DNLJ - ECOLI - GREMLIN Contacts

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DNLJ - DNA ligase

UniProt:	P15042	Sequences: MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKNNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPAPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDEAEMLRLLGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10534
Length:	671 (655)
Sequences:	4363 (2849)
Seq/√Len:	111.3

ECOLI - DNLJ LIGB
BACSU - DNLJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_Q	41_E	5.937	1.00
621_L	626_A	4.417	1.00
325_R	344_E	4.405	1.00
661_D	664_E	4.124	1.00
18_H	30_I	3.709	1.00
475_F	503_A	3.382	1.00
95_N	110_W	3.351	1.00
526_A	622_V	3.265	1.00
133_A	149_V	3.234	1.00
109_T	292_N	3.177	1.00
17_H	21_L	3.130	1.00
21_L	29_E	3.122	1.00
542_S	545_E	3.089	1.00
601_K	637_D	3.022	1.00
336_A	423_V	3.015	1.00
258_T	272_K	2.988	1.00
363_E	366_R	2.951	1.00
476_K	575_E	2.878	1.00
20_Y	25_M	2.870	1.00
323_F	344_E	2.812	1.00
4_I	49_H	2.773	1.00
323_F	374_K	2.770	1.00
17_H	29_E	2.717	1.00
478_T	481_K	2.714	1.00
129_V	158_K	2.675	1.00
396_P	399_T	2.557	1.00
272_K	276_D	2.522	1.00
337_I	415_V	2.508	1.00
85_V	311_V	2.498	1.00
494_Q	498_N	2.432	1.00
327_V	402_V	2.421	1.00
8_L	45_L	2.421	1.00
536_E	577_L	2.370	1.00
326_D	371_I	2.335	1.00
501_E	504_K	2.263	1.00
95_N	99_Q	2.260	1.00
543_I	558_S	2.230	1.00
535_L	583_W	2.228	1.00
20_Y	24_V	2.224	1.00
53_I	60_Q	2.204	1.00
328_E	342_R	2.200	1.00
650_A	654_E	2.196	1.00
238_T	292_N	2.195	1.00
44_E	48_K	2.186	1.00
127_N	166_A	2.186	1.00
14_T	18_H	2.170	1.00
126_E	131_V	2.167	1.00
126_E	167_R	2.157	1.00
18_H	21_L	2.153	1.00
319_E	378_R	2.151	1.00
476_K	579_E	2.147	1.00
262_S	265_E	2.147	1.00
361_A	365_E	2.129	1.00
539_E	570_R	2.121	1.00
7_Q	10_E	2.106	1.00
574_S	578_A	2.077	1.00
539_E	574_S	2.073	1.00
10_E	14_T	2.058	1.00
130_L	149_V	2.055	1.00
370_R	401_E	2.020	1.00
649_L	653_Q	2.015	1.00
92_L	264_E	2.013	1.00
449_M	475_F	2.010	1.00
650_A	653_Q	2.004	1.00
470_T	575_E	2.002	1.00
479_A	497_V	1.953	1.00
179_A	281_G	1.953	1.00
121_V	145_I	1.936	1.00
638_L	660_I	1.912	1.00
351_V	379_R	1.911	1.00
561_H	565_A	1.907	1.00
196_F	202_A	1.875	1.00
413_S	427_T	1.872	1.00
8_L	12_R	1.869	1.00
603_V	638_L	1.867	1.00
342_R	355_N	1.866	1.00
15_L	19_E	1.863	1.00
610_S	643_E	1.853	1.00
189_R	195_V	1.833	1.00
237_D	241_G	1.833	1.00
177_P	180_G	1.826	1.00
240_L	259_L	1.815	1.00
5_E	9_T	1.805	1.00
641_A	659_V	1.800	1.00
178_Q	283_D	1.797	1.00
245_Q	249_W	1.786	1.00
259_L	292_N	1.785	1.00
12_R	54_T	1.783	1.00
8_L	52_L	1.776	1.00
96_K	100_D	1.771	1.00
43_R	59_T	1.767	1.00
71_S	144_D	1.757	1.00
124_L	132_S	1.745	1.00
18_H	38_L	1.740	1.00
351_V	383_V	1.736	1.00
109_T	261_E	1.729	1.00
240_L	244_L	1.727	1.00
276_D	279_T	1.726	1.00
260_C	265_E	1.704	1.00
641_A	645_A	1.702	1.00
437_K	460_D	1.702	1.00
197_A	347_H	1.699	1.00
88_E	271_H	1.697	1.00
180_G	219_P	1.691	1.00
447_R	522_E	1.691	1.00
154_A	221_T	1.687	1.00
407_H	414_D	1.683	1.00
