GREMLIN Database
FECC - Fe(3+) dicitrate transport system permease protein FecC
UniProt: P15030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10288
Length: 332 (317)
Sequences: 13885 (9849)
Seq/√Len: 553.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_N278_D4.6211.00
72_A287_M3.7901.00
108_T124_I3.6261.00
22_F296_L3.5631.00
80_L211_V3.5151.00
23_W64_S3.4171.00
234_N237_R3.2881.00
73_S204_V3.1861.00
80_L242_I3.0741.00
68_V291_A3.0691.00
67_A189_V2.9201.00
271_A289_L2.8281.00
38_D52_P2.6601.00
66_V192_A2.6581.00
73_S253_C2.5561.00
73_S249_L2.5551.00
76_L287_M2.4851.00
23_W68_V2.4731.00
38_D41_R2.4061.00
103_L166_L2.3771.00
225_D239_R2.3691.00
18_L292_T2.3201.00
19_I292_T2.3011.00
76_L208_V2.2481.00
70_I253_C2.2461.00
79_T286_S2.2021.00
28_C36_G2.1601.00
275_A285_V2.1331.00
103_L163_C2.0921.00
49_P52_P2.0491.00
68_V295_L2.0391.00
70_I257_A2.0371.00
203_V252_A2.0331.00
19_I68_V2.0261.00
69_L201_L1.9651.00
63_R298_D1.9641.00
217_Q238_L1.9641.00
35_S38_D1.9521.00
26_L64_S1.9481.00
219_N279_Q1.9381.00
107_L111_L1.8971.00
22_F292_T1.8641.00
83_T279_Q1.8591.00
81_L246_V1.8301.00
106_A167_T1.7971.00
12_G285_V1.7911.00
220_L233_V1.7851.00
214_L217_Q1.7761.00
210_V245_L1.7381.00
46_G53_E1.7291.00
37_A41_R1.7071.00
192_A196_D1.7051.00
207_A249_L1.6121.00
237_R241_V1.5851.00
50_T53_E1.5831.00
129_G251_G1.5731.00
300_L304_L1.5711.00
53_E57_Q1.5701.00
214_L241_V1.5631.00
105_M125_A1.5451.00
79_T282_V1.5351.00
65_L197_V1.5351.00
19_I288_L1.5281.00
263_I294_M1.5191.00
25_S28_C1.5041.00
133_W247_L1.4961.00
207_A248_L1.4921.00
104_A124_I1.4801.00
301_A312_A1.4771.00
198_W202_P1.4761.00
42_A57_Q1.4651.00
40_T44_L1.4631.00
15_V288_L1.4521.00
193_R196_D1.4511.00
214_L238_L1.4481.00
22_F295_L1.4231.00
15_V285_V1.4161.00
300_L315_V1.4151.00
11_W285_V1.4141.00
25_S29_Y1.4061.00
77_A249_L1.3991.00
189_V294_M1.3741.00
271_A282_V1.3321.00
207_A245_L1.3171.00
66_V256_V1.3151.00
102_A167_T1.3151.00
26_L299_V1.3151.00
271_A285_V1.3121.00
198_W201_L1.3011.00
162_F321_S1.2991.00
281_N284_P1.2841.00
98_N250_V1.2831.00
202_P206_T1.2601.00
210_V214_L1.2491.00
75_A267_V1.2471.00
214_L242_I1.2391.00
69_L197_V1.2321.00
267_V293_L1.2281.00
132_S163_C1.2171.00
15_V289_L1.2121.00
229_H236_T1.2021.00
104_A128_G1.2011.00
237_R240_L1.1951.00
84_L242_I1.1941.00
19_I291_A1.1911.00
12_G281_N1.1851.00
267_V289_L1.1741.00
227_T230_T1.1681.00
102_A185_L1.1611.00
15_V292_T1.1591.00
54_A58_N1.1541.00
279_Q282_V1.1491.00
134_L138_T1.1381.00
238_L241_V1.1371.00
257_A260_V1.1331.00
