GREMLIN Database
FLIN - Flagellar motor switch protein FliN
UniProt: P15070 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10324
Length: 137 (119)
Sequences: 1033 (618)
Seq/√Len: 56.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_E70_R3.8161.00
99_I120_V3.6441.00
19_W22_A2.7121.00
67_E94_G2.4851.00
97_L120_V2.4051.00
39_F42_F2.2181.00
19_W23_L2.2051.00
22_A26_Q2.0791.00
99_I122_I2.0371.00
27_K31_S2.0011.00
18_L21_E2.0001.00
37_T42_F1.9421.00
18_L26_Q1.8581.00
64_L101_I1.8150.99
78_L117_K1.7990.99
67_E98_D1.7630.99
19_W25_E1.7340.99
66_V125_I1.7260.99
75_I83_Q1.7110.99
53_D56_L1.6580.99
108_Q124_D1.6150.99
20_A23_L1.5500.98
68_L110_E1.4690.97
65_T82_T1.4670.97
94_G124_D1.4650.97
68_L95_E1.4610.97
132_M136_S1.4340.97
44_G72_R1.4330.97
57_I103_G1.4320.97
24_S27_K1.4280.97
128_P131_R1.4190.97
22_A25_E1.4120.97
19_W26_Q1.3890.96
124_D134_R1.3700.96
105_L108_Q1.3420.95
73_M81_L1.3400.95
108_Q125_I1.3380.95
68_L82_T1.3130.95
18_L25_E1.3040.95
65_T100_L1.2830.94
113_V121_R1.2450.93
91_G104_Y1.2330.93
77_E122_I1.2320.93
81_L85_S1.2130.92
73_M78_L1.1950.92
21_E27_K1.1290.89
56_L117_K1.1230.89
70_R100_L1.1180.89
67_E93_A1.1100.89
80_R122_I1.1080.88
86_V105_L1.1080.88
73_M117_K1.0880.87
91_G127_T1.0880.87
100_L106_I1.0850.87
25_E29_T1.0810.87
112_V119_G1.0690.87
18_L30_S1.0440.85
61_P102_N1.0410.85
76_K93_A1.0390.85
105_L126_I1.0390.85
127_T131_R1.0370.85
31_S46_D1.0310.85
92_L116_D1.0290.84
18_L24_S1.0260.84
100_L117_K1.0240.84
68_L71_T1.0170.84
57_I61_P1.0120.83
66_V82_T0.9980.83
71_T92_L0.9900.82
114_V123_T0.9830.82
57_I62_V0.9740.81
93_A121_R0.9700.81
84_G112_V0.9550.80
31_S44_G0.9500.79
74_T91_G0.9320.78
97_L117_K0.9290.78
74_T136_S0.9120.76
43_G46_D0.9080.76
88_A123_T0.9050.76
62_V91_G0.8870.74
92_L95_E0.8570.72
23_L26_Q0.8480.71
127_T130_E0.8440.71
44_G47_V0.8380.70
20_A25_E0.8360.70
55_D77_E0.8250.69
56_L66_V0.8240.69
85_S93_A0.8060.67
30_S45_G0.8000.67
62_V77_E0.7950.66
28_S31_S0.7930.66
73_M114_V0.7920.66
99_I115_A0.7910.66
82_T97_L0.7830.65
25_E28_S0.7780.64
20_A26_Q0.7750.64
91_G113_V0.7700.64
132_M135_L0.7700.64
24_S44_G0.7690.63
104_Y108_Q0.7690.63
39_F114_V0.7660.63
73_M77_E0.7630.63
21_E28_S0.7620.63
62_V106_I0.7510.62
59_D110_E0.7500.62
93_A124_D0.7480.61
22_A27_K0.7360.60
55_D75_I0.7330.60
54_I90_D0.7320.60
57_I132_M0.7290.59
97_L108_Q0.7270.59
39_F113_V0.7250.59
33_S43_G0.7190.58
98_D108_Q0.7160.58
53_D60_I0.7070.57
107_A120_V0.7030.57
34_A39_F0.6920.55
68_L125_I0.6920.55
23_L28_S0.6910.55
31_S47_V0.6860.55
50_T53_D0.6770.54
129_S133_R0.6740.53
18_L27_K0.6670.53
65_T83_Q0.6630.52
55_D58_M0.6630.52
40_Q97_L0.6600.52
36_E46_D0.6540.51
19_W27_K0.6530.51
32_K40_Q0.6500.51
75_I81_L0.6500.51
45_G48_S0.6470.50
28_S47_V0.6460.50
103_G122_I0.6450.50
81_L103_G0.6450.50
26_Q29_T0.6440.50
57_I75_I0.6310.49
88_A119_G0.6280.48
113_V122_I0.6200.48
69_G109_G0.6110.47
94_G98_D0.6100.46
24_S30_S0.6090.46
105_L124_D0.6080.46
39_F68_L0.6030.46
129_S136_S0.5950.45
96_P120_V0.5890.44
53_D116_D0.5750.43
77_E124_D0.5740.43
102_N105_L0.5670.42
96_P105_L0.5650.42
82_T99_I0.5630.41
24_S29_T0.5600.41
101_I118_Y0.5590.41
99_I125_I0.5590.41
41_Q51_L0.5570.41
31_S41_Q0.5520.40
99_I109_G0.5500.40
40_Q103_G0.5450.40
105_L127_T0.5440.39
20_A24_S0.5430.39
18_L120_V0.5410.39
57_I66_V0.5410.39
34_A37_T0.5410.39
63_K76_K0.5380.39
63_K79_L0.5340.38
65_T121_R0.5310.38
67_E121_R0.5270.38
64_L97_L0.5230.37
21_E30_S0.5230.37
23_L27_K0.5220.37
88_A114_V0.5190.37
22_A49_G0.5190.37
111_V115_A0.5180.37
31_S48_S0.5150.36
21_E25_E0.5130.36
82_T101_I0.5060.36
62_V104_Y0.5050.35
61_P119_G0.5030.35
94_G116_D0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yxcB 1 0.6788 100 0.347 Contact Map
1o6aA 2 0.635 99.9 0.483 Contact Map
3uepA 2 0.6204 99.9 0.508 Contact Map
4yxbD 2 0.5839 99.9 0.518 Contact Map
1o9yA 3 0.5255 99.8 0.527 Contact Map
4tt9A 2 0.5328 99.8 0.536 Contact Map
4yx1A 2 0.5036 99.8 0.567 Contact Map
4yx7A 1 0.4745 29.1 0.928 Contact Map
3bwuD 1 0.5328 17.7 0.935 Contact Map
4b0mA 1 0.4818 14.5 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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