GREMLIN Database
HELD - Helicase IV
UniProt: P15038 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10426
Length: 684 (571)
Sequences: 2271 (1993)
Seq/√Len: 83.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
567_A573_R4.5771.00
417_Q424_K4.5321.00
416_H424_K3.6221.00
507_R532_N3.4981.00
299_D304_H3.2851.00
415_I418_A3.2111.00
542_D545_Q3.1431.00
311_W315_C3.0951.00
418_A422_L2.9401.00
413_G417_Q2.8891.00
418_A424_K2.8581.00
418_A421_I2.8261.00
413_G418_A2.7311.00
594_I649_A2.7251.00
359_W363_M2.7181.00
197_L205_V2.6941.00
348_L352_L2.6451.00
512_A651_T2.6051.00
304_H311_W2.6001.00
298_N301_A2.5491.00
414_L418_A2.5361.00
607_I649_A2.4591.00
411_F418_A2.4551.00
339_E342_F2.4361.00
411_F414_L2.3791.00
399_W403_L2.3611.00
134_Q137_S2.3331.00
420_V423_E2.3291.00
198_N502_Y2.3261.00
396_L400_K2.3021.00
415_I419_I2.2881.00
576_S591_F2.2701.00
415_I422_L2.2441.00
595_H645_L2.2291.00
416_H419_I2.1721.00
243_Q432_K2.1431.00
553_L565_I2.1351.00
233_L433_H2.1061.00
340_G345_D2.1021.00
562_R603_D2.0721.00
409_V414_L2.0631.00
441_D598_K2.0011.00
336_S340_G1.9961.00
344_D348_L1.9661.00
419_I424_K1.9641.00
414_L419_I1.9571.00
336_S339_E1.9461.00
487_H490_F1.9421.00
420_V424_K1.9191.00
204_A214_V1.8871.00
299_D311_W1.8861.00
154_E168_S1.8851.00
534_D656_R1.8671.00
572_M609_G1.8611.00
552_K555_G1.8551.00
358_R362_L1.8501.00
256_E260_R1.8451.00
305_E309_A1.8391.00
415_I421_I1.8231.00
335_W339_E1.8031.00
533_G536_K1.8031.00
299_D308_I1.7851.00
347_K350_R1.7591.00
344_D347_K1.7531.00
156_W163_L1.7501.00
415_I424_K1.7491.00
385_F389_I1.7431.00
299_D302_A1.7401.00
356_L360_V1.7381.00
381_I385_F1.7311.00
444_P485_A1.7271.00
419_I423_E1.7181.00
593_T596_A1.7041.00
390_K393_A1.6871.00
301_A304_H1.6821.00
421_I424_K1.6791.00
564_L602_A1.6751.00
311_W316_S1.6731.00
551_D554_S1.6701.00
346_E349_Q1.6661.00
340_G344_D1.6601.00
547_D551_D1.6571.00
549_L660_L1.6341.00
606_I660_L1.6271.00
336_S343_W1.6251.00
419_I422_L1.6201.00
389_I392_M1.6191.00
370_Q373_M1.6011.00
296_L299_D1.5911.00
345_D348_L1.5861.00
548_A551_D1.5861.00
336_S344_D1.5841.00
345_D349_Q1.5821.00
480_M483_T1.5801.00
300_T308_I1.5751.00
335_W341_N1.5741.00
590_D600_Q1.5711.00
343_W351_R1.5691.00
56_E62_P1.5591.00
348_L351_R1.5581.00
416_H420_V1.5571.00
414_L423_E1.5511.00
569_Y572_M1.5421.00
407_N413_G1.5391.00
506_S510_E1.5371.00
340_G343_W1.5371.00
380_E384_L1.5291.00
417_Q422_L1.5271.00
384_L387_K1.5130.99
100_S150_D1.5100.99
63_D66_V1.5100.99
302_A305_E1.5060.99
396_L399_W1.5060.99
339_E343_W1.5030.99
304_H307_F1.5010.99
