_K0.6780.99
81_I205_M0.6750.99
169_L202_V0.6750.99
83_E87_S0.6720.99
52_T57_V0.6720.99
236_P239_R0.6700.99
71_T104_L0.6660.99
184_T189_Y0.6660.99
133_D136_Q0.6660.99
142_G157_A0.6630.99
126_V152_F0.6610.99
154_G157_A0.6610.99
184_T219_V0.6610.99
64_D70_K0.6580.99
80_L84_A0.6570.99
203_I226_D0.6540.99
95_I168_K0.6480.99
162_E198_A0.6470.99
25_L40_L0.6440.99
155_Q159_N0.6420.99
237_A241_A0.6390.99
44_E51_R0.6370.99
31_T34_T0.6360.99
4_R7_Q0.6340.99
164_F217_N0.6320.99
14_L20_C0.6300.99
22_V36_I0.6260.99
44_E49_V0.6250.99
207_D210_K0.6220.98
123_L140_M0.6190.98
89_I106_M0.6190.98
121_N195_M0.6180.98
123_L152_F0.6180.98
6_R39_D0.6170.98
174_D215_S0.6160.98
199_A202_V0.6120.98
29_F36_I0.6080.98
120_T126_V0.6060.98
123_L127_N0.6060.98
34_T122_S0.6000.98
220_C225_V0.5980.98
171_M199_A0.5960.98
157_A160_A0.5940.98
124_H127_N0.5930.98
133_D147_K0.5930.98
208_S234_I0.5920.98
201_E248_D0.5890.98
191_V194_A0.5880.98
146_R186_N0.5870.98
77_K233_G0.5860.98
104_L124_H0.5860.98
119_M216_P0.5840.98
114_N134_N0.5830.98
115_N134_N0.5810.98
238_F242_L0.5800.98
94_S216_P0.5800.98
171_M196_C0.5790.98
71_T105_Q0.5720.97
182_V220_C0.5700.97
80_L232_A0.5700.97
174_D185_F0.5680.97
112_R132_L0.5650.97
156_L159_N0.5640.97
119_M139_L0.5640.97
98_D103_V0.5600.97
115_N137_T0.5590.97
158_E162_E0.5570.97
70_K189_Y0.5520.97
211_F230_T0.5520.97
171_M202_V0.5510.97
171_M219_V0.5510.97
100_G172_G0.5500.97
38_K176_I0.5490.97
175_G213_R0.5490.97
96_I169_L0.5460.97
175_G215_S0.5460.97
95_I170_F0.5450.97
233_G239_R0.5450.97
34_T174_D0.5440.97
192_S219_V0.5420.96
126_V138_I0.5390.96
155_Q188_V0.5380.96
22_V26_A0.5360.96
155_Q158_E0.5360.96
68_D71_T0.5350.96
152_F160_A0.5340.96
211_F238_F0.5300.96
122_S189_Y0.5300.96
172_G184_T0.5240.96
185_F215_S0.5240.96
202_V224_S0.5230.96
236_P243_E0.5230.96
177_D183_T0.5210.96
151_S189_Y0.5190.95
95_I106_M0.5150.95
77_K80_L0.5130.95
243_E248_D0.5120.95
97_L125_I0.5110.95
26_A32_T0.5100.95
212_G238_F0.5100.95
156_L187_E0.5090.95
70_K101_S0.5070.95
96_I119_M0.5050.95
190_T219_V0.5050.95
99_A189_Y0.5050.95
229_I250_I0.5040.95
174_D189_Y0.5030.95
178_L238_F0.5020.95
67_I150_A0.5010.95
174_D192_S0.5010.95
70_K98_D0.5010.95
139_L156_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9416 100 0.512 Contact Map
3rrlB 1 0.6732 100 0.533 Contact Map
2w48A 3 0.9144 100 0.569 Contact Map
3l7oA 2 0.607 100 0.612 Contact Map
2o0mA 1 0.6848 100 0.614 Contact Map
1o8bA 2 0.5953 100 0.625 Contact Map
1lk5A 4 0.6148 100 0.627 Contact Map
1uj6A 2 0.6148 100 0.628 Contact Map
1m0sA 2 0.6187 100 0.63 Contact Map
3uw1A 2 0.6265 100 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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