378_R	386_Q	1.682	1.00
605_L	621_L	1.677	1.00
40_R	43_R	1.660	1.00
376_V	389_N	1.649	1.00
641_A	649_L	1.645	1.00
645_A	649_L	1.637	1.00
123_I	155_I	1.630	1.00
88_E	267_L	1.623	1.00
82_L	310_A	1.622	1.00
329_F	402_V	1.620	1.00
596_S	599_A	1.615	1.00
240_L	292_N	1.615	1.00
454_M	496_V	1.613	1.00
329_F	337_I	1.607	1.00
605_L	617_A	1.597	1.00
377_I	387_V	1.590	1.00
93_A	96_K	1.587	1.00
438_E	441_K	1.585	1.00
266_V	289_I	1.577	1.00
374_K	394_E	1.564	1.00
150_R	157_L	1.556	1.00
73_I	132_S	1.551	1.00
611_Q	666_L	1.546	1.00
40_R	90_S	1.542	1.00
615_D	618_K	1.533	1.00
326_D	342_R	1.530	1.00
663_A	667_R	1.529	1.00
379_R	383_V	1.527	1.00
188_A	193_G	1.527	1.00
214_I	217_K	1.523	1.00
330_Q	340_V	1.523	1.00
206_S	215_T	1.504	1.00
519_E	559_H	1.503	1.00
254_S	282_F	1.501	1.00
612_M	666_L	1.500	1.00
293_S	296_Q	1.499	1.00
72_Q	450_D	1.496	1.00
658_E	664_E	1.494	1.00
31_P	34_E	1.491	1.00
343_L	375_V	1.490	1.00
221_T	252_P	1.485	1.00
618_K	622_V	1.481	1.00
479_A	494_Q	1.479	1.00
321_M	394_E	1.478	1.00
124_L	167_R	1.477	1.00
74_R	141_T	1.476	1.00
149_V	174_V	1.475	1.00
16_R	19_E	1.472	1.00
370_R	399_T	1.470	1.00
440_L	459_I	1.469	1.00
620_R	624_L	1.466	1.00
520_V	556_V	1.465	1.00
21_L	25_M	1.460	1.00
611_Q	663_A	1.459	1.00
524_T	556_V	1.454	1.00
116_L	175_F	1.449	1.00
98_V	291_V	1.441	1.00
83_D	306_A	1.439	1.00
543_I	561_H	1.422	1.00
604_V	636_T	1.412	1.00
39_M	43_R	1.411	1.00
527_G	549_V	1.406	1.00
649_L	659_V	1.404	1.00
365_E	401_E	1.402	1.00
85_V	90_S	1.400	1.00
442_H	513_Y	1.399	1.00
361_A	404_F	1.398	1.00
620_R	623_E	1.395	1.00
493_A	497_V	1.393	1.00
264_E	268_A	1.387	1.00
182_E	186_E	1.383	1.00
61_R	157_L	1.380	1.00
8_L	42_L	1.376	1.00
505_E	582_H	1.371	1.00
534_T	537_A	1.369	1.00
121_V	149_V	1.367	1.00
21_L	27_A	1.365	1.00
567_E	571_N	1.365	1.00
491_K	495_N	1.364	1.00
619_A	623_E	1.363	1.00
602_T	627_K	1.361	1.00
92_L	263_A	1.359	1.00
321_M	374_K	1.350	1.00
92_L	267_L	1.347	1.00
149_V	152_I	1.343	1.00
241_G	244_L	1.332	1.00
539_E	564_F	1.328	1.00
88_E	92_L	1.326	1.00
176_L	184_I	1.323	1.00
458_I	488_M	1.322	1.00
116_L	223_F	1.321	1.00
187_D	217_K	1.318	1.00
237_D	293_S	1.317	1.00
175_F	221_T	1.317	1.00
605_L	639_V	1.314	0.99
543_I	547_Q	1.314	0.99
508_F	529_A	1.306	0.99
8_L	59_T	1.301	0.99
43_R	47_T	1.297	0.99
21_L	30_I	1.295	0.99
490_P	494_Q	1.294	0.99
268_A	271_H	1.293	0.99
40_R	44_E	1.290	0.99
267_L	271_H	1.289	0.99
449_M	503_A	1.288	0.99
403_V	406_T	1.287	0.99
539_E	573_I	1.281	0.99
601_K	658_E	1.274	0.99
186_E	190_R	1.271	0.99
527_G	551_D	1.268	0.99
72_Q	141_T	1.267	0.99
121_V	222_F	1.266	0.99
245_Q	248_K	1.266	0.99
406_T	414_D	1.263	0.99
74_R	140_T	1.261	0.99
261_E	265_E	1.257	0.99
597_P	624_L	1.255	0.99
367_L	386_Q	1.252	0.99
187_D	191_T	1.250	0.99
460_D	464_E	1.250	0.99
87_D	90_S	1.249	0.99
246_F	251_L	1.245	0.99
180_G	183_K	1.243	0.99
273_V	287_V	1.242	0.99
660_I	668_L	1.235	0.99
605_L	665_M	1.233	0.99
18_H	28_P	1.227	0.99
14_T	17_H	1.226	0.99