511_V650_L1.4990.99
416_H421_I1.4970.99
304_H316_S1.4960.99
509_G512_A1.4860.99
534_D537_A1.4830.99
483_T489_N1.4810.99
357_D364_R1.4670.99
61_L64_E1.4670.99
508_I653_A1.4640.99
341_N344_D1.4640.99
604_Y656_R1.4600.99
360_V365_M1.4600.99
552_K660_L1.4560.99
385_F390_K1.4540.99
417_Q423_E1.4540.99
340_G348_L1.4530.99
300_T312_R1.4530.99
417_Q420_V1.4430.99
417_Q421_I1.4390.99
360_V364_R1.4380.99
501_T504_F1.4310.99
207_N494_E1.4260.99
395_L399_W1.4260.99
60_V66_V1.4230.99
311_W314_Q1.4200.99
66_V69_L1.4190.99
479_Q483_T1.4090.99
410_D414_L1.4010.99
46_I50_R1.3910.99
295_K298_N1.3910.99
419_I425_G1.3880.99
483_T487_H1.3860.99
422_L425_G1.3850.99
612_E664_E1.3840.99
297_E300_T1.3840.99
602_A605_V1.3840.99
335_W342_F1.3820.99
346_E351_R1.3730.99
566_L597_S1.3710.99
368_G374_I1.3700.99
439_F447_A1.3640.99
299_D312_R1.3530.99
351_R359_W1.3530.99
345_D353_A1.3480.99
567_A576_S1.3440.99
293_V296_L1.3420.99
229_R463_F1.3410.99
359_W364_R1.3410.99
564_L605_V1.3310.99
300_T303_R1.3240.99
377_A381_I1.3150.99
409_V413_G1.3120.98
408_A411_F1.3090.98
545_Q660_L1.3080.98
60_V63_D1.3030.98
336_S341_N1.2940.98
386_S389_I1.2930.98
349_Q352_L1.2930.98
301_A308_I1.2840.98
77_T81_Y1.2830.98
387_K392_M1.2830.98
415_I420_V1.2790.98
344_D349_Q1.2750.98
306_L309_A1.2750.98
397_K400_K1.2730.98
343_W348_L1.2690.98
359_W362_L1.2650.98
563_I589_I1.2640.98
389_I393_A1.2630.98
412_S424_K1.2620.98
75_G79_R1.2620.98
382_R385_F1.2620.98
416_H425_G1.2610.98
480_M486_F1.2600.98
300_T304_H1.2530.98
556_Y604_Y1.2510.98
400_K404_K1.2500.98
540_L661_F1.2460.98
295_K299_D1.2440.98
440_Q647_Y1.2380.98
412_S418_A1.2370.98
482_L487_H1.2360.98
341_N349_Q1.2330.98
607_I610_L1.2310.98
231_G235_A1.2310.98
371_A377_A1.2300.98
246_L257_M1.2280.98
363_M367_G1.2240.98
295_K300_T1.2220.98
412_S416_H1.2210.98
335_W340_G1.2180.98
273_R278_L1.2170.98
337_V344_D1.2150.97
299_D303_R1.2080.97
388_R391_L1.2060.97
412_S417_Q1.2040.97
277_A280_L1.2010.97
548_A552_K1.1990.97
351_R355_R1.1980.97
537_A658_W1.1970.97
175_Q178_T1.1970.97
447_A464_A1.1950.97
413_G416_H1.1940.97
598_K647_Y1.1920.97
120_L129_Q1.1920.97
335_W348_L1.1920.97
296_L304_H1.1870.97
420_V425_G1.1870.97
307_F316_S1.1870.97
370_Q374_I1.1850.97
131_Q141_L1.1840.97
293_V297_E1.1770.97
299_D305_E1.1670.97
418_A423_E1.1650.97
563_I604_Y1.1610.97
202_A206_V1.1610.97
411_F421_I1.1610.97
306_L310_E1.1600.97
398_A401_G1.1570.97
59_F70_H1.1560.97
546_L550_L1.1430.96
304_H315_C1.1410.96
309_A312_R1.1390.96
358_R365_M1.1390.96
472_I645_L1.1370.96
552_K556_Y1.1360.96
