GLGX - ECOLI - GREMLIN Contacts

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GLGX - Glycogen debranching enzyme

UniProt:	P15067	Sequences: MTQLAIGKPAPLGAHYDGQGVNFTLFSAHAERVELCVFDANGQEHRYDLPGHSGDIWHGYLPDARPGLRYGYRVHGPWQPAEGHRFNPAKLLIDPCARQIDGEFKDNPLLHAGHNEPDYRDNAAIAPKCVVVVDHYDWEDDAPPRTPWGSTIIYEAHVKGLTYLHPEIPVEIRGTYKALGHPVMINYLKQLGITALELLPVAQFASEPRLQRMGLSNYWGYNPVAMFALHPAYACSPETALDEFRDAIKALHKAGIEVILDIVLNHSAELDLDGPLFSLRGIDNRSYYWIREDGDYHNWTGCGNTLNLSHPAVVDYASACLRYWVETCHVDGFRFDLAAVMGRTPEFRQDAPLFTAIQNCPVLSQVKLIAEPWDIAPGGYQVGNFPPLFAEWNDHFRDAARRFWLHYDLPLGAFAGRFAASSDVFKRNGRLPSAAINLVTAHDGFTLRDCVCFNHKHNEANGEENRDGTNNNYSNNHGKEGLGGSLDLVERRRDSIHALLTTLLLSQGTPMLLAGDEHGHSQHGNNNAYCQDNQLTWLDWSQASSGLTAFTAALIHLRKRIPALVENRWWEEGDGNVRWLNRYAQPLSTDEWQNGPKQLQILLSDRFLIAINATLEVTEIVLPAGEWHAIPPFAGEDNPVITAVWQGPAHGLCVFQR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10381
Length:	657 (538)
Sequences:	8177 (5472)
Seq/√Len:	235.9

ECOLI - GLGX GLGB MALZ YGAQ SUCP AMY1 TREC
BACSU - PULA GLGB BBMA O16G3 O16G2 TREC O16G1 AMY
SULSO - Q7LX99 TREZ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_K	243_E	4.291	1.00
177_K	246_D	4.191	1.00
250_A	253_K	4.092	1.00
186_N	254_A	4.033	1.00
553_A	638_N	3.980	1.00
49_L	59_G	3.491	1.00
190_Q	552_A	3.438	1.00
189_K	254_A	3.335	1.00
244_F	248_I	3.288	1.00
196_L	251_L	3.151	1.00
519_G	547_L	3.111	1.00
245_R	327_T	3.043	1.00
206_S	217_N	2.855	1.00
138_W	329_H	2.837	1.00
358_Q	389_F	2.804	1.00
314_V	352_P	2.758	1.00
556_H	560_R	2.721	1.00
162_T	183_V	2.654	1.00
505_L	592_W	2.644	1.00
323_Y	328_C	2.584	1.00
500_L	551_T	2.568	1.00
25_L	282_I	2.506	1.00
235_C	243_E	2.490	1.00
250_A	254_A	2.473	1.00
20_G	60_Y	2.441	1.00
440_T	516_D	2.384	1.00
246_D	250_A	2.367	1.00
185_I	254_A	2.274	1.00
576_N	579_W	2.261	1.00
242_D	245_R	2.257	1.00
325_V	366_V	2.254	1.00
198_L	201_V	2.216	1.00
244_F	330_V	2.170	1.00
264_L	320_C	2.156	1.00
156_A	161_L	2.133	1.00
198_L	247_A	2.133	1.00
32_R	48_D	2.074	1.00
21_V	64_A	2.052	1.00
505_L	609_I	2.029	1.00
180_G	246_D	2.018	1.00
47_Y	59_G	2.015	1.00
36_C	91_L	1.997	1.00
150_S	565_V	1.976	1.00
267_S	288_Y	1.974	1.00
533_N	536_T	1.974	1.00
151_T	195_A	1.958	1.00
181_H	250_A	1.953	1.00
315_D	319_A	1.949	1.00
488_L	491_R	1.943	1.00
227_F	320_C	1.909	1.00
177_K	180_G	1.909	1.00
549_A	552_A	1.904	1.00
247_A	251_L	1.897	1.00
243_E	246_D	1.867	1.00
518_H	538_L	1.865	1.00
141_D	329_H	1.859	1.00
64_A	68_L	1.859	1.00
179_L	247_A	1.844	1.00
24_T	58_H	1.837	1.00
101_D	105_K	1.834	1.00
326_E	362_V	1.824	1.00
32_R	75_H	1.815	1.00
