FECC - ECOLI - GREMLIN Contacts

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FECC - Fe(3+) dicitrate transport system permease protein FecC

UniProt:	P15030	Sequences: MTAIKHPVLLWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVSWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10288
Length:	332 (317)
Sequences:	13885 (9849)
Seq/√Len:	553.2

ECOLI - FECC FEPG FEPD BTUC FECD FHUB
BACSU - FHUG FHUB YFIZ YVRB FEUB YFME YFHA YFMD FEUC YCLN YCLO
HALSA - Q9HMG0 Q9HMG7 BTUCA
SULSO - Q97ZU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_N	278_D	4.621	1.00
72_A	287_M	3.790	1.00
108_T	124_I	3.626	1.00
22_F	296_L	3.563	1.00
80_L	211_V	3.515	1.00
23_W	64_S	3.417	1.00
234_N	237_R	3.288	1.00
73_S	204_V	3.186	1.00
80_L	242_I	3.074	1.00
68_V	291_A	3.069	1.00
67_A	189_V	2.920	1.00
271_A	289_L	2.828	1.00
38_D	52_P	2.660	1.00
66_V	192_A	2.658	1.00
73_S	253_C	2.556	1.00
73_S	249_L	2.555	1.00
76_L	287_M	2.485	1.00
23_W	68_V	2.473	1.00
38_D	41_R	2.406	1.00
103_L	166_L	2.377	1.00
225_D	239_R	2.369	1.00
18_L	292_T	2.320	1.00
19_I	292_T	2.301	1.00
76_L	208_V	2.248	1.00
70_I	253_C	2.246	1.00
79_T	286_S	2.202	1.00
28_C	36_G	2.160	1.00
275_A	285_V	2.133	1.00
103_L	163_C	2.092	1.00
49_P	52_P	2.049	1.00
68_V	295_L	2.039	1.00
70_I	257_A	2.037	1.00
203_V	252_A	2.033	1.00
19_I	68_V	2.026	1.00
69_L	201_L	1.965	1.00
63_R	298_D	1.964	1.00
217_Q	238_L	1.964	1.00
35_S	38_D	1.952	1.00
26_L	64_S	1.948	1.00
219_N	279_Q	1.938	1.00
107_L	111_L	1.897	1.00
22_F	292_T	1.864	1.00
83_T	279_Q	1.859	1.00
81_L	246_V	1.830	1.00
106_A	167_T	1.797	1.00
12_G	285_V	1.791	1.00
220_L	233_V	1.785	1.00
214_L	217_Q	1.776	1.00
210_V	245_L	1.738	1.00
46_G	53_E	1.729	1.00
37_A	41_R	1.707	1.00
192_A	196_D	1.705	1.00
207_A	249_L	1.612	1.00
237_R	241_V	1.585	1.00
50_T	53_E	1.583	1.00
129_G	251_G	1.573	1.00
300_L	304_L	1.571	1.00
53_E	57_Q	1.570	1.00
214_L	241_V	1.563	1.00
105_M	125_A	1.545	1.00
79_T	282_V	1.535	1.00
65_L	197_V	1.535	1.00
19_I	288_L	1.528	1.00
263_I	294_M	1.519	1.00
25_S	28_C	1.504	1.00
133_W	247_L	1.496	1.00
207_A	248_L	1.492	1.00
104_A	124_I	1.480	1.00
301_A	312_A	1.477	1.00
198_W	202_P	1.476	1.00
42_A	57_Q	1.465	1.00
40_T	44_L	1.463	1.00
15_V	288_L	1.452	1.00
193_R	196_D	1.451	1.00
214_L	238_L	1.448	1.00
22_F	295_L	1.423	1.00
15_V	285_V	1.416	1.00
300_L	315_V	1.415	1.00
11_W	285_V	1.414	1.00
25_S	29_Y	1.406	1.00