52_L56_E1.1330.96
364_R367_G1.1330.96
304_H308_I1.1260.96
368_G375_A1.1250.96
355_R363_M1.1240.96
411_F415_I1.1100.96
343_W352_L1.1070.96
385_F392_M1.1040.96
337_V343_W1.1030.96
371_A374_I1.1010.96
307_F310_E1.0980.95
75_G78_Q1.0950.95
308_I315_C1.0910.95
340_G351_R1.0850.95
550_L554_S1.0850.95
349_Q355_R1.0840.95
386_S391_L1.0840.95
413_G424_K1.0830.95
226_L435_L1.0820.95
50_R53_V1.0820.95
64_E67_V1.0810.95
360_V363_M1.0780.95
418_A425_G1.0760.95
362_L367_G1.0760.95
347_K351_R1.0760.95
293_V300_T1.0750.95
395_L403_L1.0750.95
339_E348_L1.0740.95
307_F311_W1.0740.95
305_E311_W1.0710.95
421_I425_G1.0700.95
553_L557_A1.0700.95
352_L356_L1.0670.95
468_D471_A1.0660.95
228_A256_E1.0630.95
412_S421_I1.0630.95
346_E352_L1.0630.95
301_A309_A1.0620.95
607_I646_M1.0620.95
400_K403_L1.0610.95
574_P578_E1.0610.95
341_N345_D1.0570.94
566_L592_M1.0560.94
385_F393_A1.0560.94
300_T311_W1.0530.94
46_I53_V1.0500.94
414_L417_Q1.0490.94
51_G54_W1.0490.94
360_V367_G1.0470.94
350_R354_S1.0460.94
116_E132_I1.0380.94
77_T80_F1.0370.94
340_G352_L1.0370.94
372_E376_S1.0370.94
116_E141_L1.0360.94
504_F509_G1.0340.94
335_W351_R1.0310.94
250_G504_F1.0310.94
297_E307_F1.0270.93
335_W343_W1.0260.93
71_G75_G1.0240.93
231_G261_I1.0240.93
210_H461_T1.0200.93
356_L368_G1.0190.93
228_A232_W1.0140.93
313_K317_E1.0140.93
381_I389_I1.0130.93
47_H50_R1.0120.93
441_D647_Y1.0110.93
369_A372_E1.0040.93
67_V71_G1.0020.93
554_S558_K1.0010.93
88_W91_W0.9980.93
472_I644_R0.9960.92
298_N304_H0.9940.92
339_E351_R0.9920.92
218_A472_I0.9910.92
356_L362_L0.9910.92
373_M378_P0.9830.92
368_G371_A0.9800.92
214_V463_F0.9780.92
440_Q598_K0.9760.92
416_H423_E0.9760.92
298_N311_W0.9750.92
215_L468_D0.9740.92
63_D72_T0.9730.92
566_L594_I0.9720.91
388_R392_M0.9600.91
340_G353_A0.9590.91
417_Q425_G0.9580.91
253_A260_R0.9560.91
483_T490_F0.9560.91
367_G376_S0.9530.91
300_T315_C0.9520.91
220_S500_T0.9520.91
50_R54_W0.9500.91
312_R316_S0.9490.90
386_S390_K0.9470.90
568_R642_E0.9460.90
369_A373_M0.9450.90
411_F416_H0.9450.90
68_R72_T0.9440.90
399_W402_A0.9440.90
58_E61_L0.9360.90
385_F388_R0.9320.90
53_V62_P0.9300.90
552_K606_I0.9290.90
213_L464_A0.9230.89
256_E600_Q0.9220.89
336_S348_L0.9220.89
116_E137_S0.9210.89
383_D386_S0.9190.89
569_Y595_H0.9180.89
537_A540_L0.9160.89
437_D502_Y0.9160.89
451_A455_K0.9150.89
372_E378_P0.9150.89
440_Q568_R0.9140.89
114_T135_A0.9130.89
61_L65_K0.9120.89
387_K391_L0.9120.89
381_I391_L0.9110.89
225_V228_A0.9090.89
352_L359_W0.9090.89
384_L389_I0.9070.88
56_E61_L0.9070.88
349_Q353_A0.9060.88
361_S367_G0.9060.88