34_E	73_R	1.812	1.00
252_H	331_D	1.804	1.00
201_V	244_F	1.798	1.00
34_E	75_H	1.796	1.00
357_I	366_V	1.796	1.00
244_F	247_A	1.776	1.00
14_A	21_V	1.761	1.00
504_L	555_I	1.755	1.00
529_Y	532_D	1.755	1.00
553_A	556_H	1.743	1.00
576_N	581_N	1.741	1.00
557_L	630_I	1.739	1.00
152_I	555_I	1.735	1.00
190_Q	548_T	1.735	1.00
158_V	179_L	1.732	1.00
23_F	72_Y	1.732	1.00
579_W	582_R	1.727	1.00
523_H	531_Q	1.716	1.00
65_R	68_L	1.713	1.00
188_L	196_L	1.713	1.00
629_A	632_P	1.713	1.00
156_A	188_L	1.703	1.00
44_E	73_R	1.697	1.00
249_K	253_K	1.694	1.00
545_S	549_A	1.684	1.00
16_Y	21_V	1.648	1.00
148_W	151_T	1.648	1.00
269_E	297_H	1.643	1.00
323_Y	327_T	1.636	1.00
69_R	101_D	1.632	1.00
33_V	74_V	1.631	1.00
348_R	351_A	1.630	1.00
584_A	587_L	1.624	1.00
73_R	91_L	1.618	1.00
548_T	552_A	1.607	1.00
188_L	256_I	1.598	1.00
25_L	33_V	1.591	1.00
74_V	282_I	1.580	1.00
31_E	77_P	1.576	1.00
180_G	250_A	1.571	1.00
17_D	60_Y	1.561	1.00
241_L	328_C	1.557	1.00
146_T	151_T	1.555	1.00
489_V	521_S	1.545	1.00
34_E	48_D	1.522	1.00
570_W	575_G	1.519	1.00
153_I	437_N	1.516	1.00
537_W	540_W	1.505	1.00
561_I	607_F	1.500	1.00
322_R	356_A	1.495	1.00
306_L	313_V	1.493	1.00
16_Y	66_P	1.493	1.00
25_L	74_V	1.484	1.00
100_I	225_A	1.483	1.00
131_V	249_K	1.483	1.00
291_R	295_D	1.483	1.00
448_R	496_I	1.474	1.00
38_F	68_L	1.473	1.00
202_A	320_C	1.464	1.00
172_I	178_A	1.457	1.00
356_A	359_N	1.451	1.00
578_R	595_G	1.448	1.00
298_N	301_G	1.446	1.00
76_G	90_K	1.440	1.00
93_I	100_I	1.439	1.00
31_E	75_H	1.431	1.00
325_V	357_I	1.429	1.00
553_A	637_D	1.429	1.00
259_I	369_I	1.415	1.00
550_F	633_F	1.404	1.00
561_I	605_D	1.396	1.00
322_R	326_E	1.390	1.00
540_W	543_A	1.390	1.00
161_L	184_M	1.390	1.00
500_L	512_L	1.389	1.00
354_F	358_Q	1.382	1.00
321_L	353_L	1.381	1.00
581_N	591_E	1.379	1.00
203_Q	231_P	1.378	1.00
307_N	310_H	1.364	1.00
34_E	46_R	1.364	1.00
396_F	506_S	1.361	1.00
22_N	60_Y	1.360	1.00
549_A	553_A	1.358	1.00
496_I	519_G	1.349	1.00
156_A	179_L	1.344	1.00
229_L	244_F	1.343	1.00
188_L	192_G	1.338	1.00
412_G	586_P	1.334	1.00
139_E	249_K	1.331	1.00
195_A	259_I	1.330	1.00
36_C	73_R	1.325	1.00
353_L	368_L	1.325	1.00
24_T	56_I	1.325	1.00
156_A	196_L	1.324	1.00
514_A	538_L	1.319	1.00
539_D	542_Q	1.317	1.00
402_R	417_R	1.315	1.00
536_T	540_W	1.313	1.00
159_K	163_Y	1.313	1.00
203_Q	230_H	1.312	1.00
185_I	250_A	1.302	1.00
136_Y	246_D	1.300	1.00
610_A	620_I	1.299	1.00
398_D	402_R	1.291	1.00
97_A	100_I	1.279	1.00
147_P	150_S	1.272	1.00
352_P	356_A	1.269	1.00
593_Q	608_L	1.259	1.00
421_S	506_S	1.259	1.00
