GREMLIN Database
GUTM - Glucitol operon activator protein
UniProt: P15081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10972
Length: 119 (113)
Sequences: 219 (172)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_Q67_D4.7191.00
57_I86_I4.4681.00
39_R59_L3.6871.00
15_A79_R2.6440.96
34_L75_T2.6020.96
41_G113_A2.2230.91
36_Q50_K2.0050.85
64_R90_H1.9580.84
13_W77_F1.9510.84
52_R80_P1.8050.79
31_F72_K1.7850.78
68_T83_I1.7450.76
13_W28_N1.7250.75
69_L82_K1.6640.73
57_I83_I1.6600.72
47_G78_A1.6490.72
65_I94_L1.6020.70
6_I13_W1.5910.69
30_A69_L1.5720.68
19_L91_A1.5480.67
27_F31_F1.5030.64
45_S48_R1.4630.62
13_W114_L1.4470.61
72_K103_D1.4200.60
20_G44_R1.3960.59
33_T69_L1.3940.58
86_I102_H1.3900.58
25_S29_R1.3810.58
5_L94_L1.3500.56
12_A58_A1.3080.54
95_Q114_L1.3030.53
75_T112_L1.2670.51
27_F44_R1.2660.51
103_D106_S1.2600.51
75_T79_R1.2480.50
24_I49_F1.2060.48
13_W109_A1.1680.45
52_R56_A1.1680.45
93_D97_D1.1580.45
24_I105_L1.1570.45
96_P101_P1.1540.45
45_S53_V1.1240.43
61_D94_L1.0970.41
55_V85_A1.0940.41
45_S72_K1.0880.41
74_L98_V1.0500.39
8_V49_F1.0400.38
40_V47_G1.0360.38
55_V76_V1.0350.38
54_V95_Q1.0290.38
49_F95_Q1.0180.37
66_V76_V1.0180.37
72_K94_L1.0150.37
71_M115_K1.0110.37
109_A114_L1.0060.36
31_F61_D1.0040.36
50_K83_I1.0010.36
12_A16_Q0.9930.36
47_G109_A0.9870.35
8_V14_C0.9860.35
34_L58_A0.9850.35
11_I96_P0.9830.35
8_V54_V0.9770.35
35_C52_R0.9740.35
20_G40_V0.9700.34
39_R57_I0.9580.34
13_W80_P0.9520.33
18_A36_Q0.9480.33
7_T49_F0.9440.33
19_L54_V0.9430.33
25_S100_F0.9240.32
14_C69_L0.9230.32
66_V75_T0.9220.32
45_S112_L0.9220.32
52_R112_L0.8990.31
58_A66_V0.8970.31
13_W76_V0.8900.30
11_I62_Q0.8900.30
58_A61_D0.8900.30
34_L87_T0.8900.30
65_I88_G0.8880.30
68_T87_T0.8880.30
74_L105_L0.8860.30
53_V110_L0.8860.30
22_W72_K0.8850.30
35_C41_G0.8830.30
31_F35_C0.8600.29
14_C20_G0.8600.29
37_Q58_A0.8510.28
41_G114_L0.8240.27
13_W54_V0.8230.27
41_G59_L0.8230.27
54_V63_Q0.8160.27
85_A89_M0.8010.26
54_V114_L0.7970.26
41_G56_A0.7900.26
54_V77_F0.7870.25
67_D82_K0.7850.25
47_G54_V0.7760.25
15_A74_L0.7730.25
29_R36_Q0.7720.25
14_C18_A0.7680.25
18_A103_D0.7550.24
24_I44_R0.7550.24
5_L30_A0.7490.24
56_A112_L0.7330.23
17_L21_G0.7290.23
63_Q91_A0.7130.22
61_D101_P0.7090.22
25_S91_A0.7030.22
9_A22_W0.6960.22
31_F103_D0.6920.21
77_F96_P0.6880.21
28_N80_P0.6880.21
100_F110_L0.6870.21
46_S52_R0.6860.21
15_A57_I0.6850.21
82_K104_P0.6850.21
60_D64_R0.6760.21
17_L28_N0.6690.21
31_F42_V0.6650.20
15_A19_L0.6650.20
14_C108_N0.6610.20
40_V56_A0.6590.20
28_N44_R0.6460.20
3_S10_V0.6400.19
68_T89_M0.6290.19
99_I114_L0.6250.19
36_Q85_A0.6240.19
9_A88_G0.6240.19
27_F51_P0.6200.19
30_A67_D0.6170.19
5_L29_R0.6150.19
80_P114_L0.6150.19
53_V105_L0.6100.18
84_P87_T0.6090.18
4_A29_R0.6080.18
26_R29_R0.6000.18
79_R87_T0.5980.18
68_T108_N0.5940.18
59_L65_I0.5940.18
26_R70_F0.5880.18
38_G54_V0.5850.18
21_G81_Q0.5800.17
61_D88_G0.5800.17
4_A7_T0.5790.17
28_N47_G0.5750.17
26_R30_A0.5660.17
8_V94_L0.5610.17
10_V14_C0.5580.17
30_A71_M0.5540.17
94_L110_L0.5520.16
6_I80_P0.5470.16
84_P102_H0.5430.16
68_T71_M0.5410.16
19_L27_F0.5280.16
6_I10_V0.5280.16
49_F108_N0.5270.16
41_G45_S0.5250.16
9_A63_Q0.5240.16
6_I109_A0.5200.15
58_A104_P0.5190.15
20_G24_I0.5140.15
16_Q83_I0.5120.15
35_C39_R0.5110.15
36_Q107_Q0.5110.15
11_I65_I0.5080.15
3_S101_P0.5040.15
76_V101_P0.5040.15
18_A111_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ixzA 1 0.9328 30.7 0.927 Contact Map
2zxeA 1 0.9664 27.6 0.928 Contact Map
1mhsA 2 0.8992 24.1 0.93 Contact Map
3b8cA 1 0.8908 18.3 0.934 Contact Map
3ukmA 2 0.2689 15.6 0.936 Contact Map
3ewkA 1 0.4622 13.7 0.937 Contact Map
3ar4A 1 0.9832 11.6 0.939 Contact Map
2if6A 1 0.563 11.5 0.939 Contact Map
4i5sA 2 0.7983 8.5 0.943 Contact Map
3a0sA 1 0.4622 8.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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