77_A	249_L	1.399	1.00
189_V	294_M	1.374	1.00
271_A	282_V	1.332	1.00
207_A	245_L	1.317	1.00
66_V	256_V	1.315	1.00
102_A	167_T	1.315	1.00
26_L	299_V	1.315	1.00
271_A	285_V	1.312	1.00
198_W	201_L	1.301	1.00
162_F	321_S	1.299	1.00
281_N	284_P	1.284	1.00
98_N	250_V	1.283	1.00
202_P	206_T	1.260	1.00
210_V	214_L	1.249	1.00
75_A	267_V	1.247	1.00
214_L	242_I	1.239	1.00
69_L	197_V	1.232	1.00
267_V	293_L	1.228	1.00
132_S	163_C	1.217	1.00
15_V	289_L	1.212	1.00
229_H	236_T	1.202	1.00
104_A	128_G	1.201	1.00
237_R	240_L	1.195	1.00
84_L	242_I	1.194	1.00
19_I	291_A	1.191	1.00
12_G	281_N	1.185	1.00
267_V	289_L	1.174	1.00
227_T	230_T	1.168	1.00
102_A	185_L	1.161	1.00
15_V	292_T	1.159	1.00
54_A	58_N	1.154	1.00
279_Q	282_V	1.149	1.00
134_L	138_T	1.138	1.00
238_L	241_V	1.137	1.00
257_A	260_V	1.133	1.00
200_L	256_V	1.131	1.00
33_P	36_G	1.126	1.00
126_A	248_L	1.124	1.00
79_T	283_L	1.118	1.00
302_R	309_D	1.114	1.00
106_A	181_I	1.112	1.00
32_I	55_L	1.111	1.00
236_T	239_R	1.110	1.00
79_T	279_Q	1.109	1.00
51_L	54_A	1.104	1.00
48_T	53_E	1.093	1.00
220_L	231_L	1.091	1.00
42_A	53_E	1.087	1.00
103_L	107_L	1.085	1.00
100_G	128_G	1.084	1.00
45_P	48_T	1.083	1.00
72_A	75_A	1.082	1.00
66_V	197_V	1.081	1.00
123_F	127_C	1.078	1.00
224_S	228_A	1.073	1.00
67_A	294_M	1.072	1.00
110_A	170_T	1.069	1.00
69_L	200_L	1.068	1.00
72_A	291_A	1.060	1.00
136_V	159_L	1.058	1.00
210_V	241_V	1.056	1.00
211_V	245_L	1.056	1.00
209_P	213_L	1.054	1.00
67_A	295_L	1.053	1.00
10_L	13_L	1.039	1.00
298_D	302_R	1.039	1.00
65_L	194_W	1.036	1.00
200_L	204_V	1.031	1.00
42_A	56_V	1.031	1.00
207_A	252_A	1.026	1.00
100_G	132_S	1.018	1.00
141_G	236_T	1.018	1.00
300_L	303_A	1.017	1.00
27_F	64_S	1.015	1.00
160_S	164_M	1.015	1.00
46_G	57_Q	1.012	1.00
124_I	128_G	1.011	1.00
284_P	287_M	1.009	1.00
42_A	48_T	1.006	1.00
292_T	296_L	1.006	1.00
57_Q	61_L	1.002	1.00
99_S	163_C	1.001	1.00
23_W	295_L	0.995	1.00
206_T	209_P	0.991	1.00
236_T	240_L	0.990	1.00
260_V	294_M	0.990	1.00
282_V	286_S	0.987	1.00
317_A	322_P	0.986	1.00
169_I	173_L	0.982	1.00
117_A	120_S	0.981	1.00
17_A	21_I	0.976	1.00
29_Y	303_A	0.964	1.00
131_V	135_L	0.964	1.00
301_A	315_V	0.958	1.00
267_V	271_A	0.956	1.00
22_F	299_V	0.955	1.00
275_A	281_N	0.953	1.00
24_L	28_C	0.950	1.00
107_L	170_T	0.948	1.00
39_A	56_V	0.946	1.00
64_S	299_V	0.937	1.00
218_L	242_I	0.934	1.00
28_C	39_A	0.934	1.00
16_A	20_I	0.934	1.00
42_A	52_P	0.928	1.00