46_R	73_R	1.256	1.00
158_V	198_L	1.252	1.00
186_N	190_Q	1.252	1.00
318_S	353_L	1.247	1.00
497_H	550_F	1.247	1.00
355_T	383_G	1.245	1.00
76_G	82_E	1.244	1.00
550_F	554_L	1.239	1.00
404_W	499_L	1.234	1.00
251_L	256_I	1.233	1.00
414_F	417_R	1.232	1.00
21_V	65_R	1.231	1.00
51_G	54_G	1.230	1.00
229_L	324_W	1.227	1.00
100_I	228_A	1.227	1.00
262_I	321_L	1.226	1.00
175_T	178_A	1.221	1.00
413_A	416_G	1.216	1.00
512_L	516_D	1.215	1.00
176_Y	234_A	1.213	1.00
71_G	91_L	1.213	1.00
279_L	316_Y	1.211	1.00
168_I	173_R	1.209	1.00
146_T	195_A	1.206	1.00
22_N	58_H	1.205	1.00
500_L	554_L	1.204	1.00
312_A	315_D	1.203	1.00
151_T	194_T	1.203	1.00
448_R	452_C	1.200	1.00
176_Y	229_L	1.195	1.00
537_W	541_S	1.192	1.00
151_T	367_K	1.191	1.00
170_V	173_R	1.190	1.00
450_C	454_N	1.190	1.00
579_W	584_A	1.186	1.00
535_L	538_L	1.180	1.00
543_A	548_T	1.176	1.00
11_P	24_T	1.175	1.00
422_S	432_P	1.173	1.00
47_Y	61_L	1.173	1.00
352_P	355_T	1.171	1.00
438_L	441_A	1.171	1.00
325_V	363_L	1.171	1.00
576_N	580_L	1.167	1.00
530_C	533_N	1.164	1.00
136_Y	139_E	1.158	1.00
202_A	223_P	1.154	1.00
96_C	288_Y	1.152	1.00
557_L	631_P	1.151	1.00
131_V	134_D	1.151	1.00
552_A	556_H	1.143	1.00
185_I	251_L	1.142	1.00
195_A	257_E	1.139	1.00
497_H	546_G	1.138	1.00
38_F	69_R	1.135	1.00
186_N	189_K	1.135	1.00
197_E	392_W	1.130	1.00
61_L	64_A	1.125	1.00
187_Y	548_T	1.123	1.00
402_R	405_L	1.122	1.00
406_H	410_P	1.119	1.00
354_F	368_L	1.117	1.00
588_S	614_T	1.116	1.00
581_N	584_A	1.115	1.00
493_R	497_H	1.110	1.00
550_F	631_P	1.110	1.00
12_L	56_I	1.107	1.00
201_V	260_L	1.107	1.00
578_R	582_R	1.105	1.00
35_L	59_G	1.105	1.00
191_L	548_T	1.104	1.00
591_E	594_N	1.102	1.00
412_G	415_A	1.102	1.00
168_I	172_I	1.101	1.00
179_L	198_L	1.098	1.00
400_A	499_L	1.089	1.00
99_Q	111_H	1.086	1.00
353_L	357_I	1.086	1.00
411_L	414_F	1.081	1.00
578_R	581_N	1.081	1.00
153_I	436_I	1.075	1.00
296_Y	301_G	1.071	1.00
400_A	502_T	1.069	1.00
308_L	317_A	1.067	1.00
501_T	550_F	1.062	1.00
184_M	187_Y	1.058	1.00
227_F	319_A	1.054	1.00
305_T	340_V	1.050	1.00
452_C	500_L	1.049	1.00
169_P	172_I	1.048	1.00
26_F	312_A	1.046	1.00
350_D	354_F	1.044	1.00
181_H	186_N	1.043	1.00
146_T	150_S	1.035	1.00
161_L	179_L	1.033	1.00
504_L	512_L	1.032	1.00
399_A	413_A	1.032	1.00
440_T	499_L	1.031	1.00
622_L	627_W	1.030	1.00
322_R	363_L	1.030	1.00
244_F	260_L	1.030	1.00
140_D	329_H	1.029	1.00
12_L	24_T	1.029	1.00
152_I	559_K	1.026	1.00
229_L	323_Y	1.025	1.00
14_A	23_F	1.025	1.00
491_R	495_S	1.020	1.00
555_I	559_K	1.017	1.00
244_F	328_C	1.017	1.00
436_I	510_P	1.014	1.00