348_L353_A0.9050.88
339_E345_D0.9020.88
357_D367_G0.9020.88
441_D472_I0.8970.88
76_E79_R0.8970.88
304_H310_E0.8970.88
205_V228_A0.8960.88
295_K301_A0.8950.88
395_L400_K0.8940.88
345_D350_R0.8940.88
232_W256_E0.8920.88
592_M597_S0.8890.87
642_E646_M0.8890.87
61_L66_V0.8860.87
347_K355_R0.8860.87
374_I377_A0.8850.87
546_L579_K0.8830.87
387_K390_K0.8820.87
304_H312_R0.8800.87
413_G419_I0.8780.87
335_W338_P0.8780.87
63_D67_V0.8760.87
478_A483_T0.8710.86
49_K53_V0.8690.86
193_E197_L0.8690.86
84_L88_W0.8680.86
439_F464_A0.8660.86
411_F420_V0.8640.86
335_W345_D0.8630.86
86_A90_R0.8630.86
340_G349_Q0.8630.86
371_A376_S0.8630.86
373_M376_S0.8610.86
341_N348_L0.8600.86
358_R361_S0.8600.86
501_T595_H0.8560.85
415_I423_E0.8550.85
163_L166_I0.8540.85
273_R277_A0.8480.85
305_E308_I0.8470.85
565_I576_S0.8460.85
79_R91_W0.8450.85
433_H461_T0.8430.84
135_A141_L0.8420.84
483_T486_F0.8410.84
178_T234_L0.8410.84
129_Q132_I0.8380.84
46_I49_K0.8380.84
336_S352_L0.8380.84
73_E77_T0.8370.84
217_G512_A0.8370.84
53_V60_V0.8370.84
573_R591_F0.8350.84
409_V418_A0.8350.84
395_L398_A0.8330.84
539_T658_W0.8330.84
138_A142_P0.8320.84
300_T305_E0.8310.84
53_V57_L0.8300.84
295_K307_F0.8300.84
382_R388_R0.8300.84
415_I425_G0.8290.83
365_M369_A0.8280.83
55_G59_F0.8280.83
95_M99_A0.8270.83
386_S394_P0.8260.83
143_V148_E0.8260.83
45_A57_L0.8250.83
131_Q135_A0.8230.83
386_S393_A0.8200.83
131_Q137_S0.8200.83
412_S422_L0.8200.83
352_L355_R0.8180.83
338_P342_F0.8180.83
356_L378_P0.8180.83
391_L394_P0.8170.83
59_F62_P0.8170.83
441_D512_A0.8160.82
103_L151_N0.8150.82
347_K353_A0.8140.82
97_E141_L0.8130.82
248_A253_A0.8100.82
370_Q375_A0.8090.82
475_F478_A0.8070.82
54_W60_V0.8050.82
73_E85_D0.8050.82
336_S347_K0.8050.82
337_V342_F0.8030.81
408_A413_G0.8020.81
208_G236_R0.8010.81
57_L62_P0.8000.81
308_I311_W0.7980.81
296_L300_T0.7980.81
294_S298_N0.7970.81
314_Q317_E0.7960.81
373_M377_A0.7910.80
49_K52_L0.7900.80
344_D353_A0.7900.80
54_W57_L0.7890.80
335_W352_L0.7880.80
371_A378_P0.7870.80
352_L364_R0.7860.80
563_I606_I0.7840.80
501_T509_G0.7840.80
345_D352_L0.7840.80
406_E410_D0.7830.80
556_Y563_I0.7810.80
293_V298_N0.7810.80
414_L420_V0.7810.80
361_S364_R0.7800.80
78_Q82_H0.7800.80
301_A311_W0.7790.79
50_R57_L0.7770.79
350_R361_S0.7770.79
381_I384_L0.7770.79
132_I135_A0.7770.79
368_G373_M0.7740.79
120_L139_L0.7730.79
95_M98_I0.7710.79
359_W366_H0.7700.79
229_R440_Q0.7700.79
501_T598_K0.7700.79
384_L392_M0.7690.79
561_E587_L0.7680.78
407_N414_L0.7680.78
85_D88_W0.7680.78
336_S346_E0.7670.78
45_A51_G0.7670.78