199_Q	202_P	0.927	1.00
42_A	46_G	0.925	1.00
98_N	259_P	0.924	1.00
238_L	242_I	0.923	1.00
226_S	229_H	0.921	1.00
194_W	197_V	0.908	1.00
110_A	174_A	0.901	1.00
202_P	205_V	0.898	1.00
103_L	167_T	0.897	1.00
281_N	285_V	0.893	1.00
253_C	257_A	0.892	1.00
233_V	238_L	0.887	1.00
24_L	36_G	0.883	1.00
103_L	170_T	0.881	1.00
30_S	60_R	0.878	1.00
69_L	204_V	0.876	1.00
274_W	289_L	0.868	1.00
296_L	300_L	0.868	1.00
322_P	326_W	0.867	1.00
78_G	268_P	0.867	1.00
323_C	326_W	0.867	1.00
305_A	308_G	0.867	1.00
11_W	14_P	0.865	1.00
174_A	177_H	0.865	1.00
10_L	14_P	0.864	1.00
41_R	44_L	0.864	1.00
72_A	208_V	0.863	1.00
53_E	58_N	0.861	1.00
97_I	129_G	0.846	1.00
301_A	311_P	0.844	1.00
109_S	121_L	0.843	1.00
77_A	246_V	0.842	1.00
279_Q	284_P	0.839	1.00
225_D	229_H	0.837	1.00
34_V	56_V	0.835	1.00
219_N	280_R	0.834	1.00
41_R	45_P	0.832	1.00
11_W	15_V	0.831	1.00
73_S	77_A	0.830	1.00
16_A	288_L	0.829	1.00
215_A	280_R	0.823	1.00
20_I	24_L	0.821	1.00
141_G	146_T	0.818	1.00
93_S	98_N	0.813	1.00
41_R	46_G	0.811	1.00
214_L	245_L	0.810	1.00
116_I	120_S	0.810	1.00
105_M	121_L	0.810	1.00
99_S	102_A	0.810	1.00
278_D	281_N	0.808	1.00
181_I	185_L	0.805	1.00
272_R	282_V	0.793	1.00
64_S	295_L	0.787	1.00
211_V	242_I	0.783	1.00
137_M	236_T	0.783	1.00
205_V	209_P	0.782	1.00
63_R	302_R	0.782	1.00
179_Y	182_F	0.780	1.00
108_T	121_L	0.776	1.00
75_A	79_T	0.775	1.00
130_G	251_G	0.775	1.00
240_L	244_M	0.774	1.00
129_G	247_L	0.772	1.00
203_V	207_A	0.767	1.00
304_L	307_P	0.766	1.00
101_A	129_G	0.764	1.00
210_V	213_L	0.764	1.00
235_L	239_R	0.763	1.00
225_D	235_L	0.763	1.00
137_M	240_L	0.762	1.00
294_M	316_L	0.762	1.00
127_C	131_V	0.761	1.00
318_L	322_P	0.758	1.00
271_A	275_A	0.757	1.00
126_A	130_G	0.756	1.00
243_N	247_L	0.756	1.00
228_A	235_L	0.754	1.00
26_L	302_R	0.752	1.00
61_L	194_W	0.748	1.00
72_A	204_V	0.747	1.00
28_C	33_P	0.747	1.00
34_V	52_P	0.746	1.00
107_L	112_S	0.745	1.00
176_D	180_G	0.744	1.00
288_L	292_T	0.742	1.00
39_A	42_A	0.741	1.00
141_G	147_H	0.740	1.00
138_T	141_G	0.739	1.00
219_N	284_P	0.739	1.00
19_I	23_W	0.737	1.00
263_I	316_L	0.736	1.00
20_I	23_W	0.730	1.00
120_S	123_F	0.729	1.00
75_A	287_M	0.723	1.00
63_R	309_D	0.723	1.00
81_L	95_L	0.722	1.00
303_A	306_F	0.720	1.00
91_S	94_L	0.719	1.00
271_A	274_W	0.719	1.00
106_A	171_L	0.718	1.00
74_L	263_I	0.717	1.00
212_L	215_A	0.716	1.00
136_V	140_G	0.716	1.00
195_Q	198_W	0.715	1.00