529_Y	533_N	1.013	1.00
156_A	514_A	1.011	1.00
169_P	181_H	1.007	1.00
417_R	423_D	1.006	1.00
139_E	142_A	1.003	1.00
512_L	551_T	1.002	1.00
93_I	97_A	1.002	1.00
493_R	496_I	0.997	1.00
403_F	406_H	0.995	1.00
177_K	181_H	0.990	1.00
383_G	386_P	0.985	1.00
227_F	316_Y	0.982	1.00
37_V	47_Y	0.982	1.00
159_K	233_Y	0.981	1.00
536_T	539_D	0.976	1.00
498_A	611_I	0.975	1.00
29_H	285_R	0.974	1.00
297_H	302_C	0.973	1.00
160_G	218_Y	0.965	1.00
280_R	304_N	0.961	1.00
545_S	548_T	0.961	1.00
11_P	22_N	0.959	1.00
147_P	151_T	0.959	1.00
535_L	540_W	0.959	1.00
226_M	316_Y	0.959	1.00
225_A	228_A	0.958	1.00
50_P	58_H	0.957	1.00
295_D	344_T	0.955	1.00
206_S	222_N	0.952	1.00
322_R	362_V	0.949	1.00
161_L	187_Y	0.947	1.00
179_L	251_L	0.945	1.00
393_N	435_A	0.943	1.00
33_V	282_I	0.943	1.00
148_W	390_A	0.941	1.00
94_D	97_A	0.940	1.00
573_G	579_W	0.940	1.00
321_L	333_F	0.937	1.00
547_L	550_F	0.936	1.00
378_G	381_Q	0.935	1.00
563_A	607_F	0.935	1.00
576_N	582_R	0.935	1.00
411_L	420_A	0.934	1.00
348_R	352_P	0.934	1.00
68_L	110_L	0.932	1.00
357_I	368_L	0.930	1.00
534_Q	537_W	0.929	1.00
158_V	176_Y	0.929	1.00
589_T	593_Q	0.928	1.00
17_D	22_N	0.926	1.00
181_H	246_D	0.924	1.00
557_L	561_I	0.919	1.00
298_N	340_V	0.919	1.00
535_L	543_A	0.919	1.00
531_Q	535_L	0.911	1.00
532_D	535_L	0.909	1.00
279_L	282_I	0.908	1.00
162_T	174_G	0.907	1.00
103_E	207_E	0.904	1.00
223_P	226_M	0.904	1.00
290_I	295_D	0.903	1.00
23_F	35_L	0.902	1.00
407_Y	410_P	0.901	1.00
318_S	322_R	0.900	1.00
226_M	306_L	0.900	1.00
416_G	420_A	0.900	1.00
39_D	42_G	0.900	1.00
97_A	107_N	0.898	1.00
326_E	363_L	0.896	1.00
522_Q	539_D	0.894	0.99
28_A	55_D	0.889	0.99
260_L	330_V	0.888	0.99
577_V	582_R	0.887	0.99
29_H	283_D	0.886	0.99
493_R	546_G	0.885	0.99
530_C	536_T	0.885	0.99
546_G	549_A	0.884	0.99
497_H	547_L	0.884	0.99
172_I	181_H	0.883	0.99
607_F	630_I	0.881	0.99
415_A	420_A	0.881	0.99
291_R	297_H	0.880	0.99
532_D	537_W	0.879	0.99
494_D	497_H	0.877	0.99
501_T	611_I	0.875	0.99
137_D	249_K	0.874	0.99
202_A	260_L	0.872	0.99
129_C	132_V	0.872	0.99
39_D	43_Q	0.872	0.99
15_H	98_R	0.870	0.99
489_V	492_R	0.870	0.99
573_G	576_N	0.870	0.99
564_L	607_F	0.869	0.99
285_R	290_I	0.868	0.99
136_Y	329_H	0.866	0.99
495_S	498_A	0.866	0.99
152_I	504_L	0.866	0.99
500_L	516_D	0.863	0.99
220_G	233_Y	0.860	0.99
419_A	422_S	0.855	0.99
406_H	417_R	0.854	0.99
549_A	637_D	0.853	0.99
417_R	420_A	0.852	0.99
76_G	84_H	0.851	0.99
414_F	420_A	0.851	0.99
548_T	551_T	0.851	0.99
167_E	170_V	0.848	0.99
580_L	608_L	0.847	0.99
629_A	635_G	0.847	0.99