284_I	382_D	1.226	0.99
479_A	483_T	1.224	0.99
289_I	313_F	1.224	0.99
532_F	541_A	1.220	0.99
155_I	222_F	1.219	0.99
345_P	352_L	1.210	0.99
18_H	29_E	1.206	0.99
95_N	263_A	1.205	0.99
664_E	667_R	1.200	0.99
602_T	629_A	1.198	0.99
451_V	500_L	1.198	0.99
543_I	554_I	1.197	0.99
166_A	231_E	1.194	0.99
13_T	17_H	1.191	0.99
177_P	221_T	1.187	0.99
574_S	577_L	1.184	0.99
183_K	187_D	1.180	0.99
151_T	216_A	1.178	0.99
449_M	506_T	1.177	0.99
76_E	124_L	1.171	0.99
508_F	512_L	1.169	0.99
532_F	549_V	1.162	0.99
536_E	540_A	1.159	0.99
437_K	464_E	1.154	0.99
278_P	318_Q	1.152	0.99
407_H	412_G	1.148	0.99
472_A	575_E	1.147	0.99
448_A	513_Y	1.146	0.99
176_L	180_G	1.143	0.99
7_Q	14_T	1.139	0.99
149_V	155_I	1.138	0.99
472_A	572_V	1.137	0.99
435_Q	439_S	1.136	0.99
80_L	302_F	1.135	0.99
539_E	577_L	1.132	0.98
605_L	640_I	1.131	0.98
461_Q	485_L	1.131	0.98
491_K	494_Q	1.128	0.98
620_R	669_L	1.127	0.98
109_T	259_L	1.127	0.98
637_D	658_E	1.121	0.98
326_D	400_R	1.118	0.98
537_A	545_E	1.116	0.98
638_L	658_E	1.115	0.98
558_S	562_N	1.113	0.98
112_C	260_C	1.112	0.98
130_L	155_I	1.111	0.98
444_V	454_M	1.110	0.98
130_L	146_T	1.110	0.98
9_T	13_T	1.108	0.98
256_R	276_D	1.108	0.98
482_L	497_V	1.105	0.98
497_V	501_E	1.103	0.98
570_R	574_S	1.099	0.98
114_L	269_F	1.098	0.98
466_E	469_H	1.096	0.98
112_C	269_F	1.095	0.98
39_M	305_R	1.093	0.98
410_V	433_G	1.089	0.98
238_T	241_G	1.088	0.98
618_K	628_V	1.085	0.98
443_F	449_M	1.084	0.98
488_M	492_S	1.083	0.98
611_Q	662_E	1.082	0.98
571_N	575_E	1.080	0.98
415_V	424_A	1.077	0.98
437_K	463_V	1.075	0.98
629_A	636_T	1.072	0.98
546_L	560_V	1.066	0.98
612_M	617_A	1.066	0.98
184_I	196_F	1.060	0.98
132_S	144_D	1.060	0.98
19_E	61_R	1.054	0.98
563_F	569_N	1.051	0.98
133_A	155_I	1.050	0.98
410_V	434_A	1.048	0.98
575_E	579_E	1.046	0.97
616_D	619_A	1.044	0.97
14_T	38_L	1.043	0.97
223_F	282_F	1.041	0.97
487_R	492_S	1.041	0.97
244_L	247_K	1.037	0.97
321_M	391_V	1.037	0.97
108_V	291_V	1.034	0.97
603_V	621_L	1.032	0.97
660_I	664_E	1.032	0.97
76_E	167_R	1.031	0.97
343_L	377_I	1.025	0.97
410_V	437_K	1.023	0.97
6_Q	10_E	1.021	0.97
209_Q	214_I	1.021	0.97
414_D	566_E	1.020	0.97
268_A	272_K	1.019	0.97
271_H	274_E	1.014	0.97
114_L	273_V	1.011	0.97
333_R	516_G	1.010	0.97
531_Y	545_E	1.010	0.97
618_K	630_G	1.008	0.97
447_R	615_D	1.007	0.97
340_V	355_N	1.005	0.97
498_N	502_K	1.004	0.97
536_E	539_E	1.004	0.97
664_E	668_L	1.000	0.97
242_R	294_L	0.997	0.97
159_L	251_L	0.996	0.97
378_R	388_V	0.996	0.97
109_T	293_S	0.994	0.97
319_E	389_N	0.992	0.97
380_A	386_Q	0.990	0.96
557_A	561_H	0.990	0.96
353_V	383_V	0.987	0.96
76_E	229_V	0.981	0.96
534_T	585_A	0.981	0.96
265_E	268_A	0.981	0.96
609_L	617_A	0.980	0.96
504_K	579_E	0.978	0.96
320_Q	348_V	0.978	0.96
418_V	421_E	0.976	0.96
111_C	240_L	0.976	0.96
512_L	538_L	0.975	0.96
519_E	555_V	0.972	0.96
440_L	468_V	0.971	0.96
54_T	60_Q	0.971	0.96
349_A	379_R	0.969	0.96
79_M	122_S	0.969	0.96
486_E	492_S	0.968	0.96
361_A	417_R	0.966	0.96
444_V	496_V	0.965	0.96