200_L256_V1.1311.00
33_P36_G1.1261.00
126_A248_L1.1241.00
79_T283_L1.1181.00
302_R309_D1.1141.00
106_A181_I1.1121.00
32_I55_L1.1111.00
236_T239_R1.1101.00
79_T279_Q1.1091.00
51_L54_A1.1041.00
48_T53_E1.0931.00
220_L231_L1.0911.00
42_A53_E1.0871.00
103_L107_L1.0851.00
100_G128_G1.0841.00
45_P48_T1.0831.00
72_A75_A1.0821.00
66_V197_V1.0811.00
123_F127_C1.0781.00
224_S228_A1.0731.00
67_A294_M1.0721.00
110_A170_T1.0691.00
69_L200_L1.0681.00
72_A291_A1.0601.00
136_V159_L1.0581.00
210_V241_V1.0561.00
211_V245_L1.0561.00
209_P213_L1.0541.00
67_A295_L1.0531.00
10_L13_L1.0391.00
298_D302_R1.0391.00
65_L194_W1.0361.00
200_L204_V1.0311.00
42_A56_V1.0311.00
207_A252_A1.0261.00
100_G132_S1.0181.00
141_G236_T1.0181.00
300_L303_A1.0171.00
27_F64_S1.0151.00
160_S164_M1.0151.00
46_G57_Q1.0121.00
124_I128_G1.0111.00
284_P287_M1.0091.00
42_A48_T1.0061.00
292_T296_L1.0061.00
57_Q61_L1.0021.00
99_S163_C1.0011.00
23_W295_L0.9951.00
206_T209_P0.9911.00
236_T240_L0.9901.00
260_V294_M0.9901.00
282_V286_S0.9871.00
317_A322_P0.9861.00
169_I173_L0.9821.00
117_A120_S0.9811.00
17_A21_I0.9761.00
29_Y303_A0.9641.00
131_V135_L0.9641.00
301_A315_V0.9581.00
267_V271_A0.9561.00
22_F299_V0.9551.00
275_A281_N0.9531.00
24_L28_C0.9501.00
107_L170_T0.9481.00
39_A56_V0.9461.00
64_S299_V0.9371.00
218_L242_I0.9341.00
28_C39_A0.9341.00
16_A20_I0.9341.00
42_A52_P0.9281.00
199_Q202_P0.9271.00
42_A46_G0.9251.00
98_N259_P0.9241.00
238_L242_I0.9231.00
226_S229_H0.9211.00
194_W197_V0.9081.00
110_A174_A0.9011.00
202_P205_V0.8981.00
103_L167_T0.8971.00
281_N285_V0.8931.00
253_C257_A0.8921.00
233_V238_L0.8871.00
24_L36_G0.8831.00
103_L170_T0.8811.00
30_S60_R0.8781.00
69_L204_V0.8761.00
274_W289_L0.8681.00
296_L300_L0.8681.00
322_P326_W0.8671.00
78_G268_P0.8671.00
323_C326_W0.8671.00
305_A308_G0.8671.00
11_W14_P0.8651.00
174_A177_H0.8651.00
10_L14_P0.8641.00
41_R44_L0.8641.00
72_A208_V0.8631.00
53_E58_N0.8611.00
97_I129_G0.8461.00
301_A311_P0.8441.00
109_S121_L0.8431.00
77_A246_V0.8421.00
279_Q284_P0.8391.00
225_D229_H0.8371.00
34_V56_V0.8351.00
219_N280_R0.8341.00
41_R45_P0.8321.00
11_W15_V0.8311.00
73_S77_A0.8301.00
16_A288_L0.8291.00
215_A280_R0.8231.00
20_I24_L0.8211.00
141_G146_T0.8181.00
93_S98_N0.8131.00
41_R46_G0.8111.00
214_L245_L0.8101.00
116_I120_S0.8101.00
105_M121_L0.8101.00
99_S102_A0.8101.00
278_D281_N0.8081.00
181_I185_L0.8051.00
272_R282_V0.7931.00
64_S295_L0.7871.00
211_V242_I0.7831.00
137_M236_T0.7831.00
205_V209_P0.7821.00
63_R302_R0.7821.00
179_Y182_F0.7801.00
108_T121_L0.7761.00
75_A79_T0.7751.00