311_P	315_D	0.843	0.99
627_W	630_I	0.841	0.99
37_V	42_G	0.840	0.99
351_A	355_T	0.838	0.99
489_V	493_R	0.836	0.99
162_T	184_M	0.835	0.99
134_D	138_W	0.835	0.99
188_L	193_I	0.834	0.99
290_I	296_Y	0.833	0.99
537_W	543_A	0.833	0.99
64_A	110_L	0.832	0.99
14_A	72_Y	0.831	0.99
251_L	258_V	0.831	0.99
523_H	535_L	0.831	0.99
296_Y	300_T	0.830	0.99
50_P	59_G	0.830	0.99
500_L	547_L	0.830	0.99
381_Q	385_F	0.829	0.99
505_L	611_I	0.829	0.99
98_R	323_Y	0.828	0.99
381_Q	384_N	0.828	0.99
411_L	419_A	0.827	0.99
36_C	46_R	0.827	0.99
140_D	143_P	0.826	0.99
138_W	141_D	0.826	0.99
202_A	330_V	0.826	0.99
66_P	111_H	0.826	0.99
18_G	60_Y	0.825	0.99
501_T	633_F	0.822	0.99
493_R	547_L	0.821	0.99
539_D	543_A	0.819	0.99
135_H	138_W	0.818	0.99
298_N	305_T	0.818	0.99
349_Q	353_L	0.818	0.99
576_N	584_A	0.813	0.99
532_D	540_W	0.805	0.99
300_T	340_V	0.805	0.99
174_G	183_V	0.803	0.99
412_G	416_G	0.802	0.99
84_H	285_R	0.802	0.99
180_G	243_E	0.800	0.99
577_V	580_L	0.798	0.99
246_D	249_K	0.796	0.99
318_S	356_A	0.794	0.99
242_D	246_D	0.787	0.99
146_T	149_G	0.784	0.99
575_G	579_W	0.782	0.99
355_T	359_N	0.782	0.99
130_V	242_D	0.781	0.99
320_C	323_Y	0.781	0.99
300_T	303_G	0.780	0.99
579_W	583_Y	0.778	0.99
259_I	332_G	0.777	0.99
53_S	58_H	0.777	0.99
227_F	323_Y	0.777	0.99
136_Y	249_K	0.775	0.99
496_I	547_L	0.772	0.99
534_Q	540_W	0.769	0.98
581_N	585_Q	0.768	0.98
139_E	253_K	0.765	0.98
414_F	421_S	0.759	0.98
281_G	286_S	0.757	0.98
402_R	407_Y	0.755	0.98
21_V	110_L	0.755	0.98
98_R	327_T	0.752	0.98
538_L	543_A	0.748	0.98
168_I	178_A	0.748	0.98
589_T	592_W	0.747	0.98
418_F	590_D	0.744	0.98
411_L	421_S	0.743	0.98
414_F	611_I	0.741	0.98
321_L	335_F	0.741	0.98
176_Y	247_A	0.741	0.98
141_D	249_K	0.739	0.98
382_V	425_F	0.738	0.98
194_T	256_I	0.738	0.98
518_H	548_T	0.735	0.98
416_G	419_A	0.734	0.98
371_E	442_H	0.734	0.98
40_A	47_Y	0.734	0.98
37_V	68_L	0.732	0.98
410_P	413_A	0.731	0.98
156_A	184_M	0.731	0.98
157_H	199_L	0.728	0.98
448_R	519_G	0.725	0.98
413_A	417_R	0.724	0.98
567_N	570_W	0.723	0.98
592_W	595_G	0.723	0.98
355_T	384_N	0.721	0.98
279_L	284_N	0.721	0.98
248_I	330_V	0.720	0.98
187_Y	518_H	0.719	0.98
186_N	250_A	0.718	0.98
505_L	557_L	0.718	0.98
191_L	555_I	0.717	0.98
523_H	529_Y	0.716	0.98
35_L	61_L	0.714	0.98
158_V	201_V	0.714	0.98
618_T	621_V	0.712	0.97
286_S	289_W	0.711	0.97
523_H	530_C	0.707	0.97
152_I	193_I	0.706	0.97
441_A	511_M	0.703	0.97
608_L	622_L	0.702	0.97
133_V	136_Y	0.701	0.97
96_C	319_A	0.696	0.97
52_H	58_H	0.696	0.97
241_L	323_Y	0.696	0.97
172_I	177_K	0.695	0.97