204_V	253_C	0.714	1.00
19_I	295_L	0.712	1.00
305_A	310_L	0.710	1.00
21_I	24_L	0.706	1.00
50_T	54_A	0.705	1.00
76_L	211_V	0.705	1.00
76_L	283_L	0.704	1.00
133_W	243_N	0.703	1.00
196_D	256_V	0.703	1.00
200_L	252_A	0.703	1.00
32_I	36_G	0.701	1.00
29_Y	33_P	0.701	1.00
100_G	163_C	0.700	1.00
66_V	200_L	0.698	1.00
132_S	136_V	0.695	1.00
270_L	289_L	0.691	1.00
32_I	35_S	0.687	1.00
85_T	153_I	0.687	1.00
97_I	133_W	0.686	1.00
102_A	259_P	0.686	1.00
107_L	166_L	0.684	1.00
65_L	69_L	0.684	1.00
54_A	59_L	0.681	1.00
252_A	256_V	0.678	1.00
217_Q	233_V	0.677	1.00
174_A	178_A	0.674	1.00
293_L	297_A	0.669	1.00
213_L	217_Q	0.668	1.00
201_L	205_V	0.666	1.00
229_H	235_L	0.664	1.00
182_F	185_L	0.661	1.00
200_L	203_V	0.655	1.00
273_F	327_L	0.650	1.00
252_A	255_S	0.649	1.00
83_T	222_N	0.648	1.00
77_A	250_V	0.648	1.00
70_I	189_V	0.647	1.00
260_V	312_A	0.644	1.00
291_A	295_L	0.643	1.00
268_P	286_S	0.642	1.00
121_L	124_I	0.640	1.00
171_L	182_F	0.639	1.00
119_Y	123_F	0.638	1.00
139_A	155_A	0.636	1.00
34_V	42_A	0.635	1.00
109_S	180_G	0.635	1.00
11_W	274_W	0.634	1.00
109_S	181_I	0.633	1.00
221_L	235_L	0.632	1.00
21_I	25_S	0.632	1.00
130_G	247_L	0.631	1.00
207_A	211_V	0.631	1.00
294_M	312_A	0.631	1.00
15_V	19_I	0.628	1.00
287_M	291_A	0.628	1.00
27_F	61_L	0.627	1.00
91_S	264_G	0.626	1.00
23_W	27_F	0.625	1.00
61_L	65_L	0.624	1.00
203_V	248_L	0.624	1.00
54_A	57_Q	0.624	1.00
298_D	309_D	0.622	1.00
45_P	53_E	0.620	1.00
270_L	273_F	0.620	1.00
14_P	18_L	0.620	1.00
49_P	53_E	0.620	1.00
98_N	101_A	0.618	1.00
67_A	312_A	0.617	1.00
27_F	56_V	0.615	1.00
24_L	40_T	0.615	1.00
36_G	39_A	0.614	1.00
168_R	184_W	0.614	1.00
189_V	312_A	0.614	1.00
104_A	108_T	0.613	1.00
297_A	315_V	0.612	1.00
128_G	132_S	0.610	1.00
48_T	52_P	0.609	1.00
85_T	88_P	0.606	1.00
35_S	52_P	0.605	1.00
177_H	180_G	0.603	1.00
263_I	293_L	0.603	1.00
133_W	137_M	0.601	1.00
37_A	40_T	0.601	1.00
296_L	299_V	0.599	1.00
150_N	153_I	0.598	1.00
72_A	76_L	0.596	1.00
208_V	212_L	0.596	1.00
194_W	198_W	0.596	1.00
164_M	185_L	0.595	1.00
80_L	245_L	0.593	1.00
270_L	293_L	0.591	1.00
148_D	151_K	0.590	1.00
81_L	90_A	0.589	1.00
293_L	319_I	0.588	1.00
140_G	155_A	0.588	1.00
168_R	172_L	0.588	1.00
99_S	160_S	0.587	1.00
36_G	40_T	0.587	1.00
301_A	309_D	0.585	1.00
204_V	208_V	0.585	1.00
39_A	43_L	0.581	1.00
250_V	254_V	0.578	0.99
251_G	255_S	0.578	0.99
266_L	323_C	0.577	0.99
26_L	295_L	0.576	0.99