444_V	459_I	0.964	0.96
111_C	239_H	0.963	0.96
322_T	343_L	0.963	0.96
653_Q	659_V	0.962	0.96
175_F	223_F	0.960	0.96
425_R	518_R	0.958	0.96
638_L	668_L	0.954	0.96
30_I	34_E	0.954	0.96
263_A	266_V	0.951	0.96
183_K	186_E	0.948	0.95
324_V	390_V	0.945	0.95
30_I	38_L	0.945	0.95
362_D	422_A	0.943	0.95
188_A	194_K	0.941	0.95
441_K	456_D	0.940	0.95
186_E	189_R	0.939	0.95
12_R	16_R	0.938	0.95
506_T	583_W	0.936	0.95
19_E	39_M	0.934	0.95
347_H	352_L	0.934	0.95
609_L	662_E	0.931	0.95
170_V	246_F	0.930	0.95
395_R	399_T	0.930	0.95
84_N	306_A	0.930	0.95
481_K	484_G	0.929	0.95
244_L	257_V	0.929	0.95
45_L	52_L	0.926	0.95
102_L	296_Q	0.921	0.95
247_K	257_V	0.920	0.95
181_F	199_P	0.920	0.95
421_E	518_R	0.916	0.95
236_P	245_Q	0.916	0.95
319_E	376_V	0.915	0.95
341_A	356_A	0.914	0.95
34_E	37_R	0.914	0.95
14_T	30_I	0.914	0.95
605_L	613_S	0.913	0.94
89_E	92_L	0.913	0.94
603_V	626_A	0.911	0.94
404_F	424_A	0.910	0.94
631_S	636_T	0.909	0.94
271_H	275_E	0.909	0.94
651_K	654_E	0.909	0.94
640_I	660_I	0.908	0.94
641_A	644_A	0.907	0.94
440_L	474_L	0.906	0.94
532_F	545_E	0.906	0.94
291_V	300_L	0.906	0.94
143_E	208_R	0.903	0.94
479_A	490_P	0.902	0.94
180_G	221_T	0.899	0.94
321_M	376_V	0.897	0.94
376_V	391_V	0.894	0.94
639_V	659_V	0.893	0.94
462_L	482_L	0.892	0.94
519_E	556_V	0.891	0.94
213_R	216_A	0.891	0.94
504_K	580_G	0.889	0.94
362_D	417_R	0.888	0.94
474_L	500_L	0.887	0.94
545_E	548_K	0.886	0.94
10_E	41_E	0.885	0.94
4_I	52_L	0.884	0.93
26_D	204_A	0.884	0.93
263_A	267_L	0.883	0.93
89_E	93_A	0.878	0.93
468_V	473_D	0.877	0.93
99_Q	110_W	0.876	0.93
244_L	248_K	0.876	0.93
363_E	367_L	0.872	0.93
361_A	424_A	0.871	0.93
8_L	54_T	0.871	0.93
530_A	622_V	0.868	0.93
639_V	657_I	0.867	0.93
608_S	644_A	0.867	0.93
121_V	174_V	0.865	0.93
66_P	212_P	0.865	0.93
260_C	266_V	0.864	0.93
49_H	52_L	0.862	0.93
226_G	297_Q	0.861	0.93
502_K	505_E	0.861	0.93
621_L	665_M	0.861	0.93
300_L	308_R	0.860	0.93
324_V	389_N	0.858	0.92
13_T	16_R	0.858	0.92
367_L	390_V	0.858	0.92
508_F	538_L	0.856	0.92
6_Q	9_T	0.851	0.92
601_K	638_L	0.850	0.92
479_A	493_A	0.846	0.92
98_V	108_V	0.841	0.92
91_F	270_Y	0.841	0.92
42_L	54_T	0.840	0.92
577_L	583_W	0.839	0.92
511_F	583_W	0.838	0.92
562_N	566_E	0.836	0.91
180_G	184_I	0.836	0.91
417_R	422_A	0.836	0.91
554_I	558_S	0.835	0.91
502_K	506_T	0.833	0.91
629_A	633_S	0.833	0.91
461_Q	486_E	0.831	0.91
638_L	657_I	0.830	0.91
615_D	619_A	0.827	0.91
547_Q	554_I	0.822	0.91
348_V	383_V	0.822	0.91
55_P	129_V	0.821	0.91
19_E	35_Y	0.819	0.91
159_L	165_P	0.819	0.91
483_T	489_G	0.817	0.90
467_Y	481_K	0.817	0.90
154_A	252_P	0.813	0.90
112_C	266_V	0.811	0.90
506_T	510_R	0.810	0.90
376_V	388_V	0.810	0.90
389_N	392_L	0.810	0.90
227_V	242_R	0.808	0.90
303_V	306_A	0.807	0.90
443_F	475_F	0.806	0.90
470_T	572_V	0.806	0.90
147_S	215_T	0.805	0.90
122_S	228_G	0.801	0.90
188_A	191_T	0.800	0.90
613_S	616_D	0.799	0.89
373_D	395_R	0.798	0.89
634_K	639_V	0.797	0.89
188_A	195_V	0.796	0.89
112_C	289_I	0.796	0.89
