GREMLIN Database
AMPP - Xaa-Pro aminopeptidase
UniProt: P15034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10697
Length: 441 (359)
Sequences: 9467 (7053)
Seq/√Len: 372.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_R418_E5.8811.00
377_P414_E4.9301.00
305_Y412_I3.7731.00
182_I411_V3.5611.00
292_D296_E2.8231.00
187_R190_E2.6581.00
78_F117_Q2.6521.00
310_S313_E2.5301.00
284_T287_Q2.5131.00
286_A289_E2.5041.00
185_L380_V2.4871.00
286_A401_G2.4801.00
315_T319_V2.4261.00
299_E303_R2.4041.00
300_T321_I2.3671.00
285_Q289_E2.3631.00
215_E218_H2.3611.00
176_F376_E2.3401.00
312_L372_S2.3121.00
208_F251_E2.2931.00
238_E250_C2.2901.00
194_M223_H2.2661.00
357_L409_D2.2391.00
198_R219_E2.2201.00
54_T63_L2.2061.00
320_R324_S2.1671.00
304_L317_E2.1541.00
127_V162_T2.1461.00
218_H222_R2.1041.00
301_S318_V2.0951.00
292_D428_P2.0931.00
413_T418_E2.0811.00
186_R190_E2.0541.00
252_M279_V2.0311.00
253_R256_D2.0281.00
406_I426_K1.9561.00
300_T303_R1.9521.00
290_I404_I1.9311.00
290_I402_I1.8761.00
234_V258_V1.8621.00
383_V410_I1.8591.00
193_A424_V1.8501.00
113_E116_Q1.8311.00
250_C256_D1.7981.00
80_R83_D1.7871.00
278_P283_F1.7801.00
257_L287_Q1.7501.00
217_H221_N1.7431.00
296_E300_T1.7311.00
288_R292_D1.7211.00
48_S360_D1.7201.00
184_V267_K1.7111.00
310_S374_I1.6801.00
294_V404_I1.6661.00
272_D407_E1.6571.00
208_F211_H1.6571.00
202_K215_E1.6561.00
299_E427_K1.6511.00
261_D272_D1.6371.00
236_S250_C1.6331.00
411_V420_L1.6181.00
322_M387_L1.6071.00
200_M277_F1.5981.00
382_T409_D1.5961.00
197_T201_E1.5871.00
229_S270_A1.5741.00
210_Y249_E1.5731.00
301_S314_V1.5661.00
205_P254_D1.5621.00
219_E223_H1.5561.00
411_V418_E1.5461.00
219_E222_R1.5451.00
296_E324_S1.5391.00
214_G218_H1.5311.00
297_S321_I1.5291.00
316_G320_R1.5161.00
257_L278_P1.5121.00
127_V164_I1.5031.00
261_D407_E1.5031.00
198_R201_E1.5011.00
212_L252_M1.4961.00
293_I345_H1.4951.00
290_I389_I1.4941.00
19_Q22_P1.4871.00
212_L258_V1.4811.00
183_A187_R1.4741.00
11_R15_A1.4621.00
306_R309_T1.4481.00
376_E379_M1.4231.00
179_P183_A1.4121.00
298_L302_L1.4041.00
191_I268_G1.4031.00
13_R17_V1.3961.00
302_L410_I1.3921.00
175_L379_M1.3911.00
196_H273_I1.3721.00
213_E217_H1.3221.00
98_A101_E1.3221.00
309_T313_E1.3191.00
298_L426_K1.2971.00
285_Q288_R1.2961.00
211_H222_R1.2911.00
291_Y406_I1.2881.00
318_V353_L1.2771.00
225_A264_C1.2751.00
265_E270_A1.2741.00
51_W268_G1.2711.00
236_S252_M1.2701.00
298_L408_D1.2631.00
302_L419_N1.2611.00
25_A129_Y1.2601.00
313_E316_G1.2561.00
295_L299_E1.2521.00
185_L189_G1.2481.00
291_Y426_K1.2391.00
192_T273_I1.2371.00
95_G98_A1.2331.00
413_T416_G1.2331.00
215_E219_E1.2291.00
257_L276_T1.2281.00
299_E426_K1.2181.00
143_N146_L1.2151.00
172_E376_E1.2141.00
186_R411_V1.2121.00
198_R223_H1.2111.00
307_P377_P1.2011.00
15_A18_E1.1981.00
305_Y314_V1.1951.00
198_R222_R1.1941.00
109_L113_E1.1791.00
187_R266_Y1.1781.00