603_D655_H0.7660.78
445_Q448_A0.7660.78
550_L556_Y0.7630.78
362_L365_M0.7610.78
488_E491_G0.7610.78
53_V59_F0.7580.78
411_F422_L0.7560.77
56_E59_F0.7560.77
128_V135_A0.7560.77
358_R363_M0.7550.77
390_K394_P0.7550.77
106_Q110_I0.7540.77
357_D365_M0.7530.77
340_G346_E0.7510.77
297_E301_A0.7500.77
297_E303_R0.7490.77
114_T132_I0.7480.77
60_V65_K0.7480.77
340_G350_R0.7470.77
360_V373_M0.7450.76
395_L401_G0.7450.76
231_G267_T0.7440.76
228_A260_R0.7430.76
404_K413_G0.7410.76
407_N410_D0.7410.76
338_P341_N0.7370.76
67_V72_T0.7350.75
45_A48_C0.7340.75
355_R359_W0.7330.75
229_R647_Y0.7330.75
313_K316_S0.7330.75
293_V299_D0.7320.75
471_A645_L0.7310.75
305_E316_S0.7290.75
66_V72_T0.7280.75
611_Q661_F0.7270.75
46_I54_W0.7270.75
231_G266_H0.7270.75
392_M407_N0.7260.74
217_G220_S0.7250.74
398_A402_A0.7230.74
228_A440_Q0.7220.74
59_F63_D0.7220.74
226_L465_V0.7220.74
544_S547_D0.7190.74
131_Q140_P0.7190.74
56_E63_D0.7180.74
413_G553_L0.7180.74
50_R56_E0.7170.74
286_G300_T0.7170.74
65_K69_L0.7160.73
66_V71_G0.7160.73
343_W350_R0.7150.73
597_S602_A0.7150.73
342_F345_D0.7150.73
340_G347_K0.7130.73
348_L355_R0.7120.73
396_L408_A0.7110.73
436_V464_A0.7110.73
357_D360_V0.7110.73
205_V225_V0.7070.73
342_F348_L0.7060.72
51_G58_E0.7040.72
156_W166_I0.7040.72
597_S605_V0.7030.72
367_G371_A0.7030.72
377_A380_E0.7020.72
440_Q600_Q0.7010.72
304_H309_A0.6990.72
403_L406_E0.6990.72
360_V369_A0.6970.71
356_L361_S0.6960.71
368_G372_E0.6950.71
568_R645_L0.6950.71
504_F512_A0.6930.71
349_Q354_S0.6920.71
481_S485_A0.6920.71
301_A305_E0.6920.71
303_R308_I0.6910.71
215_L603_D0.6910.71
609_G662_N0.6910.71
335_W344_D0.6890.71
392_M395_L0.6880.70
88_W92_S0.6870.70
66_V80_F0.6850.70
345_D355_R0.6850.70
216_A439_F0.6850.70
414_L424_K0.6850.70
374_I380_E0.6820.70
357_D366_H0.6820.70
155_A163_L0.6820.70
403_L408_A0.6780.69
247_L278_L0.6770.69
133_R141_L0.6770.69
356_L364_R0.6760.69
73_E86_A0.6760.69
440_Q472_I0.6760.69
218_A568_R0.6740.69
509_G523_L0.6740.69
81_Y86_A0.6720.69
61_L67_V0.6700.68
356_L359_W0.6700.68
359_W378_P0.6700.68
248_A512_A0.6690.68
57_L60_V0.6690.68
249_F253_A0.6690.68
307_F315_C0.6690.68
410_D415_I0.6680.68
227_V257_M0.6670.68
75_G81_Y0.6670.68
78_Q81_Y0.6660.68
482_L485_A0.6660.68
47_H51_G0.6660.68
217_G469_W0.6650.68
131_Q163_L0.6640.68
198_N206_V0.6640.68
585_P588_Q0.6640.68
64_E68_R0.6640.68
365_M565_I0.6630.68
438_E470_Q0.6610.67
69_L77_T0.6610.67
72_T80_F0.6610.67
363_M370_Q0.6610.67
229_R433_H0.6580.67
116_E133_R0.6550.67
484_T612_E0.6550.67
427_F430_P0.6550.67
373_M379_E0.6550.67