532_F	546_L	0.795	0.89
116_L	254_S	0.795	0.89
624_L	669_L	0.791	0.89
119_L	203_A	0.790	0.89
327_V	370_R	0.790	0.89
448_A	514_A	0.789	0.89
46_E	57_S	0.789	0.89
483_T	493_A	0.786	0.89
46_E	58_P	0.786	0.89
651_K	655_L	0.786	0.89
243_L	253_V	0.783	0.89
114_L	256_R	0.783	0.89
69_A	210_L	0.782	0.88
258_T	269_F	0.781	0.88
39_M	59_T	0.781	0.88
130_L	133_A	0.780	0.88
329_F	404_F	0.780	0.88
240_L	257_V	0.780	0.88
95_N	266_V	0.774	0.88
76_E	132_S	0.773	0.88
509_A	586_P	0.773	0.88
82_L	288_V	0.772	0.88
44_E	47_T	0.772	0.88
247_K	255_D	0.771	0.88
174_V	207_L	0.771	0.88
46_E	59_T	0.770	0.88
511_F	581_V	0.769	0.88
33_A	37_R	0.769	0.88
9_T	12_R	0.767	0.87
53_I	56_D	0.764	0.87
461_Q	487_R	0.763	0.87
660_I	665_M	0.763	0.87
145_I	174_V	0.762	0.87
531_Y	548_K	0.761	0.87
602_T	637_D	0.759	0.87
167_R	229_V	0.759	0.87
203_A	220_L	0.758	0.87
603_V	660_I	0.753	0.87
16_R	56_D	0.752	0.86
604_V	629_A	0.751	0.86
483_T	490_P	0.751	0.86
113_E	290_K	0.750	0.86
269_F	272_K	0.749	0.86
112_C	287_V	0.749	0.86
91_F	289_I	0.748	0.86
537_A	540_A	0.748	0.86
224_C	251_L	0.747	0.86
467_Y	485_L	0.745	0.86
524_T	552_V	0.744	0.86
481_K	489_G	0.743	0.86
174_V	220_L	0.743	0.86
483_T	497_V	0.743	0.86
468_V	474_L	0.742	0.86
463_V	468_V	0.742	0.86
270_Y	313_F	0.741	0.86
436_R	463_V	0.740	0.86
183_K	219_P	0.739	0.85
658_E	668_L	0.737	0.85
595_D	624_L	0.735	0.85
68_A	210_L	0.735	0.85
207_L	215_T	0.733	0.85
610_S	663_A	0.732	0.85
73_I	144_D	0.731	0.85
454_M	474_L	0.731	0.85
520_V	560_V	0.728	0.85
164_I	249_W	0.728	0.85
123_I	133_A	0.728	0.85
488_M	493_A	0.727	0.85
328_E	340_V	0.726	0.84
471_P	572_V	0.726	0.84
182_E	189_R	0.726	0.84
374_K	391_V	0.724	0.84
8_L	49_H	0.723	0.84
12_R	53_I	0.723	0.84
99_Q	108_V	0.722	0.84
296_Q	299_Q	0.722	0.84
264_E	267_L	0.722	0.84
492_S	495_N	0.721	0.84
110_W	263_A	0.721	0.84
617_A	665_M	0.720	0.84
76_E	122_S	0.717	0.84
67_L	147_S	0.717	0.84
565_A	570_R	0.717	0.84
297_Q	309_W	0.716	0.84
40_R	85_V	0.716	0.84
445_S	448_A	0.716	0.84
368_G	401_E	0.715	0.84
440_L	471_P	0.715	0.84
392_L	395_R	0.715	0.84
236_P	241_G	0.714	0.83
442_H	448_A	0.713	0.83
123_I	130_L	0.711	0.83
461_Q	488_M	0.711	0.83
621_L	640_I	0.710	0.83
102_L	106_E	0.709	0.83
320_Q	377_I	0.706	0.83
595_D	598_F	0.706	0.83
91_F	266_V	0.706	0.83
348_V	351_V	0.705	0.83
524_T	560_V	0.704	0.83
495_N	498_N	0.703	0.83
168_L	249_W	0.703	0.83
413_S	428_G	0.703	0.83
642_G	646_G	0.700	0.82
168_L	246_F	0.700	0.82
431_I	568_S	0.700	0.82
324_V	375_V	0.700	0.82
371_I	400_R	0.699	0.82
77_V	229_V	0.699	0.82
102_L	108_V	0.699	0.82
348_V	377_I	0.699	0.82
523_A	527_G	0.698	0.82
568_S	571_N	0.697	0.82
370_R	400_R	0.696	0.82
178_Q	281_G	0.695	0.82
111_C	243_L	0.694	0.82
368_G	395_R	0.692	0.82
605_L	628_V	0.692	0.82
546_L	552_V	0.691	0.81
319_E	388_V	0.691	0.81
331_V	337_I	0.691	0.81
274_E	316_P	0.691	0.81
551_D	556_V	0.688	0.81
566_E	569_N	0.688	0.81
74_R	134_A	0.687	0.81
603_V	640_I	0.686	0.81
598_F	668_L	0.686	0.81
315_F	382_D	0.686	0.81