375_L412_I1.1731.00
380_V411_V1.1701.00
53_F173_M1.1691.00
237_G256_D1.1631.00
289_E293_I1.1551.00
196_H277_F1.1521.00
215_E222_R1.1431.00
176_F379_M1.1421.00
296_E321_I1.1381.00
381_L412_I1.1291.00
14_Q18_E1.1241.00
236_S256_D1.1241.00
380_V420_L1.1231.00
378_G411_V1.1181.00
312_L316_G1.1101.00
99_A103_L1.1081.00
180_E184_V1.1071.00
317_E321_I1.0981.00
239_N245_Y1.0971.00
309_T317_E1.0961.00
286_A389_I1.0891.00
301_S317_E1.0811.00
300_T317_E1.0791.00
203_C277_F1.0781.00
312_L370_D1.0781.00
190_E194_M1.0771.00
239_N250_C1.0681.00
288_R428_P1.0671.00
375_L381_L1.0621.00
117_Q120_Q1.0581.00
293_I296_E1.0561.00
389_I401_G1.0531.00
191_I225_A1.0521.00
210_Y214_G1.0511.00
315_T353_L1.0511.00
187_R267_K1.0461.00
19_Q23_G1.0461.00
98_A102_K1.0441.00
304_L309_T1.0401.00
198_R215_E1.0391.00
197_T424_V1.0331.00
293_I322_M1.0271.00
207_M211_H1.0261.00
26_A30_A1.0221.00
314_V317_E1.0191.00
15_A19_Q1.0161.00
297_S322_M1.0091.00
45_R48_S1.0011.00
145_A148_K1.0001.00
207_M215_E0.9971.00
302_L383_V0.9971.00
116_Q120_Q0.9961.00
228_P232_T0.9951.00
412_I417_N0.9921.00
77_L87_E0.9921.00
235_G245_Y0.9881.00
217_H228_P0.9871.00
183_A186_R0.9841.00
373_R376_E0.9821.00
180_E183_A0.9811.00
179_P413_T0.9781.00
410_I419_N0.9761.00
408_D426_K0.9751.00
196_H424_V0.9691.00
76_V109_L0.9691.00
293_I321_I0.9691.00
58_E61_A0.9631.00
49_D171_H0.9621.00
166_W169_V0.9561.00
189_G193_A0.9561.00
235_G240_G0.9521.00
250_C253_R0.9511.00
102_K105_V0.9491.00
99_A102_K0.9481.00
96_Q99_A0.9471.00
216_I220_F0.9461.00
207_M212_L0.9461.00
305_Y383_V0.9421.00
317_E320_R0.9421.00
97_D101_E0.9411.00
309_T314_V0.9401.00
243_L351_H0.9361.00
278_P287_Q0.9361.00
307_P413_T0.9361.00
302_L417_N0.9341.00
17_V65_L0.9321.00
57_N60_E0.9301.00
300_T304_L0.9291.00
314_V375_L0.9211.00
16_L28_I0.9201.00
217_H232_T0.9151.00
240_G259_L0.9141.00
367_Y381_L0.9111.00
203_C212_L0.9081.00
321_I324_S0.9061.00
198_R202_K0.9051.00
116_Q119_Y0.9041.00
19_Q172_E0.9041.00
260_I277_F0.9031.00
212_L234_V0.9021.00
289_E292_D0.9001.00
62_V65_L0.8971.00
187_R191_I0.8971.00
30_A33_E0.8971.00
197_T425_V0.8951.00
305_Y417_N0.8951.00
193_A422_A0.8941.00
368_G371_R0.8941.00
192_T271_G0.8921.00
357_L380_V0.8911.00
52_Y55_G0.8881.00
304_L314_V0.8861.00
100_P103_L0.8831.00
258_V279_V0.8811.00
355_H407_E0.8801.00
220_F264_C0.8691.00
356_W365_G0.8651.00
320_R323_V0.8641.00
53_F170_V0.8641.00
189_G409_D0.8641.00
204_R207_M0.8621.00
410_I417_N0.8611.00
14_Q17_V0.8611.00
305_Y410_I0.8581.00
286_A290_I0.8561.00
109_L117_Q0.8521.00
49_D52_Y0.8521.00
21_Q72_H0.8511.00
189_G421_T0.8481.00
117_Q121_L0.8471.00
172_E373_R0.8441.00
50_F61_A0.8441.00
194_M197_T0.8421.00
344_A347_P0.8401.00
384_E407_E0.8371.00
146_L149_L0.8331.00
318_V349_F0.8321.00
129_Y166_W0.8291.00
272_D355_H0.8251.00
311_I375_L0.8241.00
97_D100_P0.8191.00
239_N242_I0.8191.00
304_L307_P0.8161.00
15_A173_M0.8151.00