130_G251_G0.7751.00
240_L244_M0.7741.00
129_G247_L0.7721.00
203_V207_A0.7671.00
304_L307_P0.7661.00
101_A129_G0.7641.00
210_V213_L0.7641.00
235_L239_R0.7631.00
225_D235_L0.7631.00
137_M240_L0.7621.00
294_M316_L0.7621.00
127_C131_V0.7611.00
318_L322_P0.7581.00
271_A275_A0.7571.00
126_A130_G0.7561.00
243_N247_L0.7561.00
228_A235_L0.7541.00
26_L302_R0.7521.00
61_L194_W0.7481.00
72_A204_V0.7471.00
28_C33_P0.7471.00
34_V52_P0.7461.00
107_L112_S0.7451.00
176_D180_G0.7441.00
288_L292_T0.7421.00
39_A42_A0.7411.00
141_G147_H0.7401.00
138_T141_G0.7391.00
219_N284_P0.7391.00
19_I23_W0.7371.00
263_I316_L0.7361.00
20_I23_W0.7301.00
120_S123_F0.7291.00
75_A287_M0.7231.00
63_R309_D0.7231.00
81_L95_L0.7221.00
303_A306_F0.7201.00
91_S94_L0.7191.00
271_A274_W0.7191.00
106_A171_L0.7181.00
74_L263_I0.7171.00
212_L215_A0.7161.00
136_V140_G0.7161.00
195_Q198_W0.7151.00
204_V253_C0.7141.00
19_I295_L0.7121.00
305_A310_L0.7101.00
21_I24_L0.7061.00
50_T54_A0.7051.00
76_L211_V0.7051.00
76_L283_L0.7041.00
133_W243_N0.7031.00
196_D256_V0.7031.00
200_L252_A0.7031.00
32_I36_G0.7011.00
29_Y33_P0.7011.00
100_G163_C0.7001.00
66_V200_L0.6981.00
132_S136_V0.6951.00
270_L289_L0.6911.00
32_I35_S0.6871.00
85_T153_I0.6871.00
97_I133_W0.6861.00
102_A259_P0.6861.00
107_L166_L0.6841.00
65_L69_L0.6841.00
54_A59_L0.6811.00
252_A256_V0.6781.00
217_Q233_V0.6771.00
174_A178_A0.6741.00
293_L297_A0.6691.00
213_L217_Q0.6681.00
201_L205_V0.6661.00
229_H235_L0.6641.00
182_F185_L0.6611.00
200_L203_V0.6551.00
273_F327_L0.6501.00
252_A255_S0.6491.00
83_T222_N0.6481.00
77_A250_V0.6481.00
70_I189_V0.6471.00
260_V312_A0.6441.00
291_A295_L0.6431.00
268_P286_S0.6421.00
121_L124_I0.6401.00
171_L182_F0.6391.00
119_Y123_F0.6381.00
139_A155_A0.6361.00
34_V42_A0.6351.00
109_S180_G0.6351.00
11_W274_W0.6341.00
109_S181_I0.6331.00
221_L235_L0.6321.00
21_I25_S0.6321.00
130_G247_L0.6311.00
207_A211_V0.6311.00
294_M312_A0.6311.00
15_V19_I0.6281.00
287_M291_A0.6281.00
27_F61_L0.6271.00
91_S264_G0.6261.00
23_W27_F0.6251.00
61_L65_L0.6241.00
203_V248_L0.6241.00
54_A57_Q0.6241.00
298_D309_D0.6221.00
45_P53_E0.6201.00
270_L273_F0.6201.00
14_P18_L0.6201.00
49_P53_E0.6201.00
98_N101_A0.6181.00
67_A312_A0.6171.00
27_F56_V0.6151.00
24_L40_T0.6151.00
36_G39_A0.6141.00
168_R184_W0.6141.00
189_V312_A0.6141.00
104_A108_T0.6131.00
297_A315_V0.6121.00
128_G132_S0.6101.00
48_T52_P0.6091.00
85_T88_P0.6061.00
35_S52_P0.6051.00
177_H180_G0.6031.00
263_I293_L0.6031.00
133_W137_M0.6011.00
37_A40_T0.6011.00
296_L299_V0.5991.00