107_K	261_E	0.685	0.81
126_E	132_S	0.683	0.81
55_P	60_Q	0.682	0.81
85_V	91_F	0.680	0.80
211_D	218_R	0.680	0.80
389_N	393_S	0.680	0.80
239_H	297_Q	0.678	0.80
620_R	666_L	0.678	0.80
357_T	383_V	0.678	0.80
456_D	460_D	0.678	0.80
56_D	158_K	0.676	0.80
323_F	394_E	0.675	0.80
258_T	265_E	0.674	0.80
165_P	249_W	0.674	0.80
120_A	225_Y	0.673	0.80
604_V	628_V	0.673	0.80
628_V	665_M	0.672	0.80
179_A	183_K	0.672	0.80
629_A	639_V	0.671	0.80
247_K	253_V	0.671	0.80
24_V	64_A	0.669	0.79
400_R	403_V	0.669	0.79
17_H	30_I	0.668	0.79
328_E	355_N	0.667	0.79
605_L	612_M	0.667	0.79
42_L	45_L	0.667	0.79
571_N	574_S	0.667	0.79
524_T	551_D	0.666	0.79
632_V	639_V	0.664	0.79
349_A	382_D	0.664	0.79
238_T	294_L	0.663	0.79
159_L	166_A	0.662	0.79
449_M	581_V	0.662	0.79
151_T	215_T	0.662	0.79
266_V	313_F	0.662	0.79
153_R	157_L	0.660	0.78
594_I	597_P	0.659	0.78
610_S	662_E	0.658	0.78
12_R	42_L	0.654	0.78
133_A	145_I	0.653	0.78
591_A	594_I	0.653	0.78
110_W	289_I	0.653	0.78
577_L	581_V	0.651	0.77
42_L	59_T	0.651	0.77
98_V	300_L	0.650	0.77
91_F	313_F	0.650	0.77
98_V	101_R	0.650	0.77
533_G	537_A	0.650	0.77
365_E	422_A	0.648	0.77
269_F	287_V	0.648	0.77
439_S	563_F	0.648	0.77
274_E	315_F	0.647	0.77
508_F	535_L	0.647	0.77
184_I	219_P	0.645	0.77
417_R	420_G	0.645	0.77
7_Q	45_L	0.645	0.77
498_N	501_E	0.644	0.77
84_N	311_V	0.641	0.76
24_V	154_A	0.640	0.76
16_R	61_R	0.639	0.76
592_E	596_S	0.637	0.76
392_L	396_P	0.637	0.76
482_L	493_A	0.635	0.76
189_R	194_K	0.634	0.76
511_F	514_A	0.634	0.76
531_Y	549_V	0.633	0.75
534_T	584_P	0.633	0.75
66_P	69_A	0.632	0.75
429_G	566_E	0.631	0.75
91_F	95_N	0.630	0.75
224_C	253_V	0.630	0.75
369_L	390_V	0.630	0.75
20_Y	160_H	0.630	0.75
617_A	640_I	0.628	0.75
120_A	226_G	0.626	0.75
223_F	280_L	0.626	0.75
640_I	665_M	0.626	0.75
179_A	182_E	0.625	0.75
95_N	98_V	0.624	0.74
111_C	257_V	0.624	0.74
109_T	238_T	0.624	0.74
610_S	644_A	0.623	0.74
462_L	466_E	0.623	0.74
636_T	639_V	0.623	0.74
416_E	427_T	0.623	0.74
506_T	511_F	0.622	0.74
368_G	392_L	0.622	0.74
471_P	514_A	0.620	0.74
608_S	613_S	0.620	0.74
450_D	506_T	0.619	0.74
611_Q	617_A	0.618	0.74
528_L	538_L	0.618	0.74
507_T	582_H	0.618	0.74
465_K	485_L	0.617	0.74
606_T	609_L	0.616	0.74
462_L	474_L	0.616	0.74
304_A	523_A	0.615	0.73
152_I	155_I	0.615	0.73
160_H	251_L	0.615	0.73
361_A	402_V	0.613	0.73
153_R	219_P	0.613	0.73
61_R	154_A	0.612	0.73
284_I	315_F	0.611	0.73
399_T	402_V	0.611	0.73
431_I	436_R	0.610	0.73
411_C	434_A	0.608	0.73
140_T	526_A	0.608	0.73
363_E	369_L	0.607	0.72
93_A	97_R	0.607	0.72
213_R	217_K	0.606	0.72
4_I	7_Q	0.605	0.72
14_T	41_E	0.605	0.72
229_V	232_G	0.605	0.72
31_P	321_M	0.604	0.72
79_M	134_A	0.603	0.72
223_F	254_S	0.602	0.72
206_S	209_Q	0.601	0.72
603_V	637_D	0.601	0.72
127_N	167_R	0.600	0.72
274_E	382_D	0.600	0.72
537_A	541_A	0.600	0.72
15_L	39_M	0.599	0.71
452_D	502_K	0.597	0.71
154_A	175_F	0.597	0.71
336_A	422_A	0.596	0.71
535_L	539_E	0.596	0.71
447_R	513_Y	0.596	0.71
480_G	483_T	0.596	0.71
361_A	415_V	0.596	0.71