12_R178_S0.8131.00
255_G282_K0.8131.00
301_S383_V0.8101.00
306_R417_N0.8061.00
101_E104_G0.8041.00
184_V187_R0.8021.00
182_I186_R0.8021.00
290_I293_I0.7991.00
321_I343_N0.7971.00
17_V71_T0.7961.00
261_D384_E0.7931.00
234_V260_I0.7911.00
217_H225_A0.7901.00
93_R96_Q0.7891.00
113_E117_Q0.7851.00
92_R95_G0.7821.00
297_S301_S0.7771.00
193_A197_T0.7771.00
24_S127_V0.7751.00
149_L154_R0.7751.00
295_L406_I0.7711.00
255_G279_V0.7671.00
324_S343_N0.7671.00
307_P417_N0.7661.00
301_S304_L0.7651.00
209_E239_N0.7631.00
104_G108_A0.7631.00
264_C271_G0.7621.00
143_N147_E0.7621.00
18_E21_Q0.7621.00
292_D295_L0.7611.00
373_R379_M0.7571.00
270_A361_V0.7571.00
238_E391_P0.7561.00
298_L383_V0.7551.00
214_G221_N0.7531.00
195_A219_E0.7531.00
16_L19_Q0.7471.00
110_A113_E0.7451.00
81_V350_M0.7411.00
81_V110_A0.7401.00
211_H214_G0.7401.00
240_G243_L0.7391.00
386_G405_R0.7391.00
49_D131_A0.7381.00
181_E269_Y0.7381.00
16_L53_F0.7371.00
169_V172_E0.7361.00
216_I260_I0.7361.00
205_P279_V0.7351.00
100_P104_G0.7331.00
307_P414_E0.7321.00
240_G403_G0.7311.00
201_E205_P0.7291.00
115_N119_Y0.7291.00
297_S317_E0.7281.00
34_V360_D0.7281.00
17_V21_Q0.7251.00
272_D384_E0.7201.00
388_Y405_R0.7191.00
391_P401_G0.7191.00
95_G99_A0.7161.00
94_L99_A0.7131.00
240_G257_L0.7101.00
54_T75_S0.7090.99
228_P231_N0.7050.99
17_V20_M0.7050.99
286_A402_I0.7010.99
356_W363_D0.7010.99
158_T161_A0.7010.99
98_A103_L0.7000.99
191_I223_H0.7000.99
230_Y263_G0.7000.99
51_W359_L0.6980.99
313_E317_E0.6980.99
291_Y295_L0.6910.99
192_T195_A0.6900.99
348_F390_A0.6900.99
132_Q165_D0.6880.99
274_T407_E0.6870.99
208_F249_E0.6870.99
79_N83_D0.6870.99
20_M26_A0.6860.99
182_I380_V0.6860.99
202_K219_E0.6850.99
319_V349_F0.6830.99
79_N84_L0.6820.99
218_H221_N0.6810.99
261_D274_T0.6790.99
199_A212_L0.6760.99
26_A126_D0.6750.99
154_R157_L0.6750.99
244_H362_H0.6720.99
261_D355_H0.6710.99
46_Q49_D0.6680.99
254_D282_K0.6680.99
21_Q24_S0.6650.99
100_P105_V0.6650.99
380_V409_D0.6630.99
301_S353_L0.6630.99
131_A135_Y0.6630.99
300_T318_V0.6600.99
190_E193_A0.6560.99
179_P377_P0.6540.99
155_Q159_A0.6540.99
199_A260_I0.6530.99
94_L98_A0.6520.99
256_D287_Q0.6480.99
184_V266_Y0.6470.99
189_G271_G0.6430.99
26_A29_F0.6430.99
189_G420_L0.6420.99
355_H384_E0.6420.99
179_P378_G0.6410.99
52_Y173_M0.6410.99
74_H106_D0.6410.99
20_M27_L0.6410.99
204_R429_E0.6390.99
351_H362_H0.6390.99
310_S372_S0.6380.99
195_A220_F0.6360.99
371_R374_I0.6350.99
183_A190_E0.6340.99
196_H262_A0.6320.99
290_I387_L0.6300.99
236_S279_V0.6280.99
17_V73_N0.6280.99
240_G278_P0.6260.99
19_Q173_M0.6250.99
175_L376_E0.6250.99
297_S318_V0.6240.99
109_L112_S0.6230.99
314_V353_L0.6220.99
191_I266_Y0.6200.99
188_A192_T0.6190.99
377_P413_T0.6130.99
307_P376_E0.6120.99
343_N346_R0.6110.99
93_R97_D0.6110.99
283_F287_Q0.6100.98
18_E22_P0.6090.98
257_L283_F0.6090.98
101_E105_V0.6080.98
175_L373_R0.6080.98