11_W	275_A	0.574	0.99
219_N	222_N	0.573	0.99
301_A	304_L	0.573	0.99
284_P	288_L	0.572	0.99
138_T	142_G	0.572	0.99
164_M	168_R	0.571	0.99
217_Q	220_L	0.570	0.99
276_G	284_P	0.569	0.99
265_L	327_L	0.569	0.99
29_Y	299_V	0.567	0.99
108_T	120_S	0.567	0.99
266_L	324_F	0.565	0.99
75_A	290_G	0.565	0.99
241_V	245_L	0.564	0.99
246_V	251_G	0.564	0.99
213_L	216_N	0.562	0.99
155_A	158_A	0.559	0.99
66_V	70_I	0.559	0.99
270_L	323_C	0.557	0.99
137_M	141_G	0.557	0.99
41_R	48_T	0.557	0.99
56_V	61_L	0.554	0.99
280_R	284_P	0.554	0.99
271_A	286_S	0.554	0.99
28_C	40_T	0.551	0.99
206_T	210_V	0.550	0.99
135_L	138_T	0.549	0.99
12_G	16_A	0.548	0.99
266_L	270_L	0.545	0.99
19_I	64_S	0.544	0.99
81_L	97_I	0.543	0.99
234_N	241_V	0.542	0.99
242_I	246_V	0.541	0.99
247_L	251_G	0.536	0.99
189_V	257_A	0.534	0.99
295_L	299_V	0.533	0.99
31_A	307_P	0.533	0.99
111_L	114_T	0.532	0.99
211_V	283_L	0.532	0.99
99_S	164_M	0.531	0.99
127_C	130_G	0.529	0.99
299_V	303_A	0.524	0.99
131_V	134_L	0.524	0.99
97_I	136_V	0.524	0.99
195_Q	199_Q	0.522	0.99
218_L	279_Q	0.521	0.99
178_A	181_I	0.521	0.99
25_S	299_V	0.521	0.99
221_L	238_L	0.520	0.99
197_V	201_L	0.520	0.99
197_V	200_L	0.519	0.99
101_A	125_A	0.519	0.99
38_D	45_P	0.519	0.99
216_N	219_N	0.518	0.99
46_G	49_P	0.518	0.99
90_A	97_I	0.518	0.99
171_L	185_L	0.518	0.99
79_T	271_A	0.516	0.99
135_L	159_L	0.514	0.99
39_A	44_L	0.514	0.99
219_N	282_V	0.514	0.99
141_G	145_H	0.513	0.99
211_V	215_A	0.512	0.99
108_T	112_S	0.512	0.99
241_V	244_M	0.511	0.99
66_V	257_A	0.511	0.99
38_D	48_T	0.509	0.99
155_A	159_L	0.509	0.99
199_Q	252_A	0.509	0.99
105_M	124_I	0.508	0.99
260_V	316_L	0.508	0.99
140_G	152_L	0.506	0.99
17_A	20_I	0.505	0.99
14_P	17_A	0.505	0.99
86_H	225_D	0.504	0.99
265_L	268_P	0.503	0.99
12_G	288_L	0.502	0.99
23_W	65_L	0.502	0.99
172_L	314_A	0.502	0.99
204_V	209_P	0.502	0.99
261_A	266_L	0.501	0.99
97_I	188_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nq2A	2	0.9247	100	0.173	Contact Map
2qi9A	2	0.9548	100	0.186	Contact Map
4g1uA	2	0.8916	100	0.187	Contact Map
3rlbA	1	0.509	19.5	0.963	Contact Map
4tkrA	2	0.5181	14.6	0.965	Contact Map
4rfsS	1	0.5211	12.2	0.966	Contact Map
1zcdA	1	0.509	11.4	0.966	Contact Map
4huqS	1	0.4699	9.8	0.967	Contact Map
4z7fA	2	0.488	7.7	0.969	Contact Map
4xtrG	1	0.0663	6.6	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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