374_K	396_P	0.595	0.71
153_R	216_A	0.595	0.71
325_R	328_E	0.595	0.71
370_R	402_V	0.594	0.71
602_T	630_G	0.594	0.71
295_A	299_Q	0.594	0.71
86_F	208_R	0.593	0.71
619_A	622_V	0.592	0.71
42_L	58_P	0.591	0.70
184_I	202_A	0.590	0.70
629_A	635_K	0.590	0.70
141_T	510_R	0.589	0.70
212_P	216_A	0.589	0.70
474_L	493_A	0.588	0.70
145_I	149_V	0.588	0.70
284_I	383_V	0.588	0.70
43_R	83_D	0.587	0.70
575_E	578_A	0.587	0.70
508_F	583_W	0.587	0.70
639_V	655_L	0.587	0.70
61_R	151_T	0.586	0.70
449_M	583_W	0.586	0.70
188_A	210_L	0.584	0.70
41_E	44_E	0.584	0.70
147_S	212_P	0.584	0.70
123_I	251_L	0.584	0.70
507_T	584_P	0.584	0.70
243_L	257_V	0.583	0.69
531_Y	537_A	0.582	0.69
274_E	284_I	0.582	0.69
19_E	53_I	0.582	0.69
79_M	120_A	0.581	0.69
505_E	584_P	0.581	0.69
197_A	352_L	0.581	0.69
40_R	84_N	0.581	0.69
12_R	56_D	0.579	0.69
341_A	387_V	0.578	0.69
70_F	148_N	0.578	0.69
23_H	39_M	0.578	0.69
539_E	542_S	0.577	0.69
17_H	20_Y	0.577	0.69
329_F	361_A	0.577	0.69
206_S	218_R	0.577	0.69
533_G	587_I	0.576	0.68
293_S	297_Q	0.576	0.68
495_N	499_A	0.576	0.68
483_T	494_Q	0.575	0.68
5_E	52_L	0.575	0.68
86_F	378_R	0.575	0.68
538_L	564_F	0.575	0.68
487_R	493_A	0.574	0.68
602_T	635_K	0.574	0.68
605_L	609_L	0.573	0.68
567_E	570_R	0.572	0.68
151_T	219_P	0.572	0.68
458_I	496_V	0.570	0.68
449_M	514_A	0.570	0.68
478_T	493_A	0.569	0.68
509_A	526_A	0.569	0.68
7_Q	38_L	0.568	0.67
370_R	397_E	0.568	0.67
330_Q	342_R	0.568	0.67
461_Q	465_K	0.567	0.67
374_K	395_R	0.565	0.67
236_P	242_R	0.564	0.67
485_L	488_M	0.564	0.67
487_R	551_D	0.563	0.67
94_F	551_D	0.562	0.67
16_R	53_I	0.562	0.67
605_L	618_K	0.561	0.66
83_D	311_V	0.561	0.66
67_L	210_L	0.560	0.66
209_Q	215_T	0.560	0.66
12_R	45_L	0.559	0.66
478_T	501_E	0.559	0.66
357_T	363_E	0.558	0.66
275_E	278_P	0.558	0.66
122_S	134_A	0.557	0.66
547_Q	552_V	0.557	0.66
270_Y	274_E	0.557	0.66
486_E	489_G	0.557	0.66
549_V	552_V	0.556	0.66
18_H	31_P	0.556	0.66
511_F	576_L	0.556	0.66
123_I	149_V	0.555	0.66
103_K	108_V	0.555	0.66
477_L	497_V	0.555	0.66
227_V	246_F	0.555	0.66
408_C	426_C	0.554	0.65
437_K	459_I	0.554	0.65
596_S	603_V	0.553	0.65
176_L	219_P	0.553	0.65
225_Y	282_F	0.550	0.65
147_S	150_R	0.550	0.65
353_V	377_I	0.550	0.65
261_E	292_N	0.550	0.65
19_E	23_H	0.549	0.65
189_R	192_G	0.549	0.65
86_F	270_Y	0.549	0.65
603_V	668_L	0.549	0.65
329_F	415_V	0.548	0.65
462_L	465_K	0.548	0.65
472_A	579_E	0.548	0.65
596_S	624_L	0.548	0.65
79_M	169_E	0.548	0.65
547_Q	561_H	0.547	0.65
633_S	655_L	0.547	0.65
347_H	351_V	0.547	0.65
177_P	202_A	0.547	0.65
42_L	46_E	0.547	0.65
73_I	131_V	0.547	0.65
277_R	382_D	0.545	0.64
546_L	551_D	0.545	0.64
242_R	246_F	0.545	0.64
349_A	383_V	0.545	0.64
122_S	169_E	0.544	0.64
444_V	451_V	0.544	0.64
160_H	248_K	0.543	0.64
86_F	316_P	0.543	0.64
386_Q	404_F	0.543	0.64
489_G	492_S	0.543	0.64
197_A	349_A	0.542	0.64
330_Q	338_T	0.542	0.64
155_I	252_P	0.541	0.64
654_E	657_I	0.540	0.64
26_D	208_R	0.539	0.63
476_K	578_A	0.539	0.63
374_K	399_T	0.539	0.63