176_F377_P0.6070.98
242_I245_Y0.6070.98
283_F288_R0.6070.98
238_E241_C0.6060.98
159_A163_M0.6060.98
154_R159_A0.6060.98
72_H75_S0.6050.98
307_P412_I0.6050.98
216_I262_A0.6040.98
156_N159_A0.6020.98
282_K288_R0.6020.98
11_R180_E0.6020.98
92_R96_Q0.6010.98
45_R50_F0.6010.98
20_M28_I0.6000.98
56_F86_A0.6000.98
199_A216_I0.5970.98
225_A228_P0.5950.98
288_R429_E0.5940.98
47_N50_F0.5940.98
273_I421_T0.5940.98
297_S300_T0.5910.98
189_G273_I0.5910.98
76_V117_Q0.5880.98
155_Q158_T0.5860.98
195_A216_I0.5830.98
57_N61_A0.5830.98
312_L371_R0.5830.98
311_I367_Y0.5820.98
389_I402_I0.5820.98
199_A202_K0.5810.98
194_M219_E0.5810.98
117_Q122_L0.5810.98
293_I387_L0.5800.98
75_S105_V0.5790.98
192_T262_A0.5780.98
94_L97_D0.5780.98
408_D419_N0.5770.98
413_T417_N0.5770.98
300_T320_R0.5760.98
154_R158_T0.5740.98
27_L30_A0.5720.98
203_C279_V0.5720.98
144_S147_E0.5690.98
24_S29_F0.5690.98
366_V381_L0.5680.98
357_L382_T0.5670.98
196_H200_M0.5650.98
144_S148_K0.5640.97
374_I377_P0.5640.97
171_H364_V0.5630.97
87_E93_R0.5600.97
273_I409_D0.5580.97
287_Q402_I0.5560.97
56_F61_A0.5550.97
19_Q169_V0.5550.97
272_D362_H0.5540.97
273_I424_V0.5510.97
362_H405_R0.5500.97
93_R98_A0.5490.97
71_T75_S0.5490.97
123_N126_D0.5480.97
226_R267_K0.5480.97
284_T401_G0.5460.97
230_Y233_I0.5460.97
119_Y122_L0.5460.97
296_E343_N0.5440.97
93_R99_A0.5440.97
244_H351_H0.5440.97
419_N422_A0.5430.97
307_P418_E0.5430.97
145_A149_L0.5420.97
14_Q21_Q0.5410.97
96_Q100_P0.5400.97
172_E175_L0.5380.97
287_Q401_G0.5380.97
196_H199_A0.5370.97
232_T262_A0.5350.97
311_I354_S0.5350.97
81_V84_L0.5340.97
212_L260_I0.5340.97
278_P284_T0.5340.97
322_M345_H0.5330.96
28_I166_W0.5320.96
132_Q147_E0.5320.96
81_V112_S0.5260.96
20_M25_A0.5250.96
199_A215_E0.5240.96
362_H385_P0.5230.96
350_M390_A0.5230.96
11_R14_Q0.5220.96
60_E63_L0.5220.96
306_R415_T0.5220.96
119_Y123_N0.5220.96
383_V419_N0.5210.96
92_R98_A0.5210.96
259_L405_R0.5200.96
244_H403_G0.5200.96
211_H251_E0.5190.96
308_G376_E0.5190.96
83_D86_A0.5180.96
240_G402_I0.5170.96
289_E345_H0.5170.96
351_H405_R0.5170.96
235_G259_L0.5170.96
382_T385_P0.5160.96
49_D170_V0.5150.96
51_W57_N0.5140.96
30_A46_Q0.5130.96
386_G403_G0.5120.96
58_E63_L0.5110.96
313_E374_I0.5110.96
409_D420_L0.5100.96
305_Y381_L0.5070.95
26_A127_V0.5060.95
318_V322_M0.5010.95
56_F79_N0.5010.95
302_L426_K0.5010.95
188_A193_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v3zA 3 0.9909 100 0.219 Contact Map
3ig4A 4 0.941 100 0.27 Contact Map
2iw2A 2 0.9569 100 0.28 Contact Map
3cb6A 2 0.8957 100 0.291 Contact Map
3q6dA 1 0.805 100 0.294 Contact Map
4fkcA 2 0.8231 100 0.298 Contact Map
2zsgA 2 0.8027 100 0.3 Contact Map
1wn1A 2 0.7959 100 0.305 Contact Map
4r60A 2 0.8299 100 0.308 Contact Map
3biqA 1 0.8753 100 0.309 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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