409_V412_S0.6540.67
116_E135_A0.6540.67
72_T77_T0.6530.66
59_F65_K0.6510.66
131_Q134_Q0.6500.66
154_E158_K0.6490.66
253_A256_E0.6470.66
542_D572_M0.6460.66
133_R235_A0.6460.66
372_E377_A0.6450.66
362_L366_H0.6450.66
382_R387_K0.6440.65
54_W61_L0.6430.65
374_I381_I0.6420.65
451_A454_R0.6420.65
548_A660_L0.6420.65
249_F257_M0.6410.65
103_L110_I0.6410.65
57_L66_V0.6410.65
73_E81_Y0.6400.65
365_M368_G0.6390.65
355_R360_V0.6380.65
612_E660_L0.6370.65
605_V657_V0.6370.65
538_V661_F0.6350.64
281_H284_Q0.6340.64
52_L55_G0.6340.64
440_Q602_A0.6330.64
59_F64_E0.6330.64
344_D352_L0.6330.64
350_R353_A0.6320.64
197_L228_A0.6320.64
63_D68_R0.6320.64
49_K80_F0.6250.63
77_T88_W0.6240.63
343_W355_R0.6230.63
215_L254_A0.6230.63
52_L60_V0.6180.62
436_V450_L0.6180.62
406_E422_L0.6180.62
375_A382_R0.6180.62
408_A418_A0.6160.62
250_G258_D0.6160.62
407_N411_F0.6160.62
229_R598_K0.6160.62
339_E344_D0.6150.62
304_H314_Q0.6150.62
565_I584_W0.6150.62
356_L363_M0.6140.62
485_A488_E0.6130.62
357_D361_S0.6110.61
57_L61_L0.6100.61
273_R281_H0.6080.61
75_G85_D0.6070.61
336_S351_R0.6070.61
413_G420_V0.6050.61
216_A249_F0.6050.61
404_K408_A0.6050.61
567_A572_M0.6040.60
356_L374_I0.6030.60
48_C53_V0.6030.60
121_T125_T0.6020.60
70_H77_T0.5980.60
410_D413_G0.5980.60
308_I313_K0.5960.59
411_F419_I0.5950.59
115_G137_S0.5950.59
339_E346_E0.5940.59
495_R513_N0.5940.59
68_R74_W0.5930.59
338_P348_L0.5930.59
234_L463_F0.5930.59
215_L495_R0.5930.59
135_A175_Q0.5920.59
547_D579_K0.5920.59
114_T141_L0.5920.59
228_A246_L0.5910.59
47_H62_P0.5910.59
551_D555_G0.5910.59
69_L74_W0.5910.59
48_C58_E0.5910.59
539_T660_L0.5890.59
480_M484_T0.5880.58
65_K68_R0.5880.58
341_N351_R0.5870.58
140_P177_Y0.5870.58
599_G652_R0.5860.58
81_Y85_D0.5860.58
53_V58_E0.5850.58
97_E115_G0.5850.58
375_A380_E0.5840.58
395_L421_I0.5840.58
374_I378_P0.5840.58
363_M366_H0.5830.58
248_A254_A0.5830.58
545_Q608_V0.5820.58
594_I646_M0.5810.58
49_K57_L0.5810.58
175_Q182_L0.5800.57
336_S345_D0.5790.57
197_L202_A0.5780.57
312_R315_C0.5780.57
357_D362_L0.5780.57
184_E188_F0.5770.57
70_H74_W0.5770.57
547_D558_K0.5770.57
354_S359_W0.5770.57
65_K78_Q0.5760.57
341_N346_E0.5740.57
384_L390_K0.5730.57
337_V355_R0.5730.57
351_R354_S0.5730.57
406_E418_A0.5710.56
485_A490_F0.5700.56
535_K538_V0.5700.56
168_S171_L0.5700.56
337_V340_G0.5690.56
250_G257_M0.5670.56
139_L150_D0.5670.56
72_T75_G0.5660.56
198_N228_A0.5660.56
231_G250_G0.5650.55
552_K658_W0.5650.55
68_R75_G0.5640.55
202_A228_A0.5640.55
450_L454_R0.5640.55
511_V653_A0.5640.55
117_N143_V0.5640.55