150_N153_I0.5981.00
72_A76_L0.5961.00
208_V212_L0.5961.00
194_W198_W0.5961.00
164_M185_L0.5951.00
80_L245_L0.5931.00
270_L293_L0.5911.00
148_D151_K0.5901.00
81_L90_A0.5891.00
293_L319_I0.5881.00
140_G155_A0.5881.00
168_R172_L0.5881.00
99_S160_S0.5871.00
36_G40_T0.5871.00
301_A309_D0.5851.00
204_V208_V0.5851.00
39_A43_L0.5811.00
250_V254_V0.5780.99
251_G255_S0.5780.99
266_L323_C0.5770.99
26_L295_L0.5760.99
11_W275_A0.5740.99
219_N222_N0.5730.99
301_A304_L0.5730.99
284_P288_L0.5720.99
138_T142_G0.5720.99
164_M168_R0.5710.99
217_Q220_L0.5700.99
276_G284_P0.5690.99
265_L327_L0.5690.99
29_Y299_V0.5670.99
108_T120_S0.5670.99
266_L324_F0.5650.99
75_A290_G0.5650.99
241_V245_L0.5640.99
246_V251_G0.5640.99
213_L216_N0.5620.99
155_A158_A0.5590.99
66_V70_I0.5590.99
270_L323_C0.5570.99
137_M141_G0.5570.99
41_R48_T0.5570.99
56_V61_L0.5540.99
280_R284_P0.5540.99
271_A286_S0.5540.99
28_C40_T0.5510.99
206_T210_V0.5500.99
135_L138_T0.5490.99
12_G16_A0.5480.99
266_L270_L0.5450.99
19_I64_S0.5440.99
81_L97_I0.5430.99
234_N241_V0.5420.99
242_I246_V0.5410.99
247_L251_G0.5360.99
189_V257_A0.5340.99
295_L299_V0.5330.99
31_A307_P0.5330.99
111_L114_T0.5320.99
211_V283_L0.5320.99
99_S164_M0.5310.99
127_C130_G0.5290.99
299_V303_A0.5240.99
131_V134_L0.5240.99
97_I136_V0.5240.99
195_Q199_Q0.5220.99
218_L279_Q0.5210.99
178_A181_I0.5210.99
25_S299_V0.5210.99
221_L238_L0.5200.99
197_V201_L0.5200.99
197_V200_L0.5190.99
101_A125_A0.5190.99
38_D45_P0.5190.99
216_N219_N0.5180.99
46_G49_P0.5180.99
90_A97_I0.5180.99
171_L185_L0.5180.99
79_T271_A0.5160.99
135_L159_L0.5140.99
39_A44_L0.5140.99
219_N282_V0.5140.99
141_G145_H0.5130.99
211_V215_A0.5120.99
108_T112_S0.5120.99
241_V244_M0.5110.99
66_V257_A0.5110.99
38_D48_T0.5090.99
155_A159_L0.5090.99
199_Q252_A0.5090.99
105_M124_I0.5080.99
260_V316_L0.5080.99
140_G152_L0.5060.99
17_A20_I0.5050.99
14_P17_A0.5050.99
86_H225_D0.5040.99
265_L268_P0.5030.99
12_G288_L0.5020.99
23_W65_L0.5020.99
172_L314_A0.5020.99
204_V209_P0.5020.99
261_A266_L0.5010.99
97_I188_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9247 100 0.173 Contact Map
2qi9A 2 0.9548 100 0.186 Contact Map
4g1uA 2 0.8916 100 0.187 Contact Map
3rlbA 1 0.509 19.5 0.963 Contact Map
4tkrA 2 0.5181 14.6 0.965 Contact Map
4rfsS 1 0.5211 12.2 0.966 Contact Map
1zcdA 1 0.509 11.4 0.966 Contact Map
4huqS 1 0.4699 9.8 0.967 Contact Map
4z7fA 2 0.488 7.7 0.969 Contact Map
4xtrG 1 0.0663 6.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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