305_T	308_L	0.694	0.97
70_Y	75_H	0.694	0.97
522_Q	536_T	0.693	0.97
540_W	544_S	0.693	0.97
501_T	505_L	0.692	0.97
37_V	40_A	0.691	0.97
69_R	107_N	0.690	0.97
325_V	333_F	0.690	0.97
405_L	450_C	0.687	0.97
72_Y	75_H	0.687	0.97
590_D	594_N	0.685	0.97
63_D	66_P	0.685	0.97
134_D	253_K	0.684	0.97
194_T	559_K	0.684	0.97
496_I	500_L	0.681	0.97
531_Q	536_T	0.681	0.97
404_W	613_A	0.681	0.97
580_L	584_A	0.680	0.97
529_Y	537_W	0.678	0.97
134_D	249_K	0.678	0.97
267_S	306_L	0.677	0.97
27_S	30_A	0.677	0.97
441_A	444_G	0.674	0.96
448_R	451_V	0.672	0.96
75_H	85_R	0.671	0.96
204_F	207_E	0.671	0.96
453_F	521_S	0.671	0.96
101_D	108_P	0.670	0.96
168_I	171_E	0.666	0.96
378_G	385_F	0.665	0.96
396_F	400_A	0.665	0.96
193_I	256_I	0.665	0.96
136_Y	140_D	0.665	0.96
416_G	423_D	0.664	0.96
92_L	95_P	0.664	0.96
141_D	255_G	0.664	0.96
393_N	437_N	0.662	0.96
575_G	578_R	0.662	0.96
84_H	90_K	0.662	0.96
440_T	452_C	0.660	0.96
140_D	253_K	0.660	0.96
608_L	627_W	0.659	0.96
297_H	300_T	0.659	0.96
529_Y	534_Q	0.657	0.96
590_D	593_Q	0.657	0.96
538_L	542_Q	0.657	0.96
359_N	362_V	0.656	0.96
11_P	15_H	0.656	0.96
311_P	314_V	0.655	0.96
141_D	144_P	0.655	0.96
188_L	251_L	0.654	0.96
245_R	328_C	0.653	0.96
103_E	173_R	0.650	0.96
415_A	419_A	0.650	0.96
297_H	301_G	0.649	0.96
77_P	83_G	0.649	0.96
153_I	259_I	0.648	0.96
266_H	336_D	0.645	0.96
131_V	135_H	0.643	0.95
15_H	22_N	0.642	0.95
392_W	511_M	0.641	0.95
43_Q	46_R	0.640	0.95
284_N	287_Y	0.638	0.95
453_F	519_G	0.637	0.95
338_A	370_A	0.637	0.95
531_Q	534_Q	0.636	0.95
403_F	613_A	0.635	0.95
36_C	71_G	0.635	0.95
12_L	96_C	0.635	0.95
52_H	55_D	0.635	0.95
176_Y	243_E	0.635	0.95
161_L	540_W	0.634	0.95
632_P	635_G	0.634	0.95
529_Y	536_T	0.634	0.95
249_K	329_H	0.634	0.95
174_G	178_A	0.633	0.95
336_D	371_E	0.633	0.95
196_L	258_V	0.633	0.95
137_D	140_D	0.633	0.95
439_V	499_L	0.631	0.95
280_R	285_R	0.631	0.95
502_T	611_I	0.630	0.95
193_I	517_E	0.630	0.95
155_E	199_L	0.629	0.95
223_P	320_C	0.629	0.95
150_S	559_K	0.629	0.95
40_A	43_Q	0.627	0.95
245_R	323_Y	0.627	0.95
335_F	368_L	0.626	0.95
317_A	341_M	0.626	0.95
140_D	249_K	0.625	0.95
499_L	502_T	0.625	0.95
204_F	223_P	0.624	0.95
298_N	302_C	0.620	0.94
453_F	456_K	0.620	0.94
291_R	294_G	0.619	0.94
94_D	103_E	0.619	0.94
299_W	302_C	0.619	0.94
411_L	415_A	0.617	0.94
154_Y	517_E	0.616	0.94
367_K	389_F	0.615	0.94
336_D	443_D	0.614	0.94
348_R	355_T	0.613	0.94
414_F	418_F	0.613	0.94
574_D	577_V	0.613	0.94
318_S	352_P	0.611	0.94
27_S	55_D	0.611	0.94
230_H	233_Y	0.611	0.94
167_E	171_E	0.609	0.94
541_S	544_S	0.609	0.94