341_N352_L0.5630.55
565_I591_F0.5630.55
194_S231_G0.5620.55
365_M372_E0.5620.55
410_D425_G0.5600.55
506_S532_N0.5600.55
299_D307_F0.5600.55
343_W346_E0.5600.55
484_T487_H0.5590.55
569_Y593_T0.5590.55
228_A435_L0.5580.55
358_R390_K0.5580.55
533_G537_A0.5560.54
250_G256_E0.5560.54
384_L388_R0.5530.54
49_K55_G0.5520.54
380_E385_F0.5510.54
577_L591_F0.5510.54
363_M368_G0.5500.53
47_H61_L0.5490.53
450_L462_L0.5480.53
542_D612_E0.5480.53
412_S425_G0.5470.53
247_L596_A0.5450.53
196_P206_V0.5440.53
198_N202_A0.5440.53
227_V440_Q0.5430.53
178_T182_L0.5430.53
405_A421_I0.5430.53
296_L301_A0.5420.52
472_I598_K0.5410.52
50_R58_E0.5390.52
127_G133_R0.5390.52
72_T76_E0.5390.52
49_K60_V0.5380.52
49_K62_P0.5380.52
342_F349_Q0.5370.52
264_R531_T0.5360.52
380_E386_S0.5360.52
249_F441_D0.5360.52
650_L659_A0.5350.52
294_S558_K0.5350.52
56_E69_L0.5330.51
434_I462_L0.5330.51
553_L556_Y0.5330.51
211_S460_T0.5320.51
543_E550_L0.5310.51
78_Q85_D0.5290.51
67_V83_H0.5280.51
156_W161_A0.5280.51
130_Q141_L0.5280.51
388_R394_P0.5270.50
45_A49_K0.5260.50
167_E174_N0.5260.50
71_G76_E0.5260.50
98_I101_G0.5250.50
337_V345_D0.5250.50
541_L545_Q0.5250.50
153_R163_L0.5250.50
384_L565_I0.5240.50
144_N148_E0.5230.50
540_L664_E0.5220.50
69_L81_Y0.5200.50
336_S342_F0.5200.50
211_S462_L0.5200.50
413_G421_I0.5200.50
411_F417_Q0.5200.50
200_A499_D0.5190.49
270_I651_T0.5190.49
505_N533_G0.5190.49
409_V416_H0.5190.49
298_N307_F0.5180.49
74_W77_T0.5180.49
226_L260_R0.5170.49
483_T644_R0.5170.49
477_G480_M0.5160.49
228_A600_Q0.5160.49
137_S140_P0.5160.49
200_A508_I0.5160.49
343_W356_L0.5160.49
46_I58_E0.5150.49
338_P345_D0.5150.49
272_A276_H0.5150.49
235_A257_M0.5140.49
349_Q356_L0.5130.49
63_D91_W0.5130.49
198_N600_Q0.5130.49
154_E166_I0.5100.48
338_P343_W0.5080.48
65_K71_G0.5080.48
248_A505_N0.5080.48
471_A501_T0.5070.48
54_W59_F0.5070.48
69_L75_G0.5060.48
228_A454_R0.5060.48
377_A382_R0.5050.48
346_E350_R0.5040.47
97_E131_Q0.5030.47
433_H463_F0.5020.47
59_F66_V0.5020.47
60_V70_H0.5020.47
343_W347_K0.5010.47
478_A484_T0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjrA 1 0.6447 100 0.466 Contact Map
4c2tA 1 0.6594 100 0.468 Contact Map
4b3fX 1 0.8041 100 0.48 Contact Map
1uaaA 2 0.636 100 0.492 Contact Map
4c2uA 1 0.655 100 0.494 Contact Map
3lfuA 1 0.6404 100 0.495 Contact Map
2xzlA 1 0.7924 100 0.499 Contact Map
4pj3A 1 0.886 100 0.503 Contact Map
2wjyA 1 0.8289 100 0.519 Contact Map
2gk6A 1 0.7734 100 0.527 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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