665_M	669_L	0.538	0.63
325_R	342_R	0.538	0.63
364_I	404_F	0.538	0.63
47_T	53_I	0.538	0.63
5_E	8_L	0.537	0.63
273_V	284_I	0.537	0.63
92_L	96_K	0.537	0.63
612_M	665_M	0.537	0.63
319_E	386_Q	0.537	0.63
365_E	368_G	0.536	0.63
283_D	318_Q	0.536	0.63
514_A	529_A	0.535	0.63
610_S	624_L	0.534	0.63
124_L	134_A	0.534	0.63
70_F	151_T	0.533	0.63
91_F	263_A	0.532	0.62
465_K	486_E	0.532	0.62
598_F	669_L	0.532	0.62
351_V	382_D	0.532	0.62
441_K	460_D	0.532	0.62
397_E	400_R	0.532	0.62
209_Q	316_P	0.531	0.62
270_Y	287_V	0.531	0.62
518_R	559_H	0.531	0.62
108_V	296_Q	0.530	0.62
395_R	400_R	0.530	0.62
130_L	157_L	0.529	0.62
336_A	425_R	0.529	0.62
436_R	439_S	0.528	0.62
408_C	411_C	0.528	0.62
509_A	585_A	0.528	0.62
552_V	560_V	0.527	0.62
471_P	576_L	0.527	0.62
405_P	424_A	0.526	0.62
14_T	34_E	0.524	0.61
602_T	638_L	0.524	0.61
540_A	570_R	0.524	0.61
443_F	581_V	0.524	0.61
621_L	628_V	0.524	0.61
24_V	66_P	0.523	0.61
448_A	510_R	0.523	0.61
499_A	502_K	0.523	0.61
291_V	296_Q	0.522	0.61
371_I	399_T	0.522	0.61
8_L	53_I	0.522	0.61
501_E	505_E	0.521	0.61
646_G	649_L	0.521	0.61
114_L	287_V	0.520	0.61
15_L	42_L	0.520	0.61
209_Q	380_A	0.519	0.61
267_L	270_Y	0.519	0.61
634_K	645_A	0.518	0.60
135_T	145_I	0.518	0.60
8_L	15_L	0.517	0.60
446_R	452_D	0.516	0.60
556_V	559_H	0.516	0.60
469_H	473_D	0.515	0.60
620_R	665_M	0.515	0.60
392_L	397_E	0.515	0.60
367_L	370_R	0.515	0.60
415_V	427_T	0.515	0.60
119_L	209_Q	0.515	0.60
15_L	30_I	0.514	0.60
225_Y	254_S	0.514	0.60
239_H	242_R	0.514	0.60
164_I	245_Q	0.514	0.60
278_P	284_I	0.514	0.60
459_I	496_V	0.513	0.60
31_P	37_R	0.512	0.59
228_G	242_R	0.512	0.59
596_S	637_D	0.512	0.59
227_V	236_P	0.512	0.59
436_R	440_L	0.511	0.59
610_S	665_M	0.511	0.59
116_L	255_D	0.510	0.59
84_N	90_S	0.510	0.59
35_Y	39_M	0.510	0.59
26_D	143_E	0.509	0.59
543_I	557_A	0.509	0.59
506_T	582_H	0.508	0.59
223_F	253_V	0.508	0.59
457_K	460_D	0.508	0.59
594_I	599_A	0.508	0.59
73_I	134_A	0.507	0.59
175_F	252_P	0.507	0.59
485_L	489_G	0.506	0.59
535_L	538_L	0.506	0.59
572_V	575_E	0.506	0.59
362_D	365_E	0.506	0.59
138_D	141_T	0.505	0.58
270_Y	379_R	0.505	0.58
112_C	273_V	0.505	0.58
457_K	461_Q	0.504	0.58
14_T	21_L	0.504	0.58
441_K	459_I	0.503	0.58
593_E	623_E	0.503	0.58
626_A	665_M	0.502	0.58
567_E	574_S	0.502	0.58
415_V	428_G	0.502	0.58
511_F	535_L	0.502	0.58
595_D	599_A	0.502	0.58
513_Y	522_E	0.501	0.58
164_I	167_R	0.501	0.58
357_T	386_Q	0.501	0.58
532_F	538_L	0.501	0.58
370_R	392_L	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2owoA	1	0.8733	100	0.02	Contact Map
1dgsA	1	0.8569	100	0.047	Contact Map
3sgiA	1	0.5991	100	0.141	Contact Map
4glxA	1	0.8539	100	0.182	Contact Map
3uq8A	1	0.4784	100	0.527	Contact Map
3jslA	2	0.459	100	0.537	Contact Map
1zauA	1	0.4694	100	0.537	Contact Map
4lh6A	1	0.4709	100	0.541	Contact Map
1b04A	1	0.4605	100	0.546	Contact Map
4glwA	2	0.4203	100	0.551	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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