284_N	289_W	0.609	0.94
580_L	583_Y	0.608	0.94
48_D	57_W	0.607	0.94
32_R	73_R	0.607	0.94
529_Y	540_W	0.607	0.94
436_I	443_D	0.606	0.94
415_A	418_F	0.606	0.94
532_D	538_L	0.606	0.94
490_E	494_D	0.604	0.94
349_Q	354_F	0.604	0.94
183_V	186_N	0.603	0.94
588_S	591_E	0.602	0.94
414_F	419_A	0.602	0.94
417_R	421_S	0.601	0.93
168_I	183_V	0.600	0.93
99_Q	241_L	0.600	0.93
492_R	521_S	0.600	0.93
157_H	233_Y	0.598	0.93
296_Y	299_W	0.598	0.93
554_L	631_P	0.597	0.93
292_E	295_D	0.596	0.93
618_T	622_L	0.596	0.93
73_R	85_R	0.596	0.93
411_L	416_G	0.596	0.93
94_D	99_Q	0.596	0.93
192_G	556_H	0.594	0.93
556_H	559_K	0.593	0.93
520_H	536_T	0.593	0.93
447_L	451_V	0.592	0.93
252_H	258_V	0.591	0.93
205_A	224_V	0.589	0.93
92_L	282_I	0.588	0.93
172_I	175_T	0.588	0.93
574_D	582_R	0.587	0.93
179_L	196_L	0.587	0.93
421_S	425_F	0.587	0.93
532_D	536_T	0.587	0.93
367_K	390_A	0.587	0.93
306_L	316_Y	0.586	0.93
141_D	145_R	0.586	0.93
99_Q	102_G	0.585	0.93
561_I	565_V	0.585	0.93
415_A	421_S	0.584	0.93
281_G	284_N	0.584	0.93
133_V	245_R	0.583	0.92
177_K	235_C	0.583	0.92
440_T	444_G	0.583	0.92
16_Y	19_Q	0.582	0.92
412_G	420_A	0.581	0.92
286_S	310_H	0.580	0.92
416_G	421_S	0.579	0.92
185_I	189_K	0.579	0.92
582_R	585_Q	0.578	0.92
286_S	291_R	0.578	0.92
36_C	44_E	0.577	0.92
518_H	543_A	0.576	0.92
10_A	327_T	0.576	0.92
422_S	426_K	0.576	0.92
593_Q	606_R	0.573	0.92
283_D	289_W	0.573	0.92
298_N	308_L	0.572	0.92
410_P	414_F	0.570	0.92
257_E	367_K	0.568	0.91
316_Y	320_C	0.567	0.91
369_I	511_M	0.567	0.91
279_L	283_D	0.566	0.91
582_R	586_P	0.566	0.91
66_P	112_A	0.566	0.91
23_F	61_L	0.565	0.91
199_L	514_A	0.565	0.91
227_F	264_L	0.565	0.91
251_L	254_A	0.565	0.91
501_T	554_L	0.563	0.91
529_Y	535_L	0.562	0.91
394_D	397_R	0.560	0.91
373_W	397_R	0.558	0.91
551_T	554_L	0.557	0.91
129_C	133_V	0.556	0.91
334_R	443_D	0.556	0.91
513_L	520_H	0.555	0.91
72_Y	96_C	0.555	0.91
204_F	233_Y	0.553	0.90
533_N	537_W	0.552	0.90
135_H	329_H	0.551	0.90
298_N	303_G	0.551	0.90
217_N	535_L	0.550	0.90
43_Q	47_Y	0.549	0.90
94_D	100_I	0.548	0.90
27_S	283_D	0.548	0.90
413_A	422_S	0.548	0.90
618_T	623_P	0.547	0.90
413_A	420_A	0.546	0.90
502_T	613_A	0.546	0.90
321_L	357_I	0.546	0.90
72_Y	76_G	0.545	0.90
299_W	305_T	0.545	0.90
402_R	410_P	0.544	0.90
95_P	98_R	0.544	0.90
30_A	283_D	0.544	0.90
169_P	173_R	0.544	0.90
207_E	268_A	0.544	0.90
93_I	107_N	0.544	0.90
190_Q	543_A	0.543	0.90
269_E	302_C	0.543	0.90
589_T	594_N	0.543	0.90
203_Q	228_A	0.543	0.90
493_R	519_G	0.542	0.89
418_F	421_S	0.542	0.89
189_K	255_G	0.541	0.89
290_I	294_G	0.539	0.89
306_L	341_M	0.538	0.89
33_V	49_L	0.537	0.89
28_A	286_S	0.537	0.89
228_A	241_L	0.537	0.89
406_H	414_F	0.537	0.89
69_R	72_Y	0.536	0.89
224_V	268_A	0.535	0.89
582_R	590_D	0.535	0.89
436_I	442_H	0.535	0.89
132_V	137_D	0.535	0.89
187_Y	543_A	0.534	0.89
382_V	385_F	0.534	0.89
418_F	502_T	0.534	0.89
66_P	130_V	0.534	0.89
536_T	542_Q	0.534	0.89
131_V	138_W	0.534	0.89
520_H	538_L	0.533	0.89
261_D	334_R	0.533	0.89
51_G	58_H	0.533	0.89
537_W	542_Q	0.533	0.89
265_N	337_L	0.533	0.89
521_S	542_Q	0.532	0.89
614_T	618_T	0.532	0.89
26_F	310_H	0.531	0.89
440_T	446_T	0.530	0.88
100_I	203_Q	0.530	0.88
266_H	334_R	0.530	0.88
487_D	490_E	0.530	0.88
181_H	184_M	0.529	0.88
156_A	198_L	0.529	0.88
354_F	388_L	0.529	0.88
552_A	555_I	0.528	0.88
142_A	145_R	0.527	0.88
402_R	406_H	0.527	0.88
413_A	421_S	0.526	0.88
296_Y	302_C	0.526	0.88
498_A	613_A	0.525	0.88
436_I	440_T	0.525	0.88
168_I	184_M	0.524	0.88
629_A	633_F	0.524	0.88
203_Q	232_A	0.523	0.88
249_K	252_H	0.523	0.88
222_N	268_A	0.523	0.88
35_L	72_Y	0.523	0.88
409_L	413_A	0.523	0.88
206_S	232_A	0.522	0.88
354_F	357_I	0.522	0.88
38_F	42_G	0.520	0.87
454_N	492_R	0.520	0.87
358_Q	388_L	0.519	0.87
108_P	112_A	0.517	0.87
419_A	423_D	0.517	0.87
573_G	578_R	0.516	0.87
593_Q	612_N	0.515	0.87
487_D	491_R	0.514	0.87
133_V	138_W	0.513	0.87
314_V	318_S	0.513	0.87
379_G	382_V	0.513	0.87
339_A	374_D	0.513	0.87
295_D	307_N	0.512	0.87
553_A	631_P	0.511	0.87
579_W	592_W	0.511	0.87
189_K	256_I	0.510	0.86
284_N	290_I	0.510	0.86
138_W	142_A	0.510	0.86
314_V	348_R	0.509	0.86
49_L	72_Y	0.507	0.86
68_L	72_Y	0.506	0.86
135_H	139_E	0.506	0.86
60_Y	63_D	0.506	0.86
217_N	534_Q	0.506	0.86
592_W	611_I	0.505	0.86
189_K	559_K	0.505	0.86
551_T	555_I	0.505	0.86
161_L	188_L	0.504	0.86
266_H	442_H	0.504	0.86
33_V	72_Y	0.504	0.86
190_Q	549_A	0.503	0.86
261_D	336_D	0.503	0.86
415_A	422_S	0.503	0.86
93_I	108_P	0.502	0.86
344_T	352_P	0.502	0.86
575_G	586_P	0.502	0.86
414_F	425_F	0.502	0.86
278_S	281_G	0.501	0.86
264_L	317_A	0.500	0.85
531_Q	537_W	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wskA	1	0.9909	100	0.252	Contact Map
2vr5A	5	0.997	100	0.256	Contact Map
4j7rA	2	0.9802	100	0.261	Contact Map
1bf2A	1	0.9741	100	0.269	Contact Map
3wdhA	1	0.8721	100	0.317	Contact Map
2wanA	1	0.8767	100	0.322	Contact Map
2e8yA	1	0.8828	100	0.324	Contact Map
4j3vA	1	0.9148	100	0.348	Contact Map
2fhfA	1	0.9148	100	0.351	Contact Map
3k1dA	1	0.8356	100	0.362	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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